ATE536425T1 - Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon - Google Patents
Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davonInfo
- Publication number
- ATE536425T1 ATE536425T1 AT07868439T AT07868439T ATE536425T1 AT E536425 T1 ATE536425 T1 AT E536425T1 AT 07868439 T AT07868439 T AT 07868439T AT 07868439 T AT07868439 T AT 07868439T AT E536425 T1 ATE536425 T1 AT E536425T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- metabolic age
- biomarkers
- biomarkers associated
- age
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 5
- 230000002503 metabolic effect Effects 0.000 title abstract 5
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7042—Aging, e.g. cellular aging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physiology (AREA)
- Toxicology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85146806P | 2006-10-13 | 2006-10-13 | |
| PCT/US2007/081268 WO2008063783A2 (en) | 2006-10-13 | 2007-10-12 | Biomarkers related to metabolic age and methods using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE536425T1 true ATE536425T1 (de) | 2011-12-15 |
Family
ID=39430420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07868439T ATE536425T1 (de) | 2006-10-13 | 2007-10-12 | Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7781160B2 (enExample) |
| EP (3) | EP2089539B1 (enExample) |
| JP (1) | JP5363984B2 (enExample) |
| AT (1) | ATE536425T1 (enExample) |
| CA (1) | CA2666339A1 (enExample) |
| WO (1) | WO2008063783A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009259540B2 (en) | 2008-05-28 | 2015-11-05 | Basf Se | Means and methods for assessing liver toxicity |
| CA2724512A1 (en) * | 2008-05-28 | 2009-12-23 | Bennard Van Ravenzwaay | Means and methods for assessing liver enzyme induction |
| KR101068996B1 (ko) | 2008-09-18 | 2011-09-30 | 한국표준과학연구원 | 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법 |
| CN102300875B (zh) * | 2009-01-28 | 2014-07-16 | 财团法人工业技术研究院 | 肾病相关的生物标记 |
| EP2642293A1 (en) | 2012-03-22 | 2013-09-25 | Nestec S.A. | 9-oxo-octadecadienoic acid (9-oxo-HODE)as as biomarker for healthy ageing |
| EP2642296A1 (en) * | 2012-03-22 | 2013-09-25 | Nestec S.A. | p-Cresol sulphate as biomarker for healthy ageing |
| EP2642294A1 (en) * | 2012-03-22 | 2013-09-25 | Nestec S.A. | Phenylacetylglutamine as biomarker for healthy ageing |
| EP2642295A1 (en) | 2012-03-22 | 2013-09-25 | Nestec S.A. | 1-O-alkyl-2-acylglycerophosphocholine (PC-O) 40:1 as biomarker for healthy ageing |
| CL2012001566A1 (es) * | 2012-06-11 | 2013-08-09 | Univ De Santiago De Chile Univ Tecnica Federico Santa Maria | Metodo analitico para verificar la edad de la carne de animales utilizando perfiles volatiles que comprende introducir una fibra de microextraccion en fase solida en un vial que contiene la carne picada que ha sido calentada, luego desorber en el puerto de inyeccion de un cromatografo de gases, separar los gases y determinar sus concentraciones. |
| US20160196766A1 (en) * | 2013-02-20 | 2016-07-07 | Chistopher Brian Lundin | Weight management method |
| EP3049535B1 (en) * | 2013-09-27 | 2021-12-01 | The Regents of the University of California | Method to estimate the age of tissues and cell types based on epigenetic markers |
| AU2015284409B2 (en) | 2014-06-30 | 2020-06-25 | The Regents Of The University Of California | Ketobutyrate compounds and compositions for treating age-related symptoms and diseases |
| US9737761B1 (en) * | 2014-10-29 | 2017-08-22 | REVVO, Inc. | System and method for fitness testing, tracking and training |
| WO2016124574A1 (en) * | 2015-02-03 | 2016-08-11 | Pharnext | Diagnostic tools for alzheimer's disease |
| US10823699B2 (en) | 2016-07-29 | 2020-11-03 | Vital Biosciences, Inc. | Gel electrophoresis diagnostic kit and methods of using the same |
| US11353423B2 (en) | 2016-12-23 | 2022-06-07 | Vital Biosciences, Inc. | Electrophoresis diagnostic methods and kits |
| WO2018144911A1 (en) | 2017-02-02 | 2018-08-09 | Golo Llc | Formulations for weight loss and methods of use |
| CN108956790A (zh) * | 2017-05-18 | 2018-12-07 | 中国人民解放军第二军医大学第二附属医院 | 一组氨基酸标志物在急性肾损伤诊断试剂盒中的应用 |
| US12080432B1 (en) | 2017-06-01 | 2024-09-03 | The Regents Of The University Of Colorado | Plasma metabolome as a predictor of biological aging |
