JP5301990B2 - 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 - Google Patents
細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 Download PDFInfo
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/187,863 | 2005-07-25 | ||
| US11/187,863 US7531327B2 (en) | 2004-07-23 | 2005-07-25 | Methods and compositions for increasing longevity and protein yield from a cell culture |
| PCT/US2006/027820 WO2007015848A2 (en) | 2005-07-25 | 2006-07-14 | Improved methods and compositions for increasing longevity and protein yield from a cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Division JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502167A JP2009502167A (ja) | 2009-01-29 |
| JP2009502167A5 JP2009502167A5 (OSRAM) | 2009-08-27 |
| JP5301990B2 true JP5301990B2 (ja) | 2013-09-25 |
Family
ID=37709058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523951A Active JP5301990B2 (ja) | 2005-07-25 | 2006-07-14 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7531327B2 (OSRAM) |
| EP (1) | EP1910515B1 (OSRAM) |
| JP (2) | JP5301990B2 (OSRAM) |
| KR (2) | KR101518062B1 (OSRAM) |
| CN (1) | CN101273121B (OSRAM) |
| AU (1) | AU2006276182B2 (OSRAM) |
| CA (1) | CA2616799C (OSRAM) |
| WO (1) | WO2007015848A2 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| KR101802393B1 (ko) * | 2008-06-10 | 2017-11-28 | 상가모 테라퓨틱스, 인코포레이티드 | Bax- 및 bak-결함 세포주들의 제조 방법 및 조성물 |
| WO2009152413A1 (en) * | 2008-06-13 | 2009-12-17 | Centocor Ortho Biotech Inc. | Methods for obtaining high viable cell density in mammalian cell culture |
| DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| CN102369276B (zh) | 2009-02-20 | 2015-02-04 | 文特里亚生物科学公司 | 含有蛋白质组合的细胞培养基 |
| CN101899471B (zh) * | 2009-05-26 | 2014-06-11 | 中国医学科学院基础医学研究所 | 同时表达抗原特异性受体和外源基因的重组逆转录病毒载体、用其修饰的b-淋巴细胞及其用途 |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| WO2011068845A1 (en) | 2009-12-02 | 2011-06-09 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| US20120028933A1 (en) | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| JP5665065B2 (ja) | 2011-04-28 | 2015-02-04 | 国立大学法人大阪大学 | リソソーム病治療用医薬組成物 |
| WO2012151199A1 (en) | 2011-05-02 | 2012-11-08 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| CN103031277B (zh) * | 2011-09-29 | 2015-07-15 | 重庆大学 | 力生长因子在制备无血清培养耐受型哺乳动物工程细胞中的应用 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| WO2014127200A1 (en) * | 2013-02-15 | 2014-08-21 | Immunomedics, Inc. | Chimeric and humanized anti-histone antibodies |
| JP6683598B2 (ja) | 2013-03-15 | 2020-04-22 | マックスサイト インコーポレーティッド | 安定なトランスフェクトされた細胞を生成するための方法および組成物 |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| PL3055409T3 (pl) * | 2013-10-11 | 2018-10-31 | Regeneron Pharmaceuticals, Inc. | Metabolicznie zoptymalizowana hodowla komórkowa |
| ES2978993T3 (es) | 2014-02-21 | 2024-09-23 | Ibc Pharmaceuticals Inc | Terapia de enfermedades mediante la inducción de la respuesta inmunitaria a las células que expresan Trop-2 |
| CN106029098A (zh) | 2014-02-25 | 2016-10-12 | 免疫医疗公司 | 人源化rfb4抗cd22抗体 |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| CA2961774C (en) | 2014-10-07 | 2023-05-23 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| ES2926467T3 (es) | 2015-04-13 | 2022-10-26 | Maxcyte Inc | Métodos y composiciones para la modificación del ADN genómico |
| AU2016252771B2 (en) | 2015-04-22 | 2021-12-16 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells |
| EP3316885B1 (en) | 2015-07-01 | 2021-06-23 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| US10745663B2 (en) * | 2015-07-17 | 2020-08-18 | Ares Trading S.A. | Methods for modulating production profiles of recombinant proteins |
| TWI784063B (zh) * | 2017-12-27 | 2022-11-21 | 財團法人生物技術開發中心 | 具有增進蛋白質表現功效的宿主細胞及其用途 |
| SG11202013191TA (en) * | 2018-07-13 | 2021-01-28 | Lonza Ag | Methods for improving production of biological products by reducing the level of endogenous protein |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| JPWO2022239720A1 (OSRAM) | 2021-05-10 | 2022-11-17 | ||
