JP5406027B2 - ＥｐｈＢ３特異的抗体およびその使用 - Google Patents

ＥｐｈＢ３特異的抗体およびその使用 Download PDF

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Publication number
JP5406027B2
JP5406027B2 JP2009523073A JP2009523073A JP5406027B2 JP 5406027 B2 JP5406027 B2 JP 5406027B2 JP 2009523073 A JP2009523073 A JP 2009523073A JP 2009523073 A JP2009523073 A JP 2009523073A JP 5406027 B2 JP5406027 B2 JP 5406027B2
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antibody
xha
antibodies
human
xpa
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Expired - Fee Related
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Japanese (ja)
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JP2010500006A5 (enExample
JP2010500006A (ja
Inventor
ジェフ スー，
リンダ マサト，
ジュディー アブラハム，
マサヒサ ハンダ，
シー シャイヤー，
Original Assignee
ノバルティス アーゲー
ゾーマ テクノロジー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009523073A 2006-08-04 2007-08-03 ＥｐｈＢ３特異的抗体およびその使用 Expired - Fee Related JP5406027B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83577706P 2006-08-04 2006-08-04
US60/835,777 2006-08-04
PCT/US2007/075215 WO2008019326A2 (en) 2006-08-04 2007-08-03 Ephb3-specific antibody and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013107204A Division JP2013153769A (ja) 2006-08-04 2013-05-21 ＥｐｈＢ３特異的抗体およびその使用

Publications (3)

Publication Number Publication Date
JP2010500006A JP2010500006A (ja) 2010-01-07
JP2010500006A5 JP2010500006A5 (enExample) 2010-10-07
JP5406027B2 true JP5406027B2 (ja) 2014-02-05

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Family Applications (2)

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JP2009523073A Expired - Fee Related JP5406027B2 (ja) 2006-08-04 2007-08-03 ＥｐｈＢ３特異的抗体およびその使用
JP2013107204A Pending JP2013153769A (ja) 2006-08-04 2013-05-21 ＥｐｈＢ３特異的抗体およびその使用

Family Applications After (1)

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JP2013107204A Pending JP2013153769A (ja) 2006-08-04 2013-05-21 ＥｐｈＢ３特異的抗体およびその使用

Country Status (11)

Country Link
US (2) US8586716B2 (enExample)
EP (2) EP2057193B1 (enExample)
JP (2) JP5406027B2 (enExample)
KR (2) KR20140033236A (enExample)
CN (1) CN101626783A (enExample)
BR (1) BRPI0715332A2 (enExample)
CA (1) CA2659820A1 (enExample)
ES (1) ES2452067T3 (enExample)
MX (1) MX2009001341A (enExample)
RU (1) RU2009107707A (enExample)
WO (1) WO2008019326A2 (enExample)

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MX350311B (es) 2011-12-20 2017-09-01 Janssen Biotech Inc Anticuerpos anti-phf-tau y sus usos.
SG10202005460RA (en) * 2015-06-30 2020-07-29 Seattle Genetics Inc Anti-ntb-a antibodies and related compositions and methods
TWI771389B (zh) 2017-03-16 2022-07-21 美商健生生物科技公司 抗phf-tau抗體及其用途
KR102055350B1 (ko) * 2017-09-28 2019-12-13 고려대학교 산학협력단 대장암의 항암제 내성 진단용 바이오마커 및 이의 용도
CA3093200A1 (en) 2018-03-05 2019-09-12 Janssen Pharmaceutica Nv Anti-phf-tau antibodies and uses thereof
EP3786174A1 (en) * 2019-08-27 2021-03-03 Ichnos Sciences SA Methods for antibody purification
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Also Published As

Publication number Publication date
KR101437188B1 (ko) 2014-10-02
EP2420252A1 (en) 2012-02-22
BRPI0715332A2 (pt) 2013-10-08
US20140148584A1 (en) 2014-05-29
WO2008019326A3 (en) 2008-05-02
JP2010500006A (ja) 2010-01-07
US20090142261A1 (en) 2009-06-04
CN101626783A (zh) 2010-01-13
JP2013153769A (ja) 2013-08-15
EP2057193A2 (en) 2009-05-13
CA2659820A1 (en) 2008-02-14
AU2007281717A1 (en) 2008-02-14
KR20140033236A (ko) 2014-03-17
MX2009001341A (es) 2009-05-28
EP2057193B1 (en) 2013-12-18
US9006398B2 (en) 2015-04-14
ES2452067T3 (es) 2014-03-31
WO2008019326A2 (en) 2008-02-14
KR20090039799A (ko) 2009-04-22
US8586716B2 (en) 2013-11-19
RU2009107707A (ru) 2010-09-10

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