HRP20151241T1 - Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti - Google Patents

Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti Download PDF

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Publication number
HRP20151241T1
HRP20151241T1 HRP20151241TT HRP20151241T HRP20151241T1 HR P20151241 T1 HRP20151241 T1 HR P20151241T1 HR P20151241T T HRP20151241T T HR P20151241TT HR P20151241 T HRP20151241 T HR P20151241T HR P20151241 T1 HRP20151241 T1 HR P20151241T1
Authority
HR
Croatia
Prior art keywords
sam
adenosylmethionine
alzheimer
disease
treatment
Prior art date
Application number
HRP20151241TT
Other languages
English (en)
Inventor
Sigfrido Scarpa
Andrea Fuso
Rosellina Damiani
Mauro Rossini
Original Assignee
Gnosis S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gnosis S.P.A. filed Critical Gnosis S.P.A.
Publication of HRP20151241T1 publication Critical patent/HRP20151241T1/hr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/446Superoxide dismutase (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (5)

1. Upotreba S-adenozilmetionina (SAM) u kombinaciji sa supeoksid-dismutazom (SOD), naznačena time da je za pripravu lijekova za liječenje Alzheimerove bolesti.
2. Upotreba iz patentnog zahtjeva 1, naznačena time da lijek pokazuje prekomjernu eksperiju PS1 i BACE.
3. Upotreba iz patentnog zahtjeva 1, naznačena time da se lijekovi daju oralno.
4. Produkti, naznačeni time da kao jedine aktivne sastojke sadrže (i) S-adenozilmetionin i (ii) supeoksid-dismutazu u obliku kombiniranog pripravka za istovremeno, odvojeno ili uzastopno davanje u liječenju Alzheimerove bolesti.
5. Produkti kako su prijavljeni u patentnom zahtjevu 4, naznačeni time da se SAM uzima u obliku tosilata, butandisulfonata, disulfat-tosilata, disulfat-ditosilata ili disulfat-monotosilata, ili je sadržan u stanicama Saccharomyces cerevisiae obogaćenih sa SAM.
HRP20151241TT 2008-02-29 2015-11-18 Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti HRP20151241T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08425123A EP2095828A1 (en) 2008-02-29 2008-02-29 Use of S-adenosylmethionine (SAM) and superoxide dismutase (SOD) for the preparation of medicaments for the treatment of Alzeimer's disease
EP09714406.7A EP2249868B1 (en) 2008-02-29 2009-02-25 Use of s-adenosylmethionine (sam) and superoxide dismutase (sod) for the preparation of medicaments for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
HRP20151241T1 true HRP20151241T1 (hr) 2015-12-18

Family

ID=39529658

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20151241TT HRP20151241T1 (hr) 2008-02-29 2015-11-18 Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti

Country Status (25)

Country Link
US (1) US8778337B2 (hr)
EP (2) EP2095828A1 (hr)
JP (1) JP5362747B2 (hr)
KR (1) KR101297763B1 (hr)
CN (2) CN101965197A (hr)
AU (1) AU2009218723B2 (hr)
BR (1) BRPI0908024A2 (hr)
CA (1) CA2716893C (hr)
CY (1) CY1116782T1 (hr)
DK (1) DK2249868T3 (hr)
ES (1) ES2550461T3 (hr)
GE (1) GEP20125638B (hr)
HR (1) HRP20151241T1 (hr)
HU (1) HUE028183T2 (hr)
IL (1) IL207807A (hr)
MX (1) MX2010009384A (hr)
NZ (1) NZ587608A (hr)
PL (1) PL2249868T3 (hr)
PT (1) PT2249868E (hr)
RS (1) RS54442B1 (hr)
RU (1) RU2472513C2 (hr)
SI (1) SI2249868T1 (hr)
UA (1) UA97440C2 (hr)
WO (1) WO2009106302A1 (hr)
ZA (1) ZA201006085B (hr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150064423A (ko) * 2013-12-03 2015-06-11 경상대학교산학협력단 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물
KR101689681B1 (ko) * 2016-06-07 2016-12-26 경상대학교산학협력단 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물
WO2023055198A1 (ko) 2021-09-30 2023-04-06 한국한의학연구원 반하, 대추, 감초, 인삼, 건강, 황금 및 황련 혼합 추출물을 유효성분으로 포함하는, 알츠하이머 치료용 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519058A (en) * 1989-03-17 1996-05-21 Cedars-Sinai Medical Center Method for treatment with dimercaptosuccinic acid (DMSA) of hypertension, diabetic neuphropathy and atherosclerosis
CN1099224A (zh) * 1993-08-23 1995-03-01 庭野七郎 人参叶加工的食品及其制造方法
US6096778A (en) * 1997-10-07 2000-08-01 Cephalon, Inc. α-ketoamide multicatalytic protease inhibitors
US6797289B2 (en) * 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US20020025926A1 (en) * 2000-08-30 2002-02-28 Hebert Rolland F. Enantiomers of S-adenosyl-l-methionine
IT1317920B1 (it) 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
FR2822381B1 (fr) * 2001-03-20 2004-10-22 Bio Obtention Sc Extrait de cucumis melo enrobe et/ou microencapsule dans un agent liposoluble a base de matiere grasse
ITMI20012462A1 (it) * 2001-11-22 2003-05-22 Gnosis Srl Processo per la preparazione di compresse comprendenti s-adenosilmetionina
AU2003298514A1 (en) * 2002-05-17 2004-05-04 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
ATE477789T1 (de) * 2003-10-03 2010-09-15 Green Meadows Res Llc Zubereitungen die lotusextrakte und methyldonatoren enthalten
DK1731596T5 (da) 2005-06-09 2013-09-23 Gnosis Spa Tørrede, frysetørrede og/eller mikroindkapslede celler af Saccharomyces cerevisiae med et højt indhold af (S)-(+)-S-adenosyl-L-methionin

Also Published As

Publication number Publication date
MX2010009384A (es) 2010-12-21
US20110020301A1 (en) 2011-01-27
CN101965197A (zh) 2011-02-02
PL2249868T3 (pl) 2016-03-31
CN104189895A (zh) 2014-12-10
CA2716893C (en) 2014-05-20
PT2249868E (pt) 2015-11-03
KR20100126326A (ko) 2010-12-01
WO2009106302A1 (en) 2009-09-03
SI2249868T1 (sl) 2015-12-31
JP2011513257A (ja) 2011-04-28
GEP20125638B (en) 2012-09-10
CA2716893A1 (en) 2009-09-03
HUE028183T2 (en) 2016-12-28
RU2010135467A (ru) 2012-04-10
ZA201006085B (en) 2011-10-26
NZ587608A (en) 2012-07-27
US8778337B2 (en) 2014-07-15
AU2009218723A1 (en) 2009-09-03
BRPI0908024A2 (pt) 2018-11-06
DK2249868T3 (en) 2015-11-23
AU2009218723B2 (en) 2014-01-30
JP5362747B2 (ja) 2013-12-11
EP2249868A1 (en) 2010-11-17
RS54442B1 (en) 2016-06-30
IL207807A (en) 2015-08-31
IL207807A0 (en) 2010-12-30
KR101297763B1 (ko) 2013-08-20
EP2249868B1 (en) 2015-09-02
RU2472513C2 (ru) 2013-01-20
UA97440C2 (en) 2012-02-10
EP2095828A1 (en) 2009-09-02
CY1116782T1 (el) 2017-03-15
CN104189895B (zh) 2016-08-31
ES2550461T3 (es) 2015-11-10

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