JP5538239B2 - ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用 - Google Patents
ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用 Download PDFInfo
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- JP5538239B2 JP5538239B2 JP2010546254A JP2010546254A JP5538239B2 JP 5538239 B2 JP5538239 B2 JP 5538239B2 JP 2010546254 A JP2010546254 A JP 2010546254A JP 2010546254 A JP2010546254 A JP 2010546254A JP 5538239 B2 JP5538239 B2 JP 5538239B2
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- alkyl
- alkyloxy
- oxo
- piperazin
- carbonyl
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- BRDWJCZFYJZJGS-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)C(C2)C(C)(C)C1(C)c(cc1)c2cc1OC)=O Chemical compound CC(C)(C)OC(N(CC1)C(C2)C(C)(C)C1(C)c(cc1)c2cc1OC)=O BRDWJCZFYJZJGS-UHFFFAOYSA-N 0.000 description 1
- DDXBMIRCHRIPAJ-LAUBAEHRSA-N CC(C)(C)OC(N(CC1)[C@@H](C2)C(C)(C)[C@@]1(C)c1c2cc(C)c(O)c1)=O Chemical compound CC(C)(C)OC(N(CC1)[C@@H](C2)C(C)(C)[C@@]1(C)c1c2cc(C)c(O)c1)=O DDXBMIRCHRIPAJ-LAUBAEHRSA-N 0.000 description 1
- SLRHVVZKZCRPGV-PGRDOPGGSA-N CC(C)(C)OC(N(CC1)[C@@H](C2)C(C)(C)[C@@]1(C)c1c2cc(C)c(OC)c1)=O Chemical compound CC(C)(C)OC(N(CC1)[C@@H](C2)C(C)(C)[C@@]1(C)c1c2cc(C)c(OC)c1)=O SLRHVVZKZCRPGV-PGRDOPGGSA-N 0.000 description 1
- CEMXZNGBQQWRRO-BPBYQHGQSA-N CC(C)(C)OC(NCC[C@](C)(C(C)(C)[C@H](CC1)C1c1c2)c1cc(C)c2O)=O Chemical compound CC(C)(C)OC(NCC[C@](C)(C(C)(C)[C@H](CC1)C1c1c2)c1cc(C)c2O)=O CEMXZNGBQQWRRO-BPBYQHGQSA-N 0.000 description 1
- CDBJZYBRGVXUQH-FQEVSTJZSA-N CC(C)(C1(CC1)Cc1c2)[C@@](C)(CCN)c1cc1c2[o]c(C2CC2)n1 Chemical compound CC(C)(C1(CC1)Cc1c2)[C@@](C)(CCN)c1cc1c2[o]c(C2CC2)n1 CDBJZYBRGVXUQH-FQEVSTJZSA-N 0.000 description 1
- DJZKFSPYFBCWCS-IBGZPJMESA-N CC(C)(C1(CC1)Cc1c2)[C@@](C)(CCN)c1cc1c2nc(C)cn1 Chemical compound CC(C)(C1(CC1)Cc1c2)[C@@](C)(CCN)c1cc1c2nc(C)cn1 DJZKFSPYFBCWCS-IBGZPJMESA-N 0.000 description 1
- ZHABVIYFTQYSBQ-UHFFFAOYSA-N CC1(C)C(C)(CCN)c2ccc3[nH]cnc3c2CC11CC1 Chemical compound CC1(C)C(C)(CCN)c2ccc3[nH]cnc3c2CC11CC1 ZHABVIYFTQYSBQ-UHFFFAOYSA-N 0.000 description 1
- MAIOBWKEEZCYCF-DQVOVIAYSA-O CC1c2cccc(O)c2C(C2)[C@@H]2C(C)(C)[C@H]1CCNC([n]1c[n+](C)cc1)=O Chemical compound CC1c2cccc(O)c2C(C2)[C@@H]2C(C)(C)[C@H]1CCNC([n]1c[n+](C)cc1)=O MAIOBWKEEZCYCF-DQVOVIAYSA-O 0.000 description 1
- OYUIZRVVLIDFFQ-UHFFFAOYSA-N CCC(C1)(C2)c3cc(OC)ccc3CC1N2C(N1CCCCC1)=O Chemical compound CCC(C1)(C2)c3cc(OC)ccc3CC1N2C(N1CCCCC1)=O OYUIZRVVLIDFFQ-UHFFFAOYSA-N 0.000 description 1
- YSSRIRBVJGZJAV-UHFFFAOYSA-N CCC(C1)(C2)c3cc(OC)ccc3CC1N2C(N1CCOCC1)=O Chemical compound CCC(C1)(C2)c3cc(OC)ccc3CC1N2C(N1CCOCC1)=O YSSRIRBVJGZJAV-UHFFFAOYSA-N 0.000 description 1
- ONGSAOFOGMCDQN-UHFFFAOYSA-N CCC(CC1C2)(CN1C(N1CCCC1)=O)c1c2ccc(OC)c1 Chemical compound CCC(CC1C2)(CN1C(N1CCCC1)=O)c1c2ccc(OC)c1 ONGSAOFOGMCDQN-UHFFFAOYSA-N 0.000 description 1
- IWBBZUKTQRIVOA-CIAGWNDSSA-N CCC(CN[C@H](C1)C2(C)C)[C@H]2c2c1cc1nc(C3CC3)[nH]c1c2 Chemical compound CCC(CN[C@H](C1)C2(C)C)[C@H]2c2c1cc1nc(C3CC3)[nH]c1c2 IWBBZUKTQRIVOA-CIAGWNDSSA-N 0.000 description 1
- BKMNFTDNYPKMCQ-ZFANIMLASA-N CCC1(Cc(c([C@@]2(CC)C(CNC(C(F)(F)F)=O)[C@@H]2C)ccc2[N+]([O-])=O)c2OC)CC1 Chemical compound CCC1(Cc(c([C@@]2(CC)C(CNC(C(F)(F)F)=O)[C@@H]2C)ccc2[N+]([O-])=O)c2OC)CC1 BKMNFTDNYPKMCQ-ZFANIMLASA-N 0.000 description 1
