JP5236286B2 - 肝線維症に関連する遺伝的多型、その検出方法および使用 - Google Patents
肝線維症に関連する遺伝的多型、その検出方法および使用 Download PDFInfo
- Publication number
- JP5236286B2 JP5236286B2 JP2007511675A JP2007511675A JP5236286B2 JP 5236286 B2 JP5236286 B2 JP 5236286B2 JP 2007511675 A JP2007511675 A JP 2007511675A JP 2007511675 A JP2007511675 A JP 2007511675A JP 5236286 B2 JP5236286 B2 JP 5236286B2
- Authority
- JP
- Japan
- Prior art keywords
- snp
- nucleic acid
- snps
- kit
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56884604P | 2004-05-07 | 2004-05-07 | |
| US60/568,846 | 2004-05-07 | ||
| US58260904P | 2004-06-25 | 2004-06-25 | |
| US60/582,609 | 2004-06-25 | ||
| US59955404P | 2004-08-09 | 2004-08-09 | |
| US60/599,554 | 2004-08-09 | ||
| PCT/US2005/016051 WO2005111241A2 (en) | 2004-05-07 | 2005-05-09 | Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011023321A Division JP2011142914A (ja) | 2004-05-07 | 2011-02-04 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523005A JP2009523005A (ja) | 2009-06-18 |
| JP2009523005A5 JP2009523005A5 (enExample) | 2009-07-30 |
| JP5236286B2 true JP5236286B2 (ja) | 2013-07-17 |
Family
ID=35394750
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511675A Expired - Lifetime JP5236286B2 (ja) | 2004-05-07 | 2005-05-09 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2011023321A Withdrawn JP2011142914A (ja) | 2004-05-07 | 2011-02-04 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2013143224A Withdrawn JP2013233150A (ja) | 2004-05-07 | 2013-07-09 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2013143223A Expired - Lifetime JP5733844B2 (ja) | 2004-05-07 | 2013-07-09 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2015182498A Expired - Lifetime JP6124968B2 (ja) | 2004-05-07 | 2015-09-16 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2015182499A Withdrawn JP2016027815A (ja) | 2004-05-07 | 2015-09-16 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2017176520A Withdrawn JP2018023392A (ja) | 2004-05-07 | 2017-09-14 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2017176519A Expired - Fee Related JP6448149B2 (ja) | 2004-05-07 | 2017-09-14 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011023321A Withdrawn JP2011142914A (ja) | 2004-05-07 | 2011-02-04 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2013143224A Withdrawn JP2013233150A (ja) | 2004-05-07 | 2013-07-09 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2013143223A Expired - Lifetime JP5733844B2 (ja) | 2004-05-07 | 2013-07-09 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2015182498A Expired - Lifetime JP6124968B2 (ja) | 2004-05-07 | 2015-09-16 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2015182499A Withdrawn JP2016027815A (ja) | 2004-05-07 | 2015-09-16 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2017176520A Withdrawn JP2018023392A (ja) | 2004-05-07 | 2017-09-14 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| JP2017176519A Expired - Fee Related JP6448149B2 (ja) | 2004-05-07 | 2017-09-14 | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (7) | US7820380B2 (enExample) |
| EP (5) | EP2412826B1 (enExample) |
| JP (8) | JP5236286B2 (enExample) |
| CA (2) | CA2566256C (enExample) |
| WO (1) | WO2005111241A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666584B2 (en) * | 2005-09-01 | 2010-02-23 | Philadelphia Health & Education Coporation | Identification of a pin specific gene and protein (PIN-1) useful as a diagnostic treatment for prostate cancer |
| US7727725B2 (en) | 2006-04-27 | 2010-06-01 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
| EP2099467B1 (en) * | 2006-10-03 | 2017-05-10 | University Of Medicine And Dentistry Of New Jersey | Atap peptides, nucleic acids encoding the same and associated methods of use |
| WO2008132763A2 (en) * | 2007-04-30 | 2008-11-06 | Decode Genetics Ehf | Genetic variants useful for risk assessment of coronary artery disease and myocardial infarction |
| US8039212B2 (en) * | 2007-11-05 | 2011-10-18 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
| WO2009147246A1 (en) * | 2008-06-06 | 2009-12-10 | Medizinische Universität Graz | Compounds reducing or inhibiting the expression of pkd1 for diagnosis and therapy of brain tumors |
| EP2389439A4 (en) * | 2009-01-23 | 2013-02-13 | Agency Science Tech & Res | EINBASEN POLYMORPHISM IN AN INTRONIC P53 BINDING MOTIF OF THE PRKAG2 GENE |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| ME03009B (me) | 2011-09-16 | 2018-10-20 | Gilead Pharmasset Llc | Metode za lecenje hcv-a |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| ES2423154B1 (es) * | 2012-03-12 | 2014-07-15 | Universidad Autónoma de Madrid | Método in vitro de pronóstico de cirrosis hepática |
