JP5457183B2 - 癌細胞を破壊する装置及び方法 - Google Patents
癌細胞を破壊する装置及び方法 Download PDFInfo
- Publication number
- JP5457183B2 JP5457183B2 JP2009528510A JP2009528510A JP5457183B2 JP 5457183 B2 JP5457183 B2 JP 5457183B2 JP 2009528510 A JP2009528510 A JP 2009528510A JP 2009528510 A JP2009528510 A JP 2009528510A JP 5457183 B2 JP5457183 B2 JP 5457183B2
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- target tissue
- ablation
- electrodes
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 139
- 201000011510 cancer Diseases 0.000 title claims description 79
- 238000000034 method Methods 0.000 title description 72
- 238000002679 ablation Methods 0.000 claims description 114
- 230000005684 electric field Effects 0.000 claims description 78
- 238000012384 transportation and delivery Methods 0.000 claims description 48
- 238000011282 treatment Methods 0.000 claims description 48
- 239000000523 sample Substances 0.000 claims description 35
- 238000003384 imaging method Methods 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 238000002271 resection Methods 0.000 claims description 6
- 230000036760 body temperature Effects 0.000 claims description 4
- 238000005339 levitation Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 207
- 210000004027 cell Anatomy 0.000 description 117
- 230000008569 process Effects 0.000 description 23
- 230000006378 damage Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 14
- 239000012530 fluid Substances 0.000 description 9
- 230000032823 cell division Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 210000000170 cell membrane Anatomy 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000004520 electroporation Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 238000007674 radiofrequency ablation Methods 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 206010020843 Hyperthermia Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000002591 computed tomography Methods 0.000 description 4
- 238000007667 floating Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000036031 hyperthermia Effects 0.000 description 4
- 230000011278 mitosis Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000011298 ablation treatment Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 238000009206 nuclear medicine Methods 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 230000006369 cell cycle progression Effects 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002977 hyperthermial effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000031864 metaphase Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 2
- 229910001000 nickel titanium Inorganic materials 0.000 description 2
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000021953 cytokinesis Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000029115 microtubule polymerization Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000020347 spindle assembly Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000732 tissue residue Toxicity 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/06—Electrodes for high-frequency therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1407—Loop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
- A61B2018/143—Needle multiple needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1475—Electrodes retractable in or deployable from a housing
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Radiology & Medical Imaging (AREA)
- Cardiology (AREA)
- Surgical Instruments (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82566006P | 2006-09-14 | 2006-09-14 | |
| US60/825,660 | 2006-09-14 | ||
| US86348406P | 2006-10-30 | 2006-10-30 | |
| US60/863,484 | 2006-10-30 | ||
| PCT/US2007/078562 WO2008034103A2 (en) | 2006-09-14 | 2007-09-14 | Device and method for destruction of cancer cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010503496A JP2010503496A (ja) | 2010-02-04 |
| JP2010503496A5 JP2010503496A5 (https=) | 2010-11-04 |
| JP5457183B2 true JP5457183B2 (ja) | 2014-04-02 |
Family
ID=39184631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009528510A Expired - Fee Related JP5457183B2 (ja) | 2006-09-14 | 2007-09-14 | 癌細胞を破壊する装置及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US8109926B2 (https=) |
| EP (1) | EP2068739A4 (https=) |
| JP (1) | JP5457183B2 (https=) |
| CN (1) | CN101553180B (https=) |
| CA (1) | CA2663596A1 (https=) |
| WO (3) | WO2008034103A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI815047B (zh) * | 2020-10-16 | 2023-09-11 | 瑞士商諾沃庫勒有限責任公司 | 藉由使用TTFields活化STING途徑以降低癌細胞生存力的方法 |
| TWI869971B (zh) * | 2020-10-16 | 2025-01-11 | 瑞士商諾沃庫勒有限責任公司 | 藉由使用TTFields活化STING途徑以降低癌細胞生存力的方法 |
Families Citing this family (214)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040215235A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
| AU2003299471A1 (en) | 2002-05-07 | 2004-05-13 | Kai Kroll | Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| US9655676B2 (en) | 2003-05-16 | 2017-05-23 | Trod Medical | Method of percutaneous localized or focal treatment of prostate lesions using radio frequency |
| ES2729378T3 (es) * | 2003-12-24 | 2019-11-04 | Univ California | Ablación de tejido con electroporación irreversible |
| WO2007100727A2 (en) * | 2006-02-24 | 2007-09-07 | Eastern Virginia Medical School | Nanosecond pulsed electric fields cause melanomas to self-destruct |
| EP2012695B1 (en) * | 2006-03-31 | 2015-07-22 | Cook Medical Technologies LLC | Electrosurgical cutting device |
