JP5455924B2 - 速読ゲートアンペロメトリ - Google Patents
速読ゲートアンペロメトリ Download PDFInfo
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- JP5455924B2 JP5455924B2 JP2010538008A JP2010538008A JP5455924B2 JP 5455924 B2 JP5455924 B2 JP 5455924B2 JP 2010538008 A JP2010538008 A JP 2010538008A JP 2010538008 A JP2010538008 A JP 2010538008A JP 5455924 B2 JP5455924 B2 JP 5455924B2
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- 238000004082 amperometric method Methods 0.000 title description 9
- 239000012491 analyte Substances 0.000 claims description 75
- 230000005284 excitation Effects 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 43
- 238000005534 hematocrit Methods 0.000 claims description 32
- 238000009792 diffusion process Methods 0.000 claims description 21
- 239000013060 biological fluid Substances 0.000 claims description 18
- 230000004888 barrier function Effects 0.000 claims description 16
- 238000005259 measurement Methods 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 12
- 230000004044 response Effects 0.000 claims description 11
- 230000001052 transient effect Effects 0.000 claims description 10
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- 238000012545 processing Methods 0.000 claims description 5
- 239000000523 sample Substances 0.000 description 86
- 238000004458 analytical method Methods 0.000 description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 16
- 239000008103 glucose Substances 0.000 description 16
- 239000004020 conductor Substances 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 9
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- 238000006479 redox reaction Methods 0.000 description 5
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- 108090000854 Oxidoreductases Proteins 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- 230000000875 corresponding effect Effects 0.000 description 1
- 238000003869 coulometry Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
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- 238000011534 incubation Methods 0.000 description 1
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- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
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- 210000003296 saliva Anatomy 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000004832 voltammetry Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1272907P | 2007-12-10 | 2007-12-10 | |
| US61/012,729 | 2007-12-10 | ||
| PCT/US2008/080865 WO2009075951A1 (en) | 2007-12-10 | 2008-10-23 | Rapid-read gated amperometry |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506964A JP2011506964A (ja) | 2011-03-03 |
| JP2011506964A5 JP2011506964A5 (enExample) | 2011-11-24 |
| JP5455924B2 true JP5455924B2 (ja) | 2014-03-26 |
Family
ID=40120419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538008A Active JP5455924B2 (ja) | 2007-12-10 | 2008-10-23 | 速読ゲートアンペロメトリ |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8147674B2 (enExample) |
| EP (3) | EP3690058B1 (enExample) |
| JP (1) | JP5455924B2 (enExample) |
| CN (2) | CN107091870B (enExample) |
| BR (1) | BRPI0820718A2 (enExample) |
| CA (1) | CA2707300C (enExample) |
| MX (1) | MX2010006393A (enExample) |
| RU (1) | RU2491549C2 (enExample) |
| TW (1) | TWI468679B (enExample) |
