HRP20151241T1 - Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti - Google Patents
Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti Download PDFInfo
- Publication number
- HRP20151241T1 HRP20151241T1 HRP20151241TT HRP20151241T HRP20151241T1 HR P20151241 T1 HRP20151241 T1 HR P20151241T1 HR P20151241T T HRP20151241T T HR P20151241TT HR P20151241 T HRP20151241 T HR P20151241T HR P20151241 T1 HRP20151241 T1 HR P20151241T1
- Authority
- HR
- Croatia
- Prior art keywords
- sam
- adenosylmethionine
- alzheimer
- disease
- treatment
- Prior art date
Links
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title claims 6
- 229960001570 ademetionine Drugs 0.000 title claims 6
- 102000019197 Superoxide Dismutase Human genes 0.000 title claims 4
- 108010012715 Superoxide dismutase Proteins 0.000 title claims 4
- 239000003814 drug Substances 0.000 title claims 4
- 208000024827 Alzheimer disease Diseases 0.000 title claims 3
- 229940079593 drug Drugs 0.000 claims 3
- XHJLCRULHISREH-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;sulfo hydrogen sulfate Chemical compound OS(=O)(=O)OS(O)(=O)=O.CC1=CC=C(S(O)(=O)=O)C=C1 XHJLCRULHISREH-UHFFFAOYSA-N 0.000 claims 2
- SQASAHFPWITLNX-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;sulfo hydrogen sulfate Chemical compound OS(=O)(=O)OS(O)(=O)=O.CC1=CC=C(S(O)(=O)=O)C=C1.CC1=CC=C(S(O)(=O)=O)C=C1 SQASAHFPWITLNX-UHFFFAOYSA-N 0.000 claims 1
- 102100021257 Beta-secretase 1 Human genes 0.000 claims 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- VERAMNDAEAQRGS-UHFFFAOYSA-N butane-1,4-disulfonic acid Chemical compound OS(=O)(=O)CCCCS(O)(=O)=O VERAMNDAEAQRGS-UHFFFAOYSA-N 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (5)
1. Upotreba S-adenozilmetionina (SAM) u kombinaciji sa supeoksid-dismutazom (SOD), naznačena time da je za pripravu lijekova za liječenje Alzheimerove bolesti.
2. Upotreba iz patentnog zahtjeva 1, naznačena time da lijek pokazuje prekomjernu eksperiju PS1 i BACE.
3. Upotreba iz patentnog zahtjeva 1, naznačena time da se lijekovi daju oralno.
4. Produkti, naznačeni time da kao jedine aktivne sastojke sadrže (i) S-adenozilmetionin i (ii) supeoksid-dismutazu u obliku kombiniranog pripravka za istovremeno, odvojeno ili uzastopno davanje u liječenju Alzheimerove bolesti.
5. Produkti kako su prijavljeni u patentnom zahtjevu 4, naznačeni time da se SAM uzima u obliku tosilata, butandisulfonata, disulfat-tosilata, disulfat-ditosilata ili disulfat-monotosilata, ili je sadržan u stanicama Saccharomyces cerevisiae obogaćenih sa SAM.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08425123A EP2095828A1 (en) | 2008-02-29 | 2008-02-29 | Use of S-adenosylmethionine (SAM) and superoxide dismutase (SOD) for the preparation of medicaments for the treatment of Alzeimer's disease |
| EP09714406.7A EP2249868B1 (en) | 2008-02-29 | 2009-02-25 | Use of s-adenosylmethionine (sam) and superoxide dismutase (sod) for the preparation of medicaments for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151241T1 true HRP20151241T1 (hr) | 2015-12-18 |
Family
ID=39529658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151241TT HRP20151241T1 (hr) | 2008-02-29 | 2015-11-18 | Upotreba s-adenozilmetionina (sam) i superoksid-dismutaze (sod) za pripravu lijekova za lijeäśenje alzheimerove bolesti |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8778337B2 (hr) |
| EP (2) | EP2095828A1 (hr) |
| JP (1) | JP5362747B2 (hr) |
| KR (1) | KR101297763B1 (hr) |
| CN (2) | CN101965197A (hr) |
| AU (1) | AU2009218723B2 (hr) |
| BR (1) | BRPI0908024A2 (hr) |
| CA (1) | CA2716893C (hr) |
| CY (1) | CY1116782T1 (hr) |
| DK (1) | DK2249868T3 (hr) |
| ES (1) | ES2550461T3 (hr) |
| GE (1) | GEP20125638B (hr) |
| HR (1) | HRP20151241T1 (hr) |
| HU (1) | HUE028183T2 (hr) |
| IL (1) | IL207807A (hr) |
| MX (1) | MX2010009384A (hr) |
| NZ (1) | NZ587608A (hr) |
| PL (1) | PL2249868T3 (hr) |
