JP5543956B2 - 癌の処置のための方法および組成物 - Google Patents
癌の処置のための方法および組成物 Download PDFInfo
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- JP5543956B2 JP5543956B2 JP2011501983A JP2011501983A JP5543956B2 JP 5543956 B2 JP5543956 B2 JP 5543956B2 JP 2011501983 A JP2011501983 A JP 2011501983A JP 2011501983 A JP2011501983 A JP 2011501983A JP 5543956 B2 JP5543956 B2 JP 5543956B2
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- cisplatin
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- arsenic
- sodium meta
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Inorganic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US61/039,987 | 2008-03-27 | ||
| US12/408,864 US20090246291A1 (en) | 2008-03-27 | 2009-03-23 | Method and compositions for treatment of cancer |
| US12/408,864 | 2009-03-23 | ||
| PCT/US2009/038104 WO2009120697A2 (en) | 2008-03-27 | 2009-03-24 | Method and compositions for treatment of cancer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013504587A (ja) * | 2009-09-10 | 2013-02-07 | コミノックス・インコーポレイテッド | 癌幹細胞を標的とした薬剤耐性癌治療法 |
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| EP1721615A1 (en) * | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US8795738B2 (en) * | 2009-11-12 | 2014-08-05 | Board Of Regents Of The University Of Texas System | Use of arsenic for cancer therapy protection |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| JP6034288B2 (ja) * | 2010-07-18 | 2016-11-30 | ニーキ ファーマ インコーポレイテッド | ルテニウム錯体を用いる併用療法 |
| KR101806255B1 (ko) * | 2010-08-24 | 2017-12-07 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| US20120251628A1 (en) * | 2011-03-30 | 2012-10-04 | Young Joo Min | Compositions and methods for treatment of cancer |
| CA2835631A1 (en) * | 2011-05-12 | 2012-11-15 | Board Of Regents, The University Of Texas System | Use of arsenic for cancer therapy protection |
| US8834938B2 (en) | 2011-05-18 | 2014-09-16 | Board Of Regents Of The University Of Texas System | Use of arsenic for cancer therapy protection |
| US20160184356A1 (en) * | 2013-03-15 | 2016-06-30 | Ke Jian Jim Liu | Arsenic-based treatment of cancers and inflammatory disorders |
| KR101309844B1 (ko) | 2013-03-15 | 2013-09-23 | 박상채 | 항암 활성 증진용 한약재 및 이의 제조방법 |
| AU2014290012B2 (en) * | 2013-07-19 | 2020-01-16 | Onyx Therapeutics, Inc. | Peptide epoxyketone proteasome inhibitors in combination with PIM kinase inhibitors for treatment of cancers |
| MX384297B (es) * | 2016-12-01 | 2025-03-14 | Eupharma Pty Ltd | Composiciones de arsénico. |
| CA3094115A1 (en) * | 2018-03-22 | 2019-09-26 | Komipharm International Australia Pty Ltd | Pharmaceutical composition comprising meta arsenite and method of manufacture |
| CN116236505A (zh) * | 2023-03-15 | 2023-06-09 | 上海市第四人民医院 | 三氧化二砷在制备肺神经内分泌癌治疗药物中的应用 |
Family Cites Families (7)
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| ATE407683T1 (de) * | 1997-10-15 | 2008-09-15 | Polarx Biopharmaceuticals Inc | Pharmazeutische zusammensetzungen enthaltend arsentrioxid zur behandlung von multiplen myelom |
| IL136051A0 (en) * | 1997-11-10 | 2001-05-20 | Sloan Kettering Inst Cancer | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| KR20020083678A (ko) * | 2001-04-28 | 2002-11-04 | 주식회사 한국미생물연구소 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
| CA2481602C (en) * | 2002-04-10 | 2011-06-21 | Korea Microbiological Laboratories, Ltd. | Pharmaceutical composition comprising arsenite for the treatment of malignancy |
| EP1721615A1 (en) * | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US8097237B2 (en) * | 2005-08-23 | 2012-01-17 | Stc.Unm | Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma |
| US7867492B2 (en) * | 2007-10-12 | 2011-01-11 | The John Hopkins University | Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013504587A (ja) * | 2009-09-10 | 2013-02-07 | コミノックス・インコーポレイテッド | 癌幹細胞を標的とした薬剤耐性癌治療法 |
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| RU2010143893A (ru) | 2012-05-10 |
| SI2268292T1 (en) | 2018-03-30 |
| CY1120536T1 (el) | 2019-07-10 |
| RU2508116C2 (ru) | 2014-02-27 |
| CN102046187A (zh) | 2011-05-04 |
| WO2009120697A3 (en) | 2010-02-18 |
| ZA201006988B (en) | 2012-05-30 |
| US20090246291A1 (en) | 2009-10-01 |
| ES2656762T3 (es) | 2018-02-28 |
| US20180055812A1 (en) | 2018-03-01 |
| WO2009120697A2 (en) | 2009-10-01 |
| WO2009120697A4 (en) | 2010-04-15 |
| CA2719766A1 (en) | 2009-10-01 |
| PL2268292T3 (pl) | 2018-06-29 |
| MX2010010621A (es) | 2011-04-05 |
| PT2268292T (pt) | 2018-02-19 |
| LT2268292T (lt) | 2018-03-26 |
| HUE036609T2 (hu) | 2018-07-30 |
| EP2268292A4 (en) | 2011-05-11 |
| KR20110009664A (ko) | 2011-01-28 |
| AU2009228378A1 (en) | 2009-10-01 |
| EP2268292A2 (en) | 2011-01-05 |
| EP2268292B1 (en) | 2017-12-27 |
| CN104997808A (zh) | 2015-10-28 |
| BRPI0909164A2 (pt) | 2016-06-21 |
| DK2268292T3 (en) | 2018-03-12 |
| JP2014101387A (ja) | 2014-06-05 |
| KR101634138B1 (ko) | 2016-06-28 |
| AU2009228378B2 (en) | 2014-07-17 |
| JP2011515481A (ja) | 2011-05-19 |
| CA2719766C (en) | 2017-10-31 |
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