JP5377806B2 - ベクター構築物の細胞ｄｎａとの非相同組換えによる内因性遺伝子の発現 - Google Patents
ベクター構築物の細胞ｄｎａとの非相同組換えによる内因性遺伝子の発現 Download PDFInfo
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- JP5377806B2 JP5377806B2 JP2000512942A JP2000512942A JP5377806B2 JP 5377806 B2 JP5377806 B2 JP 5377806B2 JP 2000512942 A JP2000512942 A JP 2000512942A JP 2000512942 A JP2000512942 A JP 2000512942A JP 5377806 B2 JP5377806 B2 JP 5377806B2
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- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2840/00—Vectors comprising a special translation-regulating system
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| US6740503B1 (en) | 1997-09-26 | 2004-05-25 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| CA2364267A1 (en) * | 1999-02-19 | 2000-08-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| JP2003527833A (ja) | 1999-10-14 | 2003-09-24 | クロンテック・ラボラトリーズ・インコーポレーテッド | 花虫類に由来する発色団／蛍光体、およびそれらの使用法 |
| MXPA02012747A (es) | 2000-06-28 | 2003-09-25 | Amgen Inc | Moleculas del receptor de linfopoietina estromica timica y sus usos. |
| GB0018876D0 (en) * | 2000-08-01 | 2000-09-20 | Applied Research Systems | Method of producing polypeptides |
| EP1352060A2 (en) * | 2000-10-30 | 2003-10-15 | Novozymes Biotech, Inc. | Methods for expressing endogenous genes by restriction enzyme mediated integration |
| DK1451295T3 (en) | 2001-11-02 | 2015-07-06 | Athersys Inc | METHODS FOR MUTATION OF GENES IN CELLS AND ANIMALS USING THE INSERTION MUTAGENES. |
| EP1456223B1 (en) | 2001-12-19 | 2009-08-12 | The University Of Chicago | Rapidly maturing fluorescent proteins and methods for using the same |
| US7662924B2 (en) | 2002-02-22 | 2010-02-16 | The Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
| CA2899360A1 (en) | 2002-08-21 | 2004-04-08 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| US8021833B2 (en) | 2003-02-12 | 2011-09-20 | Functional Genetics, Inc. | Method for reducing HIV viral budding by administering a VPS28-specfic antibody that disrupts Gag-TSG101-VPS28 binding interactions |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US11311574B2 (en) | 2003-08-08 | 2022-04-26 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| CN104721883A (zh) | 2004-03-17 | 2015-06-24 | 雷维维科公司 | 来源于缺乏任何功能性α1,3半乳糖基转移酶表达的动物的组织产品 |
| US7250298B2 (en) | 2004-04-07 | 2007-07-31 | The University Of Chicago | Monomeric red fluorescent proteins |
| AU2005269527B2 (en) | 2004-07-26 | 2011-12-01 | Pfenex Inc. | Process for improved protein expression by strain engineering |
| ES2679282T3 (es) | 2004-10-22 | 2018-08-23 | Revivicor Inc. | Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| EP2399932B1 (en) | 2005-05-12 | 2016-11-16 | ZymoGenetics, Inc. | Compositions and methods for modulating immune responses |
| AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
| WO2007053732A2 (en) | 2005-11-01 | 2007-05-10 | Mayo Foundation For Medical Education And Research | Promoter polymorphisms of the blys gene and use in diagnostic methods |
| US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
| JP5102833B2 (ja) | 2006-07-24 | 2012-12-19 | バイオレクシス ファーマシューティカル コーポレーション | エキセンディン融合タンパク質 |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2009059305A2 (en) | 2007-11-01 | 2009-05-07 | The University Of Chicago | Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation |
| WO2009073511A2 (en) | 2007-11-30 | 2009-06-11 | Mayo Foundation For Medical Education And Research | Polymorphisms of the blys gene and use in diagnostic methods |
| EP2525808A2 (en) | 2010-01-19 | 2012-11-28 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for male reproductive disorders |
| CN102669057B (zh) * | 2011-03-18 | 2014-11-26 | 上海南方模式生物科技发展有限公司 | 一种调控动物内源基因表达的遗传修饰方法 |
| KR101948248B1 (ko) * | 2011-11-18 | 2019-02-14 | 한국생명공학연구원 | 단백질 발현 미세 조절방법 |
| US10052364B2 (en) | 2013-03-15 | 2018-08-21 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for cognitive disorders |
| US9957515B2 (en) | 2013-03-15 | 2018-05-01 | Cibus Us Llc | Methods and compositions for targeted gene modification |
| US20170081674A1 (en) * | 2014-03-14 | 2017-03-23 | Cibus Us Llc | Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair |
| WO2016081728A1 (en) | 2014-11-19 | 2016-05-26 | The Trustees Of Columbia University In The City Of New York | Osteocalcin as a treatment for frailty associated with aging |
| EP3802788B1 (en) * | 2018-05-15 | 2025-07-02 | Duke University | Systems and methods for genetic manipulation of akkermansia species |
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| US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
| WO1991006667A1 (en) * | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| US5204939A (en) * | 1989-12-14 | 1993-04-20 | Fujitsu Limited | Rule base processing system and rule evaluation control method therein |
| US5272071A (en) * | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
| CA2364267A1 (en) * | 1999-02-19 | 2000-08-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
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| NO20001497D0 (no) | 2000-03-22 |
| EP1017803A1 (en) | 2000-07-12 |
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| HK1027375A1 (en) | 2001-01-12 |
| IL135242A (en) | 2011-06-30 |
| BR9812540A (pt) | 2001-12-26 |
| KR20010024296A (ko) | 2001-03-26 |
| AU750025B2 (en) | 2002-07-11 |
| EP1017803A4 (en) | 2002-01-09 |
| NZ504185A (en) | 2003-02-28 |
| ATE471373T1 (de) | 2010-07-15 |
| IL135242A0 (en) | 2001-05-20 |
| JP2003535564A (ja) | 2003-12-02 |
| DE69841723D1 (de) | 2010-07-29 |
| EP1017803B1 (en) | 2010-06-16 |
| CN1280615A (zh) | 2001-01-17 |
| CN100582230C (zh) | 2010-01-20 |
| NO20001497L (no) | 2000-05-25 |
| CA2304642A1 (en) | 1999-04-01 |
| CA2304642C (en) | 2014-11-18 |
| DK1017803T3 (da) | 2010-08-23 |
| AU9581698A (en) | 1999-04-12 |
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