JP5278854B2 - 画像処理システムおよびプログラム - Google Patents
画像処理システムおよびプログラム Download PDFInfo
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- JP5278854B2 JP5278854B2 JP2008309073A JP2008309073A JP5278854B2 JP 5278854 B2 JP5278854 B2 JP 5278854B2 JP 2008309073 A JP2008309073 A JP 2008309073A JP 2008309073 A JP2008309073 A JP 2008309073A JP 5278854 B2 JP5278854 B2 JP 5278854B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
- A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
- A61B1/000094—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope extracting biological structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/044—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for absorption imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Signal Processing (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Endoscopes (AREA)
- Image Processing (AREA)
- Image Analysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Description
20 検体
100 内視鏡
102 先端部
105 制御部
110 撮像部
112 レンズ
114 受光部
120 ライトガイド
124 出射口
130 鉗子口
135 鉗子
138 ノズル
140 画像処理部
150 光照射部
160 撮像制御部
170 発光制御部
180 出力部
190 ICG注入部
210 オブジェクト画像取得部
212 光画像取得部
214 表面画像取得部
216 オブジェクト領域特定部
220 オブジェクト画像補正部
222 補正テーブル
230 深さ算出部
232 深さ情報格納部
250 物質量算出部
252 物質量記憶部
254 物質量更新部
260 表示制御部
410、420、610、620 血管画像
600 画像
820 分光フィルタ部
830 受光側励起光カットフィルタ部
851 第1受光素子
852 第2受光素子
853 第3受光素子
930、910、920 線
1010 発光部
1020 光源側フィルタ部
1110 励起光カットフィルタ部
1120 照射光カットフィルタ部
1110 励起光カットフィルタ部
1020 光源側フィルタ部
1220、1230 被写体画像
1222、1224、1226、1232、1234 血管画像
1321、1321、1322、1323 画像
1330 表面画像
1352 オブジェクト
1421、1422、1423 画像
1430 表面画像
1451 オブジェクト
1505 CPU
1510 ROM
1520 RAM
1530 通信インターフェイス
1540 ハードディスクドライブ
1550 フレキシブルディスク・ドライブ
1560 CD−ROMドライブ
1570 入出力チップ
1575 グラフィック・コントローラ
1580 表示デバイス
1582 ホスト・コントローラ
1584 入出力コントローラ
1590 フレキシブルディスク
1595 CD−ROM
Claims (16)
- 物体の内部に存在するオブジェクトからの複数の波長領域の光を受光する受光部と、
前記受光部が受光した複数の波長領域毎の光の量に基づいて、前記物体における波長による光の吸収率の相違を利用して、前記物体の表面から前記オブジェクトまでの深さを算出する深さ算出部と、
前記受光部が受光した光の量および前記深さ算出部が算出した前記オブジェクトまでの深さに基づいて、前記受光部が受光する光を発する、前記オブジェクト内の物質の量を算出する物質量算出部と
を備え、
前記受光部は、前記オブジェクトと略同一の量の前記物質を含む他のオブジェクトからの光を受光し、
前記深さ算出部は、前記受光部が受光した前記他のオブジェクトからの光の量および前記物質量算出部が算出した前記物質の量に基づいて、前記表面から前記他のオブジェクトまでの深さを算出し、
前記オブジェクトは血管であり、前記物質は前記血管内の血中成分であり、前記物質の量は前記血管内の血中成分の濃度である
画像処理システム。 - 前記受光部は、前記他のオブジェクトからの複数の波長領域の光を受光し、
前記深さ算出部は、前記受光部が受光した前記他のオブジェクトからの複数の波長領域毎の光の量および前記物質量算出部が算出した前記物質の量に基づいて、前記他のオブジェクトまでの深さを算出する
請求項1に記載の画像処理システム。 - 前記物質量算出部は、前記深さ算出部が算出した前記オブジェクトまでの深さが予め定められた値より小さい場合に、前記受光部が受光した前記オブジェクトからの光の量および前記深さ算出部が算出した前記オブジェクトまでの深さに基づいて、前記オブジェクト内の物質の量を算出する
請求項2に記載の画像処理システム。 - 前記深さ算出部は、前記受光部が受光した、前記表面から前記オブジェクトより深い位置に存在する前記他のオブジェクトからの複数の波長領域毎の光の量および前記物質量算出部が算出した物質の量に基づいて、前記他のオブジェクトまでの深さを算出する
請求項2または3に記載の画像処理システム。 - 前記受光部は、前記オブジェクトの内部に存在するルミネッセンス物質が発する光を含む前記オブジェクトからの光を受光し、
前記物質量算出部は、前記受光部が受光した前記ルミネッセンス物質が発する光の量および前記深さ算出部が算出した前記オブジェクトまでの深さに基づいて、前記オブジェクトの内部に存在する前記ルミネッセンス物質の量を算出する
請求項1から4のいずれか一項に記載の画像処理システム。 - 前記受光部は、前記表面から前記オブジェクトより深い位置に存在する前記他のオブジェクトの内部に存在するルミネッセンス物質が発する光を含む複数の波長領域の光を受光し、
前記深さ算出部は、前記受光部が受光した前記他のオブジェクトからの複数の波長領域毎の光の量および前記物質量算出部が算出した前記ルミネッセンス物質の量に基づいて、前記他のオブジェクトまでの深さを算出する
請求項5に記載の画像処理システム。 - オブジェクトからの複数の波長領域毎の光の量およびオブジェクトの内部に存在するルミネッセンス物質の量に対応づけて、物体の表面からオブジェクトまでの深さを格納する深さ情報格納部
をさらに備え、