| WO2008034103A2 (en) * | 2006-09-14 | 2008-03-20 | Lazure Technologies, Llc | Device and method for destruction of cancer cells |
| US7655004B2 (en) | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
| WO2008137757A1 (en) * | 2007-05-04 | 2008-11-13 | Barrx Medical, Inc. | Method and apparatus for gastrointestinal tract ablation for treatment of obesity |
| US8784338B2 (en) | 2007-06-22 | 2014-07-22 | Covidien Lp | Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size |
| BRPI0813579A2 (pt) | 2007-07-06 | 2014-12-30 | Barrx Medical Inc | Métodos para tratar uma área de sangramento em um trato gastrintestinal e para tratar ablativamente um sítio alvo dentro de uma área de sangramento de um trato gastrintestinal, e, sistema de ablação. |
| US8251992B2 (en) | 2007-07-06 | 2012-08-28 | Tyco Healthcare Group Lp | Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation |
| US8646460B2 (en) * | 2007-07-30 | 2014-02-11 | Covidien Lp | Cleaning device and methods |
| US8273012B2 (en) | 2007-07-30 | 2012-09-25 | Tyco Healthcare Group, Lp | Cleaning device and methods |
| US20090062788A1 (en) * | 2007-08-31 | 2009-03-05 | Long Gary L | Electrical ablation surgical instruments |
| US8262655B2 (en) | 2007-11-21 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Bipolar forceps |
| US8568410B2 (en) | 2007-08-31 | 2013-10-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation surgical instruments |
| US8579897B2 (en) * | 2007-11-21 | 2013-11-12 | Ethicon Endo-Surgery, Inc. | Bipolar forceps |
| CN105232148A (zh) * | 2007-09-14 | 2016-01-13 | 拉热尔技术有限公司 | 前列腺癌消融 |
| US20090076500A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
| US8480657B2 (en) * | 2007-10-31 | 2013-07-09 | Ethicon Endo-Surgery, Inc. | Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ |
| US20090112059A1 (en) | 2007-10-31 | 2009-04-30 | Nobis Rudolph H | Apparatus and methods for closing a gastrotomy |
| US8262680B2 (en) * | 2008-03-10 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Anastomotic device |
| US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US8992517B2 (en) | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
| US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US20240008911A1 (en) * | 2008-04-29 | 2024-01-11 | Virginia Tech Intellectual Properties, Inc. | Immunotherapeutic methods using electroporation |
| CA2722296A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
| US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
| US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
| US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
| US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
| US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US20240173063A1 (en) * | 2008-04-29 | 2024-05-30 | Virginia Tech Intellectual Properties Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| WO2009137800A2 (en) * | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
| EP2320820B1 (en) | 2008-05-16 | 2014-03-19 | Trod Medical | Percutaneous and laparoscopic surgical instrument |
| US8317806B2 (en) | 2008-05-30 | 2012-11-27 | Ethicon Endo-Surgery, Inc. | Endoscopic suturing tension controlling and indication devices |
| US8679003B2 (en) | 2008-05-30 | 2014-03-25 | Ethicon Endo-Surgery, Inc. | Surgical device and endoscope including same |
| US8771260B2 (en) | 2008-05-30 | 2014-07-08 | Ethicon Endo-Surgery, Inc. | Actuating and articulating surgical device |
| US8403926B2 (en) | 2008-06-05 | 2013-03-26 | Ethicon Endo-Surgery, Inc. | Manually articulating devices |
| US8361112B2 (en) | 2008-06-27 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Surgical suture arrangement |
| US20100010294A1 (en) * | 2008-07-10 | 2010-01-14 | Ethicon Endo-Surgery, Inc. | Temporarily positionable medical devices |
| US8262563B2 (en) | 2008-07-14 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Endoscopic translumenal articulatable steerable overtube |
| US8888792B2 (en) | 2008-07-14 | 2014-11-18 | Ethicon Endo-Surgery, Inc. | Tissue apposition clip application devices and methods |
| US8211125B2 (en) * | 2008-08-15 | 2012-07-03 | Ethicon Endo-Surgery, Inc. | Sterile appliance delivery device for endoscopic procedures |
| US9211155B2 (en) | 2008-08-20 | 2015-12-15 | Prostacare Pty Ltd. | Non-thermal ablation system for treating BPH and other growths |
| EP2326273B1 (en) * | 2008-08-20 | 2021-11-24 | Prostacare Pty Ltd | System including a catheter and deployable electrodes for the non-thermal ablation of tissue |
| US8529563B2 (en) * | 2008-08-25 | 2013-09-10 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8241204B2 (en) | 2008-08-29 | 2012-08-14 | Ethicon Endo-Surgery, Inc. | Articulating end cap |
| US8480689B2 (en) * | 2008-09-02 | 2013-07-09 | Ethicon Endo-Surgery, Inc. | Suturing device |
| US8409200B2 (en) | 2008-09-03 | 2013-04-02 | Ethicon Endo-Surgery, Inc. | Surgical grasping device |
| US8114119B2 (en) | 2008-09-09 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | Surgical grasping device |
| US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
| US8337394B2 (en) | 2008-10-01 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Overtube with expandable tip |
| US20100106063A1 (en) * | 2008-10-29 | 2010-04-29 | Cabochon Aesthetics, Inc. | Ultrasound Enhancing Target for Treating Subcutaneous Tissue |
