JP5503726B2 - 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品 - Google Patents

学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品 Download PDF

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JP5503726B2
JP5503726B2 JP2012501889A JP2012501889A JP5503726B2 JP 5503726 B2 JP5503726 B2 JP 5503726B2 JP 2012501889 A JP2012501889 A JP 2012501889A JP 2012501889 A JP2012501889 A JP 2012501889A JP 5503726 B2 JP5503726 B2 JP 5503726B2
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extract
plant tissue
nobiletin
tachibana
peel
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JPWO2011105568A1 (ja
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康 大泉
徹 山國
伊知郎 川畑
雅昭 吉田
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KOTARO PHARMACEUTICAL CO., LTD.
Tohoku University NUC
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KOTARO PHARMACEUTICAL CO., LTD.
Tohoku University NUC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012501889A 2010-02-26 2011-02-25 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品 Active JP5503726B2 (ja)

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JP2012501889A JP5503726B2 (ja) 2010-02-26 2011-02-25 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品

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JP2010042819 2010-02-26
JP2010042819 2010-02-26
JP2010126717 2010-06-02
JP2010126717 2010-06-02
JP2010270578 2010-12-03
JP2010270578 2010-12-03
JP2012501889A JP5503726B2 (ja) 2010-02-26 2011-02-25 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品
PCT/JP2011/054358 WO2011105568A1 (ja) 2010-02-26 2011-02-25 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品

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JP2014052426A Active JP5906267B2 (ja) 2010-02-26 2014-03-14 学習・記憶障害および運動障害などを伴う中枢神経変性疾患を改善する乾燥植物組織および植物組織抽出物ならびにこれらを含有する医薬品および食品

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JP (2) JP5503726B2 (enExample)
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Families Citing this family (14)

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CN103930106A (zh) * 2012-06-21 2014-07-16 小太郎汉方制药株式会社 中枢神经变性疾病的改善和/或治疗用组合物
CN103479743B (zh) * 2013-01-28 2015-07-08 钱昌美 治疗老年痴呆的药物组合物及其制备方法
JP6179891B2 (ja) * 2013-05-29 2017-08-16 要 有持 生産方法、加工方法、加工品及び茶
JP2015053939A (ja) * 2013-09-10 2015-03-23 久子 松野 みかんの果皮の加工食品
WO2015199118A1 (ja) * 2014-06-26 2015-12-30 日本ゼオン株式会社 培養細胞内のｅｒｋまたはａｋｔのリン酸化亢進方法、細胞の培養方法、およびリン酸化亢進剤
JP2016056149A (ja) * 2014-09-11 2016-04-21 日油株式会社 皮膚化粧料
KR20190084143A (ko) * 2014-11-12 2019-07-15 주식회사 파마코렉스 배뇨장애를 예방 또는 개선시키는 의약조성물, 배뇨장애 관련 수용체에 관한 길항제 또는 그 의약조성물 또는 길항제를 이용한 배뇨장애를 예방 또는 개선시키는 방법
JP6238089B1 (ja) * 2016-06-01 2017-11-29 株式会社三協ホールディングス 医薬組成物および食品
JP6898628B2 (ja) * 2016-06-15 2021-07-07 国立大学法人広島大学 神経変性疾患治療剤
CN107648349A (zh) * 2017-10-30 2018-02-02 江西中医药大学 代代花在制备改善睡眠障碍或改善记忆力减退或治疗阿尔茨海默病药物或保健食品中的应用
WO2019102602A1 (ja) * 2017-11-27 2019-05-31 康 大泉 スクリーニング方法
KR101894491B1 (ko) * 2018-04-30 2018-09-04 주식회사 뉴트라팜텍 지각 초임계 추출물을 유효성분으로 함유하는 기억력 또는 인지 기능 개선용 조성물
CN112402409A (zh) * 2020-12-11 2021-02-26 江汉大学 橘皮素在制备抑制β分泌酶活性药物中的应用
CN115886258B (zh) * 2022-12-30 2024-07-05 上海交大昂立股份有限公司 一种改善生理性记忆力衰减的复合益生菌组合物

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WO2002053152A1 (en) * 2001-01-08 2002-07-11 Imperial College Of Science, Technology & Medicine Composition containing flavonoids for treatment brain disorders
JP2008127325A (ja) * 2006-11-20 2008-06-05 Tokyoto Koreisha Kenkyu Fukushi Shinko Zaidan リン酸化ｍｂｐ産生促進剤

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2002053152A1 (en) * 2001-01-08 2002-07-11 Imperial College Of Science, Technology & Medicine Composition containing flavonoids for treatment brain disorders
JP2008127325A (ja) * 2006-11-20 2008-06-05 Tokyoto Koreisha Kenkyu Fukushi Shinko Zaidan リン酸化ｍｂｐ産生促進剤

