JP5456467B2 - ラットおよび他種由来の多能性細胞 - Google Patents
ラットおよび他種由来の多能性細胞 Download PDFInfo
- Publication number
- JP5456467B2 JP5456467B2 JP2009522328A JP2009522328A JP5456467B2 JP 5456467 B2 JP5456467 B2 JP 5456467B2 JP 2009522328 A JP2009522328 A JP 2009522328A JP 2009522328 A JP2009522328 A JP 2009522328A JP 5456467 B2 JP5456467 B2 JP 5456467B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- pluripotent
- medium
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
| GB0615327.4 | 2006-08-01 | ||
| GBGB0700479.9A GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
| GB0700479.9 | 2007-01-10 | ||
| PCT/GB2007/002913 WO2008015418A2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127052A Division JP2013176400A (ja) | 2006-08-01 | 2013-06-17 | ラットおよび他種由来の多能性細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009545302A JP2009545302A (ja) | 2009-12-24 |
| JP2009545302A5 JP2009545302A5 (cg-RX-API-DMAC7.html) | 2010-05-06 |
| JP5456467B2 true JP5456467B2 (ja) | 2014-03-26 |
Family
ID=37809760
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522328A Expired - Fee Related JP5456467B2 (ja) | 2006-08-01 | 2007-08-01 | ラットおよび他種由来の多能性細胞 |
| JP2013127052A Pending JP2013176400A (ja) | 2006-08-01 | 2013-06-17 | ラットおよび他種由来の多能性細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127052A Pending JP2013176400A (ja) | 2006-08-01 | 2013-06-17 | ラットおよび他種由来の多能性細胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8431395B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2049654A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5456467B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101657535B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007280216B2 (cg-RX-API-DMAC7.html) |
| GB (3) | GB0615327D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008015418A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US8357666B2 (en) * | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
| EP1999249B8 (en) * | 2006-03-30 | 2012-02-15 | The University Court Of The University of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| MX352541B (es) | 2007-04-07 | 2017-11-29 | Whitehead Inst Biomedical Res | Reprogramación de células somáticas. |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101918541A (zh) * | 2007-07-18 | 2010-12-15 | 塞拉提斯股份公司 | 衍生自hBS细胞的心肌细胞样细胞簇 |
| CA2695225C (en) | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| WO2009032194A1 (en) | 2007-08-31 | 2009-03-12 | Whitehead Institute For Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| CA2718904C (en) | 2008-03-17 | 2017-01-03 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| AU2009233845A1 (en) * | 2008-04-07 | 2009-10-15 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator |
| CA2969377C (en) | 2008-06-13 | 2019-12-03 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| EP2369916A4 (en) * | 2008-12-01 | 2013-04-10 | Univ Texas | PREPARATION AND USE OF SPERMATOGONIAL STEM CELL LINES FROM THE RAT |
| ES2645869T3 (es) | 2008-12-17 | 2017-12-11 | The Scripps Research Institute | Generación y mantenimiento de células madre |
| EP2421956A4 (en) * | 2009-04-24 | 2013-10-02 | Whitehead Biomedical Inst | COMPOSITIONS AND METHODS FOR OBTAINING OR CULTURING PLURIPOTENTER CELLS |
| JP5808331B2 (ja) * | 2009-10-16 | 2015-11-10 | ザ スクリプス リサーチ インスティテュート | 多能性細胞の誘導法 |
| EP2508595B1 (en) | 2009-12-01 | 2016-11-23 | National Cancer Center | Method for constructing chimeric rat using rat embryonic stem cells |
| EP2505639B1 (en) * | 2009-12-29 | 2018-09-19 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
| ES2624780T3 (es) | 2010-03-31 | 2017-07-17 | The Scripps Research Institute | Reprogramación de células |
| US20130059375A1 (en) * | 2010-04-02 | 2013-03-07 | Riken | Method for preparing es cells |
| ES2685171T3 (es) | 2010-06-14 | 2018-10-05 | The Scripps Research Institute | Reprogramación de células a un nuevo destino |
| CN102344490B (zh) * | 2010-07-30 | 2014-03-05 | 中国科学院上海生命科学研究院 | 抗小鼠Stk40的多克隆抗体及其制备 |
| NZ607608A (en) * | 2010-08-09 | 2014-03-28 | Takeda Pharmaceuticals Co | Method of producing pancreatic hormone-producing cells |
| JP6090855B2 (ja) * | 2010-11-17 | 2017-03-08 | 国立大学法人京都大学 | 心筋細胞および/または心筋前駆細胞増殖剤ならびに心筋細胞および/または心筋前駆細胞の増殖方法 |
| KR101975688B1 (ko) | 2010-12-22 | 2019-05-07 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| US20140127133A1 (en) * | 2011-01-24 | 2014-05-08 | Claude Brodski | Method for evaluating a mental disorder |
| US20140234963A1 (en) | 2011-06-21 | 2014-08-21 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| SI3865581T1 (sl) | 2011-08-05 | 2024-12-31 | Regeneron Pharmaceuticals, Inc. | Miši s humanizirano univerzalno lahko verigo |