| WO (1) | WO2009075951A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523326A (ja) | 2004-02-06 | 2007-08-16 | バイエル・ヘルスケア・エルエルシー | バイオセンサのための内部標準としての酸化され得る化学種、及び使用方法 |
| ES2717135T3 (es) * | 2005-07-20 | 2019-06-19 | Ascensia Diabetes Care Holdings Ag | Método para señalar al usuario para que añada una muestra adicional a una tira de prueba, método para medir la temperatura de una muestra y métodos para determinar la concentración de un analito basados en amperometría controlada |
| CA2664186C (en) | 2006-09-22 | 2021-02-23 | Bayer Healthcare Llc | Biosensor system having enhanced stability and hematocrit performance |
| WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
| BRPI0820718A2 (pt) * | 2007-12-10 | 2015-06-16 | Bayer Healthcare Llc | Amperometria com porta de leitura rápida |
| CN102227505B (zh) | 2008-12-08 | 2016-05-11 | 拜尔健康护理有限责任公司 | 用于生物传感器的低总盐试剂组合物和系统 |
| US9233788B2 (en) | 2010-01-22 | 2016-01-12 | Bayer Healthcare Llc | Biosensor desiccant system having enhanced measurement performance |
| TWI565943B (zh) | 2011-07-22 | 2017-01-11 | 拜耳保健公司 | 具有增進測量性能之生物感測器乾燥劑系統 |
| US9816957B2 (en) | 2012-12-12 | 2017-11-14 | Panasonic Healthcare Holdings Co., Ltd. | Blood component measuring device, method for measuring blood component, and bio-sensor |
| JP6356708B2 (ja) | 2013-03-15 | 2018-07-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | パルスdcブロックを有するテスト・シーケンスで分析物を電気化学的に測定する方法およびデバイス、装置とそれらを組み込むシステム |
| CA2900883C (en) | 2013-03-15 | 2017-10-24 | F. Hoffmann-La Roche Ag | Methods of failsafing electrochemical measurements of an analyte as well as devices, apparatuses and systems incorporating the same |
| CA2900607C (en) | 2013-03-15 | 2017-10-03 | F. Hoffmann-La Roche Ag | Descriptor-based methods of electrochemically measuring an analyte as well as devices, apparatuses and systems incoporating the same |
| CA2949906C (en) | 2013-03-15 | 2019-04-02 | F. Hoffmann-La Roche Ag | Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same |
| JP6356707B2 (ja) | 2013-03-15 | 2018-07-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 電気化学的測定中に高抗酸化物質レベルを検出してそれから分析物濃度をフェイルセイフする方法並びにそれを組み込んだデバイス、装置、及びシステム |
| CA2900694C (en) | 2013-03-15 | 2017-10-24 | F. Hoffmann-La Roche Ag | Methods of using information from recovery pulses in electrochemical analyte measurements as well as devices, apparatuses and systems incorporating the same |
| WO2015004900A1 (ja) | 2013-07-08 | 2015-01-15 | パナソニックヘルスケア株式会社 | 血液成分の測定装置、血液成分の測定方法 |
| KR101666978B1 (ko) * | 2014-09-17 | 2016-10-24 | 주식회사 아이센스 | 생체시료 내 분석대상물질의 농도측정방법 및 측정장치 |
| CN109690304A (zh) | 2016-07-12 | 2019-04-26 | 安晟信医疗科技控股公司 | 通过使用来自两个电极的交替输出信号进行电化学分析的方法 |
| CN110249219B (zh) * | 2016-12-05 | 2022-08-23 | 安晟信医疗科技控股公司 | 风险因素监测 |
| CN110954687B (zh) * | 2019-11-18 | 2022-06-07 | 深圳微点生物技术股份有限公司 | 一种用于凝血检测的方法与设备 |
| CA3205568A1 (en) * | 2020-12-17 | 2022-06-23 | S2G Technologies S.R.L. Startup Costituita Ai Sensi Dell'art. 4, Comma10-Bis D.L. 3/2015 Convertito Con Legge 33/2015 | Device for analysing a biological fluid |
| US12141240B2 (en) * | 2021-01-20 | 2024-11-12 | Rutgers, The State University Of New Jersey | Method of calibration using master calibration function |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4994167A (en) | 1986-04-15 | 1991-02-19 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
