JP5315048B2 - 新規チオトロピウム塩の製造方法、新規チオトロピウム塩及びその医薬組成物 - Google Patents

新規チオトロピウム塩の製造方法、新規チオトロピウム塩及びその医薬組成物 Download PDF

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Publication number
JP5315048B2
JP5315048B2 JP2008516267A JP2008516267A JP5315048B2 JP 5315048 B2 JP5315048 B2 JP 5315048B2 JP 2008516267 A JP2008516267 A JP 2008516267A JP 2008516267 A JP2008516267 A JP 2008516267A JP 5315048 B2 JP5315048 B2 JP 5315048B2
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amino
optionally substituted
tiotropium
alkyl
phenyl
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JP2008543805A5 (enExample
JP2008543805A (ja
Inventor
ミハエラ ポップ
ウデイエル ステファニー ムルデル
ペーター シーゲル
ミハエル ペー ピーペル
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
JP2008516267A 2005-06-15 2006-05-30 新規チオトロピウム塩の製造方法、新規チオトロピウム塩及びその医薬組成物 Active JP5315048B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05105270 2005-06-15
EP05105270.2 2005-06-15
PCT/EP2006/062688 WO2006134021A2 (en) 2005-06-15 2006-05-30 Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Publications (3)

Publication Number Publication Date
JP2008543805A JP2008543805A (ja) 2008-12-04
JP2008543805A5 JP2008543805A5 (enExample) 2009-07-16
JP5315048B2 true JP5315048B2 (ja) 2013-10-16

Family

ID=35057150

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008516267A Active JP5315048B2 (ja) 2005-06-15 2006-05-30 新規チオトロピウム塩の製造方法、新規チオトロピウム塩及びその医薬組成物

Country Status (16)

Country Link
US (2) US20060287530A1 (enExample)
EP (1) EP1896026B1 (enExample)
JP (1) JP5315048B2 (enExample)
KR (1) KR20080024532A (enExample)
CN (1) CN101227905A (enExample)
AR (1) AR057067A1 (enExample)
AU (1) AU2006259202B2 (enExample)
BR (1) BRPI0611763A2 (enExample)
CA (1) CA2611902C (enExample)
IL (1) IL188069A0 (enExample)
MX (1) MX2007015997A (enExample)
NZ (2) NZ564697A (enExample)
RU (2) RU2418796C2 (enExample)
TW (1) TW200718698A (enExample)
WO (1) WO2006134021A2 (enExample)
ZA (1) ZA200709331B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336126A1 (de) * 2003-11-03 2011-06-22 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend
JP5165245B2 (ja) * 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なチオトロピウム塩、その製造方法及びチオトロピウム塩を含有する医薬組成物
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
WO2008101728A1 (de) * 2007-02-23 2008-08-28 K.H.S. Pharma Holding Gmbh Verfahren zur herstellung von azoniaspironortropinestern und von nortropan-3-on verbindungen
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2009031011A2 (en) * 2007-09-05 2009-03-12 Pfizer Limited Xinafoate salt of n4-(2, 2-difluoro-4h-benz0 [1,4] 0xazin-3-one) -6-yl] -5-fluoro-n2- [3- (methylaminocar bonylmethyleneoxy) phenyl] 2, 4-pyrimidinediamine
PL388070A1 (pl) * 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością Nowe sole tiotropium
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium

Family Cites Families (28)

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US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US3808263A (en) * 1970-05-12 1974-04-30 Tanabe Seiyaku Co 6,6-dimethyl-9-alkyl-9-azabicyclo(3.3.1)nonan-3-ols
US3673195A (en) * 1970-05-25 1972-06-27 Tanabe Seiyaku Co Derivatives of 6,6,9-tri-lower alkyl-9-azabicyclo(3.3.1) nonan-3{60 -or 3{62 -ol
US4353922A (en) * 1981-03-13 1982-10-12 Syntex (U.S.A.) Inc. Anticholinergic bronchodilators
DE3546218A1 (de) * 1985-12-27 1987-07-02 Madaus & Co Dr Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE19528145A1 (de) * 1995-08-01 1997-02-06 Boehringer Ingelheim Kg Neue Arzneimittel und ihre Verwendung
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
AU1499602A (en) * 2000-10-12 2002-04-22 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
IL149984A0 (en) * 2000-10-12 2002-12-01 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
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DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
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US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
WO2004064789A2 (en) * 2003-01-16 2004-08-05 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases
JP5165245B2 (ja) * 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なチオトロピウム塩、その製造方法及びチオトロピウム塩を含有する医薬組成物
EP2336126A1 (de) * 2003-11-03 2011-06-22 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen

Also Published As

Publication number Publication date
MX2007015997A (es) 2008-03-07
AU2006259202A1 (en) 2006-12-21
NZ583872A (en) 2011-10-28
TW200718698A (en) 2007-05-16
RU2010138174A (ru) 2012-03-20
CA2611902C (en) 2013-08-27
AU2006259202B2 (en) 2012-05-10
KR20080024532A (ko) 2008-03-18
WO2006134021A2 (en) 2006-12-21
RU2418796C2 (ru) 2011-05-20
WO2006134021A3 (en) 2007-04-19
US20140316138A1 (en) 2014-10-23
EP1896026A2 (en) 2008-03-12
NZ564697A (en) 2010-04-30
US20060287530A1 (en) 2006-12-21
JP2008543805A (ja) 2008-12-04
ZA200709331B (en) 2008-10-29
EP1896026B1 (en) 2013-10-09
IL188069A0 (en) 2008-03-20
AR057067A1 (es) 2007-11-14
RU2007148256A (ru) 2009-07-20
CN101227905A (zh) 2008-07-23
BRPI0611763A2 (pt) 2010-09-28
CA2611902A1 (en) 2006-12-21

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