JP5406187B2 - 前立腺癌の代謝プロファイリング法 - Google Patents

前立腺癌の代謝プロファイリング法 Download PDF

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JP5406187B2
JP5406187B2 JP2010521202A JP2010521202A JP5406187B2 JP 5406187 B2 JP5406187 B2 JP 5406187B2 JP 2010521202 A JP2010521202 A JP 2010521202A JP 2010521202 A JP2010521202 A JP 2010521202A JP 5406187 B2 JP5406187 B2 JP 5406187B2
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cancer
sarcosine
metabolites
sample
prostate cancer
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JP2010537170A (ja
JP2010537170A5 (enExample
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アルル エム． チャナイヤン
アルン スリークマー
マシュー ダブリュー． ミッチェル
カイ エー． ロートン
アルビン ベルガー
クリストファー ビーチャー
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University of Michigan Ann Arbor
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University of Michigan System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
JP2010521202A 2007-08-16 2008-08-15 前立腺癌の代謝プロファイリング法 Active JP5406187B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US95623907P 2007-08-16 2007-08-16
US60/956,239 2007-08-16
US7554008P 2008-06-25 2008-06-25
US61/075,540 2008-06-25
US13327908P 2008-06-27 2008-06-27
US61/133,279 2008-06-27
PCT/US2008/073318 WO2009026152A1 (en) 2007-08-16 2008-08-15 Metabolomic profiling of prostate cancer

Related Child Applications (1)

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JP2013227127A Division JP2014041154A (ja) 2007-08-16 2013-10-31 前立腺癌の代謝プロファイリング法

Publications (3)

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JP2010537170A JP2010537170A (ja) 2010-12-02
JP2010537170A5 JP2010537170A5 (enExample) 2011-09-29
JP5406187B2 true JP5406187B2 (ja) 2014-02-05

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JP2010521202A Active JP5406187B2 (ja) 2007-08-16 2008-08-15 前立腺癌の代謝プロファイリング法
JP2013227127A Pending JP2014041154A (ja) 2007-08-16 2013-10-31 前立腺癌の代謝プロファイリング法