| US8157834B2 (en) | 2008-11-25 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Rotational coupling device for surgical instrument with flexible actuators |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| US20100168568A1 (en) * | 2008-12-30 | 2010-07-01 | St. Jude Medical, Atrial Fibrillation Division Inc. | Combined Diagnostic and Therapeutic Device Using Aligned Energy Beams |
| US8828031B2 (en) | 2009-01-12 | 2014-09-09 | Ethicon Endo-Surgery, Inc. | Apparatus for forming an anastomosis |
| US8361066B2 (en) * | 2009-01-12 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8252057B2 (en) | 2009-01-30 | 2012-08-28 | Ethicon Endo-Surgery, Inc. | Surgical access device |
| US9226772B2 (en) | 2009-01-30 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Surgical device |
| US8231603B2 (en) * | 2009-02-10 | 2012-07-31 | Angiodynamics, Inc. | Irreversible electroporation and tissue regeneration |
| US8632534B2 (en) | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| WO2010118387A1 (en) * | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
| US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| US20110098704A1 (en) | 2009-10-28 | 2011-04-28 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8608652B2 (en) | 2009-11-05 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Vaginal entry surgical devices, kit, system, and method |
| US20110112434A1 (en) * | 2009-11-06 | 2011-05-12 | Ethicon Endo-Surgery, Inc. | Kits and procedures for natural orifice translumenal endoscopic surgery |
| US8496574B2 (en) | 2009-12-17 | 2013-07-30 | Ethicon Endo-Surgery, Inc. | Selectively positionable camera for surgical guide tube assembly |
| US8353487B2 (en) * | 2009-12-17 | 2013-01-15 | Ethicon Endo-Surgery, Inc. | User interface support devices for endoscopic surgical instruments |
| US8506564B2 (en) | 2009-12-18 | 2013-08-13 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US9028483B2 (en) | 2009-12-18 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US20110190764A1 (en) * | 2010-01-29 | 2011-08-04 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US9005198B2 (en) * | 2010-01-29 | 2015-04-14 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| WO2011103133A2 (en) * | 2010-02-16 | 2011-08-25 | Angiodynamics, Inc. | Dual bracketed energy delivery probe and method of use |
| US20110288545A1 (en) * | 2010-04-22 | 2011-11-24 | Old Dominion University Research Foundation | Method and Device for Ablation of Cancer and Resistance to New Cancer Growth |
| US9526911B1 (en) * | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
| WO2012051433A2 (en) | 2010-10-13 | 2012-04-19 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
| US9820794B2 (en) * | 2010-11-19 | 2017-11-21 | Intermountain Invention Management, Llc | Devices for killing tumor cells and related systems and methods |
| WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
| US10092291B2 (en) | 2011-01-25 | 2018-10-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with selectively rigidizable features |
| US9233241B2 (en) | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9254169B2 (en) | 2011-02-28 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9314620B2 (en) | 2011-02-28 | 2016-04-19 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9049987B2 (en) | 2011-03-17 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Hand held surgical device for manipulating an internal magnet assembly within a patient |
| US10278774B2 (en) | 2011-03-18 | 2019-05-07 | Covidien Lp | Selectively expandable operative element support structure and methods of use |
| EP2796103B1 (en) | 2011-08-25 | 2017-02-22 | Covidien LP | Systems and devices for treatment of luminal tissue |
| US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
| EP2765939B1 (en) | 2011-10-15 | 2018-09-26 | Diros Technology Inc. | Apparatus for precisely controlling the size and shape of radiofrequency ablations |
| JP2015057080A (ja) * | 2012-01-12 | 2015-03-26 | テルモ株式会社 | 体内組織焼灼システム |
| US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
| US8986199B2 (en) | 2012-02-17 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Apparatus and methods for cleaning the lens of an endoscope |
| US9314299B2 (en) | 2012-03-21 | 2016-04-19 | Biosense Webster (Israel) Ltd. | Flower catheter for mapping and ablating veinous and other tubular locations |
| US9427255B2 (en) | 2012-05-14 | 2016-08-30 | Ethicon Endo-Surgery, Inc. | Apparatus for introducing a steerable camera assembly into a patient |
| US9078662B2 (en) | 2012-07-03 | 2015-07-14 | Ethicon Endo-Surgery, Inc. | Endoscopic cap electrode and method for using the same |
| CN104507536B (zh) | 2012-07-23 | 2017-11-14 | 皇家飞利浦有限公司 | 组合的短程治疗和电化学治疗导管 |
| US9545290B2 (en) | 2012-07-30 | 2017-01-17 | Ethicon Endo-Surgery, Inc. | Needle probe guide |
| US10314649B2 (en) | 2012-08-02 | 2019-06-11 | Ethicon Endo-Surgery, Inc. | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
| US9572623B2 (en) | 2012-08-02 | 2017-02-21 | Ethicon Endo-Surgery, Inc. | Reusable electrode and disposable sheath |
| US9259269B2 (en) * | 2012-08-07 | 2016-02-16 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
| US9277957B2 (en) | 2012-08-15 | 2016-03-08 | Ethicon Endo-Surgery, Inc. | Electrosurgical devices and methods |
| US9743975B2 (en) | 2012-10-02 | 2017-08-29 | Covidien Lp | Thermal ablation probe for a medical device |
