JP5539235B2 - アミド化合物、組成物およびそれらの使用 - Google Patents

アミド化合物、組成物およびそれらの使用 Download PDF

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JP5539235B2
JP5539235B2 JP2010548731A JP2010548731A JP5539235B2 JP 5539235 B2 JP5539235 B2 JP 5539235B2 JP 2010548731 A JP2010548731 A JP 2010548731A JP 2010548731 A JP2010548731 A JP 2010548731A JP 5539235 B2 JP5539235 B2 JP 5539235B2
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methyl
substituted
pyridin
unsubstituted
ethyl
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JP2011514894A (ja
JP2011514894A5 (enExample
Inventor
チー−リャン ウェイ,
スミスラ ゴウルガリ,
カール コーブ,
チャン ワン,
イェユ カオ,
ジョン キンケイド,
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Evotec OAI AG
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Evotec OAI AG
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Publication number Priority date Publication date Assignee Title
JP2014065737A (ja) * 2008-02-29 2014-04-17 Evotec Ag アミド化合物、組成物およびそれらの使用

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain
JP5535931B2 (ja) * 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
KR101605061B1 (ko) 2009-05-29 2016-03-21 라퀄리아 파마 인코포레이티드 칼슘 또는 나트륨 채널 차단제로서의 아릴 치환된 카복사미드 유도체
JP6165733B2 (ja) 2011-09-16 2017-07-19 ノバルティス アーゲー N−置換ヘテロシクリルカルボキサミド類
WO2013072758A1 (en) * 2011-11-15 2013-05-23 Purdue Pharma L.P. Pyrimidine diol amides as sodium channel blockers
JP6275690B2 (ja) * 2012-04-05 2018-02-07 シーエイチディーアイ ファウンデーション,インコーポレーテッド キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法
EP2774911A1 (de) * 2013-03-06 2014-09-10 LANXESS Deutschland GmbH Verfahren zur Herstellung von Halogen-N,N-dimethylbenzylaminen
ES2688452T3 (es) 2013-03-06 2018-11-02 Lanxess Deutschland Gmbh Procedimiento para la preparación de halo-N,N-dimetilbencilaminas
EP2970135B1 (en) 2013-03-14 2018-07-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
CA2903394C (en) 2013-03-14 2021-08-31 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9394258B2 (en) 2013-03-14 2016-07-19 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153172A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
JP2016514164A (ja) 2013-03-14 2016-05-19 エピザイム,インコーポレイティド アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970181B1 (en) 2013-03-14 2017-06-07 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP3363434A1 (en) 2013-03-14 2018-08-22 Epizyme Inc Arginine methyltransferase inhibitors and uses thereof
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
WO2014144169A1 (en) 2013-03-15 2014-09-18 Epizyme, Inc. Carm1 inhibitors and uses thereof
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
JP2016536350A (ja) 2013-09-26 2016-11-24 シーエイチディーアイ ファウンデーション,インコーポレーテッド キヌレニン−3−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法