| EP4455274A4 (en) * | 2021-11-26 | 2025-12-31 | Iucf Hyu | ESTABLISHMENT OF AN ERIETHROID PRECURSOR CELL LINE CAPABLE OF CONDITIONAL MATURATION USING GENE OVEREXPRESSION |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0471484A (ja) * | 1990-07-11 | 1992-03-06 | Teijin Ltd | 低凝集性細胞及びその培養方法 |
| US5550019A (en) | 1993-05-26 | 1996-08-27 | La Jolla Cancer Research Foundation | Methods of identifying compounds which alter apoptosis |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| ATE474052T1 (de) * | 1999-09-27 | 2010-07-15 | Genentech Inc | Verfahren zur herstellung von rekombinanten proteinen mittels inhibitoren von apoptose |
| AU2001294520A1 (en) | 2000-08-21 | 2002-03-04 | Clonex Development, Inc. | Methods and compositions for increasing protein yield from a cell culture |
| AU2002315534B2 (en) | 2001-07-10 | 2008-05-22 | Biogen Idec Inc. | Inhibition of apoptosis process and improvement of cell performance |
| WO2003040374A1 (en) | 2001-11-02 | 2003-05-15 | Centocor, Inc. | METHODS AND COMPOSITIONS FOR ENHANCED PROTEIN EXPRESSION AND/OR GROWTH OF CULTURED CELLS USING CO-TRANSCRIPTION OF A Bcl2 ENCODING NUCLEIC ACID |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| CA2470026A1 (en) * | 2001-12-14 | 2003-06-26 | Centocor, Inc. | Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media |
| EP1348758A1 (en) | 2002-03-28 | 2003-10-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Host cells having improved cell survival properties and methods to generate such cells |
| US20030219871A1 (en) | 2002-03-28 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Host cells having improved cell survival properties and methods to generate such cells |
| JP2006503555A (ja) * | 2002-06-26 | 2006-02-02 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | タンパク質産生方法および使用するための改変細胞 |
| JPWO2005035740A1 (ja) * | 2003-10-09 | 2006-12-21 | 協和醗酵工業株式会社 | 無血清馴化したゲノム改変細胞 |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| CN1287862C (zh) * | 2004-09-29 | 2006-12-06 | 中国人民解放军第四军医大学 | MG7-Ag模拟表位构建胃癌特异性多表位基因疫苗的方法 |
| US20070092947A1 (en) | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
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2005
- 2005-07-25 US US11/187,863 patent/US7531327B2/en active Active
-
2006
- 2006-07-14 JP JP2008523951A patent/JP5301990B2/ja active Active
- 2006-07-14 KR KR1020087002132A patent/KR101518062B1/ko active Active
- 2006-07-14 CA CA2616799A patent/CA2616799C/en active Active
- 2006-07-14 EP EP06787690.4A patent/EP1910515B1/en active Active
- 2006-07-14 AU AU2006276182A patent/AU2006276182B2/en active Active
- 2006-07-14 WO PCT/US2006/027820 patent/WO2007015848A2/en not_active Ceased
- 2006-07-14 KR KR1020137004422A patent/KR20130027579A/ko not_active Ceased
- 2006-07-14 CN CN2006800352269A patent/CN101273121B/zh active Active
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2013
- 2013-04-12 JP JP2013084178A patent/JP2013172722A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20060110793A1 (en) | 2006-05-25 |
| AU2006276182B2 (en) | 2012-02-16 |
| WO2007015848A3 (en) | 2007-10-04 |
| CA2616799A1 (en) | 2007-02-08 |
| US7531327B2 (en) | 2009-05-12 |
| WO2007015848A9 (en) | 2007-04-05 |
| EP1910515A2 (en) | 2008-04-16 |
| AU2006276182A1 (en) | 2007-02-08 |
| JP2013172722A (ja) | 2013-09-05 |
| WO2007015848B1 (en) | 2007-11-15 |
| CA2616799C (en) | 2015-11-24 |
| JP2009502167A (ja) | 2009-01-29 |
| KR20130027579A (ko) | 2013-03-15 |
| EP1910515B1 (en) | 2019-02-27 |
| EP1910515A4 (en) | 2009-03-11 |
| CN101273121B (zh) | 2012-07-04 |
| KR20080073282A (ko) | 2008-08-08 |
| WO2007015848A2 (en) | 2007-02-08 |
| CN101273121A (zh) | 2008-09-24 |
| KR101518062B1 (ko) | 2015-05-28 |
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