| US9888956B2 (en) | 2013-01-22 | 2018-02-13 | Angiodynamics, Inc. | Integrated pump and generator device and method of use |
| US10098527B2 (en) | 2013-02-27 | 2018-10-16 | Ethidcon Endo-Surgery, Inc. | System for performing a minimally invasive surgical procedure |
| US20140296843A1 (en) * | 2013-03-27 | 2014-10-02 | Bnr Technology Development, Llc | Apparatus and method for treating cancer cells and bacteria in mammals including humans |
| US9101764B2 (en) | 2013-06-03 | 2015-08-11 | Nanoblate Corp. | Methods and devices for stimulating an immune response using nanosecond pulsed electric fields |
| US10154869B2 (en) * | 2013-08-02 | 2018-12-18 | Gary M. Onik | System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation |
| WO2015021113A1 (en) | 2013-08-06 | 2015-02-12 | Memorial Sloan Kettering Cancer Center | System, method and computer-accessible medium for in-vivo tissue ablation and/or damage |
| US10390874B2 (en) | 2013-11-14 | 2019-08-27 | Rm2 Technology Llc | Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization |
| JP6723153B2 (ja) * | 2013-12-05 | 2020-07-15 | アールエフイーエムビー ホールディングス リミテッド ライアビリティ カンパニー | 生体内の望ましくない軟部組織を切除するシステム |
| CN103892920A (zh) * | 2014-04-03 | 2014-07-02 | 张道福 | 一种神经外科手术引导工具 |
| US10471254B2 (en) | 2014-05-12 | 2019-11-12 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| EP3174485B1 (en) * | 2014-07-28 | 2021-10-27 | Boston Scientific Scimed, Inc. | Multiple lead electrode probe for controlled tissue ablation |
| GB201414529D0 (en) * | 2014-08-15 | 2014-10-01 | Asalus Medical Instr Ltd | A surgical instrument |
| US12114911B2 (en) | 2014-08-28 | 2024-10-15 | Angiodynamics, Inc. | System and method for ablating a tissue site by electroporation with real-time pulse monitoring |
| WO2016089781A1 (en) | 2014-12-01 | 2016-06-09 | Electroblate, Inc. | Nanoelectroablation control and vaccination |
| WO2016100325A1 (en) | 2014-12-15 | 2016-06-23 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
| US10299858B2 (en) | 2014-12-23 | 2019-05-28 | Cook Medical Technologies Llc | Variable thickness electrosurgical snare |
| KR102128856B1 (ko) * | 2015-01-30 | 2020-07-02 | 알에프이엠비 홀딩스, 엘엘씨 | 고주파 전기적 막 파괴를 이용하여 생명체의 바람직하지 않은 연조직을 절제하는 시스템 |
| CA2975931A1 (en) * | 2015-02-04 | 2016-08-11 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for the treatment of adipose tissue and removal of unwanted body fat |
| CA2975938A1 (en) * | 2015-02-04 | 2016-08-11 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for reducing restenosis |
| CA2975926A1 (en) * | 2015-02-04 | 2016-08-11 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for the treatment of benign prostatic hyperplasia |
| WO2016127162A1 (en) * | 2015-02-06 | 2016-08-11 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for the treatment of cardiac rhythm disorders and for renal neuromodulation |
| US9775673B2 (en) * | 2015-03-26 | 2017-10-03 | Garner B. Meads, JR. | Nasal coagulation suction device and methods |
| US10806512B2 (en) * | 2015-03-26 | 2020-10-20 | Garner B. Meads, JR. | Nasal coagulation suction device and methods |
| EP3288471A1 (en) | 2015-05-01 | 2018-03-07 | Inter Science GmbH | Methods, systems, and apparatuses for tissue ablation using pulse shape designs |
| CN106308929A (zh) * | 2015-06-30 | 2017-01-11 | 四川锦江电子科技有限公司 | 一种极间放电的消融装置 |
| US11337749B2 (en) | 2015-10-07 | 2022-05-24 | Mayo Foundation For Medical Education And Research | Electroporation for obesity or diabetes treatment |
| EP3402517B1 (en) | 2016-01-15 | 2025-08-20 | RFEMB Holdings, LLC | Immunologic treatment of cancer by using a tumor ablation technic together with a combination of a ctla-4 inhibitor, a pd-1 inhibitor and gm-csf |
| US10874451B2 (en) | 2016-02-29 | 2020-12-29 | Pulse Biosciences, Inc. | High-voltage analog circuit pulser and pulse generator discharge circuit |
| US10548665B2 (en) * | 2016-02-29 | 2020-02-04 | Pulse Biosciences, Inc. | High-voltage analog circuit pulser with feedback control |
| WO2017200954A1 (en) * | 2016-05-16 | 2017-11-23 | Pulse Biosciences, Inc. | Pulse applicator |
| JP7287888B2 (ja) | 2016-06-27 | 2023-06-06 | ギャラリー,インコーポレイテッド | ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法 |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| CN106236248B (zh) * | 2016-08-30 | 2019-11-12 | 苏州涵轩信息科技有限公司 | 一种射频消融设备、系统和方法 |
| US10543357B2 (en) | 2016-09-19 | 2020-01-28 | Pulse Biosciences, Inc. | High voltage connectors for pulse generators |
| WO2018061124A1 (ja) * | 2016-09-28 | 2018-04-05 | オリンパス株式会社 | 処置具 |
| US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
| US10946193B2 (en) | 2017-02-28 | 2021-03-16 | Pulse Biosciences, Inc. | Pulse generator with independent panel triggering |
| CN107260300A (zh) * | 2017-07-20 | 2017-10-20 | 常州朗合医疗器械有限公司 | 射频消融导管及系统 |
| US10857347B2 (en) | 2017-09-19 | 2020-12-08 | Pulse Biosciences, Inc. | Treatment instrument and high-voltage connectors for robotic surgical system |
| US11648047B2 (en) | 2017-10-06 | 2023-05-16 | Vive Scientific, Llc | System and method to treat obstructive sleep apnea |
| US20190117971A1 (en) * | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Volume-filling leads for treatment of cancer with electric fields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11045648B2 (en) | 2017-11-14 | 2021-06-29 | Boston Scientific Scimed, Inc. | Irreversible electroporation through a combination of substance injection and electrical field application |