JP6449893B2 (ja) 2013-09-26 2019-01-09 シーエイチディーアイ ファウンデーション,インコーポレーテッド キヌレニン−3−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法
JP6383418B2 (ja) * 2013-11-27 2018-08-29 ジェネンテック, インコーポレイテッド 置換ベンズアミド及びその使用方法
EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
EP3140298A1 (en) 2014-05-07 2017-03-15 Pfizer Inc. Tropomyosin-related kinase inhibitors
US20170280720A1 (en) * 2014-09-17 2017-10-05 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2016044641A2 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Carm1 inhibitors and uses thereof
US10183937B2 (en) * 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
CU24411B1 (es) 2014-12-09 2019-05-03 Bayer Ag Compuesto derivado de benzamida sustituida con 1,3-tiazol-2-ilo útil para el tratamiento de trastornos neurogénicos
WO2017112576A1 (en) * 2015-12-21 2017-06-29 Dow Global Technologies Llc Methods for external base-free suzuki couplings
CN106349153B (zh) * 2016-08-25 2019-03-05 西安天一生物技术股份有限公司 2-甲基-5-乙烯基吡啶合成方法
RU2679892C1 (ru) * 2017-11-01 2019-02-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) 4-метилфениламид n-бензоил-5-бром антраниловой кислоты, проявляющий противовоспалительную активность
SG11202011010YA (en) * 2018-05-15 2020-12-30 Bayer Ag 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
MA52616A (fr) * 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
US10844044B2 (en) 2018-06-14 2020-11-24 Vanderbilt University WDR5 inhibitors and modulators
US10807959B2 (en) * 2018-08-16 2020-10-20 Vanderbilt University WDR5-MLL1 inhibitors and modulators
US12186307B2 (en) 2019-02-13 2025-01-07 Yale University Methods of treating epilepsy
MA56022A (fr) 2019-05-31 2022-04-06 Chiesi Farm Spa Dérivés d'amino quinazoline servant d'inhibiteurs de p2x3
KR102923602B1 (ko) 2019-05-31 2026-02-06 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 피리도피리미딘 유도체
JP2022116370A (ja) * 2019-06-13 2022-08-10 アグロカネショウ株式会社 新規な1-ベンジルアミン誘導体及びこれを有効成分とする農園芸用薬剤
EP3757103A1 (en) * 2019-06-27 2020-12-30 Bayer AG Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases
US20230192631A1 (en) * 2020-04-16 2023-06-22 Hoffmann-La Roche Inc. Biphenyl Derivatives
WO2021238834A1 (zh) * 2020-05-25 2021-12-02 中国医药研究开发中心有限公司 芳甲酰胺类化合物及其制备方法和医药用途
CN116745284A (zh) 2020-11-27 2023-09-12 奇斯药制品公司 作为p2x3抑制剂的酞嗪衍生物
WO2022112490A1 (en) 2020-11-27 2022-06-02 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
JP2023550830A (ja) 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ P2x3阻害剤としての(アザ)キノリン4-アミン誘導体
AU2024282595A1 (en) * 2023-05-30 2026-01-22 Samjin Pharmaceutical Co., Ltd. Novel benzamide derivative compound and pharmaceutical composition comprising same
KR20260084522A (ko) * 2024-11-29 2026-06-05 삼진제약주식회사 벤즈아미드 유도체 화합물을 포함하는 항체-약물 접합체