- PKNNXSBKCJEMDB-UHFFFAOYSA-N CN(CCC(C1)(C2OC2OC)c2c3ccc(OC)c2)C1C3O Chemical compound CN(CCC(C1)(C2OC2OC)c2c3ccc(OC)c2)C1C3O PKNNXSBKCJEMDB-UHFFFAOYSA-N 0.000 description 1
- FTIHILWIYLVGHW-UHFFFAOYSA-N COc1ccc(CC(CC2(CC3)c4ccccc4)N3C(N3CCOCC3)=O)c2c1 Chemical compound COc1ccc(CC(CC2(CC3)c4ccccc4)N3C(N3CCOCC3)=O)c2c1 FTIHILWIYLVGHW-UHFFFAOYSA-N 0.000 description 1
- LLUPRRNHMOQTMM-BBATYDOGSA-N C[C@H](C1(CC1)C1)[C@@](C)(CCNC(C(F)(F)F)=O)c2c1ccc1c2nc(C)[o]1 Chemical compound C[C@H](C1(CC1)C1)[C@@](C)(CCNC(C(F)(F)F)=O)c2c1ccc1c2nc(C)[o]1 LLUPRRNHMOQTMM-BBATYDOGSA-N 0.000 description 1
- FQQNAWAMTVKIQV-WYRIXSBYSA-N C[C@H](Cc1c2)C(C)(C)[C@@](C)(CCNC(C(F)(F)F)=O)c1cc1c2nc(C)[nH]1 Chemical compound C[C@H](Cc1c2)C(C)(C)[C@@](C)(CCNC(C(F)(F)F)=O)c1cc1c2nc(C)[nH]1 FQQNAWAMTVKIQV-WYRIXSBYSA-N 0.000 description 1
- FTYWVTACBACMJE-UJBKNGIVSA-N C[C@H]1c2cc(S(C)(=O)=O)ccc2C[C@H]2NCC1CC2(C)C Chemical compound C[C@H]1c2cc(S(C)(=O)=O)ccc2C[C@H]2NCC1CC2(C)C FTYWVTACBACMJE-UJBKNGIVSA-N 0.000 description 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151295 | 2008-02-12 | ||
| EP08151295.6 | 2008-02-12 | ||
| PCT/EP2009/000905 WO2009100872A1 (en) | 2008-02-12 | 2009-02-10 | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511817A JP2011511817A (ja) | 2011-04-14 |
| JP2011511817A5 JP2011511817A5 (https=) | 2012-03-29 |
| JP5538239B2 true JP5538239B2 (ja) | 2014-07-02 |
Family
ID=40613098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546254A Active JP5538239B2 (ja) | 2008-02-12 | 2009-02-10 | ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110028445A1 (https=) |
| EP (1) | EP2245014B1 (https=) |
| JP (1) | JP5538239B2 (https=) |
| AR (1) | AR070526A1 (https=) |
| AT (1) | ATE531696T1 (https=) |
| CA (1) | CA2711757C (https=) |
| CL (1) | CL2009000316A1 (https=) |
| TW (1) | TW200938198A (https=) |
| WO (1) | WO2009100872A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| EP2183228B1 (en) | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CL2008003407A1 (es) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1. |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5734666B2 (ja) * | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
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- 2009-02-10 JP JP2010546254A patent/JP5538239B2/ja active Active
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- 2009-02-10 WO PCT/EP2009/000905 patent/WO2009100872A1/en not_active Ceased
- 2009-02-10 US US12/866,125 patent/US20110028445A1/en not_active Abandoned
- 2009-02-11 TW TW098104360A patent/TW200938198A/zh unknown
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| AR070526A1 (es) | 2010-04-14 |
| JP2011511817A (ja) | 2011-04-14 |
| CA2711757A1 (en) | 2009-08-20 |
| EP2245014A1 (en) | 2010-11-03 |
| CL2009000316A1 (es) | 2010-04-09 |
| TW200938198A (en) | 2009-09-16 |
| ATE531696T1 (de) | 2011-11-15 |
| WO2009100872A1 (en) | 2009-08-20 |
| CA2711757C (en) | 2016-07-26 |
| US20110028445A1 (en) | 2011-02-03 |
| EP2245014B1 (en) | 2011-11-02 |
| WO2009100872A8 (en) | 2010-08-05 |
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