| KR102659146B1 (ko) | 2017-11-27 | 2024-04-22 | 프로스타캐어 피티와이 엘티디 | 전립선 질환의 치료를 위한 장치 및 방법 |
| US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
| DK4218641T3 (da) | 2017-12-26 | 2025-08-18 | Galvanize Therapeutics Inc | Optimering af energilevering til forskellige anvendelser |
| EP3742998B1 (en) * | 2018-01-23 | 2023-11-15 | Boston Scientific Scimed, Inc. | Enhanced needle array and therapies for tumor ablation |
| CN112040860B (zh) * | 2018-02-06 | 2025-05-27 | 伯恩森斯韦伯斯特(以色列)有限责任公司 | 具有交错的微电极构型的医疗探头 |
| US11224474B2 (en) | 2018-02-28 | 2022-01-18 | Prostacare Pty Ltd | System for managing high impedance changes in a non-thermal ablation system for BPH |
| US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
| US12390262B2 (en) | 2018-03-13 | 2025-08-19 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| RU2723883C2 (ru) * | 2018-07-17 | 2020-06-18 | Николай Васильевич Цугленок | Способ инициации гибели опухолевых клеток аскорбиновой и гидрозидом 3-аминофталевой кислотами и ВЧ- и СВЧ-энергией волнового излучения |
| RU2739254C2 (ru) * | 2018-07-17 | 2020-12-22 | Николай Васильевич Цугленок | Способ инициации гибели опухолевых клеток янтарной и 3-аминофталевой кислотами и ВЧ- и СВЧ-энергией волнового излучения |
| WO2020051241A1 (en) | 2018-09-04 | 2020-03-12 | Inter Science Gmbh | Methods, systems, and apparatuses for tissue ablation using a modulated exponential decay pulse |
| US20200100834A1 (en) * | 2018-09-27 | 2020-04-02 | Covidien Lp | Energy-based tissue specimen removal |
| US11135004B2 (en) * | 2018-12-24 | 2021-10-05 | Industrial Technology Research Institute | Ablation device |
| US20220133397A1 (en) * | 2019-01-23 | 2022-05-05 | Ablation Gen 2 Pty Ltd | Devices and methods for ablating tissue |
| US11571569B2 (en) | 2019-02-15 | 2023-02-07 | Pulse Biosciences, Inc. | High-voltage catheters for sub-microsecond pulsing |
| EP3937811B1 (en) | 2019-03-15 | 2024-07-10 | Boston Scientific Scimed, Inc. | Time multiplexed waveform for selective cell ablation |
| EP3937812B1 (en) | 2019-03-15 | 2025-04-23 | Boston Scientific Scimed, Inc. | Waveform generator and control for selective cell ablation |
| JP7551648B2 (ja) | 2019-04-18 | 2024-09-17 | ガルヴァナイズ セラピューティクス,インコーポレイテッド | 異常組織を治療するための器械、及びシステム、 |
| EP4480526A3 (en) | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| CN113766949B (zh) | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| US11850422B2 (en) | 2019-04-23 | 2023-12-26 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
| CN113766950A (zh) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| CN118648968A (zh) | 2019-05-09 | 2024-09-17 | 捷锐士阿希迈公司(以奥林巴斯美国外科技术名义) | 外科发生器和方法 |
| US10667855B1 (en) | 2019-05-10 | 2020-06-02 | Trod Medical Us, Llc | Dual coil ablation devices |
| CN110151300A (zh) * | 2019-05-17 | 2019-08-23 | 杭州睿笛生物科技有限公司 | 一种可协同给药的电脉冲消融装置 |
| CN110151306A (zh) * | 2019-05-17 | 2019-08-23 | 杭州睿笛生物科技有限公司 | 一种电脉冲平行电极 |
| US11642090B2 (en) | 2019-05-29 | 2023-05-09 | Sirona Medical Technologies, Inc. | Cardiac electrical mapping and ablation |
| US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
| AU2020314830B2 (en) | 2019-07-16 | 2026-01-22 | Galvanize Therapeutics, Inc. | Treatment of the reproductive tract with pulsed electric fields |
| US12214189B2 (en) | 2019-07-24 | 2025-02-04 | Virginia Tech Intellectual Properties, Inc. | Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies |
| CN110755148B (zh) * | 2019-09-20 | 2020-09-08 | 姚陈果 | 脉冲电场肿瘤消融参数优化系统 |
| DE102020124443A1 (de) * | 2019-09-26 | 2021-04-01 | Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America | Vorrichtungen, systeme und verfahren zum transportieren von hilfsmitteln durch einen engen durchgang in einem körper |
| CN114945338A (zh) | 2019-10-15 | 2022-08-26 | 波士顿科学国际有限公司 | 用于消融系统的控制系统和用户界面 |
| EP4048179A1 (en) | 2019-10-21 | 2022-08-31 | Endogenex, Inc. | Devices, systems, and methods for pulsed electric field treatment of the duodenum |
| CN110840552B (zh) * | 2019-12-10 | 2025-01-28 | 杭州睿笛生物科技有限公司 | 一种治疗房颤的电脉冲消融系统及其使用方法 |
| CN110960314B (zh) * | 2019-12-31 | 2021-06-15 | 杭州堃博生物科技有限公司 | 检测机构、射频消融导管及射频消融系统 |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| US11992260B2 (en) | 2020-03-31 | 2024-05-28 | Boston Scientific Scimed, Inc. | Smart probe identification for ablation modalities |
| WO2021216750A1 (en) * | 2020-04-22 | 2021-10-28 | Ne Scientific, Llc | Interactive multi-probe ablation guidance system and method |
| US12171484B2 (en) * | 2020-05-27 | 2024-12-24 | Medtronic, Inc. | Safety default return path for electric field therapy |
| CN111772782A (zh) * | 2020-08-10 | 2020-10-16 | 湖南菁益医疗科技有限公司 | 一种电极及消融设备 |
| US12414684B2 (en) | 2020-08-19 | 2025-09-16 | Acclarent, Inc. | ENT instrument with deformable guide having translatable imaging feature |
| US12016612B2 (en) | 2020-08-19 | 2024-06-25 | Acclarent, Inc. | ENT ablation instrument with electrode loop |
| CN116322890A (zh) * | 2020-09-30 | 2023-06-23 | 诺沃库勒有限责任公司 | 用于提供肿瘤治疗场的可植入阵列 |
| US12485279B2 (en) | 2020-11-25 | 2025-12-02 | Virginia Tech Intellectual Properties, Inc. | Methods for modulating temporal infrastructure of pulsed electric fields |
| CN112641503A (zh) * | 2020-12-25 | 2021-04-13 | 山西白求恩医院(山西医学科学院) | 一种肿瘤射频消融装置 |
| CN112933407B (zh) * | 2021-01-28 | 2024-07-23 | 杭州维纳安可医疗科技有限责任公司 | 电极结构、电极贴片及细胞分裂抑制装置 |
