CA2721007C - Derivatives of galantamine as pro-drugs for the treatment of human brain diseases - Google Patents
Derivatives of galantamine as pro-drugs for the treatment of human brain diseases Download PDFInfo
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- CA2721007C CA2721007C CA2721007A CA2721007A CA2721007C CA 2721007 C CA2721007 C CA 2721007C CA 2721007 A CA2721007 A CA 2721007A CA 2721007 A CA2721007 A CA 2721007A CA 2721007 C CA2721007 C CA 2721007C
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- Prior art keywords
- galantamine
- brain
- disease
- pro
- gln
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- 238000011282 treatment Methods 0.000 title claims abstract description 24
- 239000000651 prodrug Substances 0.000 title claims description 20
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- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 100
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/002929 WO2009127218A1 (en) | 2008-04-14 | 2008-04-14 | Derivatives of galantamine as pro-drugs for the treatment of human brain diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2721007A1 CA2721007A1 (en) | 2009-10-22 |
| CA2721007C true CA2721007C (en) | 2014-04-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2721007A Active CA2721007C (en) | 2008-04-14 | 2008-04-14 | Derivatives of galantamine as pro-drugs for the treatment of human brain diseases |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2137192B8 (enExample) |
| JP (1) | JP5504253B2 (enExample) |
| CN (1) | CN102007129B (enExample) |
| CA (1) | CA2721007C (enExample) |
| DK (1) | DK2137192T3 (enExample) |
| ES (1) | ES2463715T3 (enExample) |
| PL (1) | PL2137192T3 (enExample) |
| WO (1) | WO2009127218A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2880399T3 (es) | 2012-07-27 | 2021-11-24 | Neurodyn Life Sciences Inc | Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos |
| CN108245522A (zh) * | 2012-07-27 | 2018-07-06 | 神经动力生命科学公司 | Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 |
| WO2015148487A1 (en) * | 2014-03-25 | 2015-10-01 | Synaptec Development Llc | Treatment of autism |
| EP3122187A4 (en) * | 2014-03-25 | 2017-11-15 | Emicipi LLC | Treatment of rett syndrome |
| WO2015176069A2 (en) * | 2014-05-16 | 2015-11-19 | Synaptec Development Llc | CLEARANCE OF AMYLOID ß |
| EP4029867A1 (en) | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
| EP4186509A1 (en) | 2021-11-26 | 2023-05-31 | Alpha Cognition Inc. | Alpha-1062 for treating traumatic brain injury |
| US12208167B1 (en) | 2024-02-06 | 2025-01-28 | Alpha Cognition Inc. | Coated tablets for pH-dependent release of benzgalantamine |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
| JP2755403B2 (ja) | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6316439B1 (en) | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| AU1282099A (en) * | 1997-10-29 | 1999-05-17 | Bonnie M. Davis | Method for treatment of disorders of attention |
| WO2000032199A1 (de) | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| MXPA02005667A (es) | 1999-12-10 | 2004-09-10 | Bonnie Davis | Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos. |
| JP2003529602A (ja) | 2000-03-31 | 2003-10-07 | ザノヒェミア・ファルマツォイティカ・アーゲー | ガランタミンの新規誘導体および類似体 |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| AU2004276354B2 (en) | 2003-09-26 | 2009-07-09 | Scinopharm Taiwan, Ltd. | Resolution of a narwedine amide derivative |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| EP1777222A1 (en) * | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
-
2008
- 2008-04-14 ES ES08735211.8T patent/ES2463715T3/es active Active
- 2008-04-14 WO PCT/EP2008/002929 patent/WO2009127218A1/en not_active Ceased
- 2008-04-14 EP EP08735211.8A patent/EP2137192B8/en active Active
- 2008-04-14 CN CN200880128608.5A patent/CN102007129B/zh active Active
- 2008-04-14 JP JP2011504317A patent/JP5504253B2/ja not_active Expired - Fee Related
- 2008-04-14 CA CA2721007A patent/CA2721007C/en active Active
- 2008-04-14 DK DK08735211.8T patent/DK2137192T3/da active
- 2008-04-14 PL PL08735211T patent/PL2137192T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102007129B (zh) | 2014-05-07 |
| ES2463715T3 (es) | 2014-05-29 |
| CN102007129A (zh) | 2011-04-06 |
| PL2137192T3 (pl) | 2014-07-31 |
| CA2721007A1 (en) | 2009-10-22 |
| JP5504253B2 (ja) | 2014-05-28 |
| EP2137192B1 (en) | 2014-02-19 |
| JP2011516588A (ja) | 2011-05-26 |
| EP2137192B8 (en) | 2014-06-11 |
| EP2137192A1 (en) | 2009-12-30 |
| DK2137192T3 (da) | 2014-05-26 |
| WO2009127218A1 (en) | 2009-10-22 |
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| EEER | Examination request |