CA2615678C - Pantoprazole substitue d'un point de vue isotopique - Google Patents

Pantoprazole substitue d'un point de vue isotopique Download PDF

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Publication number
CA2615678C
CA2615678C CA2615678A CA2615678A CA2615678C CA 2615678 C CA2615678 C CA 2615678C CA 2615678 A CA2615678 A CA 2615678A CA 2615678 A CA2615678 A CA 2615678A CA 2615678 C CA2615678 C CA 2615678C
Authority
CA
Canada
Prior art keywords
compound
methoxy
difluoromethoxy
compounds
trideuteriomethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2615678A
Other languages
English (en)
Other versions
CA2615678A1 (fr
Inventor
Bernhard Kohl
Bernd Mueller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Oliver Von Richter
Felix Huth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Takeda GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda GmbH filed Critical Takeda GmbH
Publication of CA2615678A1 publication Critical patent/CA2615678A1/fr
Application granted granted Critical
Publication of CA2615678C publication Critical patent/CA2615678C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA2615678A 2005-07-26 2006-07-26 Pantoprazole substitue d'un point de vue isotopique Expired - Fee Related CA2615678C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106874.0 2005-07-26
EP05106874 2005-07-26
PCT/EP2006/064669 WO2007012651A1 (fr) 2005-07-26 2006-07-26 Pantoprazole substitue d'un point de vue isotopique

Publications (2)

Publication Number Publication Date
CA2615678A1 CA2615678A1 (fr) 2007-02-01
CA2615678C true CA2615678C (fr) 2015-01-20

Family

ID=35708921

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2615678A Expired - Fee Related CA2615678C (fr) 2005-07-26 2006-07-26 Pantoprazole substitue d'un point de vue isotopique

Country Status (8)

Country Link
EP (1) EP1912947A1 (fr)
JP (1) JP5289951B2 (fr)
CN (1) CN101268050B (fr)
AR (1) AR054583A1 (fr)
AU (1) AU2006274037B2 (fr)
CA (1) CA2615678C (fr)
TW (1) TWI410409B (fr)
WO (1) WO2007012651A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102134232B (zh) * 2005-07-26 2012-11-21 奈科明有限责任公司 同位素取代的质子泵抑制剂
WO2007041630A1 (fr) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Inhibiteurs deutériés d'atpase h+,k+ gastrique ayant des propriétés thérapeutiques renforcées
WO2008127300A2 (fr) * 2006-10-23 2008-10-23 Concert Pharmaceuticals Inc. Dérivés d'oxazolidinone et leurs procédés d'utilisation
EP2139877B1 (fr) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux
MX370608B (es) * 2007-05-01 2019-12-18 Concert Pharmaceuticals Inc Compuestos de morfinano.
EP2357183B1 (fr) 2007-05-01 2015-07-01 Concert Pharmaceuticals Inc. Composés de morphinan
EP2155697B1 (fr) * 2007-06-13 2012-11-28 Auspex Pharmaceuticals, Inc. Pipérazines substituées
EP2242493B1 (fr) * 2008-01-22 2013-06-05 Concert Pharmaceuticals Inc. Dérivés de géfitinib
JP5770997B2 (ja) * 2009-12-09 2015-08-26 大塚製薬株式会社 Ｃｙｐ３ａ４の代謝機能測定方法
CN103349655B (zh) * 2013-07-22 2015-04-29 南通广泰生化制品有限公司 枸橼酸他莫昔芬肠溶胶囊
JP2017527614A (ja) * 2014-09-02 2017-09-21 ブピンダー シン 重水素化又は非重水素化分子及び医薬製剤
GB2560750A (en) * 2017-03-24 2018-09-26 Taher Darreh Shori Biological methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
WO1995026325A2 (fr) * 1994-03-25 1995-10-05 Isotechnika Inc. Potentialisation de medicaments par deuteration_______________
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE10123129A1 (de) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10162121A1 (de) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
CN102134232B (zh) * 2005-07-26 2012-11-21 奈科明有限责任公司 同位素取代的质子泵抑制剂

Also Published As

Publication number Publication date
WO2007012651A1 (fr) 2007-02-01
CN101268050B (zh) 2012-11-28
TW200745039A (en) 2007-12-16
AU2006274037A1 (en) 2007-02-01
AR054583A1 (es) 2007-06-27
JP5289951B2 (ja) 2013-09-11
CN101268050A (zh) 2008-09-17
JP2009502872A (ja) 2009-01-29
TWI410409B (zh) 2013-10-01
CA2615678A1 (fr) 2007-02-01
EP1912947A1 (fr) 2008-04-23
AU2006274037B2 (en) 2012-04-26

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Effective date: 20160726