JP5504253B2 - ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 - Google Patents
ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 Download PDFInfo
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- JP5504253B2 JP5504253B2 JP2011504317A JP2011504317A JP5504253B2 JP 5504253 B2 JP5504253 B2 JP 5504253B2 JP 2011504317 A JP2011504317 A JP 2011504317A JP 2011504317 A JP2011504317 A JP 2011504317A JP 5504253 B2 JP5504253 B2 JP 5504253B2
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| PCT/EP2008/002929 WO2009127218A1 (en) | 2008-04-14 | 2008-04-14 | Derivatives of galantamine as pro-drugs for the treatment of human brain diseases |
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| CN108245522A (zh) * | 2012-07-27 | 2018-07-06 | 神经动力生命科学公司 | Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 |
| WO2015148487A1 (en) * | 2014-03-25 | 2015-10-01 | Synaptec Development Llc | Treatment of autism |
| EP3122187A4 (en) * | 2014-03-25 | 2017-11-15 | Emicipi LLC | Treatment of rett syndrome |
| WO2015176069A2 (en) * | 2014-05-16 | 2015-11-19 | Synaptec Development Llc | CLEARANCE OF AMYLOID ß |
| EP4029867A1 (en) | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
| EP4186509A1 (en) | 2021-11-26 | 2023-05-31 | Alpha Cognition Inc. | Alpha-1062 for treating traumatic brain injury |
| US12208167B1 (en) | 2024-02-06 | 2025-01-28 | Alpha Cognition Inc. | Coated tablets for pH-dependent release of benzgalantamine |
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| JP2755403B2 (ja) | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6316439B1 (en) | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
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| MXPA02005667A (es) | 1999-12-10 | 2004-09-10 | Bonnie Davis | Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos. |
| JP2003529602A (ja) | 2000-03-31 | 2003-10-07 | ザノヒェミア・ファルマツォイティカ・アーゲー | ガランタミンの新規誘導体および類似体 |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| AU2004276354B2 (en) | 2003-09-26 | 2009-07-09 | Scinopharm Taiwan, Ltd. | Resolution of a narwedine amide derivative |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| EP1777222A1 (en) * | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
-
2008
- 2008-04-14 ES ES08735211.8T patent/ES2463715T3/es active Active
- 2008-04-14 WO PCT/EP2008/002929 patent/WO2009127218A1/en not_active Ceased
- 2008-04-14 EP EP08735211.8A patent/EP2137192B8/en active Active
- 2008-04-14 CN CN200880128608.5A patent/CN102007129B/zh active Active
- 2008-04-14 JP JP2011504317A patent/JP5504253B2/ja not_active Expired - Fee Related
- 2008-04-14 CA CA2721007A patent/CA2721007C/en active Active
- 2008-04-14 DK DK08735211.8T patent/DK2137192T3/da active
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|---|---|
| CA2721007C (en) | 2014-04-29 |
| CN102007129B (zh) | 2014-05-07 |
| ES2463715T3 (es) | 2014-05-29 |
| CN102007129A (zh) | 2011-04-06 |
| PL2137192T3 (pl) | 2014-07-31 |
| CA2721007A1 (en) | 2009-10-22 |
| EP2137192B1 (en) | 2014-02-19 |
| JP2011516588A (ja) | 2011-05-26 |
| EP2137192B8 (en) | 2014-06-11 |
| EP2137192A1 (en) | 2009-12-30 |
| DK2137192T3 (da) | 2014-05-26 |
| WO2009127218A1 (en) | 2009-10-22 |
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