JP5253402B2 - 自発的に形成する楕円体の単層リン脂質小胞 - Google Patents

自発的に形成する楕円体の単層リン脂質小胞 Download PDF

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Publication number
JP5253402B2
JP5253402B2 JP2009533551A JP2009533551A JP5253402B2 JP 5253402 B2 JP5253402 B2 JP 5253402B2 JP 2009533551 A JP2009533551 A JP 2009533551A JP 2009533551 A JP2009533551 A JP 2009533551A JP 5253402 B2 JP5253402 B2 JP 5253402B2
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Japan
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dops
composition
long chain
dppc
phospholipid
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JP2009533551A
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Japanese (ja)
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JP2010507580A5 (https=
JP2010507580A (ja
Inventor
チ，シャオヤン
カートサラス，ジョン
ニー，ム−ピン
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Cincinnati Childrens Hospital Medical Center
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Cincinnati Childrens Hospital Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009533551A 2006-10-20 2007-10-19 自発的に形成する楕円体の単層リン脂質小胞 Expired - Fee Related JP5253402B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86231206P 2006-10-20 2006-10-20
US60/862,312 2006-10-20
PCT/US2007/081880 WO2008051818A2 (en) 2006-10-20 2007-10-19 Spontaneously forming ellipsoidal phospholipid unilamellar vesicles

Publications (3)

Publication Number Publication Date
JP2010507580A JP2010507580A (ja) 2010-03-11
JP2010507580A5 JP2010507580A5 (https=) 2010-12-02
JP5253402B2 true JP5253402B2 (ja) 2013-07-31

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ID=39325270

Family Applications (1)

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JP2009533551A Expired - Fee Related JP5253402B2 (ja) 2006-10-20 2007-10-19 自発的に形成する楕円体の単層リン脂質小胞

Country Status (7)

Country Link
US (1) US20100311844A1 (https=)
EP (1) EP2081552A2 (https=)
JP (1) JP5253402B2 (https=)
CN (1) CN101541307A (https=)
BR (1) BRPI0717475A2 (https=)
CA (1) CA2666953A1 (https=)
WO (1) WO2008051818A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7834147B2 (en) 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
ES2641272T3 (es) * 2006-04-28 2017-11-08 Children's Hospital Medical Center Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana
CN102264349A (zh) * 2008-11-07 2011-11-30 儿童医院医疗中心 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质
CN108926535B (zh) * 2011-02-01 2020-12-29 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、 其制备方法及用途
EP2745834B1 (en) 2012-12-18 2016-09-28 Jens Frauenfeld Salipro particles
LT3043814T (lt) 2013-09-13 2021-02-25 Salipro Biotech AB Antigenas ir jo gamybos būdas
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer
US12605395B2 (en) 2020-04-01 2026-04-21 University Of Cincinnati Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy
US11833254B2 (en) * 2020-05-27 2023-12-05 University Of Connecticut Discoidal nano universal platform for efficient delivery of PNAs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
IL141586A0 (en) * 1998-08-28 2002-03-10 Myelos Corp Cyclic prosaposin-derived peptide and uses thereof
US6872406B2 (en) * 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
ES2641272T3 (es) * 2006-04-28 2017-11-08 Children's Hospital Medical Center Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana
CN102264349A (zh) * 2008-11-07 2011-11-30 儿童医院医疗中心 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质

Also Published As

Publication number Publication date
CA2666953A1 (en) 2008-05-02
WO2008051818A8 (en) 2009-08-06
WO2008051818A3 (en) 2008-12-24
WO2008051818A2 (en) 2008-05-02
EP2081552A2 (en) 2009-07-29
CN101541307A (zh) 2009-09-23
BRPI0717475A2 (pt) 2014-03-11
US20100311844A1 (en) 2010-12-09
JP2010507580A (ja) 2010-03-11

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