JP5268870B2 - 核酸の自動抽出システムおよびその方法 - Google Patents

核酸の自動抽出システムおよびその方法 Download PDF

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Publication number
JP5268870B2
JP5268870B2 JP2009270047A JP2009270047A JP5268870B2 JP 5268870 B2 JP5268870 B2 JP 5268870B2 JP 2009270047 A JP2009270047 A JP 2009270047A JP 2009270047 A JP2009270047 A JP 2009270047A JP 5268870 B2 JP5268870 B2 JP 5268870B2
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reagent
sample
plate
nucleic acid
pipette tip
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JP2010127941A (ja
JP2010127941A5 (enExample
Inventor
バッハマン ハンス−ルドルフ
バルメットラー クルト
ブルヒ ヘルベルト
ブルメスター イエルグ
ハーク カールステン
クノーベル ロルフ
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エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009270047A 2008-11-28 2009-11-27 核酸の自動抽出システムおよびその方法 Active JP5268870B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08170320.9 2008-11-28
EP08170320.9A EP2192186B1 (en) 2008-11-28 2008-11-28 System and method for the automated extraction of nucleic acids

Publications (3)

Publication Number Publication Date
JP2010127941A JP2010127941A (ja) 2010-06-10
JP2010127941A5 JP2010127941A5 (enExample) 2013-05-09
JP5268870B2 true JP5268870B2 (ja) 2013-08-21

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JP2009270047A Active JP5268870B2 (ja) 2008-11-28 2009-11-27 核酸の自動抽出システムおよびその方法