| PL2793567T3 (pl) * | 2011-12-20 | 2019-09-30 | Regeneron Pharmaceuticals, Inc. | Myszy z humanizowanym łańcuchem lekkim |
| PT2847335T (pt) | 2012-04-25 | 2018-09-28 | Regeneron Pharma | Alvejamento mediado por nuclease com vetores de alvejamento grandes |
| EP3561050B1 (en) | 2013-02-20 | 2021-12-08 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| HUE040575T2 (hu) * | 2013-04-16 | 2019-03-28 | Regeneron Pharma | A patkány genom célzott módosítása |
| WO2014197934A1 (en) | 2013-06-14 | 2014-12-18 | The University Of Queensland | Renal progenitor cells |
| US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
| KR102670874B1 (ko) | 2014-03-04 | 2024-05-31 | 페이트 세러퓨틱스, 인코포레이티드 | 개선된 재프로그래밍 방법 및 세포 배양 플랫폼 |
| CA2945263A1 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
| LT3152312T (lt) | 2014-06-06 | 2020-04-27 | Regeneron Pharmaceuticals, Inc. | Tikslinio lokuso modifikavimo būdai ir kompozicijos |
| EP3461885B1 (en) | 2014-06-26 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| HUE044907T2 (hu) | 2014-11-21 | 2019-11-28 | Regeneron Pharma | Módszerek és készítmények célzott genetikai módosításhoz, párosított mutató RNS-ek használatával |
| NZ732895A (en) | 2014-12-19 | 2022-05-27 | Regeneron Pharma | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| SG11201707858TA (en) * | 2015-03-30 | 2017-10-30 | Ajinomoto Kk | Human serum albumin-containing culture medium for growth of neural stem cells |
| EP3362570A4 (en) | 2015-10-16 | 2019-03-20 | Fate Therapeutics, Inc. | PLATFORM FOR THE INDUCTION AND MAINTENANCE OF BASIC STATUS PLURIPOTENCE |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| DK3519558T3 (da) | 2016-09-28 | 2023-11-13 | Organovo Inc | Anvendelse af modificeret nyrevæv i assays |
| WO2019208787A1 (ja) * | 2018-04-27 | 2019-10-31 | 株式会社カネカ | 原始腸管細胞の製造方法 |
| CN113316634A (zh) * | 2018-11-21 | 2021-08-27 | 新加坡科技研究局 | 成熟的库普弗细胞的产生 |
| CN111238897B (zh) * | 2020-02-18 | 2023-03-28 | 上海市皮肤病医院 | 生物标本的处理方法与处理剂 |
| JP2023532061A (ja) * | 2020-07-02 | 2023-07-26 | アクセルタ リミテッド | 遅延胚由来の哺乳類家畜多能性幹細胞 |
| EP4386082A4 (en) * | 2021-08-10 | 2025-08-20 | Kaneka Corp | PROCESS FOR THE PRODUCTION OF PLURIPOTENT STEM CELLS |
| CN115927166A (zh) * | 2022-12-06 | 2023-04-07 | 云南省第一人民医院 | 一种大鼠原始内胚层干细胞分离建系的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| AU7677894A (en) | 1993-08-30 | 1995-03-22 | Northwestern University | Rat pluripotent embryonic stem cells and method of obtaining and using same |
| CA2267220A1 (en) | 1996-10-11 | 1998-04-23 | The Texas A & M University System | Methods for the generation of primordial germ cells and transgenic animal species |
| US6214795B1 (en) | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
| WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| US7455983B2 (en) | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
| US20020045260A1 (en) | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| JP2002176973A (ja) | 2000-12-14 | 2002-06-25 | Shigeo Saito | 哺乳動物胚性幹細胞とその樹立方法並びにその継代培養方法 |
| AU2003210405A1 (en) | 2002-03-05 | 2003-09-16 | Artemis Pharmaceuticals Gmbh | Inbred embryonic stem-cell derived mice |
| GB0210539D0 (en) | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| US7338957B2 (en) | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| SG149061A1 (en) * | 2003-12-23 | 2009-01-29 | Cythera Inc | Definitive endoderm |
| US8137966B2 (en) | 2004-03-04 | 2012-03-20 | Dainippon Sumitomo Pharma Co., Ltd. | Rat embryonic stem cell |
| WO2005094830A1 (en) | 2004-03-30 | 2005-10-13 | Pfizer Products Inc. | Combinations of signal transduction inhibitors |
| WO2005110438A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| WO2006026473A2 (en) | 2004-08-25 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS |
| CN101238129A (zh) | 2005-06-10 | 2008-08-06 | Irm责任有限公司 | 维持胚胎干细胞多能性的化合物 |
| JP2009517085A (ja) | 2005-11-28 | 2009-04-30 | チョンウェ ファーマ コーポレイション | 培養における細胞の無血清増殖 |
| EP1999249B8 (en) | 2006-03-30 | 2012-02-15 | The University Court Of The University of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| WO2007113705A1 (en) * | 2006-04-03 | 2007-10-11 | Koninklijke Philips Electronics N. V. | Determining tissue surrounding an object being inserted into a patient |
| EP2018167A4 (en) | 2006-05-15 | 2010-07-14 | Irm Llc | COMPOSITIONS AND METHODS AS INHIBITORS OF FGF RECEPTOR KINASES |
-
2006
- 2006-08-01 GB GBGB0615327.4A patent/GB0615327D0/en not_active Ceased
-
2007
- 2007-01-10 GB GBGB0700479.9A patent/GB0700479D0/en not_active Ceased
