JP5539727B2 - ヒドロゲルを形成する新規な注入可能なキトサン混合物 - Google Patents

ヒドロゲルを形成する新規な注入可能なキトサン混合物 Download PDF

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Publication number
JP5539727B2
JP5539727B2 JP2009540967A JP2009540967A JP5539727B2 JP 5539727 B2 JP5539727 B2 JP 5539727B2 JP 2009540967 A JP2009540967 A JP 2009540967A JP 2009540967 A JP2009540967 A JP 2009540967A JP 5539727 B2 JP5539727 B2 JP 5539727B2
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chitosan
composition
drugs
agent
gel
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Japanese (ja)
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JP2010512220A5 (enExample
JP2010512220A (ja
Inventor
ノア ベン−シャロム
ズヴィ ネヴォ
アブラハム パチョルニク
ドロール ロビンソン
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チット2ジェル リミテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2009540967A 2006-12-11 2007-12-11 ヒドロゲルを形成する新規な注入可能なキトサン混合物 Expired - Fee Related JP5539727B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87393106P 2006-12-11 2006-12-11
US60/873,931 2006-12-11
US92458207P 2007-05-21 2007-05-21
US60/924,582 2007-05-21
PCT/IL2007/001530 WO2008072230A1 (en) 2006-12-11 2007-12-11 Novel injectable chitosan mixtures forming hydrogels

Publications (3)

Publication Number Publication Date
JP2010512220A JP2010512220A (ja) 2010-04-22
JP2010512220A5 JP2010512220A5 (enExample) 2011-02-10
JP5539727B2 true JP5539727B2 (ja) 2014-07-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009540967A Expired - Fee Related JP5539727B2 (ja) 2006-12-11 2007-12-11 ヒドロゲルを形成する新規な注入可能なキトサン混合物

Country Status (5)

Country Link
EP (1) EP2121026B1 (enExample)
JP (1) JP5539727B2 (enExample)
AU (1) AU2007331071A1 (enExample)
CA (1) CA2672495C (enExample)
WO (1) WO2008072230A1 (enExample)

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FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US9034348B2 (en) 2006-12-11 2015-05-19 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
HUE042931T2 (hu) 2007-11-16 2019-07-29 Aclaris Therapeutics Inc Kompozíciók és eljárások purpura kezelésére
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
JP5746617B2 (ja) * 2008-06-11 2015-07-08 チ2ジェル リミテッドChi2Gel Ltd. キトサン混合物を形成する注入可能なヒドロゲル
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
CA2771365A1 (en) * 2009-09-01 2011-03-10 Medovent Gmbh Chitosan tissue dressing
AU2010289417B2 (en) 2009-09-02 2015-08-13 Synedgen, Inc. Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
DE102010009475B4 (de) * 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
CA2792729C (en) 2010-03-12 2016-06-28 Allergan Industrie, Sas Fluid compositions for improving skin conditions
HUE030138T2 (en) 2010-03-22 2017-04-28 Allergan Inc Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US11311644B2 (en) 2010-09-01 2022-04-26 Medoderm Gmbh Antimicrobial and/or epithelial cell growth stimulating substance and composition and tissue dressing material
CN102727925B (zh) * 2011-04-02 2014-09-17 佛山市优特医疗科技有限公司 酰化壳聚糖伤口敷料、其制备方法及其应用
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
KR102154944B1 (ko) 2011-06-03 2020-09-11 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
FR2983070B1 (fr) 2011-11-30 2014-04-25 Cytosial Biomedic Solution aqueuse homogene de chitosane injectable
KR101502579B1 (ko) * 2012-10-31 2015-03-16 충남대학교산학협력단 소수성 치환기를 갖는 글리콜 키토산 유도체, 이의 제조방법 및 용도
WO2014117146A1 (en) * 2013-01-28 2014-07-31 Rutgers, The State University Of New Jersey Growth matrices for stem cell propagation in vitro and in tissue regeneration
CN103983593A (zh) * 2013-11-20 2014-08-13 中国科学院海洋研究所 一种测定壳聚糖与壳寡糖混合物的脱乙酰度的方法
WO2015186101A1 (en) * 2014-06-05 2015-12-10 University Of The Witwatersrand, Johannesburg Wound dressing
EP4420518A3 (en) 2014-09-11 2024-11-20 Synedgen, Inc. Compositions and methods of use thereof
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
PL3256179T3 (pl) 2015-02-13 2020-05-18 Allergan Industrie, Sas Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda
FR3035327B1 (fr) 2015-04-23 2021-07-02 Cytosial Biomedic Solution aqueuse homogene de chitosane ou derive de chitosane injectable presentant un ph proche du ph physiologique
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
JP6864001B2 (ja) * 2015-11-03 2021-04-21 ゾエティス・サービシーズ・エルエルシー ゾル−ゲルポリマー組成物及びそれらの使用
CN106046397A (zh) * 2016-06-28 2016-10-26 深圳市阳光之路生物材料科技有限公司 一种关节润滑材料及其制备方法
US10576099B2 (en) 2016-10-21 2020-03-03 Covidien Lp Injectable scaffold for treatment of intracranial aneurysms and related technology
EP3972562B1 (en) * 2019-05-22 2025-09-03 Università Degli Studi Di Torino Medical device comprising a chitosan-based support structure
CN114630627A (zh) 2019-11-04 2022-06-14 柯惠有限合伙公司 用于治疗颅内动脉瘤的装置、系统和方法
WO2022198208A1 (en) 2021-03-16 2022-09-22 Covidien Lp Injectable biopolymer compositions and associated systems and methods
CN114214838B (zh) * 2021-12-13 2023-11-07 宜兴市新立织造有限公司 一种蚕丝/凝胶多向纤维夹芯半月板及其制备方法
CN114773630B (zh) * 2022-05-24 2024-06-04 湖北工业大学 一种光热杀菌的粘附性水凝胶及其制备方法与应用
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CN116173291B (zh) * 2023-03-08 2025-04-22 重庆医科大学附属第二医院 一种壳聚糖重组人源化胶原蛋白凝胶及其制备方法与应用

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Also Published As

Publication number Publication date
CA2672495C (en) 2017-01-17
EP2121026B1 (en) 2017-06-28
WO2008072230A1 (en) 2008-06-19
JP2010512220A (ja) 2010-04-22
AU2007331071A1 (en) 2008-06-19
EP2121026A1 (en) 2009-11-25
CA2672495A1 (en) 2008-06-19

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