MXPA02000537A - Heterobiciclos que contienen nitrogeno como inhibidores del factor xa. - Google Patents

Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.

Info

Publication number
MXPA02000537A
MXPA02000537A MXPA02000537A MXPA02000537A MXPA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A MX PA02000537 A MXPA02000537 A MX PA02000537A
Authority
MX
Mexico
Prior art keywords
inhibitors
nitrogen containing
factor
heterobicycles
same
Prior art date
Application number
MXPA02000537A
Other languages
English (en)
Inventor
Mimi L Quan
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of MXPA02000537A publication Critical patent/MXPA02000537A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invencion se refiere generalmente a heterobiciclos que contienen hidrogeno de las formulas A y B: (Ver formulas A y B) los cuales son inhibidores de las enzimas de serina proteasa similares a la tripsina, especialmente el factor Xa, composiciones farmaceuticas que contienen los mismos, y metodos del uso de los mismos como agentes anticoagulantes para el tratamiento y prevencion de trastornos tromboembolicos.
MXPA02000537A 1999-07-16 2000-07-12 Heterobiciclos que contienen nitrogeno como inhibidores del factor xa. MXPA02000537A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14434499P 1999-07-16 1999-07-16
PCT/US2000/018903 WO2001005784A1 (en) 1999-07-16 2000-07-12 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS

Publications (1)

Publication Number Publication Date
MXPA02000537A true MXPA02000537A (es) 2004-09-10

Family

ID=22508178

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02000537A MXPA02000537A (es) 1999-07-16 2000-07-12 Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.

Country Status (18)

Country Link
US (2) US6429205B1 (es)
EP (1) EP1196412B1 (es)
JP (1) JP2004507439A (es)
KR (1) KR20030011268A (es)
CN (1) CN1454211A (es)
AT (1) ATE268766T1 (es)
AU (1) AU2481501A (es)
BR (1) BR0013200A (es)
CA (1) CA2380727A1 (es)
DE (1) DE60011430T2 (es)
ES (1) ES2222257T3 (es)
HK (1) HK1045502B (es)
IL (1) IL147317A0 (es)
MX (1) MXPA02000537A (es)
NO (1) NO20020217L (es)
PL (1) PL357108A1 (es)
WO (1) WO2001005784A1 (es)
ZA (1) ZA200200094B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO2000076971A2 (en) 1999-06-14 2000-12-21 Eli Lilly And Company Serine protease inhibitors
AU2001236606A1 (en) * 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
WO2002000647A1 (en) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
WO2002000655A1 (en) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors
PL204653B1 (pl) 2001-09-21 2010-01-29 Bristol Myers Squibb Co Pochodna pirazolo [3, 4-c] pirydyny, jej zastosowanie i kompozycja farmaceutyczna
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
ES2427141T3 (es) * 2002-01-22 2013-10-29 E. I. Du Pont De Nemours And Company Quinazolina(di)onas para el control de plagas de invertebrados
ATE381333T1 (de) 2002-03-26 2008-01-15 Boehringer Ingelheim Pharma Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
EP1505966A4 (en) 2002-05-10 2006-08-30 Bristol Myers Squibb Co 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER
DE60322713D1 (de) 2002-08-21 2008-09-18 Boehringer Ingelheim Pharma Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
DE60329529D1 (de) * 2002-12-23 2009-11-12 Sanofi Aventis Deutschland Pyrazolderivate als faktor-xa-inhibitoren
EP1479678A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
EP1807082A4 (en) * 2004-10-26 2010-12-01 Janssen Pharmaceutica Nv INHIBITOR COMPOUNDS OF XA FACTORS
PE20060776A1 (es) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
WO2008070507A2 (en) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2008141081A1 (en) * 2007-05-10 2008-11-20 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2009149139A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP6311603B2 (ja) * 2012-06-22 2018-04-18 住友化学株式会社 縮合複素環化合物
AU2017269256B2 (en) * 2016-05-23 2021-02-25 The Rockefeller University Aminoacylindazole immunomodulators for treatment of autoimmune diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1335897A (en) 1995-12-21 1997-07-17 Du Pont Merck Pharmaceutical Company, The Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors
CA2276034A1 (en) 1996-12-23 1998-07-02 Mimi Lifen Quan Oxygen or sulfur containing 5-membered heteroaromatics as factor xa inhibitors
ATE443698T1 (de) * 1996-12-23 2009-10-15 Bristol Myers Squibb Pharma Co Stickstoffhaltige heterocyclen als faktor xa- hemmer
AU8150398A (en) 1997-06-19 1999-01-04 Du Pont Pharmaceuticals Company Inhibitors of factor xa with a neutral p1 specificity group
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
CA2314401A1 (en) 1997-12-22 1999-07-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors

Also Published As

Publication number Publication date
BR0013200A (pt) 2002-05-07
PL357108A1 (en) 2004-07-12
WO2001005784A1 (en) 2001-01-25
NO20020217D0 (no) 2002-01-15
DE60011430T2 (de) 2005-07-07
KR20030011268A (ko) 2003-02-07
HK1045502B (zh) 2004-12-10
IL147317A0 (en) 2002-08-14
CA2380727A1 (en) 2001-01-25
ATE268766T1 (de) 2004-06-15
NO20020217L (no) 2002-03-15
US6716841B2 (en) 2004-04-06
AU2481501A (en) 2001-02-05
ZA200200094B (en) 2003-04-30
ES2222257T3 (es) 2005-02-01
US20030096820A1 (en) 2003-05-22
EP1196412A1 (en) 2002-04-17
DE60011430D1 (de) 2004-07-15
EP1196412B1 (en) 2004-06-09
CN1454211A (zh) 2003-11-05
US6429205B1 (en) 2002-08-06
JP2004507439A (ja) 2004-03-11
HK1045502A1 (en) 2002-11-29

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