JP2010540610A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540610A5 JP2010540610A5 JP2010527532A JP2010527532A JP2010540610A5 JP 2010540610 A5 JP2010540610 A5 JP 2010540610A5 JP 2010527532 A JP2010527532 A JP 2010527532A JP 2010527532 A JP2010527532 A JP 2010527532A JP 2010540610 A5 JP2010540610 A5 JP 2010540610A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- nhr
- alkyl
- saturated aliphatic
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000001931 aliphatic group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000002947 alkylene group Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 10
- -1 pyrrolidino, piperidino, piperazino Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000005488 carboaryl group Chemical group 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 claims 3
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 102000003915 DNA Topoisomerases Human genes 0.000 claims 2
- 108090000323 DNA Topoisomerases Proteins 0.000 claims 2
- 239000012623 DNA damaging agent Substances 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 102000029749 Microtubule Human genes 0.000 claims 2
- 108091022875 Microtubule Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 102000007537 Type II DNA Topoisomerases Human genes 0.000 claims 2
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 claims 2
- 230000001668 ameliorated effect Effects 0.000 claims 2
- 230000000340 anti-metabolite Effects 0.000 claims 2
- 229940100197 antimetabolite Drugs 0.000 claims 2
- 239000002256 antimetabolite Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 230000005865 ionizing radiation Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 210000004688 microtubule Anatomy 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 CCCCC(CCC)CNC* Chemical compound CCCCC(CCC)CNC* 0.000 description 3
- SZQCPPRPWDXLMM-UHFFFAOYSA-N Cc1c[n](C)nc1 Chemical compound Cc1c[n](C)nc1 SZQCPPRPWDXLMM-UHFFFAOYSA-N 0.000 description 1
- QENGPZGAWFQWCZ-UHFFFAOYSA-N Cc1c[s]cc1 Chemical compound Cc1c[s]cc1 QENGPZGAWFQWCZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97770007P | 2007-10-05 | 2007-10-05 | |
| GB0719644.7 | 2007-10-05 | ||
| GBGB0719644.7A GB0719644D0 (en) | 2007-10-05 | 2007-10-05 | Therapeutic compounds and their use |
| US60/977,700 | 2007-10-05 | ||
| PCT/GB2008/003362 WO2009044162A1 (en) | 2007-10-05 | 2008-10-06 | Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine compounds and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540610A JP2010540610A (ja) | 2010-12-24 |
| JP2010540610A5 true JP2010540610A5 (enExample) | 2011-11-24 |
| JP5511668B2 JP5511668B2 (ja) | 2014-06-04 |
Family
ID=38739312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527532A Active JP5511668B2 (ja) | 2007-10-05 | 2008-10-06 | ピラジン−２−イル−ピリジン−２−イル−アミンとピラジン−２−イル−ピリミジン−４−イル−アミン化合物およびそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8058045B2 (enExample) |
| EP (1) | EP2197874B1 (enExample) |
| JP (1) | JP5511668B2 (enExample) |
| AU (1) | AU2008306625B2 (enExample) |
| CA (1) | CA2738980C (enExample) |
| DK (1) | DK2197874T3 (enExample) |
| ES (1) | ES2604947T3 (enExample) |
| GB (1) | GB0719644D0 (enExample) |
| WO (1) | WO2009044162A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3231442B1 (en) | 2006-06-23 | 2019-12-25 | ADC Therapeutics SA | Polynucleotides and polypeptide sequences involved in cancer |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| WO2010058846A1 (ja) | 2008-11-21 | 2010-05-27 | アステラス製薬株式会社 | ４，６-ジアミノニコチンアミド化合物 |
| AR076024A1 (es) * | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| NZ599041A (en) * | 2009-11-13 | 2014-05-30 | Genosco | Kinase inhibitors |
| RU2560729C2 (ru) | 2010-01-11 | 2015-08-20 | АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи | Модуляторы никотиновых ацетилхолиновых рецепторов |
