CN101674728A - 降低曲马多的副作用 - Google Patents

降低曲马多的副作用 Download PDF

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Publication number
CN101674728A
CN101674728A CN200880011692A CN200880011692A CN101674728A CN 101674728 A CN101674728 A CN 101674728A CN 200880011692 A CN200880011692 A CN 200880011692A CN 200880011692 A CN200880011692 A CN 200880011692A CN 101674728 A CN101674728 A CN 101674728A
Authority
CN
China
Prior art keywords
tramadol
inhibitor
side effect
pharmacy
pde5 inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880011692A
Other languages
English (en)
Chinese (zh)
Inventor
戴维·巴-奥尔
凯文·比尔亚德
詹姆斯·V·温克勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virex Pharmaceutical Co ltd
Ampio Pharmaceuticals Inc
Original Assignee
DMI Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DMI Biosciences Inc filed Critical DMI Biosciences Inc
Publication of CN101674728A publication Critical patent/CN101674728A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880011692A 2007-02-12 2008-02-12 降低曲马多的副作用 Pending CN101674728A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88938007P 2007-02-12 2007-02-12
US60/889,380 2007-02-12
PCT/US2008/053722 WO2008100933A2 (en) 2007-02-12 2008-02-12 Reducing side effects of tramadol

Publications (1)

Publication Number Publication Date
CN101674728A true CN101674728A (zh) 2010-03-17

Family

ID=39690762

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880011692A Pending CN101674728A (zh) 2007-02-12 2008-02-12 降低曲马多的副作用

Country Status (16)

Country Link
US (3) US20080261991A1 (enExample)
EP (2) EP2486921A1 (enExample)
JP (1) JP5550101B2 (enExample)
KR (2) KR20130122023A (enExample)
CN (1) CN101674728A (enExample)
AU (1) AU2008216363B2 (enExample)
BR (1) BRPI0807281A2 (enExample)
CA (1) CA2677691C (enExample)
DK (1) DK2114147T3 (enExample)
ES (1) ES2384127T3 (enExample)
MX (1) MX2009008511A (enExample)
NZ (1) NZ579170A (enExample)
PL (1) PL2114147T3 (enExample)
SG (1) SG178775A1 (enExample)
WO (1) WO2008100933A2 (enExample)
ZA (1) ZA200906187B (enExample)

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BRPI0807282A2 (pt) * 2007-02-12 2014-04-29 Dmi Biosciences Inc Tratamento de ejaculação precoce e disfunção erétil co-mórbidas
US8202525B2 (en) 2009-12-22 2012-06-19 Pondera Biotechnologies, LLC Methods and compositions for treating distress dysfunction and enhancing safety and efficacy of specific medications
WO2012142273A1 (en) * 2011-04-12 2012-10-18 Revogenex Inc. Intravenous administration of tramadol
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US20160228485A1 (en) * 2015-02-11 2016-08-11 Latasha M. Watts Skin medicating system
US9693949B1 (en) 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol
US9980900B2 (en) 2015-12-22 2018-05-29 Revogenex Ireland Ltd Intravenous administration of tramadol
US10022321B2 (en) 2016-06-30 2018-07-17 Revogenex Ireland Ltd. Intravenous administration of tramadol
WO2020006606A1 (en) * 2018-07-05 2020-01-09 Helium 3 Resources Pty Ltd A pharmaceutical composition and method of use of same
CA3187455A1 (en) * 2020-07-29 2022-02-03 Stephen Kwaku DORDUNOO Pharmaceutical formulations comprising tadalafil
US11504332B2 (en) * 2021-03-23 2022-11-22 Vk Research Associates Inc. Phosphodiesterase-4 inhibitor combinations, methods of making, and methods of use thereof
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Also Published As

Publication number Publication date
WO2008100933A2 (en) 2008-08-21
KR101497509B1 (ko) 2015-03-03
AU2008216363A1 (en) 2008-08-21
ZA200906187B (en) 2013-02-27
CA2677691A1 (en) 2008-08-21
JP5550101B2 (ja) 2014-07-16
CA2677691C (en) 2012-07-31
EP2114147B9 (en) 2013-04-10
EP2486921A1 (en) 2012-08-15
SG178775A1 (en) 2012-03-29
EP2114147B1 (en) 2012-05-16
ES2384127T3 (es) 2012-06-29
BRPI0807281A2 (pt) 2014-04-29
EP2114147A2 (en) 2009-11-11
MX2009008511A (es) 2010-01-20
US20080261991A1 (en) 2008-10-23
NZ579170A (en) 2012-05-25
EP2114147A4 (en) 2010-04-07
US20120018333A1 (en) 2012-01-26
PL2114147T3 (pl) 2012-10-31
AU2008216363B2 (en) 2014-05-08
JP2010518168A (ja) 2010-05-27
KR20090127277A (ko) 2009-12-10
KR20130122023A (ko) 2013-11-06
WO2008100933A3 (en) 2008-10-16
DK2114147T3 (da) 2012-06-25
HK1131730A1 (en) 2010-02-05
US20130338166A1 (en) 2013-12-19

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: WEIRUIKESI PHARMACEUTICAL CO., LTD.

Free format text: FORMER OWNER: AMPI'O PHARMACEUTICAL CO., LTD.

Effective date: 20140214

Owner name: AMPI'O PHARMACEUTICAL CO., LTD.

Free format text: FORMER OWNER: DMI BIOSCIENCES, INC.

Effective date: 20140214

TA01 Transfer of patent application right

Effective date of registration: 20140214

Address after: American Colorado

Applicant after: Virex Pharmaceutical Co.,Ltd.

Address before: American Colorado

Applicant before: Ampio Pharmaceuticals, Inc.

Effective date of registration: 20140214

Address after: American Colorado

Applicant after: Ampio Pharmaceuticals, Inc.

Address before: American Colorado

Applicant before: DMI Biosciences, Inc.

TA01 Transfer of patent application right
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100317