| PT (1) | PT2249868E (hr) |
| RS (1) | RS54442B1 (hr) |
| RU (1) | RU2472513C2 (hr) |
| SI (1) | SI2249868T1 (hr) |
| UA (1) | UA97440C2 (hr) |
| WO (1) | WO2009106302A1 (hr) |
| ZA (1) | ZA201006085B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150064423A (ko) * | 2013-12-03 | 2015-06-11 | 경상대학교산학협력단 | 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물 |
| KR101689681B1 (ko) * | 2016-06-07 | 2016-12-26 | 경상대학교산학협력단 | 오스모틴을 유효성분으로 함유하는 인지기능 개선용 조성물 |
| CN118103053A (zh) | 2021-09-30 | 2024-05-28 | 韩国韩医学研究院 | 包含半夏、大枣、甘草、人参、干姜、黄芩和黄连的混合提取物作为活性成分的用于治疗阿尔茨海默病的组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5519058A (en) * | 1989-03-17 | 1996-05-21 | Cedars-Sinai Medical Center | Method for treatment with dimercaptosuccinic acid (DMSA) of hypertension, diabetic neuphropathy and atherosclerosis |
| CN1099224A (zh) * | 1993-08-23 | 1995-03-01 | 庭野七郎 | 人参叶加工的食品及其制造方法 |
| US6096778A (en) * | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
| US6797289B2 (en) * | 1998-02-13 | 2004-09-28 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
| US20020025926A1 (en) * | 2000-08-30 | 2002-02-28 | Hebert Rolland F. | Enantiomers of S-adenosyl-l-methionine |
| IT1317920B1 (it) | 2000-10-20 | 2003-07-15 | Univ Roma | S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer. |
| US6759395B2 (en) * | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| FR2822381B1 (fr) * | 2001-03-20 | 2004-10-22 | Bio Obtention Sc | Extrait de cucumis melo enrobe et/ou microencapsule dans un agent liposoluble a base de matiere grasse |
| ITMI20012462A1 (it) * | 2001-11-22 | 2003-05-22 | Gnosis Srl | Processo per la preparazione di compresse comprendenti s-adenosilmetionina |
| AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| ATE477789T1 (de) * | 2003-10-03 | 2010-09-15 | Green Meadows Res Llc | Zubereitungen die lotusextrakte und methyldonatoren enthalten |
| ES2406412T3 (es) | 2005-06-09 | 2013-06-06 | Gnosis S.P.A. | Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina |
-
2008
- 2008-02-29 EP EP08425123A patent/EP2095828A1/en not_active Withdrawn
-
2009
- 2009-02-25 MX MX2010009384A patent/MX2010009384A/es active IP Right Grant
- 2009-02-25 NZ NZ587608A patent/NZ587608A/xx unknown
- 2009-02-25 JP JP2010548015A patent/JP5362747B2/ja not_active Expired - Fee Related
- 2009-02-25 ES ES09714406.7T patent/ES2550461T3/es active Active
- 2009-02-25 DK DK09714406.7T patent/DK2249868T3/en active
- 2009-02-25 WO PCT/EP2009/001323 patent/WO2009106302A1/en active Application Filing
- 2009-02-25 SI SI200931313T patent/SI2249868T1/sl unknown
- 2009-02-25 RU RU2010135467/15A patent/RU2472513C2/ru active
- 2009-02-25 UA UAA201010400A patent/UA97440C2/ru unknown
- 2009-02-25 CA CA2716893A patent/CA2716893C/en active Active
- 2009-02-25 BR BRPI0908024A patent/BRPI0908024A2/pt not_active Application Discontinuation
- 2009-02-25 EP EP09714406.7A patent/EP2249868B1/en active Active
- 2009-02-25 PT PT97144067T patent/PT2249868E/pt unknown
- 2009-02-25 CN CN2009801064845A patent/CN101965197A/zh active Pending
- 2009-02-25 KR KR1020107018940A patent/KR101297763B1/ko active IP Right Grant
- 2009-02-25 US US12/919,515 patent/US8778337B2/en active Active
- 2009-02-25 AU AU2009218723A patent/AU2009218723B2/en active Active
- 2009-02-25 HU HUE09714406A patent/HUE028183T2/en unknown
- 2009-02-25 GE GEAP200911930A patent/GEP20125638B/en unknown
- 2009-02-25 CN CN201410384204.XA patent/CN104189895B/zh active Active
- 2009-02-25 RS RS20150717A patent/RS54442B1/en unknown
- 2009-02-25 PL PL09714406T patent/PL2249868T3/pl unknown
-
2010
- 2010-08-26 IL IL207807A patent/IL207807A/en active IP Right Grant
- 2010-08-26 ZA ZA2010/06085A patent/ZA201006085B/en unknown
-
2015
- 2015-10-12 CY CY20151100917T patent/CY1116782T1/el unknown
- 2015-11-18 HR HRP20151241TT patent/HRP20151241T1/hr unknown
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