JP5346820B2 - Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体 - Google Patents

Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体 Download PDF

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Publication number
JP5346820B2
JP5346820B2 JP2009553239A JP2009553239A JP5346820B2 JP 5346820 B2 JP5346820 B2 JP 5346820B2 JP 2009553239 A JP2009553239 A JP 2009553239A JP 2009553239 A JP2009553239 A JP 2009553239A JP 5346820 B2 JP5346820 B2 JP 5346820B2
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antibody
seq
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antibodies
antigen
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JP2010521147A5 (Direct
JP2010521147A (ja
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アントニオ・ランツァヴェッキア
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Humabs LLC
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Humabs LLC
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    • C07K16/108—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2009553239A 2007-03-13 2008-03-13 Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体 Expired - Fee Related JP5346820B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89461207P 2007-03-13 2007-03-13
US60/894,612 2007-03-13
PCT/IB2008/001527 WO2008110937A2 (en) 2007-03-13 2008-03-13 Antibodies against h5n1 strains of influenza a virus

Publications (3)

Publication Number Publication Date
JP2010521147A JP2010521147A (ja) 2010-06-24
JP2010521147A5 JP2010521147A5 (Direct) 2011-05-06
JP5346820B2 true JP5346820B2 (ja) 2013-11-20

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JP2009553239A Expired - Fee Related JP5346820B2 (ja) 2007-03-13 2008-03-13 Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体

Country Status (5)

Country Link
US (2) US8124092B2 (Direct)
EP (1) EP2125886A2 (Direct)
JP (1) JP5346820B2 (Direct)
CN (1) CN102046654A (Direct)
WO (1) WO2008110937A2 (Direct)

