JP5289951B2 - 同位体置換されたパントプラゾール - Google Patents

同位体置換されたパントプラゾール Download PDF

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Publication number
JP5289951B2
JP5289951B2 JP2008523355A JP2008523355A JP5289951B2 JP 5289951 B2 JP5289951 B2 JP 5289951B2 JP 2008523355 A JP2008523355 A JP 2008523355A JP 2008523355 A JP2008523355 A JP 2008523355A JP 5289951 B2 JP5289951 B2 JP 5289951B2
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JP
Japan
Prior art keywords
compound
methoxy
difluoromethoxy
formula
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008523355A
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English (en)
Japanese (ja)
Other versions
JP2009502872A (ja
Inventor
コール ベルンハルト
ミュラー ベルント
ハーグ ディーター
ジーモン ヴォルフガング−アレクサンダー
ツェッヒ カール
ダーヴィド ミヒャエル
フォン リヒター オリヴァー
フート フェリクス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Takeda GmbH
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Filing date
Publication date
Application filed by Takeda GmbH filed Critical Takeda GmbH
Publication of JP2009502872A publication Critical patent/JP2009502872A/ja
Application granted granted Critical
Publication of JP5289951B2 publication Critical patent/JP5289951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2008523355A 2005-07-26 2006-07-26 同位体置換されたパントプラゾール Expired - Fee Related JP5289951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106874.0 2005-07-26
EP05106874 2005-07-26
PCT/EP2006/064669 WO2007012651A1 (fr) 2005-07-26 2006-07-26 Pantoprazole substitue d'un point de vue isotopique

Publications (2)

Publication Number Publication Date
JP2009502872A JP2009502872A (ja) 2009-01-29
JP5289951B2 true JP5289951B2 (ja) 2013-09-11

Family

ID=35708921

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008523355A Expired - Fee Related JP5289951B2 (ja) 2005-07-26 2006-07-26 同位体置換されたパントプラゾール

Country Status (8)

Country Link
EP (1) EP1912947A1 (fr)
JP (1) JP5289951B2 (fr)
CN (1) CN101268050B (fr)
AR (1) AR054583A1 (fr)
AU (1) AU2006274037B2 (fr)
CA (1) CA2615678C (fr)
TW (1) TWI410409B (fr)
WO (1) WO2007012651A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101358509B1 (ko) * 2005-07-26 2014-02-05 다케다 게엠베하 동위 원소 치환된 양성자 펌프 억제제
US7598273B2 (en) 2005-10-06 2009-10-06 Auspex Pharmaceuticals, Inc Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
EP2099299A4 (fr) * 2006-10-23 2011-11-30 Concert Pharmaceuticals Inc Dérivés d'oxazolidinone et leurs procédés d'utilisation
EP2139877B1 (fr) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux
EP2152709B1 (fr) * 2007-05-01 2012-02-22 Concert Pharmaceuticals Inc. Composés de morphinane
ES2577477T3 (es) 2007-05-01 2016-07-15 Concert Pharmaceuticals Inc. Compuestos morfinanos
AU2008266124A1 (en) * 2007-06-13 2008-12-24 Auspex Pharmaceuticals, Inc. Substituted piperazines
US7855204B2 (en) * 2008-01-22 2010-12-21 Concert Pharmaceuticals Inc. Derivatives of gefitinib
JP5770997B2 (ja) * 2009-12-09 2015-08-26 大塚製薬株式会社 Ｃｙｐ３ａ４の代謝機能測定方法
CN103349655B (zh) * 2013-07-22 2015-04-29 南通广泰生化制品有限公司 枸橼酸他莫昔芬肠溶胶囊
MX2017002750A (es) * 2014-09-02 2017-08-02 Singh Bhupinder Metodo para marcar una molecula deuterada o no deuterada y formulaciones farmaceuticas para tratamiento.
GB2560750A (en) * 2017-03-24 2018-09-26 Taher Darreh Shori Biological methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
WO1995026325A2 (fr) * 1994-03-25 1995-10-05 Isotechnika Inc. Potentialisation de medicaments par deuteration_______________
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE10123129A1 (de) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10162121A1 (de) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
KR101358509B1 (ko) * 2005-07-26 2014-02-05 다케다 게엠베하 동위 원소 치환된 양성자 펌프 억제제

Also Published As

Publication number Publication date
TW200745039A (en) 2007-12-16
EP1912947A1 (fr) 2008-04-23
CA2615678A1 (fr) 2007-02-01
AR054583A1 (es) 2007-06-27
CA2615678C (fr) 2015-01-20
AU2006274037A1 (en) 2007-02-01
TWI410409B (zh) 2013-10-01
JP2009502872A (ja) 2009-01-29
AU2006274037B2 (en) 2012-04-26
WO2007012651A1 (fr) 2007-02-01
CN101268050B (zh) 2012-11-28
CN101268050A (zh) 2008-09-17

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