JP5504253B2 - ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 - Google Patents
ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 Download PDFInfo
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- JP5504253B2 JP5504253B2 JP2011504317A JP2011504317A JP5504253B2 JP 5504253 B2 JP5504253 B2 JP 5504253B2 JP 2011504317 A JP2011504317 A JP 2011504317A JP 2011504317 A JP2011504317 A JP 2011504317A JP 5504253 B2 JP5504253 B2 JP 5504253B2
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| PCT/EP2008/002929 WO2009127218A1 (en) | 2008-04-14 | 2008-04-14 | Derivatives of galantamine as pro-drugs for the treatment of human brain diseases |
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| JP2011516588A JP2011516588A (ja) | 2011-05-26 |
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| PT3417862T (pt) | 2012-07-27 | 2021-08-06 | Neurodyn Life Sciences Inc | Biodisponibilidade cerebral da galantamina melhorada através de formulações selecionadas e administração transmucosal de pró-fármacos lipofílicos |
| US20170182058A1 (en) | 2014-03-25 | 2017-06-29 | Emicipi Llc | Treatment of rett syndrome |
| WO2015148487A1 (en) * | 2014-03-25 | 2015-10-01 | Synaptec Development Llc | Treatment of autism |
| US11219627B2 (en) * | 2014-05-16 | 2022-01-11 | Synaptec Development Llc | Clearance of amyloid beta |
| EP4029867A1 (en) | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
| EP4186509A1 (en) | 2021-11-26 | 2023-05-31 | Alpha Cognition Inc. | Alpha-1062 for treating traumatic brain injury |
| US12208167B1 (en) | 2024-02-06 | 2025-01-28 | Alpha Cognition Inc. | Coated tablets for pH-dependent release of benzgalantamine |
| US12551491B1 (en) * | 2025-07-23 | 2026-02-17 | Alpha Cognition Inc. | Dosage regimens for benzgalantamine |
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| US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
| JP2755403B2 (ja) | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6316439B1 (en) | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| AU1282099A (en) | 1997-10-29 | 1999-05-17 | Bonnie M. Davis | Method for treatment of disorders of attention |
| WO2000032199A1 (de) | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| EP2311463A1 (en) | 1999-12-10 | 2011-04-20 | Bonnie M. Davis | Analogs of galanthamine and lycoramine as modulators of nicotinic receptors |
| PL202463B1 (pl) | 2000-03-31 | 2009-06-30 | Sanochemia Pharmazeutika Ag | Pochodne galantaminy, sposób ich wytwarzania, środek leczniczy zawierajacy te pochodne, zastosowanie pochodnej galantaminy do wytwarzania środków leczniczych, sposób wytwarzania środków leczniczych oraz sposób oddzielania (+)- i (-)-izomerów |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| CN1875004B (zh) | 2003-09-26 | 2010-06-23 | 台湾神隆股份有限公司 | 那维啶酰胺衍生物的拆分 |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| EP1777222A1 (en) | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
-
2008
- 2008-04-14 CN CN200880128608.5A patent/CN102007129B/zh active Active
- 2008-04-14 PL PL08735211T patent/PL2137192T3/pl unknown
- 2008-04-14 EP EP08735211.8A patent/EP2137192B8/en active Active
- 2008-04-14 CA CA2721007A patent/CA2721007C/en active Active
- 2008-04-14 ES ES08735211.8T patent/ES2463715T3/es active Active
- 2008-04-14 JP JP2011504317A patent/JP5504253B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102007129B (zh) | 2014-05-07 |
| DK2137192T3 (da) | 2014-05-26 |
| PL2137192T3 (pl) | 2014-07-31 |
| EP2137192B8 (en) | 2014-06-11 |
| CN102007129A (zh) | 2011-04-06 |
| CA2721007C (en) | 2014-04-29 |
| EP2137192A1 (en) | 2009-12-30 |
| EP2137192B1 (en) | 2014-02-19 |
| WO2009127218A1 (en) | 2009-10-22 |
| CA2721007A1 (en) | 2009-10-22 |
| ES2463715T3 (es) | 2014-05-29 |
| JP2011516588A (ja) | 2011-05-26 |
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