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ES2662519T3 (es) 2008-07-25 2018-04-06 Institute For Research In Biomedicine Anticuerpos neutralizantes contra el virus de la gripe A y usos de estos
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
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EP2350128B1 (en) 2008-10-22 2014-10-01 Institute for Research in Biomedicine Methods for producing antibodies from plasma cells
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WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
CA2807664A1 (en) * 2010-08-12 2012-02-16 Theraclone Sciences, Inc. Anti-hemagglutinin antibody compositions and methods of use thereof
CN102775469B (zh) * 2011-05-12 2018-02-09 厦门大学 甲型流感病毒核衣壳蛋白的抗原表位及其用途
US9587010B2 (en) 2011-07-18 2017-03-07 The Institute For Research In Biomedicine Neutralizing anti-influenza A virus antibodies and uses thereof
JP2013087069A (ja) * 2011-10-17 2013-05-13 Toyobo Co Ltd Ｈ５亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体
CN104302321A (zh) 2011-12-05 2015-01-21 特瑞利斯生物科学有限责任公司 可用于被动流感免疫的抗体
WO2013105896A1 (en) * 2012-01-12 2013-07-18 Temasek Life Sciences Laboratory Limited Monoclonal antibodies targeting neutralizing epitopes on h5 influenza virus of clade 2.3
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
CA2890669A1 (en) 2012-11-13 2014-05-22 Genetech, Inc. Anti-hemagglutinin antibodies and methods of use
CN105209071A (zh) * 2013-03-14 2015-12-30 抗非特公司 用于提高疗效的基于鼻内递送中和抗体的组合物和方法
EP3733244A1 (en) 2013-10-02 2020-11-04 Medlmmune, LLC Neutralizing anti-influenza a antibodies and uses thereof
US10639370B2 (en) 2014-02-04 2020-05-05 Contrafect Corporation Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
CN106795216B (zh) 2014-02-04 2021-04-20 抗非特公司 可用于被动流感免疫的抗体及其组合物、组合和使用方法
JP6614523B2 (ja) * 2014-03-28 2019-12-04 地方独立行政法人神奈川県立産業技術総合研究所 インフルエンザウイルスのｒｎａ依存性ｒｎａポリメラーゼのｐｂ２サブユニットに対するモノクローナル抗体
KR101628331B1 (ko) * 2014-03-28 2016-06-08 주식회사 녹십자엠에스 인플루엔자 a 바이러스 특이적 단클론 항체 및 이를 이용한 인플루엔자 감염 치료 및 진단 방법
CN113173990B (zh) 2014-07-15 2024-10-29 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
WO2016200543A2 (en) 2015-05-13 2016-12-15 The Trustees Of The University Of Pennsylvania Aav-mediated expression of anti-inluenza antibodies and methods of use thereof
ES2894777T3 (es) 2015-06-01 2022-02-15 Medimmune Llc Neutralización de moléculas de unión anti-influenza y usos de las mismas
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
KR20250130692A (ko) 2016-01-13 2025-09-02 메디뮨 엘엘씨 인플루엔자 a의 치료 방법
US20170240617A1 (en) 2016-02-24 2017-08-24 Visterra, Inc. Formulations of antibody molecules to influenza virus
PL238020B1 (pl) * 2016-09-12 2021-06-28 Inst Biotechnologii I Antybiotykow Kompozycja przeciwciał monoklonalnych przeciwko hemaglutyninie wirusów grypy serotypu H5 i jej zastosowanie, hybrydomy produkujące rzeczone przeciwciała, sposób diagnozowania infekcji wirusami grypy serotypu H5 oraz zestawy diagnostyczne
CA3052487A1 (en) 2017-02-28 2018-09-07 The Trustees Of The University Of Pennsylvania Influenza vaccines based on aav vectors
SG10201912973XA (en) 2017-02-28 2020-03-30 Univ Pennsylvania Adeno-associated virus (aav) clade f vector and uses therefor
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
AU2018275359C1 (en) 2017-06-02 2022-02-03 Pfizer Inc. Antibodies specific for FLT3 and their uses
CA3132521A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2021142413A1 (en) * 2020-01-12 2021-07-15 Vanderbilt University Human antibodies to crimean congo hemorrhagic fever virus
WO2021202815A1 (en) * 2020-03-31 2021-10-07 Northeastern University Colorimetric and multiplexed isothermal rna-and antibody-based assay for sars-cov-2 and other viral diagnostics and cell analysis
CN114181302B (zh) * 2020-09-14 2023-03-24 东莞市朋志生物科技有限公司 针对甲型流感病毒的抗体、试剂盒和载体
US12319747B2 (en) * 2023-07-03 2025-06-03 Medicovestor, Inc. Methods of using anti-SP17 immunotherapeutics
US12364777B2 (en) 2023-10-20 2025-07-22 Medicovestor, Inc. Homodimeric antibodies for use in treating cancers and methods of use
US12116410B1 (en) 2023-12-26 2024-10-15 Medicovestor, Inc. Methods of manufacturing dimeric antibodies

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CA2637837A1 (en) * 2006-01-26 2007-08-09 Hx Diagnostics, Inc. Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof
CN103435697A (zh) * 2006-05-15 2013-12-11 航道生物技术有限责任公司 流感病毒的中和抗体
CA2663388C (en) * 2006-09-07 2017-01-17 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
CN101541832B (zh) * 2006-09-07 2014-11-12 克鲁塞尔荷兰公司 能中和流感病毒h5n1的人结合分子及其应用
US20100150941A1 (en) 2006-09-13 2010-06-17 Dso National Laboratories Hemagglutinin antibody and uses thereof
BRPI0707728A2 (pt) 2006-09-15 2011-05-10 Fraunhofer Usa, Inc. anticorpos de gripe, composiÇço compreendendo os mesmos e seus usos em diagnàsticos e anÁlises clÍnicas
CN102046654A (zh) * 2007-03-13 2011-05-04 胡马斯有限公司 针对甲型流感病毒h5n1株系的抗体

Also Published As

Publication number Publication date
WO2008110937A2 (en) 2008-09-18
WO2008110937A3 (en) 2009-04-30
JP2010521147A (ja) 2010-06-24
EP2125886A2 (en) 2009-12-02
US20100278834A1 (en) 2010-11-04
CN102046654A (zh) 2011-05-04
US20120114664A1 (en) 2012-05-10
US8124092B2 (en) 2012-02-28

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