JP5363984B2 - 代謝年齢に関するバイオマーカー及びその使用方法 - Google Patents

代謝年齢に関するバイオマーカー及びその使用方法 Download PDF

Info

Publication number
JP5363984B2
JP5363984B2 JP2009532611A JP2009532611A JP5363984B2 JP 5363984 B2 JP5363984 B2 JP 5363984B2 JP 2009532611 A JP2009532611 A JP 2009532611A JP 2009532611 A JP2009532611 A JP 2009532611A JP 5363984 B2 JP5363984 B2 JP 5363984B2
Authority
JP
Japan
Prior art keywords
age
acid
biomarkers
level
metabolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009532611A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010507075A (ja
JP2010507075A5 (enExample
Inventor
ライアルズ、ジョン
ミルバーン、マイク
ミチェル、マシュー、ダブリュー．
ロートン、ケイ、エイ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolon Inc
Original Assignee
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
Publication of JP2010507075A publication Critical patent/JP2010507075A/ja
Publication of JP2010507075A5 publication Critical patent/JP2010507075A5/ja
Application granted granted Critical
Publication of JP5363984B2 publication Critical patent/JP5363984B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7042—Aging, e.g. cellular aging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2009532611A 2006-10-13 2007-10-12 代謝年齢に関するバイオマーカー及びその使用方法 Active JP5363984B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85146806P 2006-10-13 2006-10-13
US60/851,468 2006-10-13
PCT/US2007/081268 WO2008063783A2 (en) 2006-10-13 2007-10-12 Biomarkers related to metabolic age and methods using the same

Publications (3)

Publication Number Publication Date
JP2010507075A JP2010507075A (ja) 2010-03-04
JP2010507075A5 JP2010507075A5 (enExample) 2011-01-27
JP5363984B2 true JP5363984B2 (ja) 2013-12-11

Family

ID=39430420

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009532611A Active JP5363984B2 (ja) 2006-10-13 2007-10-12 代謝年齢に関するバイオマーカー及びその使用方法

Country Status (6)