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731469A (en) 1953-10-23 1956-01-17 Searle & Co N-dialkylaminoalkyl derivatives of diarylisonicotinamides
US3424760A (en) 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3424761A (en) 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
DE2502588A1 (de) 1975-01-23 1976-07-29 Troponwerke Dinklage & Co Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CA1316920C (en) 1987-06-12 1993-04-27 Terry N. Myers Hindered amine light stabilizers containing aromatic carboxy groups and derivatives
JPS6413083A (en) 1987-07-07 1989-01-17 Akishiro Nakamura Streptonigrin derivative and medicinal composition
US4916145A (en) 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
GB9600063D0 (en) 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives
US6037324A (en) 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
EP1177188B1 (en) 1999-05-12 2005-10-12 Ortho-McNeil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
US6531478B2 (en) 2000-02-24 2003-03-11 Cheryl P. Kordik Amino pyrazole derivatives useful for the treatment of obesity and other disorders
AU2001294557A1 (en) * 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
AU2002247208A1 (en) * 2001-03-05 2002-09-19 Icos Corporation Selective pde3b inhibitors and use of the same in therapy
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
EP1392643B1 (en) * 2001-05-18 2005-09-14 Abbott Laboratories Trisubstituted-n- (1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors
WO2008011131A2 (en) 2006-07-21 2008-01-24 Takeda Pharmaceutical Company Limited Amide compounds
TW200304374A (en) 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
EP1503997A1 (en) 2002-05-14 2005-02-09 Axys Pharmaceuticals, Inc. Cysteine protease inhibitors
AU2003242252A1 (en) 2002-06-07 2003-12-22 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
US20060122184A1 (en) 2002-12-05 2006-06-08 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
US20060100245A1 (en) 2002-12-19 2006-05-11 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues
WO2005032471A2 (en) 2003-10-03 2005-04-14 Merck & Co., Inc. Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
JP2007517781A (ja) 2003-12-19 2007-07-05 メルク エンド カムパニー インコーポレーテッド アルツハイマー病治療用のフェニルアミドおよびピリジルアミド系β−セクレターゼ阻害薬
WO2005073193A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2007537257A (ja) * 2004-05-13 2007-12-20 メルク エンド カムパニー インコーポレーテッド アルツハイマー病の治療用ベータセクレターゼ阻害剤として有用なフェニルカルボキサミド化合物
TW200640877A (en) 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
JP5198256B2 (ja) 2005-05-04 2013-05-15 エボテク エージー 縮合複素環式化合物、並びにそれらの組成物及び使用
EP1919861A2 (de) 2005-08-11 2008-05-14 Boehringer Ingelheim International GmbH Verbindungen zur behandlung der alzheimer erkrankung
CA2618474A1 (en) * 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Compounds for treating alzheimer's disease
MX2008002014A (es) * 2005-08-15 2008-03-27 Hoffmann La Roche Derivados de piperidina y piperazina como antagonistas de p2x3.
ES2612890T3 (es) 2005-09-01 2017-05-19 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
ES2562056T3 (es) 2005-09-01 2016-03-02 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores P2X3 y P2X2/3
SI1924264T1 (sl) 2005-09-01 2013-12-31 F. Hoffmann-La Roche Ag Diaminopirimidini kot modulatorji p2x3 in p2x2/3
AU2006286576B2 (en) 2005-09-01 2012-06-14 F. Hoffmann-La Roche Ag Diaminopyrimidines as P2X3 and P3X2/3 modulators
US7838676B2 (en) 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
ES2596706T3 (es) 2006-06-29 2017-01-11 F. Hoffmann-La Roche Ag Arilamidas con sustitución de tetrazol
WO2008023159A1 (en) 2006-08-24 2008-02-28 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
CL2007002920A1 (es) 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
JP5084839B2 (ja) * 2006-11-09 2012-11-28 エフ.ホフマン−ラ ロシュ アーゲー チアゾール及びオキサゾール置換アリールアミド
WO2008119773A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
US8076345B2 (en) 2007-04-17 2011-12-13 Evotec Ag 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof
WO2009058298A1 (en) 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain
EP2215048B1 (en) 2007-10-31 2015-10-28 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
US7989454B2 (en) * 2007-12-17 2011-08-02 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
KR101405746B1 (ko) 2007-12-17 2014-06-10 에프. 호프만-라 로슈 아게 트리아졸 치환된 아릴아미드 유도체 및 p2x3 및/또는 p2x2/3 퓨린성 수용체 길항제로서의 용도
DK2234976T3 (da) 2007-12-17 2013-06-24 Hoffmann La Roche Nye pyrazol-substituerede arylamider
BR122019016794B8 (pt) 2007-12-17 2021-07-27 Hoffmann La Roche derivados de arilamida substituídos por tetrazol, composição farmacêutica que os compreende e seu uso no tratamento de uma condição inflamatória e/ou autoimune
ES2570628T3 (es) 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
WO2009110985A2 (en) * 2008-02-29 2009-09-11 Renovis, Inc. Amide compounds, compositions and uses thereof
US20110237578A1 (en) * 2008-09-18 2011-09-29 Zhi-Liang Wei Amide compounds, compositions and uses thereof
CA2741666C (en) 2008-10-31 2017-04-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
BRPI0922645A2 (pt) 2008-12-16 2019-09-24 Hoffmann La Roche "arilamidas tiadiazol substituídas".
US8946231B2 (en) 2009-03-23 2015-02-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
JP2012521429A (ja) 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のp2x3受容体アンタゴニスト
WO2010111058A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
US20100320456A1 (en) * 2009-06-19 2010-12-23 Epv Solar, Inc. Method for Fabricating a Doped and/or Alloyed Semiconductor
EP2445868B1 (en) 2009-06-22 2013-12-18 F.Hoffmann-La Roche Ag Biphenyl amides useful as p2x3 and/or p2x2/3 receptors modulators
CA2754654A1 (en) 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014065737A (ja) * 2008-02-29 2014-04-17 Evotec Ag アミド化合物、組成物およびそれらの使用

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