| PL3173427T3 (pl) | 2011-03-31 | 2019-11-29 | Adc Therapeutics Sa | Przeciwciała przeciwko antygenowi związanemu z nerkami 1 i ich fragmenty wiążące antygen |
| SG10201604682VA (en) * | 2011-06-10 | 2016-07-28 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| WO2013052393A1 (en) * | 2011-10-05 | 2013-04-11 | Merck Sharp & Dohme Corp. | 3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| BR112014010938A2 (pt) * | 2011-11-09 | 2017-05-16 | Cancer Res Tech Ltd | compostos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrila e seu uso terapêutico |
| AU2013209234B2 (en) | 2012-01-09 | 2017-11-09 | Adc Therapeutics Sa | Method for treating breast cancer |
| WO2013106614A1 (en) * | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
| WO2013106612A1 (en) * | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors |
| CN104254533B (zh) | 2012-01-13 | 2017-09-08 | 百时美施贵宝公司 | 用作激酶抑制剂的噻唑或噻二唑取代的吡啶基化合物 |
| PL2855448T3 (pl) * | 2012-05-15 | 2017-09-29 | Cancer Research Technology Ltd | 5-[[4-[[morfolino-2-ilo]metyloamino]-5-(trifluorometylo)-2-pirydylo]amino]pirazyno-2-karbonitryl i jego zastosowanie terapeutyczne |
| PE20150953A1 (es) | 2012-11-08 | 2015-06-20 | Bristol Myers Squibb Co | Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa |
| TWI620737B (zh) * | 2012-11-08 | 2018-04-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| WO2014074657A1 (en) | 2012-11-08 | 2014-05-15 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
| JP2017001954A (ja) * | 2013-11-08 | 2017-01-05 | 石原産業株式会社 | 含窒素飽和複素環化合物 |
| CN109952303B (zh) * | 2016-10-14 | 2022-10-21 | 林伯士拉克许米公司 | Tyk2抑制剂及其用途 |
| JP7569688B2 (ja) | 2017-12-22 | 2024-10-18 | ハイバーセル，インコーポレイテッド | ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| CN110872277B (zh) * | 2019-11-14 | 2021-06-04 | 浙江大学 | N-取代芳环-2-氨基嘧啶类化合物及用途 |
| CN110684083B (zh) * | 2019-12-06 | 2020-05-15 | 北京诺赛启研再生医学研究院有限公司 | 抑制黑色素合成的偶联物ii及其在药品和化妆品中的应用 |
| TW202241427A (zh) * | 2021-01-30 | 2022-11-01 | 香港商曙方醫藥有限公司 | 作為激酶抑制劑之雜環化合物及其用途 |
| TW202328096A (zh) | 2021-08-27 | 2023-07-16 | 南韓商柳韓洋行 | 作為egfr抑制劑之含五員雜芳基之胺基吡啶化合物 |
| TW202317106A (zh) | 2021-08-27 | 2023-05-01 | 南韓商柳韓洋行 | 作為egfr抑制劑之取代胺基吡啶化合物 |
| CN117777048B (zh) * | 2023-09-25 | 2024-09-20 | 上海科利生物医药有限公司 | 一种手性2-羟甲基吗啉-4-羧酸叔丁酯的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US805369A (en) * | 1904-10-14 | 1905-11-21 | David Marshall | Tomato-peeling machine. |
| US807554A (en) * | 1905-05-25 | 1905-12-19 | Francis S Heffernan | Non-refillable bottle. |
| US3032984A (en) * | 1959-05-12 | 1962-05-08 | United Aircraft Corp | Rocket pump starting system |
| US3101444A (en) * | 1959-06-30 | 1963-08-20 | John R Montgomery | Electronic pressure measuring means for internal combustion engines responsive to pressure caused spark gap resistance change |
| US3035065A (en) * | 1959-11-05 | 1962-05-15 | Union Carbide Corp | Isomaleimides and a process for the preparation thereof |
| US3093297A (en) * | 1961-09-25 | 1963-06-11 | New York Air Brake Co | Hydrostatic transmission |
| US5037285A (en) * | 1983-04-13 | 1991-08-06 | American National Can Company | Apparatus for injection molding and injection blow molding multi-layer articles |
| US5011597A (en) * | 1988-10-11 | 1991-04-30 | Canzoneri Anthony S | Single cell vertical static flow flotation unit |
| US5034869A (en) * | 1989-11-28 | 1991-07-23 | Choi Young J | Device for fixing a ceiling lamp to a ceiling |
| US5121126A (en) * | 1991-03-12 | 1992-06-09 | Bell Atlantic Network Services Inc. | Beacon enhanced telecommunications system and method |
| US6039718A (en) * | 1998-01-20 | 2000-03-21 | Bracco Research Usa | Multiple use universal connector |
| JP3809786B2 (ja) * | 2001-10-01 | 2006-08-16 | ソニー株式会社 | カートリッジ |
| US7271261B2 (en) | 2001-10-19 | 2007-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