- 2007-08-01 WO PCT/GB2007/002913 patent/WO2008015418A2/en not_active Ceased
- 2007-08-01 EP EP07766403A patent/EP2049654A2/en not_active Withdrawn
- 2007-08-01 GB GB0716426A patent/GB2451523B/en not_active Expired - Fee Related
- 2007-08-01 US US11/832,317 patent/US8431395B2/en not_active Expired - Fee Related
- 2007-08-01 JP JP2009522328A patent/JP5456467B2/ja not_active Expired - Fee Related
- 2007-08-01 CN CN200780036720.1A patent/CN101657535B/zh not_active Expired - Fee Related
- 2007-08-01 AU AU2007280216A patent/AU2007280216B2/en not_active Ceased
- 2007-08-01 CN CN201410720584.XA patent/CN104531610A/zh active Pending
-
2013
- 2013-04-05 US US13/857,449 patent/US20130333058A1/en not_active Abandoned
- 2013-06-17 JP JP2013127052A patent/JP2013176400A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007280216A1 (en) | 2008-02-07 |
| WO2008015418A3 (en) | 2008-04-10 |
| GB0716426D0 (en) | 2007-10-10 |
| GB2451523A8 (en) | 2009-02-18 |
| JP2013176400A (ja) | 2013-09-09 |
| WO2008015418A2 (en) | 2008-02-07 |
| CN101657535B (zh) | 2016-03-02 |
| CN104531610A (zh) | 2015-04-22 |
| US20130333058A1 (en) | 2013-12-12 |
| JP2009545302A (ja) | 2009-12-24 |
| GB2451523A (en) | 2009-02-04 |
| AU2007280216B2 (en) | 2012-12-20 |
| GB0700479D0 (en) | 2007-02-21 |
| EP2049654A2 (en) | 2009-04-22 |
| CN101657535A (zh) | 2010-02-24 |
| GB0615327D0 (en) | 2006-09-13 |
| US20080066197A1 (en) | 2008-03-13 |
| GB2451523B (en) | 2010-03-17 |
| US8431395B2 (en) | 2013-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5456467B2 (ja) | ラットおよび他種由来の多能性細胞 | |
| US11773368B2 (en) | Culture method for differentiating primordial germ cells into functionally mature oocytes | |
| Sofikitis et al. | Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment | |
| Fang et al. | Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos | |
| EP0701608B1 (en) | Embryonic stem cells for making chimeric and transgenic ungulates | |
| Xue et al. | Porcine pluripotent stem cells derived from IVF embryos contribute to chimeric development in vivo | |
| JP5807862B2 (ja) | ラット胚性幹細胞を用いたキメララットの作製法 | |
| JP4314372B2 (ja) | 精巣細胞由来多能性幹細胞の製造方法 | |
| US20120142092A1 (en) | Rat embryonic stem cell | |
| JP2022529589A (ja) | 哺乳類の拡大ポテンシャル幹細胞のための培地、その組成物および方法 | |
| US20070298496A1 (en) | Method of deriving pluripotent stem cells from a single blastomere | |
| JPWO2018225802A1 (ja) | 多能性幹細胞から生殖系列幹細胞様細胞への分化誘導方法 | |
| US20110283374A1 (en) | Method for producing heterogenous embryonic chimeric animal using a stem cell | |
| Zhang et al. | An Alternative Method for Long‐Term Culture of Chicken Embryonic Stem Cell In Vitro | |
| AU2006269884A1 (en) | Therapeutic reprogramming of germ line stem cells | |
| Ledesma et al. | Progress in producing chimeric ungulate livestock for agricultural applications | |
| AU2013201718B2 (en) | Pluripotent cells from rat and other species | |
| Oback et al. | Pluripotent stem cells in livestock | |
| Heo et al. | Production of somatic chimera chicks by injection of bone marrow cells into recipient blastoderms | |
| Villafranca Locher | Fusion of bovine fibroblasts to mouse embryonic stem cells: a model to study nuclear reprogramming | |
| Davies et al. | Embryonic stem cells and the capture of pluripotency | |
| Rasmussen et al. | Embryonic stem cells in the pig: characterization and differentiation into neural cells | |
| Meek | Experimental approaches to establish rat embryonic stem cells | |
| JPWO2007108393A1 (ja) | 雄性生殖系列幹細胞のインビトロ増殖方法 | |
| Tada et al. | Nuclear Reprogramming" and" Epigenetic Reprogramming |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100317 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100317 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20101203 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120814 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121113 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121120 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121213 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20121214 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130219 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130617 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130730 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130802 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130827 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131118 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20131217 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140108 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |