AU2002317039B2 - Methods of inducing differentiation of stem cells - Google Patents

Methods of inducing differentiation of stem cells Download PDF

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Publication number
AU2002317039B2
AU2002317039B2 AU2002317039A AU2002317039A AU2002317039B2 AU 2002317039 B2 AU2002317039 B2 AU 2002317039B2 AU 2002317039 A AU2002317039 A AU 2002317039A AU 2002317039 A AU2002317039 A AU 2002317039A AU 2002317039 B2 AU2002317039 B2 AU 2002317039B2
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Prior art keywords
cell
cells
embryonic
population
tissue
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AU2002317039A
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AU2002317039A1 (en
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Christine Lindsay Mummery
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NETHERLANDS INSTITUUT VOOR ONTWIKKELINGSBIOLOGIE
ES Cell International Pte Ltd
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Netherlands Inst Voor Ontwikkelingsbiologie
ES Cell International Pte Ltd
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Priority claimed from AUPR6560A external-priority patent/AUPR656001A0/en
Priority claimed from AUPS1180A external-priority patent/AUPS118002A0/en
Application filed by Netherlands Inst Voor Ontwikkelingsbiologie, ES Cell International Pte Ltd filed Critical Netherlands Inst Voor Ontwikkelingsbiologie
Priority to AU2002317039A priority Critical patent/AU2002317039B2/en
Publication of AU2002317039A1 publication Critical patent/AU2002317039A1/en
Application granted granted Critical
Publication of AU2002317039B2 publication Critical patent/AU2002317039B2/en
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1329—Cardiomyocytes
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    • C12N2502/28—Vascular endothelial cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
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AU2002317039A 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells Ceased AU2002317039B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002317039A AU2002317039B2 (en) 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AUPR6560A AUPR656001A0 (en) 2001-07-24 2001-07-24 Methods of inducing differentiation of stem cells
AUPR6560 2001-07-24
AUPS1180 2002-03-18
AUPS1180A AUPS118002A0 (en) 2002-03-18 2002-03-18 Methods of inducing differentiation of stem cells
AU2002317039A AU2002317039B2 (en) 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells
PCT/AU2002/000978 WO2003010303A1 (en) 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells

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AU2002317039A1 AU2002317039A1 (en) 2003-05-29
AU2002317039B2 true AU2002317039B2 (en) 2007-10-04

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AU2002317039A Ceased AU2002317039B2 (en) 2001-07-24 2002-07-23 Methods of inducing differentiation of stem cells

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US (2) US8728457B2 (enExample)
EP (1) EP1421182A4 (enExample)
JP (1) JP5479661B2 (enExample)
AU (1) AU2002317039B2 (enExample)
CA (1) CA2452256A1 (enExample)
GB (2) GB2394958B (enExample)
WO (1) WO2003010303A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1379869A4 (en) * 2001-03-15 2004-08-11 Xiao Yong Fu METHOD FOR THERAPEUTICALLY TREATING A CLINICALLY DETECTED CARDIOPATHOLOGICAL FORM IN A MAMMAL
GB2393734B (en) * 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
EP1572984B8 (en) 2002-12-16 2016-06-01 Technion Research & Development Foundation Ltd. Feeder-free, xeno-free culture system for human embryonic stem cells
AU2003901099A0 (en) * 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
WO2004113515A2 (en) * 2003-06-20 2004-12-29 Axiogenesis Ag Tissue modeling in embryonic stem (es) cell system
JP4667241B2 (ja) * 2003-06-27 2011-04-06 旭化成株式会社 細胞分化抑制剤、これを用いた細胞培養方法、培養液及び培養された細胞株
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems
DK1745144T3 (da) 2004-05-11 2011-02-07 Axiogenesis Ag Analysefremgangsmåde til opsporing af lægemidler på grundlag af in vitro-differentierede celler
CA2569242A1 (en) 2004-06-01 2005-12-15 Es Cell International Pte Ltd Improved cardiomyocyte differentiation
US20050277124A1 (en) * 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
CN101228264B (zh) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 使灵长类多能干细胞分化成心肌细胞系细胞
US20070054397A1 (en) * 2005-08-26 2007-03-08 Harald Ott Adult cardiac uncommitted progenitor cells
US8476070B2 (en) 2005-08-29 2013-07-02 Technion Research & Development Foundation Limited Media for culturing stem cells
US7732202B2 (en) * 2005-10-21 2010-06-08 International Stem Cell Corporation Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
ES2704401T3 (es) 2006-08-02 2019-03-18 Technion Res & Dev Foundation Métodos de expansión de células madre embrionarias en un cultivo en suspensión
JP5230969B2 (ja) * 2007-06-14 2013-07-10 公益財団法人先端医療振興財団 心筋芽細胞を含むシート
CN105400735A (zh) * 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
RU2417052C2 (ru) * 2008-08-06 2011-04-27 Владимир Михайлович Музалевский Способ стимулирования зоны роста стволовых клеток по методу музалевского
KR101109125B1 (ko) 2009-03-24 2012-02-15 한국과학기술연구원 줄기세포를 혈관세포로 분화시키는 방법 및 이를 이용한 생체 내 혈관신생 유도
WO2010110596A2 (en) * 2009-03-24 2010-09-30 Korea Institute Of Science And Technology Method for differentiation of stem cells into vascular cells and the induction of angiogenesis using the same
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP2521587B1 (en) * 2010-01-08 2020-04-08 Wake Forest University Health Sciences Delivery system
US9428735B2 (en) 2010-02-25 2016-08-30 The Johns Hopkins University Smooth muscle-like cells (SMLCs) dervided from human pluripotent stem cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
WO2013033213A1 (en) 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US9045038B2 (en) 2011-12-22 2015-06-02 Eaton Corporation Liquid trap with integral jet pump
WO2013130820A1 (en) * 2012-02-29 2013-09-06 The Johns Hopkins University Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation
US9506037B2 (en) 2013-03-15 2016-11-29 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
US9994825B2 (en) 2013-03-15 2018-06-12 The Johns Hopkins University Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018076060A1 (en) 2016-10-26 2018-05-03 Genea Ip Holdings Pty Ltd Improved generation of muscle lineage cells and therapeutic uses thereof
US11746331B2 (en) * 2017-01-27 2023-09-05 Kaneka Corporation Endodermal cell population, and method for producing cell population of any of three germ layers from pluripotent cell
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
EP3696617B1 (fr) * 2019-02-14 2023-07-05 Glashütter Uhrenbetrieb GmbH Mecanisme d'affichage de mois et d'annee bissextile pour piece d'horlogerie
EP3976069A4 (en) 2019-05-31 2023-07-19 Figene, LLC FIBROBLAST THERAPY FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014469A2 (en) * 2000-08-15 2002-02-21 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2324591A1 (en) * 1998-04-09 1999-10-21 Bresagen Limited Cell differentiation/proliferation and maintenance factor and uses thereof
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
IL129966A (en) * 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
US6280718B1 (en) * 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
WO2001048151A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
GB2393734B (en) * 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014469A2 (en) * 2000-08-15 2002-02-21 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Developmental Biology, 1997, 191: 167-181, claims 1-39 *
Journal of Thoracic and Cardiovascular Surgery, November 1995, 110(5): 1442-8, claims 40-44 *
Proc. Natl. Acad. Sci. USA, June 1994, 91: 5286-90, claims 1-4, 25-26 *
Transplantation, 27 June 1998, 65(12): 1563-9 *

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