Country Link
US (3) US7781160B2 (enExample)
EP (3) EP2428587A3 (enExample)
JP (1) JP5363984B2 (enExample)
AT (1) ATE536425T1 (enExample)
CA (1) CA2666339A1 (enExample)
WO (1) WO2008063783A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022259950A1 (ja) * 2021-06-10 2022-12-15 国立大学法人千葉大学 老化の評価方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153131A1 (en) * 2008-05-28 2009-12-23 Basf Se Means and methods for assessing liver enzyme induction
CN102105792A (zh) 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法
KR101068996B1 (ko) 2008-09-18 2011-09-30 한국표준과학연구원 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법
BRPI1007483B1 (pt) * 2009-01-28 2021-11-30 Bio Preventive Medicine Corporation Método de diagnóstico de nefropatia in vitro, método in vitro para o monitoramento de progresso de nefropatia, método in vitro para o monitoramento da eficácia de um tratamento de nefropatia, método in vitro de avaliação de toxicidade renal de um agente e kit para diagnóstico de nefropatia
EP2642294A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. Phenylacetylglutamine as biomarker for healthy ageing
EP2642293A1 (en) 2012-03-22 2013-09-25 Nestec S.A. 9-oxo-octadecadienoic acid (9-oxo-HODE)as as biomarker for healthy ageing
EP2642295A1 (en) 2012-03-22 2013-09-25 Nestec S.A. 1-O-alkyl-2-acylglycerophosphocholine (PC-O) 40:1 as biomarker for healthy ageing
EP2642296A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. p-Cresol sulphate as biomarker for healthy ageing
CL2012001566A1 (es) * 2012-06-11 2013-08-09 Univ De Santiago De Chile Univ Tecnica Federico Santa Maria Metodo analitico para verificar la edad de la carne de animales utilizando perfiles volatiles que comprende introducir una fibra de microextraccion en fase solida en un vial que contiene la carne picada que ha sido calentada, luego desorber en el puerto de inyeccion de un cromatografo de gases, separar los gases y determinar sus concentraciones.
US20160196766A1 (en) * 2013-02-20 2016-07-07 Chistopher Brian Lundin Weight management method
WO2015048665A2 (en) * 2013-09-27 2015-04-02 The Regents Of The University Of California Method to estimate the age of tissues and cell types based on epigenetic markers
JP2017520553A (ja) 2014-06-30 2017-07-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 加齢関連症状及び疾患を治療するためのケト酪酸化合物ならびに組成物
US9737761B1 (en) * 2014-10-29 2017-08-22 REVVO, Inc. System and method for fitness testing, tracking and training
WO2016124574A1 (en) * 2015-02-03 2016-08-11 Pharnext Diagnostic tools for alzheimer's disease
US10823699B2 (en) 2016-07-29 2020-11-03 Vital Biosciences, Inc. Gel electrophoresis diagnostic kit and methods of using the same
CA3048210A1 (en) 2016-12-23 2018-06-28 Vital Biosciences, Inc. Electrophoresis diagnostic methods and kits
WO2018144911A1 (en) 2017-02-02 2018-08-09 Golo Llc Formulations for weight loss and methods of use
CN108956790A (zh) * 2017-05-18 2018-12-07 中国人民解放军第二军医大学第二附属医院 一组氨基酸标志物在急性肾损伤诊断试剂盒中的应用
US12080432B1 (en) 2017-06-01 2024-09-03 The Regents Of The University Of Colorado Plasma metabolome as a predictor of biological aging
CN107273699A (zh) * 2017-07-07 2017-10-20 成都脉安科健生物科技有限公司 营养指导方案获取方法、装置及电子设备
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
JP7437767B2 (ja) * 2018-04-24 2024-02-26 学校法人沖縄科学技術大学院大学学園 ヒトの老化バイオマーカーとしての、唾液及び尿の代謝物の使用
CN108663448B (zh) * 2018-05-14 2021-07-13 中国医学科学院医药生物技术研究所 一种复方氨基酸注射液中有关物质的检测方法
WO2020252206A1 (en) * 2019-06-12 2020-12-17 Huntington Medical Research Institutes Methods for evaluation and treatment of alzheimer's disease and applications thereof
CN110658286B (zh) * 2019-11-19 2022-07-08 浙江树人学院（浙江树人大学） 利用rp-hplc法同时快速检测苯乳酸和4-羟基苯乳酸含量的方法
CN113125589B (zh) * 2021-03-17 2022-01-04 广东省农业科学院农业质量标准与监测技术研究所 一种代谢组学分析技术鉴定鸭屎香单丛茶的应用
CN116798518B (zh) * 2023-06-05 2024-03-08 中南大学湘雅医院 构建代谢物衰老分数及代谢衰老速率的方法及其应用
CN120280160B (zh) * 2025-06-10 2025-09-19 上海交通大学医学院附属仁济医院 代谢衰老的识别模型构建系统、存储介质及试剂盒

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096787A (en) * 1990-08-03 1992-03-17 Globe-Union Inc. Hydrostatic pump with static resistance for a mobile vehicle battery
JP3350189B2 (ja) * 1993-04-30 2002-11-25 本田技研工業株式会社 電気自動車用バッテリボックス装置
JPH11301077A (ja) 1998-04-23 1999-11-02 Olympus Optical Co Ltd ドットコード評価装置及びドットコード評価方法
JPH11301078A (ja) 1998-04-27 1999-11-02 Ricoh Co Ltd 複合装置
JPH11301079A (ja) 1998-04-27 1999-11-02 Canon Inc 印刷方法、印刷システムおよび記録媒体
CA2381777C (en) * 1999-08-12 2011-10-04 Wisconsin Alumni Research Foundation Identification of genetic markers of biological age and metabolism
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP3792547B2 (ja) * 2001-07-19 2006-07-05 株式会社タニタ 生体測定装置
EP1451345A4 (en) * 2001-08-15 2006-03-01 Elixir Pharmaceuticals Inc MARKERS ASSOCIATED WITH AGE
WO2003107270A2 (en) * 2002-06-14 2003-12-24 Pfizer Limited Metabolic phenotyping
WO2004085996A2 (en) 2003-03-20 2004-10-07 Albert Einstein College Of Medicine Of Yeshiva University Biomarkers for longevity and disease and uses thereof
AU2004251654A1 (en) * 2003-06-02 2005-01-06 Icoria, Inc. Use of genes differentially expressed during aging of liver for treatment and diagnosis
JP4255321B2 (ja) 2003-06-25 2009-04-15 本田技研工業株式会社 アシスト搬送方法及びその装置
JP4384896B2 (ja) * 2003-11-14 2009-12-16 フィールファイン株式会社 年齢アセスメントシステム及びプログラム
JP2006134676A (ja) 2004-11-05 2006-05-25 Fuji Electric Fa Components & Systems Co Ltd 加熱温度制御装置
JP2006134678A (ja) 2004-11-05 2006-05-25 Toyota Central Res & Dev Lab Inc 固体高分子型燃料電池及び燃料電池システム
JP2006134677A (ja) 2004-11-05 2006-05-25 Fuji Electric Holdings Co Ltd 固体高分子型燃料電池用セパレータ及びその製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022259950A1 (ja) * 2021-06-10 2022-12-15 国立大学法人千葉大学 老化の評価方法

