JP5276676B2 - Ｅｒｋ阻害剤である化合物 - Google Patents

Ｅｒｋ阻害剤である化合物 Download PDF

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Publication number
JP5276676B2
JP5276676B2 JP2010547732A JP2010547732A JP5276676B2 JP 5276676 B2 JP5276676 B2 JP 5276676B2 JP 2010547732 A JP2010547732 A JP 2010547732A JP 2010547732 A JP2010547732 A JP 2010547732A JP 5276676 B2 JP5276676 B2 JP 5276676B2
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JP
Japan
Prior art keywords
substituted
group
triazolyl
moiety
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2010547732A
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English (en)
Japanese (ja)
Other versions
JP2011513225A (ja
Inventor
アラン ビー． クーパー，
ヤン ナン，
ヨンキ デン，
ジェラルド ダブリュー． ジュニア シップス，
ネン−ヤン シー，
ヒュー ワイ． チュー，
ジョセフ エム． ケリー，
サブラーマニヤム グディパティ，
ロナルド ジェイ． ドール，
メーヒュル エフ． パテル，
ジャグディシュ エー． デサイ，
ジェイムス ジェイ−エス ワン，
サニル パリワル，
ホン−チャン ツイ，
ソバーナ バブ ボガ，
アブドゥル−バシト アラーサン，
シャオレイ ガオ，
リャン チュー，
シン ヤオ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5276676(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2011513225A publication Critical patent/JP2011513225A/ja
Application granted granted Critical
Publication of JP5276676B2 publication Critical patent/JP5276676B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010547732A 2008-02-21 2009-02-19 Ｅｒｋ阻害剤である化合物 Expired - Fee Related JP5276676B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21
US61/030,407 2008-02-21
PCT/US2009/034447 WO2009105500A1 (en) 2008-02-21 2009-02-19 Compounds that are erk inhibitors

Publications (2)

Publication Number Publication Date
JP2011513225A JP2011513225A (ja) 2011-04-28
JP5276676B2 true JP5276676B2 (ja) 2013-08-28

Family

ID=40601237

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010547732A Expired - Fee Related JP5276676B2 (ja) 2008-02-21 2009-02-19 Ｅｒｋ阻害剤である化合物

Country Status (23)

Country Link
US (1) US8716483B2 (enExample)
EP (1) EP2260031B1 (enExample)
JP (1) JP5276676B2 (enExample)
KR (1) KR20100117123A (enExample)
CN (1) CN102015693B (enExample)
AR (1) AR070460A1 (enExample)
AU (1) AU2009215534B8 (enExample)
BR (1) BRPI0908120A8 (enExample)
CA (1) CA2714479A1 (enExample)
CL (1) CL2009000394A1 (enExample)
CO (1) CO6300939A2 (enExample)
EC (1) ECSP10010415A (enExample)
ES (1) ES2556353T3 (enExample)
IL (1) IL207530A (enExample)
MX (1) MX2010009268A (enExample)
MY (1) MY152271A (enExample)
NZ (1) NZ587504A (enExample)
PE (1) PE20091491A1 (enExample)
RU (1) RU2525389C2 (enExample)
SG (1) SG188179A1 (enExample)
TW (1) TWI398441B (enExample)
WO (1) WO2009105500A1 (enExample)
ZA (2) ZA201005909B (enExample)

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EP2584903B1 (en) * 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
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RU2701156C9 (ru) 2012-07-18 2019-12-18 Саншайн Лейк Фарма Ко., Лтд. Азотсодержащие гетероциклические производные и их применение в фармацевтических препаратах
WO2014052566A1 (en) * 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP2900241B1 (en) * 2012-09-28 2018-08-08 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
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BR112017012547A2 (pt) * 2014-12-18 2018-03-13 Merck Sharp & Dohme Corp. Composições de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h- indazol-5-il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il) fenil)-3,6-diidropiridin-1(2h)-il)-2-oxoetil)-3-(metiltio) pirrolidina-3-carboxamida para preparações farmacêuticas
BR112017012558A2 (pt) * 2014-12-19 2018-01-02 Merck Sharp & Dohme Composições de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h- indazol-5-il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il) fenil)-3,6-diidropiridin-1(2h)-il)-2-oxoetil)-3-(metiltio) pirrolidina-3-carboxamida para preparações farmacêuticas
HRP20200805T1 (hr) 2015-04-03 2020-10-16 Recurium Ip Holdings, Llc Spirociklički spojevi
US20180250232A1 (en) * 2015-09-03 2018-09-06 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
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CN114867529B (zh) 2019-10-09 2024-09-27 拜耳公司 作为农药的新的杂芳基三唑化合物
JP7326622B2 (ja) 2019-12-06 2023-08-15 メッドシャイン ディスカバリー インコーポレイテッド Ｅｒｋ阻害剤としてのスピロ系化合物およびその使用

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Also Published As

Publication number Publication date
ES2556353T3 (es) 2016-01-15
TWI398441B (zh) 2013-06-11
AU2009215534B8 (en) 2014-07-10
CN102015693B (zh) 2014-10-29
BRPI0908120A8 (pt) 2017-10-24
CN102015693A (zh) 2011-04-13
MY152271A (en) 2014-09-15
AR070460A1 (es) 2010-04-07
ZA201005909B (en) 2014-03-26
EP2260031B1 (en) 2015-10-07
MX2010009268A (es) 2010-09-14
EP2260031A1 (en) 2010-12-15
AU2009215534A2 (en) 2010-12-23
TW200948799A (en) 2009-12-01
US20110189192A1 (en) 2011-08-04
CL2009000394A1 (es) 2011-02-11
WO2009105500A1 (en) 2009-08-27
US8716483B2 (en) 2014-05-06
KR20100117123A (ko) 2010-11-02
PE20091491A1 (es) 2009-09-25
AU2009215534A8 (en) 2014-07-10
AU2009215534A1 (en) 2009-08-27
ES2556353T8 (es) 2017-10-13
ECSP10010415A (es) 2010-09-30
IL207530A (en) 2014-08-31
RU2010138635A (ru) 2012-03-27
ZA201400396B (en) 2014-12-23
SG188179A1 (en) 2013-03-28
CA2714479A1 (en) 2009-08-27
BRPI0908120A2 (enExample) 2017-08-22
RU2525389C2 (ru) 2014-08-10
AU2009215534B2 (en) 2014-06-26
CO6300939A2 (es) 2011-07-21
NZ587504A (en) 2012-09-28
IL207530A0 (en) 2010-12-30
JP2011513225A (ja) 2011-04-28

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