| ES2422874B1 (es) * | 2012-03-12 | 2014-07-15 | Universidad Autnoma De Madrid | Método in vitro de pronóstico de fibrosis hepática grave |
| CN103570553B (zh) | 2012-08-01 | 2016-08-10 | 中国科学院兰州化学物理研究所 | 一种通过催化烷基化制备n-取代胺类化合物的方法 |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| UA118256C2 (uk) | 2013-01-31 | 2018-12-26 | Гіліад Фармассет Елелсі | Комбінований склад двох противірусних сполук |
| WO2015014763A2 (en) * | 2013-08-02 | 2015-02-05 | Echosens | Non-invasive system for calculating a human or animal, reliable, standardized and complete score |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| CN110446785B (zh) * | 2017-01-23 | 2024-04-26 | 瑞泽恩制药公司 | Hsd17b13变体及其应用 |
| KR20190139869A (ko) | 2017-04-11 | 2019-12-18 | 리제너론 파마슈티칼스 인코포레이티드 | 하이드록시스테로이드 (17-베타) 탈수소효소(hsd17b) 패밀리의 구성원의 조절인자의 활성도를 스크리닝하기 위한 검정 |
| US10961583B2 (en) | 2017-10-11 | 2021-03-30 | Regeneron Phramaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| CA3091146A1 (en) | 2018-03-21 | 2019-09-26 | Regeneron Pharmaceuticals, Inc. | 17.beta.-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof |
| US11216742B2 (en) | 2019-03-04 | 2022-01-04 | Iocurrents, Inc. | Data compression and communication using machine learning |
| WO2021051009A1 (en) * | 2019-09-11 | 2021-03-18 | City Of Hope | Methods and compositions to direct breakdown of insulin mrna in benign fashion |
| EP4055174A4 (en) * | 2019-11-08 | 2024-01-03 | The Board Of Regents Of The University Of Texas System | Transgene cassettes, aav vectors and aav viral vectors for the expression of human codon-optimized slc6a1 |
| WO2021222623A1 (en) * | 2020-04-29 | 2021-11-04 | Washington University | Compositions and methods for inhibiting viral recognition sites |
| KR102455051B1 (ko) * | 2020-05-08 | 2022-10-17 | 가톨릭대학교 산학협력단 | 혈청내 Daxx 단백질의 측정을 통한 만성 간질환의 진단 |
| GB202008269D0 (en) * | 2020-06-02 | 2020-07-15 | Oxford Biodynamics Ltd | Detecting a chromosome marker |
| US12097498B2 (en) | 2020-12-31 | 2024-09-24 | 3M Innovative Properties Company | Nanopatterned films with patterned surface chemistry |
| IL308883A (en) * | 2021-05-28 | 2024-01-01 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF MUCIN 5AC (MUC5AC), COMPOSITIONS THEREOF, AND METHODS OF USE |
| IL311468A (en) * | 2021-09-22 | 2024-05-01 | Imagine Pharma Llc | Compositions and methods for the proliferation of insulin- and glucagon-secreting cells from type 1 diabetic pancreatic tissue and their therapeutic uses |
| CA3238030A1 (en) * | 2021-11-12 | 2023-05-19 | Research Institute At Nationwide Children's Hospital | Materials and methods for slc6a1 gene therapy |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| FR2540122B1 (fr) | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| NO870613L (no) | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
| US5004565A (en) | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5856522A (en) | 1995-05-04 | 1999-01-05 | Tropix, Inc. | Method of using synthesis of 1,2-dioxetanes and kits therefore |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| DE68928853T2 (de) | 1988-05-20 | 1999-08-05 | Cetus Corp., Emeryville, Calif. | Befestigung von sequenzspezifischen proben |
| US4988167A (en) | 1988-08-10 | 1991-01-29 | Fergason James L | Light blocking and vision restoration apparatus with glint control |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994073A (en) | 1990-08-30 | 1999-11-30 | Tropix, Inc. | Enhancement of chemiluminescent assays |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| EP0655090B1 (en) | 1992-04-27 | 2000-12-27 | The Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| DE69333969T2 (de) | 1992-10-30 | 2006-09-14 | The General Hospital Corp., Boston | Wechselwirkendes Fallensystem zur Isolierung von Proteinen |
| EP1262564A3 (en) | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US6027923A (en) | 1993-07-23 | 2000-02-22 | Bio-Rad Laboratories, Inc. | Linked linear amplification of nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5773628A (en) | 1994-11-14 | 1998-06-30 | Tropix, Inc. | 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use |
| US5591591A (en) | 1995-02-09 | 1997-01-07 | Tropix, Inc. | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US5801115A (en) | 1995-09-05 | 1998-09-01 | Kataleuna Gmbh | Catalyst composition and methods for using and preparing same |
| US5679803A (en) | 1995-10-25 | 1997-10-21 | Tropix, Inc. | 1,2 chemiluminescent dioxetanes of improved performance |
| EP2573101B1 (en) | 1996-02-09 | 2016-04-20 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| JP2000508912A (ja) | 1996-04-19 | 2000-07-18 | スペクトラ バイオメディカル,インコーポレイテッド | 多型形態と複数の表現型との相関付け |
