JP5544660B2 - ヒトアドレナリンβ３受容体リガンド、これを含む食品及び医薬品 - Google Patents
ヒトアドレナリンβ３受容体リガンド、これを含む食品及び医薬品 Download PDFInfo
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- JP5544660B2 JP5544660B2 JP2010516877A JP2010516877A JP5544660B2 JP 5544660 B2 JP5544660 B2 JP 5544660B2 JP 2010516877 A JP2010516877 A JP 2010516877A JP 2010516877 A JP2010516877 A JP 2010516877A JP 5544660 B2 JP5544660 B2 JP 5544660B2
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| JP2010516877A JP5544660B2 (ja) | 2008-06-11 | 2009-06-11 | ヒトアドレナリンβ３受容体リガンド、これを含む食品及び医薬品 |
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| JP2010516877A JP5544660B2 (ja) | 2008-06-11 | 2009-06-11 | ヒトアドレナリンβ３受容体リガンド、これを含む食品及び医薬品 |
| PCT/JP2009/060682 WO2009151094A1 (ja) | 2008-06-11 | 2009-06-11 | ヒトアドレナリンβ3受容体リガンド、これを含む食品及び医薬品 |
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| JPWO2009151094A1 JPWO2009151094A1 (ja) | 2011-11-17 |
| JP5544660B2 true JP5544660B2 (ja) | 2014-07-09 |
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| JP2014013224A Pending JP2014080432A (ja) | 2008-06-11 | 2014-01-28 | ヒトアドレナリンβ３受容体リガンド、これを含む食品及び医薬品 |
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| EP (1) | EP2316445A4 (enExample) |
| JP (2) | JP5544660B2 (enExample) |
| KR (1) | KR101274543B1 (enExample) |
| CN (1) | CN102149375B (enExample) |
| CA (1) | CA2727223C (enExample) |
| WO (1) | WO2009151094A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2922552T3 (es) * | 2014-11-03 | 2022-09-16 | Nestle Sa | Métodos que utilizan la temperatura facial para evaluar el impacto posterior a la ingestión de los ingredientes alimentarios en la oxidación de grasas |
| US9561206B2 (en) * | 2015-01-07 | 2017-02-07 | The United States Of America, As Represented By The Secretary Of The Navy | Use of heptadecanoic acid (C17:0) to detect risk of and treat hyperferritinemia and metabolic syndrome |
| EP3661600A4 (en) | 2017-10-23 | 2021-08-11 | Epitracker, Inc. | FATTY ACID ANALOGS AND ITS USE IN THE TREATMENT OF DISEASES RELATED TO METABOLISM SYNDROME |
| AU2019274431B2 (en) | 2018-05-23 | 2025-03-13 | Epitracker, Inc. | Compositions and methods for diagnosis and treatment of conditions related to the quality of aging and longevity |
| EP3908374A4 (en) | 2019-01-09 | 2022-12-28 | Epitracker, Inc. | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES |
| JP7404382B2 (ja) | 2019-03-04 | 2023-12-25 | エピトラッカー インコーポレイテッド | 脂肪酸アナログ、ならびに認知機能障害、行動症状および慢性疼痛の処置におけるそれらの使用 |
| JP7500037B2 (ja) * | 2019-07-24 | 2024-06-17 | 国立大学法人 東京大学 | 血中尿酸値低下剤及び血中尿酸値低下用食品組成物 |
| WO2023080939A1 (en) | 2021-11-03 | 2023-05-11 | Epitracker, Inc. | Pentadecanoylcarnitine for treatment of conditions related to the quality of aging and longevity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996031240A1 (en) * | 1995-04-07 | 1996-10-10 | Brandeis University | Increasing the hdl level and the hdl/ldl ratio in human serum by balancing saturated and polyunsaturated dietary fatty acids |
| JP2005179264A (ja) * | 2003-12-19 | 2005-07-07 | Shokubutsu Kogaku Kenkyusho:Kk | 体重増加抑制剤 |
| WO2008000440A1 (en) * | 2006-06-27 | 2008-01-03 | Lipid Nutrition B.V. | Use of a polyunsaturated fatty acid compound |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2173545C (en) * | 1995-04-07 | 2004-06-29 | Kalyana Sundram | Increasing the hdl level and the hdl/ldl ratio in human serum by balancing saturated and polyunsaturated dietary fatty acids |
| EP1285590A1 (en) * | 2001-08-08 | 2003-02-26 | Société des Produits Nestlé S.A. | Lipid blends |
| RU2305547C2 (ru) * | 2001-08-23 | 2007-09-10 | Вестгейт Байолоджикал Лимитед | Применение апопротеинов сыворотки молока в профилактике или лечении микробной или вирусной инфекции |
