JP5345136B2 - 微細加工分離チャネルに試料及びキャリア液を分配する装置 - Google Patents

微細加工分離チャネルに試料及びキャリア液を分配する装置 Download PDF

Info

Publication number
JP5345136B2
JP5345136B2 JP2010508864A JP2010508864A JP5345136B2 JP 5345136 B2 JP5345136 B2 JP 5345136B2 JP 2010508864 A JP2010508864 A JP 2010508864A JP 2010508864 A JP2010508864 A JP 2010508864A JP 5345136 B2 JP5345136 B2 JP 5345136B2
Authority
JP
Japan
Prior art keywords
flow distribution
pillar
chromatographic separation
distribution region
microfabricated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010508864A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010528276A (ja
JP2010528276A5 (https=
Inventor
デスメト，ゲルト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vrije Universiteit Brussel VUB
Original Assignee
Vrije Universiteit Brussel VUB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vrije Universiteit Brussel VUB filed Critical Vrije Universiteit Brussel VUB
Publication of JP2010528276A publication Critical patent/JP2010528276A/ja
Publication of JP2010528276A5 publication Critical patent/JP2010528276A5/ja
Application granted granted Critical
Publication of JP5345136B2 publication Critical patent/JP5345136B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2010508864A 2007-05-23 2008-05-23 微細加工分離チャネルに試料及びキャリア液を分配する装置 Active JP5345136B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2007/055008 2007-05-23
EP2007055008 2007-05-23
PCT/EP2008/056369 WO2008142160A1 (en) 2007-05-23 2008-05-23 Device for the distribution of sample and carrier liquid across a micro-fabricated separation channel

Publications (3)

Publication Number Publication Date
JP2010528276A JP2010528276A (ja) 2010-08-19
JP2010528276A5 JP2010528276A5 (https=) 2012-06-21
JP5345136B2 true JP5345136B2 (ja) 2013-11-20

Family

ID=39745221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010508864A Active JP5345136B2 (ja) 2007-05-23 2008-05-23 微細加工分離チャネルに試料及びキャリア液を分配する装置

Country Status (5)

Country Link
US (1) US8652420B2 (https=)
JP (1) JP5345136B2 (https=)
CN (1) CN101688854A (https=)
DK (1) DK2150809T3 (https=)
WO (1) WO2008142160A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009043057A2 (en) 2007-09-27 2009-04-02 Massachusetts Institute Of Technology Cell rolling separation
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
WO2011159232A1 (en) * 2010-06-15 2011-12-22 Ge Healthcare Bio-Sciences Ab Fluid distributor unit
US20140138312A1 (en) * 2011-06-09 2014-05-22 Waters Technologies Corporation Reducing Dispersion Due To Vias In Planar Microfluidic Separation Devices
KR101911435B1 (ko) * 2011-09-26 2018-10-25 삼성전자주식회사 유체 제어 장치, 이를 포함하는 필터 및 바이오칩
US20140227777A1 (en) * 2011-09-30 2014-08-14 Brigham And Women's Hospital Cell sorting by 3d flow and adhesive rolling
JP6075735B2 (ja) * 2011-09-30 2017-02-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 配列された微小構造を用いて流体流れをプログラムするデバイスおよび方法
KR101911436B1 (ko) * 2011-12-13 2018-10-25 삼성전자주식회사 높은 종횡비를 갖는 세포 포획용 필터
EP2618149B1 (en) 2012-01-20 2016-07-27 Ortho-Clinical Diagnostics, Inc. Assay device having uniform flow around corners
US9103468B2 (en) * 2012-07-30 2015-08-11 University Of South Carolina Enhanced flow boiling in microchannels by high frequency microbubble-excited and -modulated oscillations
BE1022314B1 (nl) * 2013-02-05 2016-03-15 PharmaFluidics N.V. Chemische reactor inrichting
EP3396355A1 (en) * 2017-04-27 2018-10-31 Pharmafluidics NV Lateral detection of fluid properties
BE1027013B1 (nl) * 2019-01-31 2020-09-01 Pharmafluidics N V Filter voor chemische reactoren
BE1028976B1 (nl) * 2020-12-30 2022-08-01 Pharmafluidics N V Pilaarstructuren
CN112816608B (zh) * 2021-01-22 2025-05-13 中国科学院上海微系统与信息技术研究所 微色谱柱及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US6156273A (en) * 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
EP1044047A4 (en) * 1997-11-14 2008-04-16 Biotage Inc LIQUID CHROMATOGRAPHY COLUMN
EP0977030B1 (en) * 1998-07-29 2001-03-21 Hewlett-Packard Company Chip for performing an electrophoretic separation of molecules and method using same
EP1154828A1 (en) * 1999-02-25 2001-11-21 Pall Corporation Chromatography devices and flow distributor arrangements used in chromatography devices
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
US20060065528A1 (en) 2004-02-03 2006-03-30 Gabriel Lopez Nanostructured devices for separation and analysis
SE528233C2 (sv) 2005-06-20 2006-09-26 Aamic Ab Metod och medel för att åstadkomma vätsketransport
US8288151B2 (en) * 2005-06-29 2012-10-16 Canon Kabushiki Kaisha Biochemical reaction cassette
JP4878200B2 (ja) * 2005-06-29 2012-02-15 キヤノン株式会社 生化学反応カセット

Also Published As

Publication number Publication date
CN101688854A (zh) 2010-03-31
US8652420B2 (en) 2014-02-18
WO2008142160A1 (en) 2008-11-27
JP2010528276A (ja) 2010-08-19
US20100166611A1 (en) 2010-07-01
DK2150809T3 (da) 2019-08-05

Similar Documents

Publication Publication Date Title
JP5345136B2 (ja) 微細加工分離チャネルに試料及びキャリア液を分配する装置
JP2010528276A5 (https=)
CN105102113B (zh) 化学反应器装置
ES2817998T3 (es) Método para fusionar o poner en contacto gotitas de reactor y de reactivo en un dispositivo microfluídico o milifluídico
JP2003503184A (ja) 少量の液体試料の形成および輸送の空気制御
US20160084806A1 (en) Micro-Machined Frit and Flow Distribution Devices for Liquid Chromatography
CN113791016B (zh) 乳状液生成及微观渗流监测一体化实验装置、监测方法
JP2020169911A (ja) 液滴アレイ測定に関する装置及び方法
JP2021511203A (ja) メソスケールおよび／またはナノスケールの凝縮装置および方法
JP2016165704A (ja) マイクロ流路チップ及びマイクロ流路装置
KR100838129B1 (ko) 미세 유체 소자 및 이를 구비한 진단 및 분석 장치
EP2150809B1 (en) Device for the distribution of sample and carrier liquid across a micro-fabricated separation channel
JP5304980B2 (ja) 流体輸送のためのマイクロリアクター
CN213669345U (zh) 一种微滴快速生成芯片
JP2005147840A (ja) マイクロフローデバイス用プラスチック基板
US20210101149A1 (en) Open Microfluidic System And Various Functional Arrangements Therefore
JP6192007B2 (ja) マイクロデバイス及びバイオアッセイシステム
AU2005313184B2 (en) Device for fluid transport
KR20160093467A (ko) 파티클 분리 장치
Fujii et al. Volume controlled high throughput picoliter droplet generation system using cascade multi-stage separation channel
CN121263687A (zh) 化学反应器中的空隙跨度减小结构

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110426

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110426

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120423

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20121114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130206

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130724

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130813

R150 Certificate of patent or registration of utility model

Ref document number: 5345136

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250