| WO1997045559A1 (en) | 1996-05-29 | 1997-12-04 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5800999A (en) | 1996-12-16 | 1998-09-01 | Tropix, Inc. | Dioxetane-precursor-labeled probes and detection assays employing the same |
| EP0988529B1 (en) | 1997-04-25 | 2013-06-12 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| US6119096A (en) | 1997-07-31 | 2000-09-12 | Eyeticket Corporation | System and method for aircraft passenger check-in and boarding using iris recognition |
| US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US20030092019A1 (en) * | 2001-01-09 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
| WO2002072889A2 (en) | 2001-01-12 | 2002-09-19 | Applera Corporation | Methods and compositions for microarray control |
| US20030119010A1 (en) * | 2001-03-01 | 2003-06-26 | University Of Queensland | Polynucleotides and polypeptides linked to a disease or condition |
| JP2004537289A (ja) * | 2001-05-11 | 2004-12-16 | ゲノム セラピューティックス コーポレーション | 骨量および脂質レベルを調整するhbm変異型 |
| GB0209812D0 (en) * | 2002-04-30 | 2002-06-05 | Renovo Ltd | Genetic testing |
-
2005
- 2005-05-09 US US11/124,367 patent/US7820380B2/en not_active Expired - Fee Related
- 2005-05-09 EP EP11165258.2A patent/EP2412826B1/en not_active Expired - Lifetime
- 2005-05-09 WO PCT/US2005/016051 patent/WO2005111241A2/en not_active Ceased
- 2005-05-09 EP EP11165274.9A patent/EP2423327B1/en not_active Expired - Lifetime
- 2005-05-09 CA CA2566256A patent/CA2566256C/en not_active Expired - Lifetime
- 2005-05-09 EP EP05746576A patent/EP1745154B1/en not_active Expired - Lifetime
- 2005-05-09 EP EP11165250.9A patent/EP2423326B1/en not_active Expired - Lifetime
- 2005-05-09 JP JP2007511675A patent/JP5236286B2/ja not_active Expired - Lifetime
- 2005-05-09 CA CA2852855A patent/CA2852855C/en not_active Expired - Lifetime
- 2005-05-09 EP EP11165266.5A patent/EP2412827B1/en not_active Expired - Lifetime
-
2010
- 2010-09-20 US US12/886,016 patent/US8071302B2/en not_active Expired - Fee Related
-
2011
- 2011-02-04 JP JP2011023321A patent/JP2011142914A/ja not_active Withdrawn
- 2011-10-27 US US13/283,344 patent/US20120276528A1/en not_active Abandoned
-
2013
- 2013-02-11 US US13/764,086 patent/US20140072957A1/en not_active Abandoned
- 2013-07-09 JP JP2013143224A patent/JP2013233150A/ja not_active Withdrawn
- 2013-07-09 JP JP2013143223A patent/JP5733844B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-13 US US14/797,998 patent/US20160032388A1/en not_active Abandoned
- 2015-09-16 JP JP2015182498A patent/JP6124968B2/ja not_active Expired - Lifetime
- 2015-09-16 JP JP2015182499A patent/JP2016027815A/ja not_active Withdrawn
-
2017
- 2017-09-14 JP JP2017176520A patent/JP2018023392A/ja not_active Withdrawn
- 2017-09-14 JP JP2017176519A patent/JP6448149B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-27 US US15/964,883 patent/US10718023B2/en not_active Expired - Fee Related
-
2020
- 2020-06-08 US US16/895,440 patent/US20210025000A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5236286B2 (ja) | 肝線維症に関連する遺伝的多型、その検出方法および使用 | |
| JP6529193B2 (ja) | 心筋梗塞に関連する遺伝的多型、その検出方法および使用 | |
| JP6537150B2 (ja) | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 | |
| US11408034B2 (en) | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof | |
| DK2121979T3 (en) | Genetic markers for risk management of cardiac arrhythmia | |
| JP2009521205A (ja) | 発作に関連する遺伝的多型、その検出方法および使用 | |
| EP2639317B1 (en) | Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof | |
| JP2013542735A (ja) | 静脈血栓症と関連する遺伝子多型およびスタチン応答、その検出方法ならびにその用途 | |
| JP2009520460A (ja) | 心筋梗塞に関連する遺伝的多型、その検出方法および使用 | |
| EP1476067A2 (en) | Novel compositions and methods for cancer | |
| JP2006521812A (ja) | 慢性関節リウマチに関連する遺伝的多型、その検出方法および使用 | |
| JP2009523006A (ja) | 脈管疾患に関連する遺伝的多型、その検出方法および使用 | |
| US20090258003A1 (en) | Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof | |
| JP2009523405A (ja) | 冠動脈心疾患に関連する遺伝的多型、その検出方法および使用 | |
| CA2826522C (en) | Genetic polymorphism in pnlpa3 associated with liver fibrosis methods of detection and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101108 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110204 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110204 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111108 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120130 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120904 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121227 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130124 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130326 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130327 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5236286 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160405 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |