CN102131810B - 作为抗hiv剂的二酮稠合的吡咯并哌啶类和吡咯并哌嗪类 - Google Patents

作为抗hiv剂的二酮稠合的吡咯并哌啶类和吡咯并哌嗪类 Download PDF

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Publication number
CN102131810B
CN102131810B CN200980133292.3A CN200980133292A CN102131810B CN 102131810 B CN102131810 B CN 102131810B CN 200980133292 A CN200980133292 A CN 200980133292A CN 102131810 B CN102131810 B CN 102131810B
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CN
China
Prior art keywords
compound
group
alkyl
formula
hiv
Prior art date
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Expired - Fee Related
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CN200980133292.3A
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English (en)
Chinese (zh)
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CN102131810A (zh
Inventor
汪涛
植田泰次
L·G·哈曼
张钟兴
尹志伟
A·雷盖罗-任
D·J·卡里尼
J·斯维多斯基
刘峥
B·L·约翰逊
N·A·米恩威尔
J·F·卡多
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN102131810A publication Critical patent/CN102131810A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980133292.3A 2008-06-25 2009-06-24 作为抗hiv剂的二酮稠合的吡咯并哌啶类和吡咯并哌嗪类 Expired - Fee Related CN102131810B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7537408P 2008-06-25 2008-06-25
US61/075,374 2008-06-25
US61/075374 2008-06-25
PCT/US2009/048427 WO2009158394A1 (en) 2008-06-25 2009-06-24 Diketo azolopiperidines and azolopiperazines as anti-hiv agents

Publications (2)

Publication Number Publication Date
CN102131810A CN102131810A (zh) 2011-07-20
CN102131810B true CN102131810B (zh) 2014-02-26

Family

ID=41137086

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980133292.3A Expired - Fee Related CN102131810B (zh) 2008-06-25 2009-06-24 作为抗hiv剂的二酮稠合的吡咯并哌啶类和吡咯并哌嗪类

Country Status (6)

Country Link
US (2) US7960406B2 (enExample)
EP (1) EP2303876B1 (enExample)
JP (1) JP5433690B2 (enExample)
CN (1) CN102131810B (enExample)
ES (1) ES2462403T3 (enExample)
WO (1) WO2009158394A1 (enExample)

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US8835454B2 (en) 2011-08-29 2014-09-16 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as HIV attachment inhibitors
PT2807153T (pt) 2012-01-25 2020-06-18 Novartis Ag Compostos heterocíclicos e métodos para seu uso
PT2812332T (pt) 2012-02-08 2017-11-15 Viiv Healthcare Uk (No 4) Ltd Métodos para a preparação do composto profármaco piperazina inibidor da conjugação ao vih
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9655888B2 (en) * 2012-08-09 2017-05-23 VIIV Healthcare UK (No.5) Limited Tricyclic alkene derivatives as HIV attachment inhibitors
US9586957B2 (en) * 2013-03-27 2017-03-07 VIIV Healthcare UK (No.5) Limited 2-keto amide derivatives as HIV attachment inhibitors
CN105229006A (zh) * 2013-03-27 2016-01-06 百时美施贵宝公司 作为hiv吸附抑制剂的哌嗪和高哌嗪衍生物
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CA2971104A1 (en) * 2014-12-18 2016-06-23 ViiV Healthcare UK (No.4) Limited A process for preparing halogenated azaindole compounds using boroxine
US20170362262A1 (en) * 2014-12-18 2017-12-21 ViiV Healthcare UK (No.4) Limited A process for preparing halogenated azaindole compounds using pybrop
US9550779B2 (en) * 2014-12-30 2017-01-24 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
US10153966B1 (en) * 2015-03-12 2018-12-11 Alarm.Com Incorporated Hybrid mesh network monitoring signaling environment
KR102708936B1 (ko) 2015-11-20 2024-09-25 포르마 세라퓨틱스 인크. 유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논
WO2017205538A1 (en) * 2016-05-24 2017-11-30 Genentech, Inc. Pyrazolopyridine derivatives for the treatment of cancer

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Also Published As

Publication number Publication date
JP2011526283A (ja) 2011-10-06
US7960406B2 (en) 2011-06-14
JP5433690B2 (ja) 2014-03-05
WO2009158394A1 (en) 2009-12-30
EP2303876A1 (en) 2011-04-06
CN102131810A (zh) 2011-07-20
US8124615B2 (en) 2012-02-28
US20100009993A1 (en) 2010-01-14
US20110212971A1 (en) 2011-09-01
ES2462403T3 (es) 2014-05-22
EP2303876B1 (en) 2014-03-19

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Granted publication date: 20140226

Termination date: 20190624