CN101273121B - 用于增加细胞培养物的寿命和蛋白收率的改良方法和组合物 - Google Patents

用于增加细胞培养物的寿命和蛋白收率的改良方法和组合物 Download PDF

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CN101273121B
CN101273121B CN2006800352269A CN200680035226A CN101273121B CN 101273121 B CN101273121 B CN 101273121B CN 2006800352269 A CN2006800352269 A CN 2006800352269A CN 200680035226 A CN200680035226 A CN 200680035226A CN 101273121 B CN101273121 B CN 101273121B
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CN101273121A (zh
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D·M·戈登伯格
Z·屈
C·H·张
E·A·罗西
J·-D·杨
黛安·诺德斯特龙
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Immunomedics Inc
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CN2006800352269A 2005-07-25 2006-07-14 用于增加细胞培养物的寿命和蛋白收率的改良方法和组合物 Active CN101273121B (zh)

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US11/187,863 2005-07-25
US11/187,863 US7531327B2 (en) 2004-07-23 2005-07-25 Methods and compositions for increasing longevity and protein yield from a cell culture
PCT/US2006/027820 WO2007015848A2 (en) 2005-07-25 2006-07-14 Improved methods and compositions for increasing longevity and protein yield from a cell culture

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CN101273121B true CN101273121B (zh) 2012-07-04

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US (1) US7531327B2 (OSRAM)
EP (1) EP1910515B1 (OSRAM)
JP (2) JP5301990B2 (OSRAM)
KR (2) KR20130027579A (OSRAM)
CN (1) CN101273121B (OSRAM)
AU (1) AU2006276182B2 (OSRAM)
CA (1) CA2616799C (OSRAM)
WO (1) WO2007015848A2 (OSRAM)

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US7531327B2 (en) 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US20070092947A1 (en) * 2005-10-20 2007-04-26 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
EP2294191B1 (en) * 2008-06-10 2016-09-28 Sangamo BioSciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
EP2331678B1 (en) * 2008-06-13 2015-09-30 Janssen Biotech, Inc. Methods for obtaining high viable cell density in mammalian cell culture
DE102008051574A1 (de) * 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
US20160095939A1 (en) 2014-10-07 2016-04-07 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
US20120315697A1 (en) 2009-02-20 2012-12-13 Ventria Bioscience Cell Culture Media Containing Combinations of Proteins
CN101899471B (zh) * 2009-05-26 2014-06-11 中国医学科学院基础医学研究所 同时表达抗原特异性受体和外源基因的重组逆转录病毒载体、用其修饰的b-淋巴细胞及其用途
CN102482701B (zh) 2009-09-16 2015-05-13 免疫医疗公司 I类抗-cea抗体及其使用
CA2782194C (en) 2009-12-02 2018-01-16 Immunomedics, Inc. Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer
US20120028933A1 (en) 2010-07-28 2012-02-02 Baust John M Cell Culture Media Supplement and Method of Molecular Stress Control
US9138465B2 (en) 2011-04-28 2015-09-22 Osaka University Pharmaceutical composition for treating lysosomal storage disease
JP6024025B2 (ja) 2011-05-02 2016-11-09 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． 少容量投与用のアロタイプ選択抗体の限外濾過濃縮
CN103031277B (zh) * 2011-09-29 2015-07-15 重庆大学 力生长因子在制备无血清培养耐受型哺乳动物工程细胞中的应用
WO2014028560A2 (en) 2012-08-14 2014-02-20 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
WO2014127200A1 (en) * 2013-02-15 2014-08-21 Immunomedics, Inc. Chimeric and humanized anti-histone antibodies
CN105378071B (zh) 2013-03-15 2021-04-20 美克斯细胞有限公司 用于产生稳定转染细胞的方法和组合物
MX376623B (es) * 2013-10-11 2025-03-07 Regeneron Pharma Cultivo celular metabolicamente optimizado.
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
EP3107577B1 (en) 2014-02-21 2024-03-20 IBC Pharmaceuticals, Inc. Disease therapy by inducing immune response to trop-2 expressing cells
EP3110445A4 (en) 2014-02-25 2017-09-27 Immunomedics, Inc. Humanized rfb4 anti-cd22 antibody
EP3160504B1 (en) 2014-06-24 2020-09-16 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
ES2926467T3 (es) 2015-04-13 2022-10-26 Maxcyte Inc Métodos y composiciones para la modificación del ADN genómico
EP3286224A4 (en) 2015-04-22 2018-11-14 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
EP3316885B1 (en) 2015-07-01 2021-06-23 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
US10745663B2 (en) * 2015-07-17 2020-08-18 Ares Trading S.A. Methods for modulating production profiles of recombinant proteins
TWI784063B (zh) * 2017-12-27 2022-11-21 財團法人生物技術開發中心 具有增進蛋白質表現功效的宿主細胞及其用途
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EP1910515B1 (en) 2019-02-27
CA2616799A1 (en) 2007-02-08
EP1910515A4 (en) 2009-03-11
JP2013172722A (ja) 2013-09-05
WO2007015848A3 (en) 2007-10-04
AU2006276182A1 (en) 2007-02-08
KR101518062B1 (ko) 2015-05-28
EP1910515A2 (en) 2008-04-16
WO2007015848B1 (en) 2007-11-15
KR20130027579A (ko) 2013-03-15
KR20080073282A (ko) 2008-08-08
CN101273121A (zh) 2008-09-24
JP5301990B2 (ja) 2013-09-25
CA2616799C (en) 2015-11-24
JP2009502167A (ja) 2009-01-29
WO2007015848A9 (en) 2007-04-05
WO2007015848A2 (en) 2007-02-08
US20060110793A1 (en) 2006-05-25
US7531327B2 (en) 2009-05-12
AU2006276182B2 (en) 2012-02-16

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