JP5479661B2 - 幹細胞の分化を誘導する方法 - Google Patents

幹細胞の分化を誘導する方法 Download PDF

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JP5479661B2
JP5479661B2 JP2003515654A JP2003515654A JP5479661B2 JP 5479661 B2 JP5479661 B2 JP 5479661B2 JP 2003515654 A JP2003515654 A JP 2003515654A JP 2003515654 A JP2003515654 A JP 2003515654A JP 5479661 B2 JP5479661 B2 JP 5479661B2
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cells
cell
embryonic
cardiomyocytes
differentiation
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JP2004535820A (ja
JP2004535820A5 (enExample
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ママリー，クリスティン・リンゼイ
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イーエス・セル・インターナショナル・ピーティーイー・リミテッド
ネザーランズ・インスティテュート・フォール・オントヴィッケリングスビオロヒー
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Priority claimed from AUPS1180A external-priority patent/AUPS118002A0/en
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JP2003515654A 2001-07-24 2002-07-23 幹細胞の分化を誘導する方法 Expired - Fee Related JP5479661B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPR6560A AUPR656001A0 (en) 2001-07-24 2001-07-24 Methods of inducing differentiation of stem cells
AUPR6560 2001-07-24
AUPS1180 2002-03-18
AUPS1180A AUPS118002A0 (en) 2002-03-18 2002-03-18 Methods of inducing differentiation of stem cells
PCT/AU2002/000978 WO2003010303A1 (en) 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells

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JP2004535820A JP2004535820A (ja) 2004-12-02
JP2004535820A5 JP2004535820A5 (enExample) 2011-06-02
JP5479661B2 true JP5479661B2 (ja) 2014-04-23

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US (2) US8728457B2 (enExample)
EP (1) EP1421182A4 (enExample)
JP (1) JP5479661B2 (enExample)
AU (1) AU2002317039B2 (enExample)
CA (1) CA2452256A1 (enExample)
GB (2) GB2394958B (enExample)
WO (1) WO2003010303A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111562734A (zh) * 2019-02-14 2020-08-21 格拉斯许特钟表有限公司 用于钟表的月份和闰年显示机构

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1379869A4 (en) * 2001-03-15 2004-08-11 Xiao Yong Fu METHOD FOR THERAPEUTICALLY TREATING A CLINICALLY DETECTED CARDIOPATHOLOGICAL FORM IN A MAMMAL
GB2393734B (en) * 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
EP1572984B8 (en) 2002-12-16 2016-06-01 Technion Research & Development Foundation Ltd. Feeder-free, xeno-free culture system for human embryonic stem cells
AU2003901099A0 (en) * 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
WO2004113515A2 (en) * 2003-06-20 2004-12-29 Axiogenesis Ag Tissue modeling in embryonic stem (es) cell system
JP4667241B2 (ja) * 2003-06-27 2011-04-06 旭化成株式会社 細胞分化抑制剤、これを用いた細胞培養方法、培養液及び培養された細胞株
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems
DK1745144T3 (da) 2004-05-11 2011-02-07 Axiogenesis Ag Analysefremgangsmåde til opsporing af lægemidler på grundlag af in vitro-differentierede celler
CA2569242A1 (en) 2004-06-01 2005-12-15 Es Cell International Pte Ltd Improved cardiomyocyte differentiation
US20050277124A1 (en) * 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
CN101228264B (zh) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 使灵长类多能干细胞分化成心肌细胞系细胞
US20070054397A1 (en) * 2005-08-26 2007-03-08 Harald Ott Adult cardiac uncommitted progenitor cells
US8476070B2 (en) 2005-08-29 2013-07-02 Technion Research & Development Foundation Limited Media for culturing stem cells
US7732202B2 (en) * 2005-10-21 2010-06-08 International Stem Cell Corporation Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
ES2704401T3 (es) 2006-08-02 2019-03-18 Technion Res & Dev Foundation Métodos de expansión de células madre embrionarias en un cultivo en suspensión
JP5230969B2 (ja) * 2007-06-14 2013-07-10 公益財団法人先端医療振興財団 心筋芽細胞を含むシート
CN105400735A (zh) * 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
RU2417052C2 (ru) * 2008-08-06 2011-04-27 Владимир Михайлович Музалевский Способ стимулирования зоны роста стволовых клеток по методу музалевского
KR101109125B1 (ko) 2009-03-24 2012-02-15 한국과학기술연구원 줄기세포를 혈관세포로 분화시키는 방법 및 이를 이용한 생체 내 혈관신생 유도
WO2010110596A2 (en) * 2009-03-24 2010-09-30 Korea Institute Of Science And Technology Method for differentiation of stem cells into vascular cells and the induction of angiogenesis using the same
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP2521587B1 (en) * 2010-01-08 2020-04-08 Wake Forest University Health Sciences Delivery system
US9428735B2 (en) 2010-02-25 2016-08-30 The Johns Hopkins University Smooth muscle-like cells (SMLCs) dervided from human pluripotent stem cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
WO2013033213A1 (en) 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US9045038B2 (en) 2011-12-22 2015-06-02 Eaton Corporation Liquid trap with integral jet pump
WO2013130820A1 (en) * 2012-02-29 2013-09-06 The Johns Hopkins University Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation
US9506037B2 (en) 2013-03-15 2016-11-29 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
US9994825B2 (en) 2013-03-15 2018-06-12 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018076060A1 (en) 2016-10-26 2018-05-03 Genea Ip Holdings Pty Ltd Improved generation of muscle lineage cells and therapeutic uses thereof
US11746331B2 (en) * 2017-01-27 2023-09-05 Kaneka Corporation Endodermal cell population, and method for producing cell population of any of three germ layers from pluripotent cell
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
EP3976069A4 (en) 2019-05-31 2023-07-19 Figene, LLC FIBROBLAST THERAPY FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2324591A1 (en) * 1998-04-09 1999-10-21 Bresagen Limited Cell differentiation/proliferation and maintenance factor and uses thereof
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
IL129966A (en) * 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
US6280718B1 (en) * 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
WO2001048151A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
WO2002014469A2 (en) * 2000-08-15 2002-02-21 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
GB2393734B (en) * 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111562734A (zh) * 2019-02-14 2020-08-21 格拉斯许特钟表有限公司 用于钟表的月份和闰年显示机构
CN111562734B (zh) * 2019-02-14 2021-11-23 格拉斯许特钟表有限公司 用于钟表的月份和闰年显示机构

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