JP5394249B2 - Ｉａｐ阻害剤とｆｌｔ３阻害剤の組合せ剤 - Google Patents
Ｉａｐ阻害剤とｆｌｔ３阻害剤の組合せ剤 Download PDFInfo
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- JP5394249B2 JP5394249B2 JP2009539434A JP2009539434A JP5394249B2 JP 5394249 B2 JP5394249 B2 JP 5394249B2 JP 2009539434 A JP2009539434 A JP 2009539434A JP 2009539434 A JP2009539434 A JP 2009539434A JP 5394249 B2 JP5394249 B2 JP 5394249B2
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- methylamino
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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| PCT/US2007/085579 WO2008067280A2 (en) | 2006-11-28 | 2007-11-27 | Combination of iap inhibitors and flt3 inhibitors |
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| WO2006122408A1 (en) | 2005-05-18 | 2006-11-23 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| AU2006308453B9 (en) | 2005-10-25 | 2011-12-01 | Pharmascience Inc. | IAP BIR domain binding compounds |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| BRPI0711591A2 (pt) | 2006-05-16 | 2011-11-16 | Aegera Therapeutics, Inc. | composto de ligação de domìnio bir da iap |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| EP2296650B1 (en) | 2008-05-16 | 2020-05-06 | Novartis AG | Immunomodulation by iap inhibitors |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| JP2014528409A (ja) | 2011-09-30 | 2014-10-27 | テトラロジック ファーマシューティカルズ コーポレーション | 増殖性疾患（がん）の治療において使用するためのＳＭＡＣ模倣体（ビリナパント（ｂｉｒｉｎａｐａｎｔ）） |
| KR20160030099A (ko) | 2013-06-25 | 2016-03-16 | 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 | 세포내 감염의 치료 방법 |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| BR112021016522A2 (pt) | 2019-02-22 | 2021-10-26 | Hanmi Pharm. Co., Ltd. | Composição farmacêutica para o tratamento da leucemia mieloide aguda |
| EP3928780A4 (en) | 2019-02-22 | 2022-12-07 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION CONTAINING A FLT3 INHIBITOR AND HYPOMETHYLATING AGENT FOR THE TREATMENT OF ACUTE MYELOIC LEUKEMIA |
| KR20200102948A (ko) | 2019-02-22 | 2020-09-01 | 한미약품 주식회사 | Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물 |
| JP2022522534A (ja) | 2019-04-02 | 2022-04-19 | アリゴス セラピューティクス インコーポレイテッド | Ｐｒｍｔ５を標的にする化合物 |
| EP3991733A4 (en) | 2019-06-27 | 2023-07-05 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents |
| HUP2200468A1 (hu) | 2020-04-29 | 2023-03-28 | X Chem Zrt | IAP antagonisták és gyógyászati alkalmazásuk |
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- 2007-11-27 JP JP2009539434A patent/JP5394249B2/ja not_active Expired - Fee Related
- 2007-11-27 PT PT07868853T patent/PT2089024E/pt unknown
- 2007-11-27 WO PCT/US2007/085579 patent/WO2008067280A2/en not_active Ceased
-
2009
- 2009-05-04 IL IL198551A patent/IL198551A0/en unknown
- 2009-05-22 TN TNP2009000206A patent/TN2009000206A1/fr unknown
- 2009-05-27 GT GT200900142A patent/GT200900142A/es unknown
- 2009-06-03 MA MA31946A patent/MA30966B1/fr unknown
- 2009-06-24 NO NO20092417A patent/NO20092417L/no not_active Application Discontinuation
- 2009-06-25 CO CO09066298A patent/CO6210722A2/es not_active Application Discontinuation
- 2009-06-26 EC EC2009009472A patent/ECSP099472A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6210722A2 (es) | 2010-10-20 |
| RU2456983C2 (ru) | 2012-07-27 |
| TN2009000206A1 (en) | 2010-10-18 |
| JP2010511059A (ja) | 2010-04-08 |
| PT2089024E (pt) | 2011-08-31 |
| US20100056467A1 (en) | 2010-03-04 |
| PL2089024T3 (pl) | 2011-10-31 |
| ATE509629T1 (de) | 2011-06-15 |
| EP2089024A2 (en) | 2009-08-19 |
| BRPI0719543A2 (pt) | 2014-02-25 |
| WO2008067280A2 (en) | 2008-06-05 |
| RU2009124590A (ru) | 2011-01-10 |
| WO2008067280A3 (en) | 2008-08-07 |
| NO20092417L (no) | 2009-08-25 |
| IL198551A0 (en) | 2010-02-17 |
| AU2007325280B2 (en) | 2011-03-10 |
| KR20090087094A (ko) | 2009-08-14 |
| ECSP099472A (es) | 2009-10-30 |
| MA30966B1 (fr) | 2009-12-01 |
| AU2007325280A1 (en) | 2008-06-05 |
| MX2009005621A (es) | 2009-06-12 |
| CA2670498A1 (en) | 2008-06-05 |
| US8492429B2 (en) | 2013-07-23 |
| EP2089024B1 (en) | 2011-05-18 |
| GT200900142A (es) | 2010-06-24 |
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