JP5290085B2 - 赤血球を白血球減少させる装置 - Google Patents
赤血球を白血球減少させる装置 Download PDFInfo
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Description
本出願は2001年12月10日に出願された(本文と一致しない程度に全体的に参照することによりここに組み入れられる)米国特許出願第60/339653の優先権を請求するものである。
血漿交換方法の始動する種々の他の作動は好ましくは中でも以上に挙げた特許に記載のように行われる。しかしながら、一般に、ここでは図7、図8および図9の概略図を特定的に参照して、並びに図1ないし図5を連続参照して、或る基本特徴を説明する。濾過およびRBC採取は、使用した添加剤溶液組立体および特定の処理器を除いて、図11、図12および図13の変更実施例の場合とほぼ同じである。
前記装置2を利用してドナー4に対する血漿交換手順を行うための1つの好適なプロトコルを以下に要約する。初めに、オペレータが使い捨てプラスチック組立体8を血液成分分離装置6に装填する。このプロトコルに従って、オペレータは種々のバッグ{例えば、採取バッグ954(使用されるなら、94);図7参照、以下に更に説明する}を血液成分分離装置6の夫々のフック(例えば、図7のフック996を参照)に吊るす。1つのバッグを使用する場合、オペレータは次いでカセット組立体110を装置6における遠心ロータ組立体568に設けられている場合のチャンネルハウジング204内の装置6および/または血液処理容器352に装填する。
Claims (19)
- 血液を少なくとも1つの高いヘマトクリット値の赤血球成分に分離して前記高いヘマトクリット値の赤血球成分を採取し且つ白血球減少するための血漿交換装置用の使い捨てアッセンブリであって、
ドナー/患者から血液を取出すための血液取出しアッセンブリと、
この血液取出しアッセンブリからの血液を受入れて収容する血液処理容器と、
この血液処理容器を有し、血液処理容器に収容された血液を高いヘマトクリット値の赤血球を含む血液成分に分離するための分離装置と、
前記血液取出しアッセンブリを前記血液処理容器に連結し、前記血液取出しアッセンブリからの血液を前記血液処理容器に圧送して送るループと、
前記血液処理容器に連結された赤血球採取アッセンブリとを具備しており、この赤血球採取アッセンブリは、
前記血液処理容器からの高いヘマトクリット値の赤血球を受入れて、白血球を分離して前記赤血球を出口側から排出するよう血液処理容器に入口側が連結された第1の白血球減少フィルタと、
前記第1の白血球減少フィルタの出口側に連結された赤血球採取容器とを備えており、
前記血液処理容器への前記圧送による血液の受入れ圧力によって、前記赤血球は、前記血液処理容器から前記第1の白血球減少フィルタを通って前記赤血球採取容器へと流されて、赤血球採取容器に採取するように構成されている使い捨てアッセンブリ。 - 前記赤血球採取アッセンブリは、更に前記第1の白血球減少フィルタへの高いヘマトクリット値の赤血球の流しが完了した後に、溶液を前記第1の白血球減少フィルタを通るように流し、前記高いヘマトクリット値の赤血球との混合のために前記溶液を前記赤血球採取容器に採取するようになっている請求項1に記載の使い捨てアッセンブリ。
- 前記溶液は、保存溶液である請求項2に記載の使い捨てアッセンブリ。
- 前記溶液は、塩水である請求項2に記載の使い捨てアッセンブリ。
- 前記溶液は、前記第1の白血球減少フィルタへの前記高いヘマトクリット値の赤血球を流している間、前記第1の白血球減少フィルタを通って流れ、それにより前記溶液を前記高いヘマトクリット値の赤血球と混合し、前記溶液および前記高いヘマトクリット値の赤血球を前記赤血球採取容器に採取する請求項2ないし4のいずれか1に記載の使い捨てアッセンブリ。
- 保存溶液容器と、
前記保存溶液容器と前記赤血球採取容器との間に連結されている第1配管路と、
保存溶液を前記第1配管路を通して前記赤血球採取容器に送るために前記第1配管路を開放するための、前記第1配管路に設けられたクランプとを更に備えている請求項1ないし5のいずれか1に記載の使い捨てアッセンブリ。 - 保存溶液容器と、
前記赤血球採取容器に連結されていて、前記保存溶液容器に選択的に連結可能である第1配管路と、
保存溶液を通すように前記第1配管路を前記保存溶液容器に連結するための、前記第1配管路に設けられたスパイクコネクタとを更に備えている請求項1ないし5のいずれか1に記載の使い捨てアッセンブリ。 - 保存溶液容器と、
前記赤血球採取容器に連結されていて、前記保存溶液容器に選択的に連結可能である第1配管路を更に備えており、
前記第1配管路には、前記第1配管路を、保存溶液を圧送するようになっているポンプと関連させるためのポンプループが形成されている請求項1ないし5のいずれか1に記載の使い捨てアッセンブリ。 - 前記赤血球採取容器に連結されて前記赤血球採取容器から空気を受入れるための空気除去バッグを更に備えている請求項1ないし5のいずれか1に記載の使い捨てアッセンブリ。
- 前記赤血球採取容器は、第1赤血球採取容器であり、前記赤血球採取アッセンブリは、前記第1の白血球減少フィルタに連結され且つ前記第1の白血球減少フィルタの後に配置されている第2赤血球採取容器を更に備えており、前記使い捨てアッセンブリは、更に、高いヘマトクリット値の赤血球を前記分離装置から前記第1の白血球減少フィルタに通し、且つこれを通して前記第1および第2赤血球採取容器に同時に通すようになっている請求項1ないし9のいずれか1に記載の使い捨てアッセンブリ。