| CN107273699A (zh) * | 2017-07-07 | 2017-10-20 | 成都脉安科健生物科技有限公司 | 营养指导方案获取方法、装置及电子设备 |
| US11484273B2 (en) * | 2018-03-06 | 2022-11-01 | International Business Machines Corporation | Determining functional age indices based upon sensor data |
| WO2019208588A1 (en) * | 2018-04-24 | 2019-10-31 | Okinawa Institute Of Science And Technology School Corporation | Novel trimethyl ammonium metabolites in human blood cells that increase by aging |
| CN108663448B (zh) * | 2018-05-14 | 2021-07-13 | 中国医学科学院医药生物技术研究所 | 一种复方氨基酸注射液中有关物质的检测方法 |
| WO2020252206A1 (en) * | 2019-06-12 | 2020-12-17 | Huntington Medical Research Institutes | Methods for evaluation and treatment of alzheimer's disease and applications thereof |
| CN110658286B (zh) * | 2019-11-19 | 2022-07-08 | 浙江树人学院（浙江树人大学） | 利用rp-hplc法同时快速检测苯乳酸和4-羟基苯乳酸含量的方法 |
| CN113125589B (zh) * | 2021-03-17 | 2022-01-04 | 广东省农业科学院农业质量标准与监测技术研究所 | 一种代谢组学分析技术鉴定鸭屎香单丛茶的应用 |
| JPWO2022259950A1 (enExample) * | 2021-06-10 | 2022-12-15 | ||
| CN116798518B (zh) * | 2023-06-05 | 2024-03-08 | 中南大学湘雅医院 | 构建代谢物衰老分数及代谢衰老速率的方法及其应用 |
| CN120280160B (zh) * | 2025-06-10 | 2025-09-19 | 上海交通大学医学院附属仁济医院 | 代谢衰老的识别模型构建系统、存储介质及试剂盒 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096787A (en) * | 1990-08-03 | 1992-03-17 | Globe-Union Inc. | Hydrostatic pump with static resistance for a mobile vehicle battery |
| JP3350189B2 (ja) * | 1993-04-30 | 2002-11-25 | 本田技研工業株式会社 | 電気自動車用バッテリボックス装置 |
| JPH11301077A (ja) | 1998-04-23 | 1999-11-02 | Olympus Optical Co Ltd | ドットコード評価装置及びドットコード評価方法 |
| JPH11301079A (ja) | 1998-04-27 | 1999-11-02 | Canon Inc | 印刷方法、印刷システムおよび記録媒体 |
| JPH11301078A (ja) | 1998-04-27 | 1999-11-02 | Ricoh Co Ltd | 複合装置 |
| US6569624B1 (en) * | 1999-08-12 | 2003-05-27 | Wisconsin Alumni Research Foundation | Identification of genetic markers of biological age and metabolism |
| JP2003530130A (ja) * | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| JP3792547B2 (ja) * | 2001-07-19 | 2006-07-05 | 株式会社タニタ | 生体測定装置 |
| CA2457370A1 (en) * | 2001-08-15 | 2003-02-27 | Elixir Pharmaceuticals, Inc. | Age-associated markers |
| RU2004136317A (ru) * | 2002-06-14 | 2006-01-27 | Пфайзер Инк. (US) | Метаболическое фенотипирование |
| WO2004085996A2 (en) | 2003-03-20 | 2004-10-07 | Albert Einstein College Of Medicine Of Yeshiva University | Biomarkers for longevity and disease and uses thereof |
| CA2527957A1 (en) * | 2003-06-02 | 2005-01-06 | Ohio University | Use of genes differentially expressed during aging of liver for treatment and diagnosis |
| JP4255321B2 (ja) | 2003-06-25 | 2009-04-15 | 本田技研工業株式会社 | アシスト搬送方法及びその装置 |
| JP4384896B2 (ja) * | 2003-11-14 | 2009-12-16 | フィールファイン株式会社 | 年齢アセスメントシステム及びプログラム |
| JP2006134678A (ja) | 2004-11-05 | 2006-05-25 | Toyota Central Res & Dev Lab Inc | 固体高分子型燃料電池及び燃料電池システム |
| JP2006134676A (ja) | 2004-11-05 | 2006-05-25 | Fuji Electric Fa Components & Systems Co Ltd | 加熱温度制御装置 |
| JP2006134677A (ja) | 2004-11-05 | 2006-05-25 | Fuji Electric Holdings Co Ltd | 固体高分子型燃料電池用セパレータ及びその製造方法 |
-
2007
- 2007-10-12 WO PCT/US2007/081268 patent/WO2008063783A2/en not_active Ceased
- 2007-10-12 AT AT07868439T patent/ATE536425T1/de active
- 2007-10-12 EP EP07868439A patent/EP2089539B1/en active Active
- 2007-10-12 EP EP14157698.3A patent/EP2813580A1/en not_active Withdrawn
- 2007-10-12 US US11/871,752 patent/US7781160B2/en active Active
- 2007-10-12 CA CA002666339A patent/CA2666339A1/en not_active Abandoned
- 2007-10-12 JP JP2009532611A patent/JP5363984B2/ja active Active
- 2007-10-12 EP EP11181263A patent/EP2428587A3/en not_active Withdrawn
-
2010
- 2010-07-13 US US12/835,307 patent/US20100279337A1/en not_active Abandoned
-
2015
- 2015-11-23 US US14/948,457 patent/US20160116461A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2666339A1 (en) | 2008-05-29 |
| EP2428587A2 (en) | 2012-03-14 |
| US20100279337A1 (en) | 2010-11-04 |
| EP2089539A4 (en) | 2010-03-17 |
| US7781160B2 (en) | 2010-08-24 |
| JP2010507075A (ja) | 2010-03-04 |
| JP5363984B2 (ja) | 2013-12-11 |
| EP2089539A2 (en) | 2009-08-19 |
| WO2008063783A2 (en) | 2008-05-29 |
| US20160116461A1 (en) | 2016-04-28 |
| WO2008063783A3 (en) | 2008-12-24 |
| EP2428587A3 (en) | 2012-07-18 |
| US20080124752A1 (en) | 2008-05-29 |
| EP2813580A1 (en) | 2014-12-17 |
| EP2089539B1 (en) | 2011-12-07 |
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