JP5433690B2 - 抗−ｈｉｖ薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン - Google Patents

抗−ｈｉｖ薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン Download PDF

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Publication number
JP5433690B2
JP5433690B2 JP2011516575A JP2011516575A JP5433690B2 JP 5433690 B2 JP5433690 B2 JP 5433690B2 JP 2011516575 A JP2011516575 A JP 2011516575A JP 2011516575 A JP2011516575 A JP 2011516575A JP 5433690 B2 JP5433690 B2 JP 5433690B2
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compound
alkyl
formula
conr
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Japanese (ja)
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JP2011526283A (ja
JP2011526283A5 (enExample
Inventor
タオ・ワン
泰次 植田
ローレンス・ジー・ハマン
チャン・チョンシン
チウェイ・イン
アリシア・レゲイロ−レン
デイビッド・ジェイ・カリーニ
ジェイコブ・スウィドースキ
リュー・チェン
バリー・エル・ジョンソン
ニコラス・エイ・ミーンウェル
ジョン・エフ・カドウ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2011516575A 2008-06-25 2009-06-24 抗−ｈｉｖ薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン Expired - Fee Related JP5433690B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7537408P 2008-06-25 2008-06-25
US61/075,374 2008-06-25
PCT/US2009/048427 WO2009158394A1 (en) 2008-06-25 2009-06-24 Diketo azolopiperidines and azolopiperazines as anti-hiv agents

Publications (3)

Publication Number Publication Date
JP2011526283A JP2011526283A (ja) 2011-10-06
JP2011526283A5 JP2011526283A5 (enExample) 2012-07-26
JP5433690B2 true JP5433690B2 (ja) 2014-03-05

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ID=41137086

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JP2011516575A Expired - Fee Related JP5433690B2 (ja) 2008-06-25 2009-06-24 抗−ｈｉｖ薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン

Country Status (6)

Country Link
US (2) US7960406B2 (enExample)
EP (1) EP2303876B1 (enExample)
JP (1) JP5433690B2 (enExample)
CN (1) CN102131810B (enExample)
ES (1) ES2462403T3 (enExample)
WO (1) WO2009158394A1 (enExample)

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US7579510B2 (en) 2006-02-03 2009-08-25 Grt, Inc. Continuous process for converting natural gas to liquid hydrocarbons
EP2696937B1 (en) * 2011-04-12 2017-05-17 VIIV Healthcare UK (No.5) Limited Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
ES2616268T3 (es) 2011-08-29 2017-06-12 VIIV Healthcare UK (No.5) Limited Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH
PT2807153T (pt) 2012-01-25 2020-06-18 Novartis Ag Compostos heterocíclicos e métodos para seu uso
BR112014019289A8 (pt) 2012-02-08 2017-07-11 Bristol Myers Squibb Co Métodos para a preparação do composto de prome-dicamento de piperazina inibidor da ligação do hiv
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
ES2616432T3 (es) * 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de alquenos tricíclicos como inhibidores de la unión del VIH
CN105283455B (zh) * 2013-03-27 2017-06-16 百时美施贵宝公司 作为hiv吸附抑制剂的2‑酮基酰胺衍生物
EP2978762A1 (en) * 2013-03-27 2016-02-03 Bristol-Myers Squibb Company Piperazine and homopiperazine derivatives as hiv attachment inhibitors
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
PT3233853T (pt) * 2014-12-18 2019-05-27 Viiv Healthcare Uk No 4 Ltd Processo para preparar compostos de azaindole halogenados utilizando boroxina
US20170362262A1 (en) * 2014-12-18 2017-12-21 ViiV Healthcare UK (No.4) Limited A process for preparing halogenated azaindole compounds using pybrop
US9550779B2 (en) * 2014-12-30 2017-01-24 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
US10153966B1 (en) * 2015-03-12 2018-12-11 Alarm.Com Incorporated Hybrid mesh network monitoring signaling environment
KR102708936B1 (ko) 2015-11-20 2024-09-25 포르마 세라퓨틱스 인크. 유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논
EP3464286B1 (en) * 2016-05-24 2021-08-18 Genentech, Inc. Pyrazolopyridine derivatives for the treatment of cancer

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US4354924A (en) * 1980-06-25 1982-10-19 Chevron Research Company Dual component chromia silicate cracking catalyst
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US6469006B1 (en) 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US6573262B2 (en) 2000-07-10 2003-06-03 Bristol-Myers Sqibb Company Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
KR20030079979A (ko) 2001-02-02 2003-10-10 브리스톨-마이어스스퀴브컴파니 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US6825201B2 (en) 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
US7348337B2 (en) * 2002-05-28 2008-03-25 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20040063744A1 (en) 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20040106104A1 (en) 2002-06-11 2004-06-03 Pin-Fang Lin Viral envelope mediated fusion assay
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Also Published As

Publication number Publication date
WO2009158394A1 (en) 2009-12-30
US8124615B2 (en) 2012-02-28
ES2462403T3 (es) 2014-05-22
US20110212971A1 (en) 2011-09-01
CN102131810A (zh) 2011-07-20
JP2011526283A (ja) 2011-10-06
CN102131810B (zh) 2014-02-26
EP2303876A1 (en) 2011-04-06
EP2303876B1 (en) 2014-03-19
US20100009993A1 (en) 2010-01-14
US7960406B2 (en) 2011-06-14

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