DK1017803T3 - Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA - Google Patents

Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA

Info

Publication number
DK1017803T3
DK1017803T3 DK98949508.0T DK98949508T DK1017803T3 DK 1017803 T3 DK1017803 T3 DK 1017803T3 DK 98949508 T DK98949508 T DK 98949508T DK 1017803 T3 DK1017803 T3 DK 1017803T3
Authority
DK
Denmark
Prior art keywords
expression
gene
genes
methods
nucleic acid
Prior art date
Application number
DK98949508.0T
Other languages
Danish (da)
English (en)
Inventor
John J Harrington
Original Assignee
Abt Holding Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abt Holding Co filed Critical Abt Holding Co
Application granted granted Critical
Publication of DK1017803T3 publication Critical patent/DK1017803T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK98949508.0T 1997-09-26 1998-09-25 Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA DK1017803T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94122397A 1997-09-26 1997-09-26
US15964398A 1998-09-24 1998-09-24
PCT/US1998/020094 WO1999015650A1 (en) 1997-09-26 1998-09-25 Expression of endogenous genes by non-homologous recombination of a vector construct with cellular dna

Publications (1)

Publication Number Publication Date
DK1017803T3 true DK1017803T3 (da) 2010-08-23

Family

ID=26856150

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98949508.0T DK1017803T3 (da) 1997-09-26 1998-09-25 Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA

Country Status (14)

Country Link
EP (1) EP1017803B1 (enExample)
JP (1) JP5377806B2 (enExample)
KR (1) KR20010024296A (enExample)
CN (1) CN100582230C (enExample)
AT (1) ATE471373T1 (enExample)
AU (1) AU750025B2 (enExample)
BR (1) BR9812540A (enExample)
CA (1) CA2304642C (enExample)
DE (1) DE69841723D1 (enExample)
DK (1) DK1017803T3 (enExample)
IL (2) IL135242A0 (enExample)
NO (1) NO20001497L (enExample)
NZ (1) NZ504185A (enExample)
WO (1) WO1999015650A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740503B1 (en) 1997-09-26 2004-05-25 Athersys, Inc. Compositions and methods for non-targeted activation of endogenous genes
US6897066B1 (en) 1997-09-26 2005-05-24 Athersys, Inc. Compositions and methods for non-targeted activation of endogenous genes
WO2001027150A2 (en) 1999-10-14 2001-04-19 Clontech Laboratories Inc. Anthozoa derived chromo/fluoroproteins and methods for using the same
CN1384881A (zh) * 1999-02-19 2002-12-11 阿瑟西斯公司 非靶向活化内源基因的组合物和方法
PT2077279E (pt) 2000-06-28 2012-09-14 Amgen Inc Moléculas do receptor de linfopoietina estromal tímica e suas utilizações
GB0018876D0 (en) 2000-08-01 2000-09-20 Applied Research Systems Method of producing polypeptides
EP1352060A2 (en) * 2000-10-30 2003-10-15 Novozymes Biotech, Inc. Methods for expressing endogenous genes by restriction enzyme mediated integration
US7767454B2 (en) 2001-11-02 2010-08-03 Abt Holding Company Methods for mutating genes in cells using insertional mutagenesis
WO2003054158A2 (en) 2001-12-19 2003-07-03 The University Of Chicago Rapidly maturing fluorescent proteins and methods for using the same
US7662924B2 (en) 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
EP1534819B1 (en) 2002-08-21 2009-12-09 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004071462A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2857051A1 (en) 2004-03-17 2005-09-29 David Ayares Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
JP4755174B2 (ja) 2004-04-07 2011-08-24 ザ ユニヴァーシティー オヴ シカゴ 単量体赤色蛍光タンパク質
JP2008507294A (ja) 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド 菌株遺伝子操作による改善されたタンパク質発現のための方法
ES2679282T3 (es) 2004-10-22 2018-08-23 Revivicor Inc. Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
US20070054360A1 (en) 2005-05-12 2007-03-08 Zeren Gao Compositions and methods for modulating immune responses
CA2617930A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
US7749704B2 (en) 2005-11-01 2010-07-06 Mayo Foundation For Medical Education And Research Promoter polymorphisms of the BLyS gene and use in diagnostic methods
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
ES2371495T3 (es) 2006-07-24 2012-01-03 Biorexis Pharmaceutical Corporation Proteínas de fusión de exendina.
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US8679749B2 (en) 2007-11-01 2014-03-25 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
WO2009073511A2 (en) 2007-11-30 2009-06-11 Mayo Foundation For Medical Education And Research Polymorphisms of the blys gene and use in diagnostic methods
WO2011090971A2 (en) 2010-01-19 2011-07-28 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for male reproductive disorders
CN102669057B (zh) * 2011-03-18 2014-11-26 上海南方模式生物科技发展有限公司 一种调控动物内源基因表达的遗传修饰方法
KR101948248B1 (ko) * 2011-11-18 2019-02-14 한국생명공학연구원 단백질 발현 미세 조절방법
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US10052364B2 (en) 2013-03-15 2018-08-21 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for cognitive disorders
CA2942407C (en) * 2014-03-14 2023-09-26 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
WO2016081728A1 (en) 2014-11-19 2016-05-26 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for frailty associated with aging
EP3802788B1 (en) 2018-05-15 2025-07-02 Duke University Systems and methods for genetic manipulation of akkermansia species