Also Published As

Publication number Publication date
WO2008063783A2 (en) 2008-05-29
US20080124752A1 (en) 2008-05-29
US20160116461A1 (en) 2016-04-28
CA2666339A1 (en) 2008-05-29
EP2813580A1 (en) 2014-12-17
WO2008063783A3 (en) 2008-12-24
EP2089539A2 (en) 2009-08-19
JP2010507075A (ja) 2010-03-04
ATE536425T1 (de) 2011-12-15
EP2089539B1 (en) 2011-12-07
US20100279337A1 (en) 2010-11-04
EP2428587A3 (en) 2012-07-18
EP2428587A2 (en) 2012-03-14
US7781160B2 (en) 2010-08-24
EP2089539A4 (en) 2010-03-17

Similar Documents

Publication Publication Date Title
JP5363984B2 (ja) 代謝年齢に関するバイオマーカー及びその使用方法
JP2010507075A5 (enExample)
AU2008279778B2 (en) Method for Determining Insulin Sensitivity with Biomarkers
EP2227689B1 (en) Biomarkers for fatty liver disease and methods using the same
CN104956228A (zh) 己酰甘氨酸作为增重和肥胖倾向的生物标志物
Loft et al. Association between 8-oxo-7, 8-dihydroguanine excretion and risk of lung cancer in a prospective study
Eng et al. Identification and assessment of markers of biotin status in healthy adults
CN105026935B (zh) 异戊酰甘氨酸作为增重和肥胖倾向的生物标志物
Cordero et al. Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma
Gulsun et al. Possible relationship between amino acids, aggression and psychopathy
Castells-Nobau et al. Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways
Humann-Ziehank et al. Selenium speciation in paired serum and cerebrospinal fluid samples of sheep
Chen et al. Non‐invasive metabolic biomarkers in initial cognitive impairment in patients with diabetes: A systematic review and meta‐analysis
Stanescu et al. Long‐term follow‐up with filter paper samples in patients with propionic acidemia
Moore et al. Targeted metabolomics with Ultraperformance liquid chromatography–mass spectrometry (UPLC-MS) highlights metabolic differences in healthy and atopic Staffordshire bull terriers fed two different diets, a pilot study
Jian et al. Identification of pyruvic and maleic acid as potential markers for disease activity and prognosis in chronic urticaria
Kerksick et al. Intramuscular phosphagen status and the relationship to muscle performance across the age spectrum
Taylor et al. The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes
Al Rashid et al. Association of the serum metabolomic profile by nuclear magnetic resonance spectroscopy with sperm parameters: a cross-sectional study of 325 men
Barbosa et al. Fructose supplementation shifts rat brain metabolism in experimental migraine
Kulkarani et al. Hypomagnesemia in alcohol dependent population from the lower socio-economic background who were consuming illicit liquor and attending the de-addiction center
Liu et al. Effects of zinc supplementation on metabolomic profiles in tanzanian infants: a randomized trial
Platt et al. Neuromuscular weakness and collapse
Gomez-Casati et al. Molecular basis of clinical metabolomics
LT et al. Durham, NC 27713 (US)

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101012

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101012

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101027

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20101201

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20111130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111202

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120223

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120301

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120427

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120509

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120531

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121227

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130702

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130725

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130827

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130906

R150 Certificate of patent or registration of utility model

Ref document number: 5363984

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250