| EP1441725A1 (en) | 2001-10-26 | 2004-08-04 | Aventis Pharmaceuticals Inc. | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| CA2484209C (en) * | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| US7202244B2 (en) | 2002-05-29 | 2007-04-10 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| GB0215775D0 (en) * | 2002-07-06 | 2002-08-14 | Astex Technology Ltd | Pharmaceutical compounds |
| GB0305152D0 (en) * | 2003-03-06 | 2003-04-09 | Novartis Ag | Organic compounds |
| MXPA06001098A (es) | 2003-07-29 | 2006-04-24 | Irm Llc | Compuestos y composiciones utiles como inhibidores de proteina cinasa. |
| WO2005035541A1 (en) * | 2003-10-07 | 2005-04-21 | Amedis Pharmaceuticals Ltd. | Silicon compounds and their use |
| CA2542105C (en) | 2003-10-08 | 2011-08-02 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| CN1882345A (zh) | 2003-10-16 | 2006-12-20 | 希龙公司 | 作为raf激酶抑制剂以治疗癌症的2,6－二取代的喹唑啉、喹喔啉、喹啉和异喹啉 |
| US7642354B2 (en) | 2004-04-13 | 2010-01-05 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| WO2007000240A1 (en) | 2005-06-28 | 2007-01-04 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of rho-kinase |
| JP5405316B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| ES2485040T3 (es) | 2007-03-16 | 2014-08-12 | The Scripps Research Institute | Inhibidores de cinasa de adhesión focal |
| EP2014657A1 (de) * | 2007-06-21 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Diaminopyrimidine als Modulatoren des EP2-Rezeptors |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
-
2007
- 2007-10-05 GB GBGB0719644.7A patent/GB0719644D0/en not_active Ceased
-
2008
- 2008-10-06 CA CA2738980A patent/CA2738980C/en active Active
- 2008-10-06 WO PCT/GB2008/003362 patent/WO2009044162A1/en not_active Ceased
- 2008-10-06 DK DK08806506.5T patent/DK2197874T3/en active
- 2008-10-06 JP JP2010527532A patent/JP5511668B2/ja active Active
- 2008-10-06 ES ES08806506.5T patent/ES2604947T3/es active Active
- 2008-10-06 EP EP08806506.5A patent/EP2197874B1/en active Active
- 2008-10-06 AU AU2008306625A patent/AU2008306625B2/en active Active
- 2008-10-06 US US12/680,891 patent/US8058045B2/en active Active
-
2011
- 2011-09-23 US US13/241,887 patent/US8367658B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540610A5 (enExample) | ||
| Yuan et al. | Discovery of new 4-indolyl quinazoline derivatives as highly potent and orally bioavailable P-glycoprotein inhibitors | |
| CA2729436C (en) | Pyrazolo-quinazolines | |
| US20220193242A1 (en) | Immunophilin-dependent inhibitors and uses thereof | |
| CN103635189B (zh) | 用于治疗癌症的含有cdk4/6抑制剂和pi3k抑制剂的联合治疗 | |
| EP2089394B1 (en) | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | |
| JP5498796B2 (ja) | 置換ピラゾロ−キナゾリン誘導体、これらの調製方法及びキナーゼ阻害剤としてのこれらの使用 | |
| US10166246B2 (en) | TGR5 agonist complexes for treating diabetes and cancer | |
| JP2017530999A5 (enExample) | ||
| JP2007529421A5 (enExample) | ||
| JP2009537498A5 (enExample) | ||
| JP2020531447A5 (enExample) | ||
| ZA200504298B (en) | substituted pyrrolo-pyrazole derivatives as kinaseinhibitors. | |
| ATE344033T1 (de) | Vinylphenyl-derivate als glk-aktivatoren | |
| JP2006502163A5 (enExample) | ||
| JP2011515397A5 (enExample) | ||
| SE0402735D0 (sv) | Novel compounds | |
| JP2016517878A5 (enExample) | ||
| US20250108052A1 (en) | Immunophilin binding agents and uses thereof | |
| JP2013533276A (ja) | タンパク質キナーゼ活性の調整剤としてのイソオキサゾロ−キナゾリン | |
| JP2015536997A5 (enExample) | ||
| JP2012531456A5 (enExample) | ||
| NO20070088L (no) | 1-, (3R)-amino-4-(2-fluor-fenyl)-butyl !-pyrrolidin-(2R)-karboksylsyre-benzyl amin derivater og beslektede forbindelser som dipeptidyl-peptidase IV (DPP??IV) inhibitorer for behandling av type 2 | |
| WO2020068600A1 (en) | Ubiquitin-specific-processing protease 7 (usp7) modulators and uses thereof | |
| JP2011509306A5 (enExample) |