CN101583604B - 4-氨基嘧啶的合成方法 - Google Patents

4-氨基嘧啶的合成方法 Download PDF

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Publication number
CN101583604B
CN101583604B CN2008800026343A CN200880002634A CN101583604B CN 101583604 B CN101583604 B CN 101583604B CN 2008800026343 A CN2008800026343 A CN 2008800026343A CN 200880002634 A CN200880002634 A CN 200880002634A CN 101583604 B CN101583604 B CN 101583604B
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China
Prior art keywords
salt
mixture
formyl radical
solvent
formamido group
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Chinese (zh)
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CN101583604A (zh
Inventor
维尔纳·邦拉蒂
拉尔法·哈尔特
里恩哈德·卡治
尤拉·莱提诺伊斯
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DSM IP Assets BV
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008800026343A 2007-01-19 2008-01-17 4-氨基嘧啶的合成方法 Active CN101583604B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07001136.6 2007-01-19
EP20070001136 EP1972620A1 (en) 2007-01-19 2007-01-19 Synthesis of 4-amino-pyrimidines
PCT/EP2008/000320 WO2008087021A1 (en) 2007-01-19 2008-01-17 Synthesis of 4-amino-pyrimidines

Publications (2)

Publication Number Publication Date
CN101583604A CN101583604A (zh) 2009-11-18
CN101583604B true CN101583604B (zh) 2013-03-06

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ID=38224299

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CN2008800026343A Active CN101583604B (zh) 2007-01-19 2008-01-17 4-氨基嘧啶的合成方法

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US (1) US8198443B2 (enExample)
EP (2) EP1972620A1 (enExample)
JP (1) JP5289331B2 (enExample)
KR (1) KR101428123B1 (enExample)
CN (1) CN101583604B (enExample)
WO (1) WO2008087021A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103420918B (zh) * 2013-07-22 2015-04-22 新发药业有限公司 维生素b1关键中间体2-甲基-4-氨基-5-氨基甲基嘧啶的简便制备方法
CN103435556B (zh) * 2013-08-26 2014-11-26 新发药业有限公司 维生素b1中间体2-甲基-4-氨基-5-氨基甲基嘧啶的合成方法
CN107602482A (zh) * 2017-09-05 2018-01-19 常州大学 一种2‑甲基‑4‑氨基‑5‑(甲酰氨甲基)嘧啶水解工艺
CN107602481A (zh) * 2017-09-05 2018-01-19 常州大学 一种2‑甲基‑4‑氨基‑5‑(甲酰氨甲基)嘧啶水解工艺
CN113252829B (zh) * 2021-05-07 2023-09-22 镇江高等职业技术学校 一种灌溉水中盐酸乙脒的测定方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172515A1 (de) * 1984-08-25 1986-02-26 BASF Aktiengesellschaft Alpha-(o-chlorphenyl)-aminomethylen-beta-formylaminopropionitril, Verfahren zu seiner Herstellung sowie Verwendung zur Herstellung von 2-Methyl-4-amino-5-formylaminomethylpyrimidin
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789815A (fr) * 1970-03-27 1973-04-06 Stauffer Chemical Co Vinylphosphonates copolycondenses et leur utilisation comme agents retardant l'inflammation
JPS5518702B2 (enExample) * 1972-05-12 1980-05-21
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
US4942085A (en) * 1989-01-23 1990-07-17 American Cyanamid Company Method of manufacturing a sag-resistant bonded particulate article
US5140047A (en) * 1991-05-03 1992-08-18 Smithkline Beecham Corporation Lipoxygenase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172515A1 (de) * 1984-08-25 1986-02-26 BASF Aktiengesellschaft Alpha-(o-chlorphenyl)-aminomethylen-beta-formylaminopropionitril, Verfahren zu seiner Herstellung sowie Verwendung zur Herstellung von 2-Methyl-4-amino-5-formylaminomethylpyrimidin
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
姬明理等.2-甲基-4-氨基-5-甲酰胺甲基嘧啶的合成.《应用化工》.2005,第34卷(第8期),513-514. *

Also Published As

Publication number Publication date
EP1972620A1 (en) 2008-09-24
WO2008087021A1 (en) 2008-07-24
US20100016591A1 (en) 2010-01-21
CN101583604A (zh) 2009-11-18
KR20090101254A (ko) 2009-09-24
JP2010516644A (ja) 2010-05-20
EP2102172A1 (en) 2009-09-23
EP2102172B1 (en) 2015-08-12
KR101428123B1 (ko) 2014-08-07
JP5289331B2 (ja) 2013-09-11
US8198443B2 (en) 2012-06-12

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