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US (1) US20090047269A1 (enExample)
EP (2) EP2179292B1 (enExample)
JP (2) JP5406187B2 (enExample)
AU (1) AU2008289172B2 (enExample)
CA (1) CA2695674A1 (enExample)
WO (1) WO2009026152A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2061899B1 (en) 2006-09-19 2012-08-29 Metabolon Inc. Biomarkers for prostate cancer and methods using the same
WO2009020521A2 (en) 2007-08-03 2009-02-12 The Brigham And Women's Hospital, Inc. Identification and treatment of estrogen responsive prostate tumors
JP5754137B2 (ja) * 2008-06-20 2015-07-29 味の素株式会社 前立腺癌の評価方法、前立腺癌評価装置、前立腺癌評価方法、前立腺癌評価プログラム、記録媒体、前立腺癌評価システム、および情報通信端末装置
PL2438445T3 (pl) * 2009-06-04 2014-12-31 Metanomics Health Gmbh Sposoby diagnozowania raków gruczołu krokowego
EP2488666A4 (en) * 2009-10-13 2013-05-29 Purdue Research Foundation BIOMARKERS AND IDENTIFICATION METHOD FOR THE EARLY DETECTION AND PREDICTION OF THE REPRESENTATION OF BREAST CANCER BY NMR
EP3438656A3 (en) * 2009-10-30 2019-05-01 Keio University Anticancer agent sensitivity-determining marker
JP2013515270A (ja) * 2009-12-22 2013-05-02 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌の代謝学的プロファイリング
WO2011088030A1 (en) * 2010-01-15 2011-07-21 Bryan William Jones Disease diagnosis and treatment using computational molecular phenotyping
EP2354794A1 (en) * 2010-01-29 2011-08-10 IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. Diagnosing prostate cancer relapse
JP2011247869A (ja) * 2010-04-27 2011-12-08 Kobe Univ メタボローム解析手法を用いた特定疾患の検査方法
WO2011146683A1 (en) * 2010-05-19 2011-11-24 Metabolon, Inc. Methods and reagents for metabolomics and histology in a biological sample and a kit for the same
CA2807811A1 (en) * 2010-07-28 2012-02-02 Metabolon Inc. Biomarkers for prostate cancer and methods using the same
EP2841948A1 (en) * 2012-04-27 2015-03-04 Eastern Virginia Medical School Quantitation of biomarkers for the detection of prostate cancer
WO2014074821A1 (en) * 2012-11-09 2014-05-15 Dana-Farber Cancer Institute, Inc. Metabolic profiling in tissue and serum is indicative of tumor differentiation in prostate cancer
WO2014089431A1 (en) * 2012-12-06 2014-06-12 Dana-Farber Cancer Institute, Inc. Metabolomic profiling defines oncogenes driving prostate tumors
KR101462206B1 (ko) 2013-06-26 2014-11-20 한국과학기술연구원 트립토판 대사 변화를 이용한 위암 진단용 기초 정보 제공 방법
JP6222629B2 (ja) * 2013-08-29 2017-11-01 花王株式会社 排尿障害のバイオマーカー
WO2015050366A1 (ko) * 2013-10-04 2015-04-09 주식회사 씨스퀘어 사르코신 대사산물 중 포름알데히드 또는 과산화물을 이용한 전립선암 진단 시험지, 그 제조 방법 및 이를 이용한 전립선암 진단 방법
KR101838133B1 (ko) 2013-10-04 2018-03-14 주식회사 씨스퀘어 사르코신 대사산물 중 포름알데히드를 이용한 전립선암 진단 시험지, 그 제조 방법 및 이를 이용한 전립선암 진단에 필요한 정보를 제공하는 방법
GB201408875D0 (en) 2014-05-19 2014-07-02 Cambridge Oncometrix Ltd Diagnostic method
WO2017210097A1 (en) 2016-06-02 2017-12-07 Metabolon, Inc. Mass spectrometry method for detection and quantitation of metabolites
EP3490677A4 (en) * 2016-07-07 2020-05-13 Berg LLC LIPID, PROTEIN AND METABOLIC MARKERS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER
KR101962882B1 (ko) 2017-06-01 2019-03-28 한국과학기술연구원 구연산염 검출 센서 및 이를 이용한 구연산염 검출 방법
CN114641690A (zh) * 2019-09-03 2022-06-17 远景科学私人有限公司 用于确认、检测和评估前列腺癌进展的方法以及相关治疗
WO2021138611A2 (en) * 2020-01-03 2021-07-08 Femtera Laboratories Reliable metabolite biomarkers for multiple urological cancers
CN115552025A (zh) * 2020-02-05 2022-12-30 克利夫兰诊所基金会 基于苯乙酰谷氨酰胺水平的疾病检测和治疗
CN113804901B (zh) * 2020-06-15 2023-06-23 南京市口腔医院 用于口腔鳞癌早期无创诊断的血清脂质标志物及其应用
KR102379017B1 (ko) * 2020-08-18 2022-03-28 서울대학교 산학협력단 13c 또는 2h 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물
CN113440533B (zh) * 2021-07-01 2022-02-01 江南大学 水苏糖在制备用于治疗去势抵抗性前列腺癌药物中的应用
CN115184478A (zh) * 2022-04-26 2022-10-14 沈阳药科大学 一种基于“纤维内衍生化”策略的血浆中70种氨基类物质的定量分析方法及其用途
KR102719659B1 (ko) * 2023-03-29 2024-10-17 경희대학교 산학협력단 퀴놀리늄계 화합물 및 이의 제조방법, 시트르산염 검출센서, 전립선암 진단센서 및 전립선암 진단방법
TW202528739A (zh) * 2023-09-05 2025-07-16 國立臺灣大學 用於前列腺癌的生物標記
GB2634269A (en) * 2023-10-04 2025-04-09 Aberystwyth Univ Biomarkers for prostate cancer