| WO2022176202A1 (ja) * | 2021-02-22 | 2022-08-25 | 日本ライフライン株式会社 | 電源装置およびアブレーションシステム |
| AU2022254861B2 (en) | 2021-04-07 | 2024-01-18 | Btl Medical Development A.S. | Pulsed field ablation device and method |
| IL309432B2 (en) | 2021-07-06 | 2025-02-01 | Btl Medical Dev A S | Device and method for ablation (burning) by electric pulse field |
| CN114652434B (zh) * | 2022-02-16 | 2023-09-26 | 电子科技大学 | 一种基于mems微针束的多窗口微波消融方法及其装置 |
| CN115177357B (zh) * | 2022-07-12 | 2026-04-17 | 深圳迈微医疗科技有限公司 | 双模态组织消融装置 |
| CN115253067A (zh) * | 2022-07-28 | 2022-11-01 | 上海美生医疗器械有限公司 | 植入式电极装置的电极部 |
| CN115317789A (zh) * | 2022-07-28 | 2022-11-11 | 上海美生医疗器械有限公司 | 具有多个电场发生触点的电极装置 |
| WO2024075034A1 (en) | 2022-10-05 | 2024-04-11 | Btl Medical Technologies S.R.O. | Pulsed field ablation device and method |
| CN115779273A (zh) * | 2022-11-03 | 2023-03-14 | 赛福凯尔(绍兴)医疗科技有限公司 | 电场能量聚焦的发射装置及方法 |
| CN116636922B (zh) * | 2023-05-12 | 2024-05-03 | 心诺普医疗技术(北京)有限公司 | 磁感应热消融球囊导管及消融方法 |
| CN118058828B (zh) * | 2024-04-17 | 2024-06-18 | 天津市鹰泰利安康医疗科技有限责任公司 | 一种双模态复合胰腺癌肿瘤的消融方法及系统 |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4346715A (en) * | 1978-07-12 | 1982-08-31 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Hyperthermia heating apparatus |
| US4448198A (en) | 1979-06-19 | 1984-05-15 | Bsd Medical Corporation | Invasive hyperthermia apparatus and method |
| US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
| CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| WO1985002779A1 (en) | 1983-12-27 | 1985-07-04 | Board Of Trustees Of Leland Stanford Junior Univer | Catheter for treatment of tumors and method for using same |
| US4723161A (en) * | 1985-03-20 | 1988-02-02 | Nec Corporation | Method and arrangement of coding digital image signals utilizing interframe correlation |
| FR2582947B1 (fr) | 1985-06-07 | 1988-05-13 | Cgr Mev | Dispositif de traitement par hyperthermie |
| US4860752A (en) | 1988-02-18 | 1989-08-29 | Bsd Medical Corporation | Invasive microwave array with destructive and coherent phase |
| US7549424B2 (en) * | 1991-10-18 | 2009-06-23 | Pro Surg, Inc. | Method and apparatus for tissue treatment with laser and electromagnetic radiation |
| US5681282A (en) * | 1992-01-07 | 1997-10-28 | Arthrocare Corporation | Methods and apparatus for ablation of luminal tissues |
| US6296638B1 (en) * | 1993-05-10 | 2001-10-02 | Arthrocare Corporation | Systems for tissue ablation and aspiration |
| US5370677A (en) | 1992-03-06 | 1994-12-06 | Urologix, Inc. | Gamma matched, helical dipole microwave antenna with tubular-shaped capacitor |
| US5277201A (en) | 1992-05-01 | 1994-01-11 | Vesta Medical, Inc. | Endometrial ablation apparatus and method |
| US6749604B1 (en) * | 1993-05-10 | 2004-06-15 | Arthrocare Corporation | Electrosurgical instrument with axially-spaced electrodes |
| DE69434185T2 (de) | 1993-06-10 | 2005-06-02 | Imran, Mir A., Los Altos Hills | Urethrales gerät zur ablation mittels hochfrequenz |
| US5807395A (en) * | 1993-08-27 | 1998-09-15 | Medtronic, Inc. | Method and apparatus for RF ablation and hyperthermia |
| US6071280A (en) * | 1993-11-08 | 2000-06-06 | Rita Medical Systems, Inc. | Multiple electrode ablation apparatus |
| US5472441A (en) * | 1993-11-08 | 1995-12-05 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
| US5599345A (en) * | 1993-11-08 | 1997-02-04 | Zomed International, Inc. | RF treatment apparatus |
| US5536267A (en) * | 1993-11-08 | 1996-07-16 | Zomed International | Multiple electrode ablation apparatus |
| US6056744A (en) * | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
| US5630426A (en) * | 1995-03-03 | 1997-05-20 | Neovision Corporation | Apparatus and method for characterization and treatment of tumors |
| US5868740A (en) * | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
| US6149620A (en) * | 1995-11-22 | 2000-11-21 | Arthrocare Corporation | System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid |
| US6080150A (en) * | 1995-08-15 | 2000-06-27 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
| US6235023B1 (en) * | 1995-08-15 | 2001-05-22 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
| US5863290A (en) * | 1995-08-15 | 1999-01-26 | Rita Medical Systems | Multiple antenna ablation apparatus and method |
| US5810804A (en) | 1995-08-15 | 1998-09-22 | Rita Medical Systems | Multiple antenna ablation apparatus and method with cooling element |
| US6090105A (en) * | 1995-08-15 | 2000-07-18 | Rita Medical Systems, Inc. | Multiple electrode ablation apparatus and method |
| US6246912B1 (en) * | 1996-06-27 | 2001-06-12 | Sherwood Services Ag | Modulated high frequency tissue modification |
| US5993447A (en) * | 1996-08-16 | 1999-11-30 | United States Surgical | Apparatus for thermal treatment of tissue |
| ES2353846T3 (es) * | 1997-04-11 | 2011-03-07 | United States Surgical Corporation | Aparato para ablación con rf y controlador del mismo. |
| US5792140A (en) * | 1997-05-15 | 1998-08-11 | Irvine Biomedical, Inc. | Catheter having cooled multiple-needle electrode |
| US6050992A (en) | 1997-05-19 | 2000-04-18 | Radiotherapeutics Corporation | Apparatus and method for treating tissue with multiple electrodes |
| US6652515B1 (en) * | 1997-07-08 | 2003-11-25 | Atrionix, Inc. | Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall |
| US6440127B2 (en) | 1998-02-11 | 2002-08-27 | Cosman Company, Inc. | Method for performing intraurethral radio-frequency urethral enlargement |