| EP1508335B1 (en) * | 2002-05-27 | 2011-09-28 | Morinaga & Co. Ltd. | Compositions comprising a cocoa fraction for use in the treatment of periodontitis caused by bacteria belonging to genus porphyromonas, prevotella, fusobacterium or actinobacillus |
| JP2004075653A (ja) * | 2002-06-19 | 2004-03-11 | Nisshin Oillio Ltd | 体脂肪分解促進剤および飲食物 |
| WO2004022049A1 (ja) * | 2002-09-05 | 2004-03-18 | The Nisshin Oillio Group, Ltd. | 痩身剤およびその飲食物 |
| AU2003261928A1 (en) * | 2002-09-05 | 2004-03-29 | The Nisshin Oillio Group, Ltd. | Agents, foods and drinks controlling lipid metabolism |
| JP5102435B2 (ja) | 2002-10-08 | 2012-12-19 | 株式会社リコム | キトサン含有多糖、その製造方法及び用途 |
| JP2006096666A (ja) | 2002-10-31 | 2006-04-13 | Kaneka Corp | 選択的ヒトβ３アドレナリン受容体アゴニスト剤 |
| JP2005015358A (ja) * | 2003-06-25 | 2005-01-20 | Pharma Design Inc | 摂食障害の治療に供される医薬組成物 |
| US20080146657A1 (en) * | 2003-11-04 | 2008-06-19 | Hiroshi Tsuboi | Plant-Origin Alpha3-Adrenoceptor Agonist and Use of the Same |
| US20060084637A1 (en) * | 2004-10-18 | 2006-04-20 | Maria Alemany | Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same |
| US20080200707A1 (en) * | 2005-01-04 | 2008-08-21 | Mochida-Pharmaceuticals Pharmaceutical Co., Ltd. | Lipotoxicity Relieving Agent |
| CA2593768C (en) * | 2005-01-04 | 2014-02-18 | Mochida Pharmaceutical Co., Ltd. | Use of .omega.3 unsaturated fatty acids for relieving lipotoxicity |
| GB0514463D0 (en) * | 2005-01-31 | 2005-08-17 | Loders Croklaan Bv | Use of pinolenic acid |
-
2009
- 2009-06-11 CN CN200980131312.3A patent/CN102149375B/zh not_active Expired - Fee Related
- 2009-06-11 WO PCT/JP2009/060682 patent/WO2009151094A1/ja not_active Ceased
- 2009-06-11 CA CA2727223A patent/CA2727223C/en active Active
- 2009-06-11 US US12/997,498 patent/US20110098358A1/en not_active Abandoned
- 2009-06-11 JP JP2010516877A patent/JP5544660B2/ja active Active
- 2009-06-11 KR KR1020117000640A patent/KR101274543B1/ko not_active Expired - Fee Related
- 2009-06-11 EP EP09762524A patent/EP2316445A4/en not_active Withdrawn
-
2014
- 2014-01-28 JP JP2014013224A patent/JP2014080432A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996031240A1 (en) * | 1995-04-07 | 1996-10-10 | Brandeis University | Increasing the hdl level and the hdl/ldl ratio in human serum by balancing saturated and polyunsaturated dietary fatty acids |
| JP2005179264A (ja) * | 2003-12-19 | 2005-07-07 | Shokubutsu Kogaku Kenkyusho:Kk | 体重増加抑制剤 |
| WO2008000440A1 (en) * | 2006-06-27 | 2008-01-03 | Lipid Nutrition B.V. | Use of a polyunsaturated fatty acid compound |
Non-Patent Citations (2)
| Title |
|---|
| JPN6009041483; Ｂａｒｒｅ Ｄ． Ｅ．: 'Ｐｏｔｅｎｔｉａｌ ｏｆ Ｅｖｅｎｉｎｇ Ｐｒｉｍｒｏｓｅ， Ｂｏｒａｇｅ， Ｂｌａｃｋ Ｃｕｒｒａｎｔ， ａｎｄ Ｆｕｎｇａｌ Ｏｉｌｓ ｉｎ Ｈｕｍａｎ Ｈｅａｌｔｈ' Ｎｕｔｒｉｔｉｏｎ ＆ Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．４５, 2001, ｐ．４７-５７ * |
| JPN6013036925; Ｅｍｉｌｉｏ Ｈｅｒｒｅｒａ， Ｅｎｃａｒｎａｃｉｏｎ Ａｍｕｓｑｕｉｖａｒ， ａｎｄ Ｊｕｄｉｔｈ Ｃａｃｈｏ: 'Ｃｈａｎｇｅｓ ｉｎ ｄｉｅｔａｒｙ ｆａｔｔｙ ａｃｉｄｓ ｍｏｄｉｆｙ ｔｈｅ ｄｅｃｒｅａｓｅｄ ｌｉｐｏｌｙｔｉｃ beta３-ａｄｒｅｎｅｒｇｉｃ ｒｅｓｐｏｎｓｅ ｔｏ ｈｙｐｅｒｉｎｓｕｌｉ' Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌｕｍｅ４９， Ｉｓｓｕｅ９, 200009, １１８０-１１８７, Ｅｌｓｅｖｉｅｒ * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102149375B (zh) | 2015-09-30 |
| JPWO2009151094A1 (ja) | 2011-11-17 |
| CN102149375A (zh) | 2011-08-10 |
| CA2727223C (en) | 2014-10-07 |
| EP2316445A1 (en) | 2011-05-04 |
| EP2316445A4 (en) | 2011-12-21 |
| CA2727223A1 (en) | 2009-12-17 |
| JP2014080432A (ja) | 2014-05-08 |
| KR101274543B1 (ko) | 2013-06-17 |
| US20110098358A1 (en) | 2011-04-28 |
| WO2009151094A1 (ja) | 2009-12-17 |
| KR20110017437A (ko) | 2011-02-21 |
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