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
WO1991006667A1 (en) * 1989-11-06 1991-05-16 Cell Genesys, Inc. Production of proteins using homologous recombination
US5204939A (en) * 1989-12-14 1993-04-20 Fujitsu Limited Rule base processing system and rule evaluation control method therein
US5272071A (en) * 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5561053A (en) * 1994-08-05 1996-10-01 Genentech, Inc. Method for selecting high-expressing host cells
CN1384881A (zh) * 1999-02-19 2002-12-11 阿瑟西斯公司 非靶向活化内源基因的组合物和方法

Also Published As

Publication number Publication date
WO1999015650A9 (en) 2000-09-08
ATE471373T1 (de) 2010-07-15
CA2304642A1 (en) 1999-04-01
CN100582230C (zh) 2010-01-20
AU750025B2 (en) 2002-07-11
JP5377806B2 (ja) 2013-12-25
HK1027375A1 (en) 2001-01-12
EP1017803B1 (en) 2010-06-16
BR9812540A (pt) 2001-12-26
IL135242A (en) 2011-06-30
CA2304642C (en) 2014-11-18
JP2003535564A (ja) 2003-12-02
NO20001497D0 (no) 2000-03-22
CN1280615A (zh) 2001-01-17
EP1017803A4 (en) 2002-01-09
EP1017803A1 (en) 2000-07-12
NZ504185A (en) 2003-02-28
WO1999015650A1 (en) 1999-04-01
NO20001497L (no) 2000-05-25
IL135242A0 (en) 2001-05-20
DE69841723D1 (de) 2010-07-29
KR20010024296A (ko) 2001-03-26
AU9581698A (en) 1999-04-12

Similar Documents

Publication Publication Date Title
DK1017803T3 (da) Ekspression af endogene gener ved ikke-homolog rekombination af et vektorkonstrukt med cellulært DNA
Prévôt et al. Characterization of a novel RNA‐binding region of eIF4GI critical for ribosomal scanning
Rubin et al. Selective stimulation of translational expression by Alu RNA
SG141233A1 (en) Control of gene expression
WO1999036516A3 (en) Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
MX9606476A (es) Inhibicion citoplasmica de expresion de genes.
ATE366814T1 (de) Gl50 moleküle, sowie verwendungen derselben
WO2000049162A8 (en) Compositions and methods for non-targeted activation of endogenous genes
Sumiyama et al. Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements
Cioffi et al. An IgH Enhancer That Drives Transcription through Basic Helix-Loop-Helix and Oct Transcription Factor Binding Motifs: FUNCTIONAL ANALYSIS OF THE Eµ3′ ENHANCER OF THE CATFISH
EP1412374A4 (en) NEW PGC-1 ISOFORMS AND THEIR USES
DE60130465D1 (de) Mutierte muskelspezifische enhancer
Borovsky et al. Juvenile hormone affects the splicing of Culex quinquefasciatus early trypsin messenger RNA
Christophides et al. Expression and function of the Drosophila melanogaster ADH in male Ceratitis capitata adults: a potential strategy for medfly genetic sexing based on gene‐transfer technology
ATE470716T1 (de) 18480 humane proteinkinasemoleküle und ihre verwendungen
AU2001249649A1 (en) 16836, a novel human phospholipase c family member and uses thereof
WO2001092495A3 (en) A human lysyl ixodase (47765) and uses thereof
Richter et al. Are single-strand-specific DNA binding proteins needed for mammalian DNA replication?
WO2001066765A3 (en) 26583, a serine/threonine phosphatase and uses thereof
Morris Fluorescence activated cell sorting of transiently transfected As4. 1 cells shows renin enhancer directs on/off switching of renin promoter in vitro
WO2002006485A3 (en) 47885, a novel human ubiquitin-activating enzyme and uses therefor
Liu et al. Target-Stabilized Base Editors Enable Robust High-Fidelity RNA Editing
KR880003008A (ko) 우역 바이러스의 항원 단백질을 코드화 하는 dna
AU2001285204A1 (en) Atcr-1, a human acyltransferase and uses thereof
Pavlova et al. The structure and evolution of the MaSMC4 gene of common vole Microtus arvalis (Arvicolidae, Rodentia)