| US6517534B1 (en) * | 1998-02-11 | 2003-02-11 | Cosman Company, Inc. | Peri-urethral ablation |
| US5968041A (en) * | 1998-04-02 | 1999-10-19 | Vida Care, Inc. | Directable thermal energy delivery apparatus |
| US7198635B2 (en) * | 2000-10-17 | 2007-04-03 | Asthmatx, Inc. | Modification of airways by application of energy |
| US6136020A (en) * | 1998-06-26 | 2000-10-24 | Faour; Ali M. | Treatment for prostatitis and apparatus therefor |
| US6537272B2 (en) | 1998-07-07 | 2003-03-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
| US6212433B1 (en) | 1998-07-28 | 2001-04-03 | Radiotherapeutics Corporation | Method for treating tumors near the surface of an organ |
| US6148236A (en) * | 1998-11-04 | 2000-11-14 | Urologix, Inc. | Cancer treatment system employing supplemented thermal therapy |
| US6666875B1 (en) * | 1999-03-05 | 2003-12-23 | Olympus Optical Co., Ltd. | Surgical apparatus permitting recharge of battery-driven surgical instrument in noncontact state |
| US6738663B2 (en) | 1999-04-09 | 2004-05-18 | Oncostim, A Minnesota Corporation | Implantable device and method for the electrical treatment of cancer |
| US6939346B2 (en) * | 1999-04-21 | 2005-09-06 | Oratec Interventions, Inc. | Method and apparatus for controlling a temperature-controlled probe |
| US7053063B2 (en) * | 1999-07-21 | 2006-05-30 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes in tissue |
| EP1228370A2 (en) * | 1999-11-10 | 2002-08-07 | Structural Bioinformatics Inc. | Computationally derived protein structures in pharmacogenomics |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7016725B2 (en) * | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7146210B2 (en) * | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| JP5280600B2 (ja) * | 2000-02-17 | 2013-09-04 | パルティ、ヨーラム | 分裂中の細胞を破壊するための方法および装置 |
| US6944504B1 (en) * | 2000-02-23 | 2005-09-13 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microwave medical treatment apparatus and method |
| NZ522128A (en) * | 2000-03-31 | 2003-08-29 | Rita Medical Systems Inc | Tissue biopsy and treatment apparatus and method |
| US6477426B1 (en) * | 2000-06-20 | 2002-11-05 | Celsion Corporation | System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors |
| US6962587B2 (en) * | 2000-07-25 | 2005-11-08 | Rita Medical Systems, Inc. | Method for detecting and treating tumors using localized impedance measurement |
| US6892099B2 (en) * | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US8251986B2 (en) * | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| WO2002058578A1 (en) * | 2000-11-13 | 2002-08-01 | Wit Ip Corporation | Treatment catheters with thermally insulated regions |
| US6866624B2 (en) * | 2000-12-08 | 2005-03-15 | Medtronic Ave,Inc. | Apparatus and method for treatment of malignant tumors |
| US20020087151A1 (en) * | 2000-12-29 | 2002-07-04 | Afx, Inc. | Tissue ablation apparatus with a sliding ablation instrument and method |
| US6743226B2 (en) | 2001-02-09 | 2004-06-01 | Cosman Company, Inc. | Adjustable trans-urethral radio-frequency ablation |
| JP4346826B2 (ja) * | 2001-02-28 | 2009-10-21 | 瑞穂医科工業株式会社 | 携帯型電気手術器、それを備えた携帯型電気手術器システムおよび携帯型電気手術器の制御方法 |
| CA2445392C (en) | 2001-05-10 | 2011-04-26 | Rita Medical Systems, Inc. | Rf tissue ablation apparatus and method |
| US7135029B2 (en) * | 2001-06-29 | 2006-11-14 | Makin Inder Raj S | Ultrasonic surgical instrument for intracorporeal sonodynamic therapy |
| US6994706B2 (en) * | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US6835864B2 (en) * | 2001-09-05 | 2004-12-28 | Aaron John Luck | Method and device for treating minor wounds |
| EP1460945B1 (en) * | 2001-09-14 | 2013-01-09 | ArthroCare Corporation | Electrosurgical apparatus for tissue treatment & removal |
| AU2002327779B2 (en) * | 2001-09-28 | 2008-06-26 | Angiodynamics, Inc. | Impedance controlled tissue ablation apparatus and method |
| WO2003049631A1 (en) | 2001-12-12 | 2003-06-19 | Tissuelink Medical, Inc. | Fluid-assisted medical devices, systems and methods |
| US6850804B2 (en) * | 2002-01-18 | 2005-02-01 | Calfacior Corporation | System method and apparatus for localized heating of tissue |
| US6993394B2 (en) * | 2002-01-18 | 2006-01-31 | Calfacion Corporation | System method and apparatus for localized heating of tissue |
| US6895282B2 (en) * | 2002-10-04 | 2005-05-17 | Boston Scientific Scimed, Inc. | Induction heating for the delivery of thermal therapy |
| WO2004047659A2 (en) | 2002-11-27 | 2004-06-10 | Christopher Paul Hancock | Tissue ablation apparatus and method of ablating tissue |
| US7238182B2 (en) * | 2003-04-25 | 2007-07-03 | Medtronic, Inc. | Device and method for transurethral prostate treatment |
| US6958064B2 (en) | 2003-11-14 | 2005-10-25 | Boston Scientific Scimed, Inc. | Systems and methods for performing simultaneous ablation |
| ES2729378T3 (es) * | 2003-12-24 | 2019-11-04 | Univ California | Ablación de tejido con electroporación irreversible |
| US7491200B2 (en) * | 2004-03-26 | 2009-02-17 | Arthrocare Corporation | Method for treating obstructive sleep disorder includes removing tissue from base of tongue |
| US20050222646A1 (en) * | 2004-04-06 | 2005-10-06 | Kai Kroll | Method and device for treating cancer with modified output electrical therapy |
| CA2563817C (en) * | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| US20050261672A1 (en) * | 2004-05-18 | 2005-11-24 | Mark Deem | Systems and methods for selective denervation of heart dysrhythmias |