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US (1) US20100137574A1 (enExample)
EP (1) EP2192186B1 (enExample)
JP (1) JP5268870B2 (enExample)
CN (1) CN101747397B (enExample)
CA (1) CA2686597C (enExample)
ES (1) ES2567067T3 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5846773B2 (ja) 2010-06-29 2016-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ サンプルの分配
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
EP2703820B1 (en) * 2012-08-31 2019-08-28 F. Hoffmann-La Roche AG Mobile tip waste rack
TWI477755B (zh) * 2013-06-04 2015-03-21 Genereach Biotechnology Corp 核酸萃取設備
CN103789198B (zh) * 2014-02-27 2015-09-16 苏州天隆生物科技有限公司 全自动核酸提取仪
ES2854880T3 (es) * 2014-06-11 2021-09-23 Hoffmann La Roche Procedimiento y sistema para el análisis de diagnóstico in vitro
CN105940305B (zh) * 2014-06-17 2019-08-27 深圳迈瑞生物医疗电子股份有限公司 提取物分离装置及其工作方法
KR102363674B1 (ko) * 2015-04-06 2022-02-15 메소 스케일 테크놀러지즈, 엘엘시 소모성 진탕 장치를 포함하는, 전기화학발광을 이용하여 검정법을 수행하기 위한 고처리율 시스템
CN106701527A (zh) * 2015-08-11 2017-05-24 广州康昕瑞基因健康科技有限公司 一种试剂工作站
CN105223054B (zh) * 2015-10-13 2019-06-11 毛坤云 生物检材载体批量快速去除装置及去除方法
JP6771903B2 (ja) * 2016-02-29 2020-10-21 シスメックス株式会社 検体前処理装置、検体前処理カートリッジおよび検体前処理方法
CN109982778A (zh) * 2016-09-23 2019-07-05 阿谢尔德克斯有限公司 流体系统及相关方法
US20200363299A1 (en) * 2016-11-23 2020-11-19 Hangzhou Gene-Meta Medical Device Co., Ltd. Apparatus for automating pretreatment of nucleic acid detection
CN106754349A (zh) * 2017-01-13 2017-05-31 广东顺德工业设计研究院(广东顺德创新设计研究院) 加热振动装置及包括该加热振动装置的核酸提取设备
CN107557356B (zh) * 2017-09-05 2023-06-09 南京万承生物科技有限公司 一种小型多通道文库构建仪及构建文库的方法
SG11202002507UA (en) * 2018-03-02 2020-04-29 Psomagen Inc Method and system for high-throughput particle handling by use of magnetic fields and device
WO2019182903A1 (en) * 2018-03-20 2019-09-26 Nugen Technologies, Inc. Methods for linear sample processing
CN108949553B (zh) * 2018-08-23 2024-04-30 苏州英芮诚生化科技有限公司 一种核酸提取仪用弃废液装置
US20210403846A1 (en) * 2018-11-16 2021-12-30 Aixinno Limited Lab-ware and handling system to handle lab-ware in a cell culture process
CN110208063A (zh) * 2019-06-27 2019-09-06 中国农业科学院农业质量标准与检测技术研究所 一种在线自动化磁性纳米材料震荡-解吸装置
CN112226354A (zh) * 2020-09-10 2021-01-15 襄阳市远杰精密机械有限公司 一种多样本通用型全自动核酸提取仪
CN112920948A (zh) * 2021-03-31 2021-06-08 苏州博捷特生物科技有限公司 一种核酸检测前处理仪
EP4349953A4 (en) * 2021-05-31 2025-06-04 Universal Bio Research Co., Ltd. SAMPLE TREATMENT DEVICE
CN113308364A (zh) * 2021-06-09 2021-08-27 北京京东方技术开发有限公司 核酸提取基板、核酸提取设备和核酸提取方法
CN113583812B (zh) * 2021-08-04 2023-11-28 上海思路迪生物医学科技有限公司 一种适用于模块化工作站的核酸提取系统及方法
CN118922523A (zh) * 2022-09-30 2024-11-08 深圳华大生命科学研究院 生物芯片的自动化控制系统及其自动化控制方法
CN117247834B (zh) * 2023-11-17 2024-01-30 北京万泰生物药业股份有限公司 高通量全自动核酸检测仪器及方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3115501B2 (ja) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
DE29623597U1 (de) * 1996-11-08 1999-01-07 Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg Temperierblock mit Temperiereinrichtungen
US5779907A (en) * 1996-12-06 1998-07-14 Systems Research Laboratories, Inc. Magnetic microplate separator
JP4015227B2 (ja) * 1997-05-16 2007-11-28 プレシジョン・システム・サイエンス株式会社 磁性体粒子を用いた化学反応処理装置及びその方法
EP2316571A3 (en) * 1998-05-01 2011-07-27 Gen-Probe Incorporated Automated diagnostic analyzer and method
EP1876451A3 (en) * 1998-07-27 2012-02-29 Hitachi, Ltd. Handling method of body fluid sample and analysis apparatus using the same
JP3609945B2 (ja) * 1998-08-28 2005-01-12 株式会社日立製作所 自動分析方法及び装置
JP3391734B2 (ja) * 1998-07-27 2003-03-31 株式会社日立製作所 生体サンプルの取扱い方法及び分析装置
DE59912484D1 (de) * 1998-07-31 2005-10-06 Tecan Trading Ag Maennedorf Magnetseparator
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
DE19917375C2 (de) 1999-04-16 2001-09-27 Hamilton Bonaduz Ag Bonaduz Pipettiereinheit
WO2001011364A1 (en) * 1999-08-09 2001-02-15 Precision System Science Co., Ltd. Method for automatic labeling using dispenser, method for automatically separating target substance, method for determining base sequence, and automatic dispensing system
JP4045475B2 (ja) * 1999-09-06 2008-02-13 東洋紡績株式会社 核酸・蛋白質精製装置
US7250303B2 (en) * 2001-07-20 2007-07-31 Ortho-Clinical Diagnostics, Inc. Chemistry system for a clinical analyzer
US20030059823A1 (en) * 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
JP3996416B2 (ja) * 2001-09-21 2007-10-24 Ｊｕｋｉ株式会社 核酸ハイブリダイゼーションにおけるｂ／ｆ分離方法
JP2003093038A (ja) * 2001-09-21 2003-04-02 Juki Corp ハイブリダイゼーション装置及びこれを用いたサンプル中の核酸検出方法
JP4017369B2 (ja) * 2001-09-28 2007-12-05 株式会社ヤクルト本社 核酸抽出装置
US20080014610A1 (en) * 2004-06-02 2008-01-17 Arkray,Inc. Container for Nucleic Acid Extraction, Method of Cleaning Solid Matrix and Relevant Cleaning Mechanism, and Method of Purifying Nucleic Acid
EP1615037A1 (en) * 2004-07-06 2006-01-11 Boehringer Mannheim Gmbh An apparatus for liquid handling with multiple transfer tools
JP4630786B2 (ja) * 2005-10-04 2011-02-09 キヤノン株式会社 生化学処理装置、ｄｎａ増幅精製装置、該装置を含むｄｎａ検査装置
JP4804278B2 (ja) * 2006-08-30 2011-11-02 ユニバーサル・バイオ・リサーチ株式会社 マイクロプレート分割処理装置およびマイクロプレート分割処理方法
JP5156905B2 (ja) * 2007-04-20 2013-03-06 独立行政法人科学技術振興機構 アプタマー生成装置、アプタマー生成方法

Also Published As

Publication number Publication date
CA2686597A1 (en) 2010-05-28
JP2010127941A (ja) 2010-06-10
CN101747397B (zh) 2015-02-11
ES2567067T3 (es) 2016-04-19
EP2192186A1 (en) 2010-06-02
CN101747397A (zh) 2010-06-23
CA2686597C (en) 2016-10-11
US20100137574A1 (en) 2010-06-03
EP2192186B1 (en) 2016-03-09

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