JP5289331B2 - ４−アミノ−ピリミジンの合成 - Google Patents

４−アミノ−ピリミジンの合成 Download PDF

Info

Publication number
JP5289331B2
JP5289331B2 JP2009545869A JP2009545869A JP5289331B2 JP 5289331 B2 JP5289331 B2 JP 5289331B2 JP 2009545869 A JP2009545869 A JP 2009545869A JP 2009545869 A JP2009545869 A JP 2009545869A JP 5289331 B2 JP5289331 B2 JP 5289331B2
Authority
JP
Japan
Prior art keywords
solvent
mixture
acetamidine
salt
formyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009545869A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010516644A (ja
JP2010516644A5 (enExample
Inventor
ヴェルナー ボンラス，
ラルフ ハーター，
レインハード カージ，
ウラ レチノワ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of JP2010516644A publication Critical patent/JP2010516644A/ja
Publication of JP2010516644A5 publication Critical patent/JP2010516644A5/ja
Application granted granted Critical
Publication of JP5289331B2 publication Critical patent/JP5289331B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009545869A 2007-01-19 2008-01-17 ４−アミノ−ピリミジンの合成 Active JP5289331B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07001136.6 2007-01-19
EP20070001136 EP1972620A1 (en) 2007-01-19 2007-01-19 Synthesis of 4-amino-pyrimidines
PCT/EP2008/000320 WO2008087021A1 (en) 2007-01-19 2008-01-17 Synthesis of 4-amino-pyrimidines

Publications (3)

Publication Number Publication Date
JP2010516644A JP2010516644A (ja) 2010-05-20
JP2010516644A5 JP2010516644A5 (enExample) 2013-05-23
JP5289331B2 true JP5289331B2 (ja) 2013-09-11

Family

ID=38224299

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009545869A Active JP5289331B2 (ja) 2007-01-19 2008-01-17 ４−アミノ−ピリミジンの合成

Country Status (6)

Country Link
US (1) US8198443B2 (enExample)
EP (2) EP1972620A1 (enExample)
JP (1) JP5289331B2 (enExample)
KR (1) KR101428123B1 (enExample)
CN (1) CN101583604B (enExample)
WO (1) WO2008087021A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103420918B (zh) * 2013-07-22 2015-04-22 新发药业有限公司 维生素b1关键中间体2-甲基-4-氨基-5-氨基甲基嘧啶的简便制备方法
CN103435556B (zh) * 2013-08-26 2014-11-26 新发药业有限公司 维生素b1中间体2-甲基-4-氨基-5-氨基甲基嘧啶的合成方法
CN107602482A (zh) * 2017-09-05 2018-01-19 常州大学 一种2‑甲基‑4‑氨基‑5‑(甲酰氨甲基)嘧啶水解工艺
CN107602481A (zh) * 2017-09-05 2018-01-19 常州大学 一种2‑甲基‑4‑氨基‑5‑(甲酰氨甲基)嘧啶水解工艺
CN113252829B (zh) * 2021-05-07 2023-09-22 镇江高等职业技术学校 一种灌溉水中盐酸乙脒的测定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789815A (fr) * 1970-03-27 1973-04-06 Stauffer Chemical Co Vinylphosphonates copolycondenses et leur utilisation comme agents retardant l'inflammation
JPS5518702B2 (enExample) * 1972-05-12 1980-05-21
DE3431270A1 (de) * 1984-08-25 1986-03-06 Basf Ag, 6700 Ludwigshafen Alpha-(o-chlorphenyl)-aminomethylen-beta-formylaminopropionitril, verfahren zu seiner herstellung sowie verwendung zur herstellung von 2-methyl-4-amino-5-formylaminomethylpyrimidin
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
US4942085A (en) * 1989-01-23 1990-07-17 American Cyanamid Company Method of manufacturing a sag-resistant bonded particulate article
US5140047A (en) * 1991-05-03 1992-08-18 Smithkline Beecham Corporation Lipoxygenase inhibitors

Also Published As

Publication number Publication date
EP1972620A1 (en) 2008-09-24
WO2008087021A1 (en) 2008-07-24
US20100016591A1 (en) 2010-01-21
CN101583604B (zh) 2013-03-06
CN101583604A (zh) 2009-11-18
KR20090101254A (ko) 2009-09-24
JP2010516644A (ja) 2010-05-20
EP2102172A1 (en) 2009-09-23
EP2102172B1 (en) 2015-08-12
KR101428123B1 (ko) 2014-08-07
US8198443B2 (en) 2012-06-12

Similar Documents

Publication Publication Date Title
KR101821090B1 (ko) Ｎ-아실비페닐 알라닌의 제조 방법
JP5289331B2 (ja) ４−アミノ−ピリミジンの合成
US20090137803A1 (en) 5-protected aminopyrimidine compound, production method thereof and intermediate therefor
JP5618306B2 (ja) 置換４−アミノ−ピリミジンの新規合成
WO2003051849A1 (en) Process for producing quinazolin-4-one and derivative thereof
JP4356111B2 (ja) Ｎ−（２−アミノ−１，２−ジシアノビニル）ホルムアミジンの製造方法
EP1927590B1 (en) Method for producing 1-substituted-5-acylimidazole compound
US6620932B2 (en) 2-alkoxy-5-methoxypyrimidines or their tautomeric forms and methods for producing the same
US20070078272A1 (en) Processes for preparing tetrahydropyran-4-one and pyran-4-one
EP1577304A1 (en) Production method of aminopyrimidine compound
JP4512100B2 (ja) 置換ベンゾピラン化合物の製造方法
WO2012081036A2 (en) A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
Suyama et al. Regioselective preparation of N-substituted 3, 5-diamino-1, 2, 4-oxadiazoles
JP3103447B2 (ja) Ｎ−（２−クロロピリジン−５−イル−メチル）−エチレンジアミン
JP4178793B2 (ja) キナゾリン−４−オン誘導体の製造法
KR101132590B1 (ko) Ｎ-(2-아미노-1,2-디시아노비닐)이미데이트류의 제조 방법
JP4923698B2 (ja) ４−アミノテトラヒドロピラン化合物の製法
PL209729B1 (pl) Sposób wytwarzania chlorowodorku 2-[(2,3,4-trihydroksyfenylo)metylo]hydrazydu D,L-seryny
JPS6322567A (ja) 新規ピリミジン化合物および該化合物を用いる２−低級アルキル−４−アミノ−５−アミノメチルピリミジンの製造法
WO2003064377A1 (en) 4,5-substituted-2-formylaminobenzamides and processes for their production and conversion
WO2006098705A1 (en) Process for producing biphenyl-tetrazole compounds
WO2000034288A1 (en) Process for removal of cyanide from reactions producing 1,3 diones
EP2001869A1 (en) Process for producing biphenyl-tetrazole compounds
JP2005255597A (ja) ３，３，３−トリアルコキシプロピオン酸アルキルの製造方法
JP2002302484A (ja) 新規イミダゾール誘導体及びその製造方法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130115

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20130411

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130507

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130604

R150 Certificate of patent or registration of utility model

Ref document number: 5289331

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250