| US4897162A (en) | 1986-11-14 | 1990-01-30 | The Cleveland Clinic Foundation | Pulse voltammetry |
| WO1989009397A1 (en) | 1988-03-31 | 1989-10-05 | Matsushita Electric Industrial Co., Ltd. | Biosensor and process for its production |
| US5131999A (en) | 1990-01-16 | 1992-07-21 | The National University Of Singapore | Voltammetric detector for flow analysis |
| AU658177B2 (en) * | 1991-03-07 | 1995-04-06 | Masimo Corporation | Signal processing apparatus and method |
| US5756362A (en) | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
| US5620579A (en) | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US5708247A (en) | 1996-02-14 | 1998-01-13 | Selfcare, Inc. | Disposable glucose test strips, and methods and compositions for making same |
| JP3828578B2 (ja) | 1996-04-22 | 2006-10-04 | イムラ・ジャパン株式会社 | Coガスセンサおよびcoガス濃度測定方法 |
| US6391558B1 (en) * | 1997-03-18 | 2002-05-21 | Andcare, Inc. | Electrochemical detection of nucleic acid sequences |
| JP2002505008A (ja) | 1997-06-16 | 2002-02-12 | エラン コーポレーション ピーエルシー | 分析物のin vivo測定のためのセンサーをキャリブレートし、試験する方法と、このような方法に用いるためのデバイス |
| US6576117B1 (en) | 1998-05-20 | 2003-06-10 | Arkray | Method and apparatus for electrochemical measurement using statistical technique |
| JP4352108B2 (ja) * | 1998-12-15 | 2009-10-28 | アークレイ株式会社 | 基質の定量方法 |
| US6475372B1 (en) | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
| JP2001021525A (ja) * | 1999-07-02 | 2001-01-26 | Akebono Brake Res & Dev Center Ltd | バイオセンサを用いた測定方法 |
| JP4288775B2 (ja) | 1999-07-29 | 2009-07-01 | 株式会社エクォス・リサーチ | Coガスセンサ |
| CA2385842C (en) * | 1999-09-20 | 2008-12-09 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
| JP4050434B2 (ja) | 1999-11-29 | 2008-02-20 | 松下電器産業株式会社 | サンプルの弁別方法 |
| JP3972063B2 (ja) | 2001-01-17 | 2007-09-05 | アークレイ株式会社 | センサを用いる定量分析方法および定量分析装置 |
| WO2002077633A1 (en) | 2001-03-23 | 2002-10-03 | The Regents Of The University Of California | Open circuit potential amperometry and voltammetry |
| DE10119527A1 (de) | 2001-04-12 | 2002-11-07 | Sitec Sensortechnik Gmbh | Verfahren zur mobilen oder stationären Erfassung von Körperfunktions- und Stoffwechseldaten eines lebenden Körpers und Einrichtung zur Durchführung des Verfahrens |
| US6721586B2 (en) | 2001-06-12 | 2004-04-13 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
| US20030113933A1 (en) | 2001-12-18 | 2003-06-19 | Rasmus Jansson | Analysis of components in liquids |
| CN1615434A (zh) | 2002-01-15 | 2005-05-11 | 埃葛梅崔克斯股份有限公司 | 适用于处理电化学信号的方法和装置 |
| EP1541998B1 (en) | 2002-07-25 | 2011-05-18 | ARKRAY, Inc. | Sample analyzing method and sample analyzing device |
| WO2004053476A1 (en) | 2002-12-09 | 2004-06-24 | Otre Ab | Simplified signal processing method for voltammetry |
| JP4449431B2 (ja) | 2003-11-19 | 2010-04-14 | パナソニック株式会社 | 基質濃度の測定方法 |
| GB2428484B (en) | 2004-01-29 | 2008-09-10 | Siemens Ag | Method for measuring the concentration or change in concentration of a redox-active substance and associated device |
| EP1751533A2 (en) * | 2004-05-14 | 2007-02-14 | Bayer Healthcare, LLC | Voltammetric systems for assaying biological analytes |
| KR101365933B1 (ko) | 2004-10-12 | 2014-02-24 | 바이엘 헬스케어 엘엘씨 | 샘플 내 분석물의 농도를 측정하기 위한 전기화학 시스템 |
| WO2006047290A2 (en) * | 2004-10-21 | 2006-05-04 | Bayer Healthcare Llc | Method of determining the concentration of an analyte in a body fluid and system therefor |