- 前記赤血球採取容器は、第1赤血球採取容器であり、前記赤血球採取アッセンブリは、前記第1の白血球減少フィルタに連結され且つ前記第1の白血球減少フィルタの後に配置されている第2赤血球採取容器を更に備えており、前記使い捨てアッセンブリは、更に、高いヘマトクリット値の赤血球を前記分離装置から前記第1の白血球減少フィルタに通し、且つこれを通してまず前記第1および第2赤血球採取容器のうちの一方に、次いで前記第1および第2赤血球採取容器のうちの他方に通すようになっている請求項1ないし9のいずれか1に記載の使い捨てアッセンブリ。
- 前記赤血球採取容器は、第1赤血球採取容器であり、前記赤血球採取アッセンブリは、第2赤血球採取容器および第2の白血球減少フィルタを備えており、前記第2の白血球減少フィルタは、前記第2赤血球採取容器と連通して配置されており、前記使い捨てアッセンブリは、更に、高いヘマトクリット値の赤血球を前記分離装置から前記第1および第2の白血球減少フィルタに同時に通し、かくして前記第1および第2赤血球採取容器に同時に通すようになっている請求項1ないし9のいずれか1に記載の使い捨てアッセンブリ。
- 前記赤血球採取容器は、第1赤血球採取容器であり、前記赤血球採取アッセンブリは、第2赤血球採取容器および第2の白血球減少フィルタを備えており、前記第2の白血球減少フィルタは、前記第2赤血球採取容器と連通して配置されており、前記使い捨てアッセンブリは、更に、高いヘマトクリット値の赤血球を前記分離装置から前記第1の白血球減少フィルタに通してまず前記第1赤血球採取容器に、次いで前記第2の白血球減少フィルタに通して前記第2赤血球採取容器に入れるようになっている請求項1ないし9のいずれか1に記載の使い捨てアッセンブリ。
- 血小板を採取するように、前記血液処理容器に連結されて、前記分離装置により、前記血液から分離された血小板を受入れるための血小板採取バッグを備えている請求項1ないし13のいずれか1に記載の使い捨てアッセンブリ。
- 前記分離装置により血液処理容器内の血液から血漿を採取するように、前記血液処理容器に連結される血漿採取バッグを備えている請求項1ないし14のいずれか1に記載の使い捨てアッセンブリ。
- 前記血液取出しアッセンブリと、前記血液処理容器と、前記赤血球採取アッセンブリとの間でそれらに連結されているカセットを備えたカセットアッセンブリを備えており、前記カセットアッセンブリは血液および血液成分を通すための一体の流体通路を備えている請求項15に記載の使い捨てアッセンブリ。
- 前記カセットアッセンブリおよび前記血液処理容器に連結されている流入管路を更に具備し、
前記カセットアッセンブリは更に、
流入ポンプと協働するようになっている流入配管ループと、
前記流入配管ループおよび前記流入管路に連結されている流体通路とを備えており、それにより受入れられた血液は前記流入ポンプの圧送作用下で前記流入配管ループ、前記流体通路および流入管路を通って流れて分離された赤血球を血液処理容器から前記白血球減少フィルタを通って流れるようになっている請求項16に記載の使い捨てアッセンブリ。
- 前記カセットに設けられ、保存溶液を前記白血球減少フィルタを通して圧送するためのポンプと協働するようになっている配管ループを更に備えている請求項17に記載の使い捨てアッセンブリ。
- 保存溶液を前記白血球減少フィルタを通して圧送するためのポンプと協働するようになっている溶液配管ループを更に備えている請求項1に記載の使い捨てアッセンブリ。
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- 2002-12-10 JP JP2003550836A patent/JP4837893B2/ja not_active Expired - Lifetime
- 2002-12-10 EP EP10003389.3A patent/EP2208502B1/en not_active Expired - Lifetime
- 2002-12-10 AU AU2002364550A patent/AU2002364550A1/en not_active Abandoned
- 2002-12-10 EP EP02799928A patent/EP1455860B1/en not_active Expired - Lifetime
- 2002-12-10 WO PCT/US2002/039590 patent/WO2003049787A1/en active Application Filing
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Also Published As
Publication number | Publication date |
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US20070282242A1 (en) | 2007-12-06 |
JP2005512623A (ja) | 2005-05-12 |
US7052606B2 (en) | 2006-05-30 |
AU2002364550A1 (en) | 2003-06-23 |
EP2208502B1 (en) | 2019-05-08 |
US7682329B2 (en) | 2010-03-23 |
JP2009268917A (ja) | 2009-11-19 |
US20060184086A1 (en) | 2006-08-17 |
EP2208502A1 (en) | 2010-07-21 |
EP1455860A1 (en) | 2004-09-15 |
WO2003049787A1 (en) | 2003-06-19 |
JP4837893B2 (ja) | 2011-12-14 |
ATE522237T1 (de) | 2011-09-15 |
US20030106861A1 (en) | 2003-06-12 |
US7789847B2 (en) | 2010-09-07 |
EP1455860B1 (en) | 2011-08-31 |
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