JP5419355B2 - 選択的な５ｈｔ２ａアンタゴニストとしての置換されたビスアリールおよびヘテロアリール化合物 - Google Patents

選択的な５ｈｔ２ａアンタゴニストとしての置換されたビスアリールおよびヘテロアリール化合物 Download PDF

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JP5419355B2
JP5419355B2 JP2007555276A JP2007555276A JP5419355B2 JP 5419355 B2 JP5419355 B2 JP 5419355B2 JP 2007555276 A JP2007555276 A JP 2007555276A JP 2007555276 A JP2007555276 A JP 2007555276A JP 5419355 B2 JP5419355 B2 JP 5419355B2
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fluoro
benzyl
methyl
ylmethyl
indol
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JP2008530120A5 (enExample
JP2008530120A (ja
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デイヴィッド・マーク・フィンク
ヘレン・カサリン・スミス
リチャード・サイモン・トッド
ポール・ロバート・イーストウッド
ヘイゼル・ハント
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アベンティス・ファーマスーティカルズ・インコーポレイテツド
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D277/62—Benzothiazoles
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007555276A 2005-02-10 2006-02-10 選択的な５ｈｔ２ａアンタゴニストとしての置換されたビスアリールおよびヘテロアリール化合物 Expired - Fee Related JP5419355B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65191105P 2005-02-10 2005-02-10
US60/651,911 2005-02-10
PCT/US2006/004879 WO2006086705A1 (en) 2005-02-10 2006-02-10 Substituted bis aryl and heteroaryl compounds as selective 5ht2a antagonists

Publications (3)

Publication Number Publication Date
JP2008530120A JP2008530120A (ja) 2008-08-07
JP2008530120A5 JP2008530120A5 (enExample) 2009-03-05
JP5419355B2 true JP5419355B2 (ja) 2014-02-19

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US (1) US7625889B2 (enExample)
EP (1) EP1851199B1 (enExample)
JP (1) JP5419355B2 (enExample)
KR (1) KR20070107037A (enExample)
CN (1) CN101115717A (enExample)
AR (1) AR052903A1 (enExample)
AU (1) AU2006213634A1 (enExample)
BR (1) BRPI0606740A2 (enExample)
CA (1) CA2598429A1 (enExample)
CR (1) CR9260A (enExample)
DO (1) DOP2006000032A (enExample)
GT (1) GT200600042A (enExample)
IL (1) IL185173A0 (enExample)
MA (1) MA29289B1 (enExample)
MX (1) MX2007008606A (enExample)
NO (1) NO20074583L (enExample)
PA (1) PA8662501A1 (enExample)
PE (1) PE20061088A1 (enExample)
RU (1) RU2007133655A (enExample)
TN (1) TNSN07272A1 (enExample)
TW (1) TW200640859A (enExample)
UY (1) UY29372A1 (enExample)
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SA05260357B1 (ar) 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
ES2336142T3 (es) 2005-08-19 2010-04-08 Aventis Pharmaceuticals Inc. Combinacion de un agente hipnotico y un compuesto sustituido, con bis arilo y heteroarilo y aplicacion terapeutica del mismo.
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CA2644069A1 (en) * 2006-02-28 2007-09-07 Helicon Therapeutics, Inc. Therapeutic piperazines as pde4 inhibitors
AR060336A1 (es) 2006-03-31 2008-06-11 Schering Corp Derivados de indazolilpirazinilo inhibidores de proteinquinasas, composiciones farmaceuticas que los contienen y usos como agentes anticancer,entre otros.
CA2646076C (en) 2006-05-18 2015-06-30 Arena Pharmaceuticals, Inc. Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
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TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
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EP2704573A4 (en) * 2011-05-03 2014-10-15 Merck Sharp & Dohme AMINOMETHYL biaryl BENZOTRIAZOL DERIVATIVES
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US7625889B2 (en) 2009-12-01
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