| US8452365B2 (en) * | 2005-05-25 | 2013-05-28 | Bayer Healthcare Llc | Methods of using Raman spectral information in determining analyte concentrations |
| ES2717135T3 (es) | 2005-07-20 | 2019-06-19 | Ascensia Diabetes Care Holdings Ag | Método para señalar al usuario para que añada una muestra adicional a una tira de prueba, método para medir la temperatura de una muestra y métodos para determinar la concentración de un analito basados en amperometría controlada |
| KR101477815B1 (ko) * | 2005-09-30 | 2015-01-02 | 바이엘 헬스케어 엘엘씨 | 게이트형 전압 전류 측정법 |
| US7468125B2 (en) | 2005-10-17 | 2008-12-23 | Lifescan, Inc. | System and method of processing a current sample for calculating a glucose concentration |
| BRPI0711433A2 (pt) * | 2006-05-08 | 2011-11-16 | Bayer Healthcare Llc | sistema de detecção de saìda anormal para um biosensor |
| CA2664186C (en) * | 2006-09-22 | 2021-02-23 | Bayer Healthcare Llc | Biosensor system having enhanced stability and hematocrit performance |
| CA2667295C (en) * | 2006-10-24 | 2018-02-20 | Bayer Healthcare Llc | Transient decay amperometry |
| JP5604298B2 (ja) | 2007-07-26 | 2014-10-08 | ニプロ ダイアグナスティックス,インコーポレーテッド | 時間分解電流測定法を用いて被分析物の濃度を測定する方法及びシステム |
| US8101062B2 (en) | 2007-07-26 | 2012-01-24 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
| BRPI0820718A2 (pt) * | 2007-12-10 | 2015-06-16 | Bayer Healthcare Llc | Amperometria com porta de leitura rápida |
-
2008
- 2008-10-23 BR BRPI0820718-6A patent/BRPI0820718A2/pt not_active Application Discontinuation
- 2008-10-23 CN CN201710080974.9A patent/CN107091870B/zh active Active
- 2008-10-23 RU RU2010128649/15A patent/RU2491549C2/ru active
- 2008-10-23 MX MX2010006393A patent/MX2010006393A/es active IP Right Grant
- 2008-10-23 JP JP2010538008A patent/JP5455924B2/ja active Active
- 2008-10-23 CA CA2707300A patent/CA2707300C/en not_active Expired - Fee Related
- 2008-10-23 EP EP20165626.1A patent/EP3690058B1/en active Active
- 2008-10-23 EP EP18176551.2A patent/EP3395954B1/en active Active
- 2008-10-23 CN CN200880120045.5A patent/CN101896619B/zh active Active
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| Publication number | Publication date |
|---|---|
| RU2010128649A (ru) | 2012-01-20 |
| TW200925592A (en) | 2009-06-16 |
| EP2222867B1 (en) | 2018-07-11 |
| US20190331630A1 (en) | 2019-10-31 |
| US10908112B2 (en) | 2021-02-02 |
| US10345255B2 (en) | 2019-07-09 |
| WO2009075951A1 (en) | 2009-06-18 |
| US20150219586A1 (en) | 2015-08-06 |
| US8147674B2 (en) | 2012-04-03 |
| US20210148851A1 (en) | 2021-05-20 |
| CA2707300A1 (en) | 2009-06-18 |
| JP2011506964A (ja) | 2011-03-03 |
| CN101896619A (zh) | 2010-11-24 |
| EP3690058A1 (en) | 2020-08-05 |
| US9034160B2 (en) | 2015-05-19 |
| EP3690058B1 (en) | 2021-12-29 |
| EP2222867A1 (en) | 2010-09-01 |
| EP3395954A1 (en) | 2018-10-31 |
| RU2491549C2 (ru) | 2013-08-27 |
| CN101896619B (zh) | 2017-04-05 |
| CA2707300C (en) | 2017-09-26 |
| MX2010006393A (es) | 2010-06-25 |
| US20120211361A1 (en) | 2012-08-23 |
| BRPI0820718A2 (pt) | 2015-06-16 |
| US20090145779A1 (en) | 2009-06-11 |
| TWI468679B (zh) | 2015-01-11 |
| EP3395954B1 (en) | 2020-07-01 |
| CN107091870B (zh) | 2019-10-08 |
| CN107091870A (zh) | 2017-08-25 |
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