JP5511668B2 - ピラジン−２−イル−ピリジン−２−イル−アミンとピラジン−２−イル−ピリミジン−４−イル−アミン化合物およびそれらの使用 - Google Patents

ピラジン−２−イル−ピリジン−２−イル−アミンとピラジン−２−イル−ピリミジン−４−イル−アミン化合物およびそれらの使用 Download PDF

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Publication number
JP5511668B2
JP5511668B2 JP2010527532A JP2010527532A JP5511668B2 JP 5511668 B2 JP5511668 B2 JP 5511668B2 JP 2010527532 A JP2010527532 A JP 2010527532A JP 2010527532 A JP2010527532 A JP 2010527532A JP 5511668 B2 JP5511668 B2 JP 5511668B2
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independently
nhr
alkyl
present
saturated aliphatic
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Japanese (ja)
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JP2010540610A (ja
JP2010540610A5 (enExample
Inventor
コリンス，イアン
リーダー，ジョン，チャールズ
マシューズ，トーマス，ピーター
ミン チュン，カイ
プロイジー，ニコラス
ウィリアムス，デビッド，ヒュー
クレア，サクビンダー，シン
スカンロン，ジェーン，エリザベス
ピトン，ネリー
アディソン，グリン，ジョナサン
チェリー，マイケル
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010527532A 2007-10-05 2008-10-06 ピラジン−２−イル−ピリジン−２−イル−アミンとピラジン−２−イル−ピリミジン−４−イル−アミン化合物およびそれらの使用 Active JP5511668B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97770007P 2007-10-05 2007-10-05
US60/977,700 2007-10-05
GB0719644.7 2007-10-05
GBGB0719644.7A GB0719644D0 (en) 2007-10-05 2007-10-05 Therapeutic compounds and their use
PCT/GB2008/003362 WO2009044162A1 (en) 2007-10-05 2008-10-06 Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine compounds and their use

Publications (3)

Publication Number Publication Date
JP2010540610A JP2010540610A (ja) 2010-12-24
JP2010540610A5 JP2010540610A5 (enExample) 2011-11-24
JP5511668B2 true JP5511668B2 (ja) 2014-06-04

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Country Status (9)

Country Link
US (2) US8058045B2 (enExample)
EP (1) EP2197874B1 (enExample)
JP (1) JP5511668B2 (enExample)
AU (1) AU2008306625B2 (enExample)
CA (1) CA2738980C (enExample)
DK (1) DK2197874T3 (enExample)
ES (1) ES2604947T3 (enExample)
GB (1) GB0719644D0 (enExample)
WO (1) WO2009044162A1 (enExample)

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TWI825663B (zh) * 2016-10-14 2023-12-11 美商林伯士拉克許米公司 Tyk2抑制劑及其用途
JP7569688B2 (ja) 2017-12-22 2024-10-18 ハイバーセル，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
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Also Published As

Publication number Publication date
US8367658B2 (en) 2013-02-05
ES2604947T3 (es) 2017-03-10
US20100311730A1 (en) 2010-12-09
AU2008306625A1 (en) 2009-04-09
JP2010540610A (ja) 2010-12-24
CA2738980C (en) 2015-12-01
US8058045B2 (en) 2011-11-15
CA2738980A1 (en) 2009-04-09
EP2197874B1 (en) 2016-08-31
GB0719644D0 (en) 2007-11-14
US20120040967A1 (en) 2012-02-16
EP2197874A1 (en) 2010-06-23
AU2008306625B2 (en) 2014-10-16
WO2009044162A1 (en) 2009-04-09
DK2197874T3 (en) 2016-12-19

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