前記深さ算出部は、前記受光部が受光した前記他のオブジェクトからの複数の波長領域毎の光の量、前記物質量算出部が算出した前記ルミネッセンス物質の量、および前記深さ情報格納部が格納している深さに基づいて、前記他のオブジェクトまでの深さを算出する
請求項6に記載の画像処理システム。 - 前記受光部は、前記オブジェクトの中に注入されることによって前記オブジェクトの内部に存在している前記ルミネッセンス物質が発する光を含む複数の波長領域の光を受光し、
前記物質量算出部は、前記オブジェクトの中に注入されることによって前記オブジェクトの内部に存在しているルミネッセンス物質の量を算出する
請求項5から7のいずれか一項に記載の画像処理システム。 - 前記物質量算出部が算出した前記オブジェクトの内部の前記ルミネッセンス物質の量を記憶する物質量記憶部と、
前記物質量算出部が新たに算出した前記ルミネッセンス物質の量が、前記物質量記憶部が記憶している前記ルミネッセンス物質の量より予め定められた量以上変化したことを条件として、前記物質量記憶部が記憶している前記ルミネッセンス物質の量を、前記物質量算出部が新たに算出した前記ルミネッセンス物質の量で更新する物質量更新部と
をさらに備える請求項8に記載の画像処理システム。 - 前記表面を通じて撮像された前記他のオブジェクトの画像であるオブジェクト画像を取得するオブジェクト画像取得部と、
前記深さ算出部が算出した前記他のオブジェクトまでの深さに応じた点広がり関数の逆フィルタを用いて、前記オブジェクト画像取得部が取得した前記オブジェクト画像におけるぼけを補正するオブジェクト画像補正部と
をさらに備える請求項1から9のいずれか一項に記載の画像処理システム。 - 前記オブジェクト画像補正部は、前記深さ算出部が算出した前記他のオブジェクトまでの深さに応じた前記点広がり関数の逆フィルタを用いて、前記他のオブジェクトから前記表面までの間で前記他のオブジェクトからの光が散乱されることによる前記オブジェクト画像におけるぼけを補正する
請求項10に記載の画像処理システム。 - 前記表面から前記他のオブジェクトまでの深さに対応づけて、前記点広がり関数の逆フィルタを格納する補正テーブル
をさらに備え、
前記オブジェクト画像補正部は、前記深さ算出部が算出した前記他のオブジェクトまでの深さに対応づけて前記補正テーブルが格納している前記逆フィルタを用いて、前記オブジェクト画像におけるぼけを補正する
請求項11に記載の画像処理システム。 - 前記オブジェクト画像補正部により補正された前記オブジェクト画像の表示を、前記深さに応じて制御する表示制御部
をさらに備える請求項10から12のいずれか一項に記載の画像処理システム。 - 前記表示制御部は、前記オブジェクト画像補正部により補正された前記オブジェクト画像における前記オブジェクトの像の明るさまたは色を、前記深さに応じて変化させて表示させる
請求項13に記載の画像処理システム。 - 前記物質は、前記血管内に注入されたルミネッセンス物質を含む
請求項1から7のいずれか一項に記載の画像処理システム。 - コンピュータに、
物体の内部に存在するオブジェクトからの複数の波長領域の光を受光する受光部で受光された複数の波長領域毎の光の量に基づいて、前記物体における波長による光の吸収率の相違を利用して、前記物体の表面から前記オブジェクトまでの深さを算出する深さ算出部、
前記受光部が受光した光の量および前記深さ算出部が算出した前記オブジェクトまでの深さに基づいて、前記受光部が受光する光を発する、前記オブジェクト内の物質の量を算出する物質量算出部
として機能させ、
前記受光部は、前記オブジェクトと略同一の量の前記物質を含む他のオブジェクトからの光を受光し、
前記深さ算出部は、前記受光部が受光した前記他のオブジェクトからの光の量および前記物質量算出部が算出した前記物質の量に基づいて、前記表面から前記他のオブジェクトまでの深さを算出し、
前記オブジェクトは血管であり、前記物質は前記血管内の血中成分であり、前記物質の量は前記血管内の血中成分の濃度である
プログラム。
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JP2008309073A JP5278854B2 (ja) | 2007-12-10 | 2008-12-03 | 画像処理システムおよびプログラム |
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JP2009160386A JP2009160386A (ja) | 2009-07-23 |
JP5278854B2 true JP5278854B2 (ja) | 2013-09-04 |
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US (1) | US8260016B2 (ja) |
EP (1) | EP2070469A1 (ja) |
JP (1) | JP5278854B2 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US7822452B2 (en) * | 2004-08-11 | 2010-10-26 | Glt Acquisition Corp. | Method for data reduction and calibration of an OCT-based blood glucose monitor |
US7254429B2 (en) * | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
JP2006122195A (ja) * | 2004-10-27 | 2006-05-18 | Olympus Corp | 内視鏡光学系 |
WO2006062895A2 (en) * | 2004-12-06 | 2006-06-15 | Cambridge Research And Instrumentation, Inc. | Systems and methods for in-vivo optical imaging and measurement |
JP4391998B2 (ja) * | 2006-03-07 | 2009-12-24 | オリンパス株式会社 | 内視鏡装置 |
JP5376206B2 (ja) * | 2007-12-05 | 2013-12-25 | 富士フイルム株式会社 | 位置特定システムおよびプログラム |
-
2008
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- 2008-12-09 EP EP08021396A patent/EP2070469A1/en not_active Withdrawn
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JP2009160386A (ja) | 2009-07-23 |
EP2070469A1 (en) | 2009-06-17 |
US8260016B2 (en) | 2012-09-04 |
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