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
FI875739A0 (fi) * 1986-04-28 1987-12-28 Boehringer Mannheim Gmbh Foerfarande och reagens foer paovisning av hjaertskador eller -sjukdomar.
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US5614396A (en) 1990-06-14 1997-03-25 Baylor College Of Medicine Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
GB9223084D0 (en) 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
KR100334858B1 (ko) 1993-02-19 2006-01-27 니뽄 신야쿠 가부시키가이샤 핵산공중합체를함유하는의약조성물
WO1995034671A1 (en) 1994-06-10 1995-12-21 Genvec, Inc. Complementary adenoviral vector systems and cell lines
CA2203809C (en) 1994-10-28 2008-06-03 James M. Wilson Recombinant adenovirus and methods of use thereof
US5872154A (en) 1995-02-24 1999-02-16 The Trustees Of The University Of Pennsylvania Method of reducing an immune response to a recombinant adenovirus
US5707618A (en) 1995-03-24 1998-01-13 Genzyme Corporation Adenovirus vectors for gene therapy
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6019978A (en) 1995-06-05 2000-02-01 The Wistar Institute Of Anatomy And Biology Replication-defective adenovirus human type 5 recombinant as a vaccine carrier
EP1445322B2 (en) 1995-06-15 2012-06-06 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5854206A (en) 1995-08-25 1998-12-29 Corixa Corporation Compounds and methods for treatment and diagnosis of prostate cancer
US5994316A (en) 1996-02-21 1999-11-30 The Immune Response Corporation Method of preparing polynucleotide-carrier complexes for delivery to cells
EP0914335A2 (en) 1996-03-15 1999-05-12 Corixa Corporation Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer
US5994132A (en) 1996-10-23 1999-11-30 University Of Michigan Adenovirus vectors
US20030185830A1 (en) 1997-02-25 2003-10-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
EP1005546A2 (en) 1997-02-25 2000-06-07 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
US6080912A (en) 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals
ES2324503T3 (es) 1997-04-10 2009-08-07 Stichting Katholieke Universiteit University Medical Centre Nijmegen Pca3, genes pca3 y metodos de uso.
US5830730A (en) 1997-05-08 1998-11-03 The Regents Of The University Of California Enhanced adenovirus-assisted transfection composition and method
AU756549B2 (en) 1997-07-11 2003-01-16 Crucell Holland B.V. Interleukin-3 gene therapy for cancer
US5972639A (en) 1997-07-24 1999-10-26 Irori Fluorescence-based assays for measuring cell proliferation
US6300136B1 (en) * 1997-09-03 2001-10-09 The Trustees Of The University Of Pennsylvania Methods for diagnosis and treatment of tumors in humans
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
JP2003528029A (ja) 1998-08-14 2003-09-24 アヴェンティス ファーマシューティカルズ インコーポレイテッド 遺伝子治療用のアデノウイルス配合物
WO2000012738A1 (en) 1998-08-27 2000-03-09 Aventis Pharma S.A. Targeted adenovirus vectors for delivery of heterologous genes
US6828429B1 (en) 1999-03-26 2004-12-07 Henry M. Jackson Foundation For The Advancement Of Military Medicine Prostate-specific gene, PCGEM1, and the methods of using PCGEM1 to detect, treat, and prevent prostate cancer
WO2001078652A2 (en) * 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2001098754A1 (en) 2000-06-22 2001-12-27 Atto Instruments Llc High efficiency cell analysis system and high throughput drug screening system
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20030134677A1 (en) * 2001-09-27 2003-07-17 Salah Obied Method and apparatus for generating real-time embedded software for a chance game
US20070078093A1 (en) * 2003-10-16 2007-04-05 The Administrators Of The Tulane Educational Fund Methods and compositions for treating cancer
JP2005162714A (ja) * 2003-12-05 2005-06-23 Shoken Seika Kagi Kofun Yugenkoshi グリシンｎメチルトランスフェラーゼモノクローナル抗体およびその使用方法
US20060010505A1 (en) 2004-06-18 2006-01-12 Washington University High throughput cancer pharmaceutical screening using drosophila
US20070055456A1 (en) 2005-08-31 2007-03-08 Daniel Raftery NMR method for differentiating complex mixtures
EP2061899B1 (en) * 2006-09-19 2012-08-29 Metabolon Inc. Biomarkers for prostate cancer and methods using the same

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EP2179292A4 (en) 2010-08-25
EP2597464A3 (en) 2013-07-31
HK1143418A1 (en) 2010-12-31
JP2014041154A (ja) 2014-03-06
JP2010537170A (ja) 2010-12-02
EP2597464A2 (en) 2013-05-29
EP2179292B1 (en) 2012-11-28
CA2695674A1 (en) 2009-02-26
EP2179292A1 (en) 2010-04-28
US20090047269A1 (en) 2009-02-19
WO2009026152A1 (en) 2009-02-26
AU2008289172A1 (en) 2009-02-26
EP2597464B1 (en) 2015-02-25
AU2008289172B2 (en) 2013-01-17

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