| AU2005289828A1 (en) * | 2004-09-24 | 2006-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for the non-thermal, electrically-induced closure of blood vessels |
| US7261710B2 (en) | 2004-10-13 | 2007-08-28 | Medtronic, Inc. | Transurethral needle ablation system |
| ES2344215T3 (es) | 2004-12-07 | 2010-08-20 | Standen Ltd. | Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo. |
| EP3666328B1 (en) | 2004-12-27 | 2022-04-06 | Novocure GmbH | Treating a tumor or the like with electric fields at different orientations |
| US8211104B2 (en) | 2005-01-06 | 2012-07-03 | Boston Scientific Scimed, Inc. | Co-access bipolar ablation probe |
| US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| US20060282122A1 (en) | 2005-06-08 | 2006-12-14 | Yoram Palti | Treating cancer with electric fields that are guided to desired locations within a body |
| US20060293730A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US20070135879A1 (en) * | 2005-12-08 | 2007-06-14 | Mcintyre Jon T | Cylindrical device for delivering energy to tissue |
| US20080033422A1 (en) * | 2006-08-04 | 2008-02-07 | Turner Paul F | Microwave applicator with margin temperature sensing element |
| WO2008034103A2 (en) | 2006-09-14 | 2008-03-20 | Lazure Technologies, Llc | Device and method for destruction of cancer cells |
-
2007
- 2007-09-14 WO PCT/US2007/078562 patent/WO2008034103A2/en not_active Ceased
- 2007-09-14 US US11/855,940 patent/US8109926B2/en not_active Expired - Fee Related
- 2007-09-14 US US11/855,977 patent/US7680543B2/en not_active Expired - Fee Related
- 2007-09-14 CA CA002663596A patent/CA2663596A1/en not_active Abandoned
- 2007-09-14 CN CN200780034204.5A patent/CN101553180B/zh not_active Expired - Fee Related
- 2007-09-14 US US11/855,956 patent/US7722606B2/en not_active Expired - Fee Related
- 2007-09-14 WO PCT/US2007/078559 patent/WO2008034100A2/en not_active Ceased
- 2007-09-14 WO PCT/US2007/078567 patent/WO2008034107A2/en not_active Ceased
- 2007-09-14 EP EP07842548A patent/EP2068739A4/en not_active Withdrawn
- 2007-09-14 JP JP2009528510A patent/JP5457183B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-13 US US12/759,611 patent/US8915911B2/en not_active Expired - Fee Related
-
2012
- 2012-01-05 US US13/344,373 patent/US9308039B2/en not_active Expired - Fee Related
-
2014
- 2014-11-06 US US14/535,166 patent/US20150066024A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI815047B (zh) * | 2020-10-16 | 2023-09-11 | 瑞士商諾沃庫勒有限責任公司 | 藉由使用TTFields活化STING途徑以降低癌細胞生存力的方法 |
| TWI869971B (zh) * | 2020-10-16 | 2025-01-11 | 瑞士商諾沃庫勒有限責任公司 | 藉由使用TTFields活化STING途徑以降低癌細胞生存力的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2663596A1 (en) | 2008-03-20 |
| WO2008034100A3 (en) | 2008-07-24 |
| EP2068739A4 (en) | 2013-01-23 |
| US7680543B2 (en) | 2010-03-16 |
| EP2068739A2 (en) | 2009-06-17 |
| WO2008034107A3 (en) | 2008-11-27 |
| CN101553180B (zh) | 2013-08-07 |
| US20080071264A1 (en) | 2008-03-20 |
| CN101553180A (zh) | 2009-10-07 |
| US9308039B2 (en) | 2016-04-12 |
| US8915911B2 (en) | 2014-12-23 |
| JP2010503496A (ja) | 2010-02-04 |
| US7722606B2 (en) | 2010-05-25 |
| US20150066024A1 (en) | 2015-03-05 |
| US8109926B2 (en) | 2012-02-07 |
| HK1138166A1 (en) | 2010-08-20 |
| WO2008034100A2 (en) | 2008-03-20 |
| US20080071265A1 (en) | 2008-03-20 |
| WO2008034103A3 (en) | 2008-11-20 |
| US20080071262A1 (en) | 2008-03-20 |
| US20120232550A1 (en) | 2012-09-13 |
| WO2008034107A2 (en) | 2008-03-20 |
| WO2008034103A2 (en) | 2008-03-20 |
| US20110015630A1 (en) | 2011-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5457183B2 (ja) | 癌細胞を破壊する装置及び方法 | |
| US20170258518A1 (en) | Multi-tine probe and treatment by activation of opposing tines | |
| US9775671B2 (en) | Multi-layer electrode ablation probe and related methods | |
| EP1301138B1 (en) | Tumor ablation needle | |
| CN111615371B (zh) | 用于肿瘤消融的增强的针阵列及治疗 | |
| US20060025764A1 (en) | Systems and methods for performing simultaneous ablation | |
| US20140221992A1 (en) | Systems and methods for creating a lesion using transjugular approach | |
| WO2007059769A1 (en) | Method and apparatus for substantial and uniform ablation about a linear bipolar array of electrodes | |
| WO2004082497A1 (en) | Apparatus for treating tissue using implanted electrode devices | |
| US20160184006A1 (en) | Ablation probe with deployable electrodes | |
| WO2013076439A1 (en) | Apparatus for destroying solid tumours in- situ | |
| HK1138166B (en) | Device for destruction of cancer cells | |
| WO2013076440A1 (en) | Radio frequency surgical probe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100914 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100914 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120629 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120703 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121003 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121011 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121105 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130402 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130702 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20131210 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140109 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5457183 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |