JP5362747B2 - アルツハイマー病の治療用医薬品の調製のためのs−アデノシルメチオニン(sam)およびスーパーオキシドジスムターゼ(sod)の使用 - Google Patents

アルツハイマー病の治療用医薬品の調製のためのs−アデノシルメチオニン(sam)およびスーパーオキシドジスムターゼ(sod)の使用 Download PDF

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JP5362747B2
JP5362747B2 JP2010548015A JP2010548015A JP5362747B2 JP 5362747 B2 JP5362747 B2 JP 5362747B2 JP 2010548015 A JP2010548015 A JP 2010548015A JP 2010548015 A JP2010548015 A JP 2010548015A JP 5362747 B2 JP5362747 B2 JP 5362747B2
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sam
sod
disease
adenosylmethionine
alzheimer
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Japanese (ja)
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JP2011513257A (ja
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シグフリド スカルパ、
アンドレア フソ、
ロゼリナ ダミアニ、
マウロ ロッシーニ、
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ニョシス ソシエタ ペル アチオニ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/446Superoxide dismutase (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2010548015A 2008-02-29 2009-02-25 アルツハイマー病の治療用医薬品の調製のためのs−アデノシルメチオニン(sam)およびスーパーオキシドジスムターゼ(sod)の使用 Expired - Fee Related JP5362747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08425123.0 2008-02-29
EP08425123A EP2095828A1 (en) 2008-02-29 2008-02-29 Use of S-adenosylmethionine (SAM) and superoxide dismutase (SOD) for the preparation of medicaments for the treatment of Alzeimer's disease
PCT/EP2009/001323 WO2009106302A1 (en) 2008-02-29 2009-02-25 Use of s-adenosylmethionine (sam) and superoxide dismutase (sod) for the preparation of medicaments for the treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
JP2011513257A JP2011513257A (ja) 2011-04-28
JP5362747B2 true JP5362747B2 (ja) 2013-12-11

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JP2010548015A Expired - Fee Related JP5362747B2 (ja) 2008-02-29 2009-02-25 アルツハイマー病の治療用医薬品の調製のためのs−アデノシルメチオニン(sam)およびスーパーオキシドジスムターゼ(sod)の使用

Country Status (25)

Country Link
US (1) US8778337B2 (ko)
EP (2) EP2095828A1 (ko)
JP (1) JP5362747B2 (ko)
KR (1) KR101297763B1 (ko)
CN (2) CN101965197A (ko)
AU (1) AU2009218723B2 (ko)
BR (1) BRPI0908024A2 (ko)
CA (1) CA2716893C (ko)
CY (1) CY1116782T1 (ko)
DK (1) DK2249868T3 (ko)
ES (1) ES2550461T3 (ko)
GE (1) GEP20125638B (ko)
HR (1) HRP20151241T1 (ko)
HU (1) HUE028183T2 (ko)
IL (1) IL207807A (ko)
MX (1) MX2010009384A (ko)
NZ (1) NZ587608A (ko)
PL (1) PL2249868T3 (ko)
PT (1) PT2249868E (ko)
RS (1) RS54442B1 (ko)
RU (1) RU2472513C2 (ko)
SI (1) SI2249868T1 (ko)
UA (1) UA97440C2 (ko)
WO (1) WO2009106302A1 (ko)
ZA (1) ZA201006085B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150064423A (ko) * 2013-12-03 2015-06-11 경상대학교산학협력단 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물
KR101689681B1 (ko) * 2016-06-07 2016-12-26 경상대학교산학협력단 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물
KR20230047320A (ko) 2021-09-30 2023-04-07 한국 한의학 연구원 반하, 대추, 감초, 인삼, 건강, 황금 및 황련 혼합 추출물을 유효성분으로 포함하는, 알츠하이머 치료용 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519058A (en) * 1989-03-17 1996-05-21 Cedars-Sinai Medical Center Method for treatment with dimercaptosuccinic acid (DMSA) of hypertension, diabetic neuphropathy and atherosclerosis
CN1099224A (zh) * 1993-08-23 1995-03-01 庭野七郎 人参叶加工的食品及其制造方法
US6096778A (en) * 1997-10-07 2000-08-01 Cephalon, Inc. α-ketoamide multicatalytic protease inhibitors
US6797289B2 (en) * 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US20020025926A1 (en) * 2000-08-30 2002-02-28 Hebert Rolland F. Enantiomers of S-adenosyl-l-methionine
IT1317920B1 (it) 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
FR2822381B1 (fr) * 2001-03-20 2004-10-22 Bio Obtention Sc Extrait de cucumis melo enrobe et/ou microencapsule dans un agent liposoluble a base de matiere grasse
ITMI20012462A1 (it) * 2001-11-22 2003-05-22 Gnosis Srl Processo per la preparazione di compresse comprendenti s-adenosilmetionina
AU2003298514A1 (en) * 2002-05-17 2004-05-04 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
WO2005041996A1 (en) * 2003-10-03 2005-05-12 GREEN MEADOWS RESEARCH, LLC A & L Goodbody Lotus and methyl donors
PT1731596E (pt) 2005-06-09 2013-05-10 Gnosis Spa Células de saccharomyces cerevisiae secas, liofilizadas e/ou microencapsuladas com um teor elevado de (s)-(+)-s-adenosill- metionina

Also Published As

Publication number Publication date
AU2009218723A1 (en) 2009-09-03
ZA201006085B (en) 2011-10-26
HUE028183T2 (en) 2016-12-28
PT2249868E (pt) 2015-11-03
CN104189895B (zh) 2016-08-31
EP2095828A1 (en) 2009-09-02
IL207807A0 (en) 2010-12-30
IL207807A (en) 2015-08-31
KR101297763B1 (ko) 2013-08-20
PL2249868T3 (pl) 2016-03-31
CN101965197A (zh) 2011-02-02
BRPI0908024A2 (pt) 2018-11-06
KR20100126326A (ko) 2010-12-01
SI2249868T1 (sl) 2015-12-31
US20110020301A1 (en) 2011-01-27
RU2010135467A (ru) 2012-04-10
NZ587608A (en) 2012-07-27
CA2716893A1 (en) 2009-09-03
CA2716893C (en) 2014-05-20
WO2009106302A1 (en) 2009-09-03
US8778337B2 (en) 2014-07-15
CN104189895A (zh) 2014-12-10
DK2249868T3 (en) 2015-11-23
EP2249868A1 (en) 2010-11-17
AU2009218723B2 (en) 2014-01-30
RU2472513C2 (ru) 2013-01-20
EP2249868B1 (en) 2015-09-02
JP2011513257A (ja) 2011-04-28
GEP20125638B (en) 2012-09-10
CY1116782T1 (el) 2017-03-15
HRP20151241T1 (hr) 2015-12-18
ES2550461T3 (es) 2015-11-10
UA97440C2 (en) 2012-02-10
MX2010009384A (es) 2010-12-21
RS54442B1 (en) 2016-06-30

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