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JPN6013056058; 山國徹　他: '臨床に必要な神経薬理・化学　陳皮成分ｎｏｂｉｌｅｔｉｎ　の抗アルツハイマー病作用' Ｃｌｉｎ　Ｎｅｕｒｏｓｃｉ Ｖｏｌ．２６，Ｎｏ．１１, 2008, Ｐａｇｅ．１１７８-１１７９ *
JPN6013056059; 伊藤忠信: '現代社会におけるストレスと漢方の役割　抑肝散加陳皮半夏および柴胡加竜骨牡蛎湯の中枢機能調節に対する作' ＰｒｏｇＭｅｄ Ｖｏｌ．１７，Ｎｏ．４, 1997, Ｐａｇｅ．８２３-８３０ *
JPN6013056060; 坂井有美子　他: '独自ブランド創出のための機能性，芳香性に優れたカンキツ新品種の育成　２）機能性成分高含有系統の早期選抜方' 佐賀県果樹試験場業務年報 Ｖｏｌ．２００６, 2006, Ｐａｇｅ．２３-２４ *
JPN6013056061; 前川哲男　他: '地域自生カンキツ「新姫」と「タチバナ」に含まれるフラボノイドの含量' 関東東海北陸農業研究成果情報 Ｖｏｌ．２００３，Ｎｏ，２, 2004, ｐｐ．４６-４７ *
JPN6013056062; ＮＡＧＡＳＥ　Ｈｉｒｏｙｕｋｉ　ｅｔ　ａｌ: 'Ｎｏｂｉｌｅｔｉｎ　ａｎｄ　ｉｔｓ　ｒｅｌａｔｅｄ　ｆｌａｖｏｎｏｉｄｓ　ｗｉｔｈＣＲＥ-ｄｅｐｅｎｄｅｎｔ　ｔｒａｎｓｃｒｉｐｔｉｏｎ-ｓｔｉｍｕｌａｔｉｎｇ　ａｎｄ　ｎｅｕｒｉｔｅｇｅｎｉｃａｃｔ' Ｂｉｏｃｈｅｍ　Ｂｉｏｐｈｙｓ　Ｒｅｓ　Ｃｏｍｍｕｎ Ｖｏｌ．３３７，Ｎｏ．４, 2005, ａｇｅ．１３３０-１３３６ *
JPN6013056063; ＤＡＴＬＡ　Ｋｒｉｓｈｎａ　Ｐ．ｅｔ　ａｌ: 'Ｓｈｏｒｔ-Ｔｅｒｍ　Ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ　ｗｉｔｈ　ＰｌａｎｔＥｘｔｒａｃｔｓ　Ｒｉｃｈ　ｉｎ　Ｆｌａｖｏｎｏｉｄｓ　Ｐｒｏｔｅｃｔ　Ｎｉｇｒｏｓｔｒｉａｔａｌ　ＤｏｐａｍｉｎｅｒｇｉｃＮ' Ｊ　Ａｍ　Ｃｏｌｌ　Ｎｕｔｒ Ｖｏｌ．２６，Ｎｏ．４, 2007, Ｐａｇｅ．３４１-３４９ *
JPN6013056064; ＨＷＡＮＧ　Ｓａｍ-Ｌｏｎｇ　ｅｔ　ａｌ: 'Ｎｅｕｒｏｐｒｏｔｅｃｔｉｖｅ　Ｅｆｆｅｃｔｓ　ｏｆ　ｔｈｅ　ＣｉｔｒｕｓＦｌａｖａｎｏｎｅｓ　ａｇａｉｎｓｔ　Ｈ２Ｏ２-Ｉｎｄｕｃｅｄ　Ｃｙｔｏｔｏｘｉｃｉｔｙ　ｉｎ　ＰＣ１２　Ｃｅｌｌｓ' Ｊ．　Ａｇｒｉｃ　Ｆｏｏｄ　Ｃｈｅｍ Ｖｏｌ．５６，Ｎｏ．３, 2008, Ｐａｇｅ．８５９-８６４ *
JPN6013056065; ＸＵ　Ｇ．　Ｈ　ｅｔ　ａｌ: 'Ｍｉｎｅｒａｌｓ，　Ｐｈｅｎｏｌｉｃ　Ｃｏｍｐｏｕｎｄｓ，　ａｎｄ　ＡｎｔｉｏｘｉｄａｎｔＣａｐａｃｉｔｙ　ｏｆ　Ｃｉｔｒｕｓ　Ｐｅｅｌ　Ｅｘｔｒａｃｔ　ｂｙ　Ｈｏｔ　Ｗａｔｅｒ' Ｊ　Ｆｏｏｄ　Ｓｃｉ Ｖｏｌ．７３，Ｎｏ．１, 2008, ｐｐ．Ｃ１１-Ｃ１８ *
JPN6013056066; Ｋａｗａｉｉ，Ｓａｔｏｒｕ　ｅｔ　ａｌ: 'Ｑｕａｎｔｉｔａｔｉｖｅ　Ｓｔｕｄｙ　ｏｆ　Ｆｌａｖｏｎｏｉｄｓ　ｉｎ　Ｌｅａｖｅｓ　ｏｆ　Ｃｉｔｒｕｓ　Ｐｌａｎｔｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ａｇｒｉｃｕｌｔｕｒａｌ　ａｎｄ　Ｆｏｏｄ　Ｃｈｅｍｉｓｔｒｙ ４８（９）, 2000, ｐｐ．３８６５-３８７１ *
JPN6013056159; ＯＳＡＫＡ　Ｎａｏｙａ　ｅｔ　ａｌ: 'Ｐｒｏｔｅｃｔｉｖｅ　ｅｆｆｅｃｔｓ　ｏｆ　ｔｈｅ　ｅｘｔｒａｃｔ　ｆｒｏｍＡＵＲＡＮＴＩＩ　ＮＯＢＩＬＩＳ　ＰＥＲＩＣＡＲＰＩＵＭ　ｏｎ　ＮＭＤＡ　ｒｅｃｅｐｔｏｒ　ａｎｔａｇｏｎｉｓｔＭＫ-８０１' Ｊ　Ｐｈａｒｍａｃｏｌ　Ｓｃｉ Ｖｏｌ．１０６，Ｎｏ．Ｓｕｐｐｌｅｍｅｎｔ　１, 2008, Ｐａｇｅ．１７６Ｐ *

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CN102883716A (zh) 2013-01-16
WO2011105568A1 (ja) 2011-09-01
JPWO2011105568A1 (ja) 2013-06-20
CN102883716B (zh) 2014-05-07
JP5906267B2 (ja) 2016-04-20
HK1178792A1 (zh) 2013-09-19
JP2014111664A (ja) 2014-06-19

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