JP5221381B2 - 卵巣癌を判定するためのｈｅ４及び他の生化学マーカーの使用 - Google Patents
卵巣癌を判定するためのｈｅ４及び他の生化学マーカーの使用 Download PDFInfo
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Classifications
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
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| WO2000076014A2 (en) * | 1999-06-09 | 2000-12-14 | Moltech Corporation | Methods of preparing electrochemical cells |
| US7270960B2 (en) | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US20090075305A1 (en) * | 2005-05-02 | 2009-03-19 | The Brigham And Womern's Hospital, Inc. | Diagnostic serum antibody profiling |
| ES2748397T3 (es) * | 2006-01-04 | 2020-03-16 | Fujirebio Diagnostics Inc | Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres de ovario |
| US20070212721A1 (en) * | 2006-01-27 | 2007-09-13 | Tripath Imaging, Inc. | Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor |
| WO2008049239A1 (en) | 2006-10-27 | 2008-05-02 | Mount Sinai Hospital | Endometrial biomarkers |
| KR20100015438A (ko) * | 2007-03-09 | 2010-02-12 | 트리패스 이미징, 인코포레이티드 | Ｈｅ4 모노클로날 항체 및 이의 사용 방법 |
| JP5144742B2 (ja) * | 2007-03-29 | 2013-02-13 | フジレビオ ダイアグノスティックス インコーポレイテッド | 乳がんの評価のためのｈｅ４の使用 |
| CN101377502A (zh) * | 2007-08-31 | 2009-03-04 | 北京科美东雅生物技术有限公司 | 肿瘤相关抗原72-4化学发光免疫分析测定试剂盒及其制备方法 |
| US8642347B2 (en) * | 2008-01-31 | 2014-02-04 | The Brigham And Women's Hospital, Inc. | Urinary CA125 peptides as biomarkers of ovarian cancer |
| WO2009145815A2 (en) * | 2008-04-01 | 2009-12-03 | The Brigham And Women's Hospital, Inc. | Biomarkers of ovarian cancer |
| CN103180732B (zh) * | 2010-08-26 | 2017-09-08 | 华盛顿大学商业中心 | 检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 |
| KR20200013118A (ko) | 2011-02-17 | 2020-02-05 | 후지레비오 다이어그노스틱스, 인코포레이티드 | ＨＥ4ａ의 결정을 위해 사용되는 조성물들 및 방법들 |
| CN103582815A (zh) * | 2011-02-24 | 2014-02-12 | 佛米利昂公司 | 用于卵巢癌的生物标志物组、诊断方法和测试试剂盒 |
| CN102735840B (zh) * | 2011-04-13 | 2014-06-04 | 中国医学科学院肿瘤研究所 | 用于诊断或筛查卵巢癌的试剂 |
| US9980982B2 (en) | 2011-06-06 | 2018-05-29 | Women & Infants Hospital Of Rhode Island | HE4 based therapy for malignant disease |
| DE102012205164B4 (de) | 2012-03-29 | 2021-09-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Projektionsdisplay und Verfahren zur Projektion virtueller Bilder |
| CN103575902B (zh) * | 2012-08-03 | 2015-07-29 | 河南生生医疗器械有限公司 | 一种时间分辨荧光法四项综合检测卵巢癌试剂盒及其应用 |
| CN102890083B (zh) * | 2012-09-28 | 2016-08-10 | 辽宁科骏生物有限公司 | 化学发光底物溶液和含其的试剂盒及应用其的检测方法 |
| CN104655858B (zh) * | 2015-03-12 | 2016-02-10 | 德迈基生物技术（北京）有限公司 | 定量检测人附睾分泌蛋白-4的荧光免疫层析试剂盒及其制备方法 |
| CA2981068C (en) | 2015-03-26 | 2021-12-14 | Women & Infants Hospital Of Rhode Island | Therapy for malignant disease comprising the inhibition of human epididymal secretory protein e4 and immune checkpoint inhibitors |
| RU2585959C1 (ru) * | 2015-06-22 | 2016-06-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ дифференциальной диагностики асцитно-инфильтративной формы рака яичников и абдоминального туберкулёза |
| US10267802B2 (en) | 2015-09-23 | 2019-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of prognosis and diagnosis of ovarian cancer |
| RU2624508C1 (ru) * | 2016-06-29 | 2017-07-04 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования длительности ремиссии у больных раком вульвы |
| TWI823836B (zh) * | 2016-07-08 | 2023-12-01 | 美商建南德克公司 | 人類副睪蛋白４（ｈｅ４）用於評定癌症治療反應性之用途 |
| CA3175499A1 (en) | 2020-04-21 | 2021-10-28 | University Of Rochester | Inhibitors of human epididymus protein 4 |
| CN111781364B (zh) * | 2020-08-25 | 2023-07-21 | 北京信诺卫康科技有限公司 | Wnt7a和HE4联合用作早期卵巢癌生物标志物以及试剂盒 |
| WO2022140116A1 (en) | 2020-12-21 | 2022-06-30 | Freenome Holdings, Inc. | Markers for the early detection of colon cell proliferative disorders |
| WO2023195629A1 (ko) * | 2022-04-08 | 2023-10-12 | 아주대학교산학협력단 | He4 검출용 펩타이드 및 그 용도 |
| US20240385195A1 (en) * | 2022-04-08 | 2024-11-21 | Ajou University Industry-Academic Cooperation Foundation | Peptide for detecting ca125 and use thereof |
| CN120254284B (zh) * | 2025-06-03 | 2025-08-22 | 杭州广科安德生物科技有限公司 | 一种用于预测子宫内膜癌复发或转移风险的生物标志物及其应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| CA1289880C (en) * | 1985-12-06 | 1991-10-01 | Jeffrey L. Winkelhake | Anti-human ovarian cancer immunotoxins and methods of use thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| EP0318554B2 (en) | 1987-05-21 | 2005-01-12 | Micromet AG | Targeted multifunctional proteins |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US6998106B1 (en) * | 1998-12-01 | 2006-02-14 | Duke University | Radioconjugation of internalizing antibodies |
| US6770445B1 (en) | 1999-02-26 | 2004-08-03 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| CA2369433A1 (en) | 1999-02-26 | 2000-08-31 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| WO2002046765A2 (en) * | 2000-11-08 | 2002-06-13 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| ATE468534T1 (de) * | 2002-08-06 | 2010-06-15 | Univ Johns Hopkins | Verwendung von biomarkern zum nachweis von eierstockkrebs |
| JP4678516B2 (ja) * | 2002-08-16 | 2011-04-27 | アヴァントラ バイオサイエンスィズ コーポレーション | 材料の分離、反応、および顕微鏡分析のための基板 |
| JP2006514284A (ja) * | 2003-02-05 | 2006-04-27 | サイファージェン バイオシステムズ インコーポレイテッド | 羊水内環境の非侵襲性評価 |
| US7619068B2 (en) * | 2003-05-09 | 2009-11-17 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| CN1266475C (zh) * | 2003-06-05 | 2006-07-26 | 马旭 | 一种用于诊断早期卵巢癌的四粘蛋白酶联免疫检测试剂盒 |
| EP2336779B1 (en) * | 2004-02-19 | 2013-07-31 | Yale University | Kit for the identification of ovarian cancer protein biomarkers using proteomic techniques |
| WO2005098446A2 (en) * | 2004-03-31 | 2005-10-20 | The Johns Hopkins University | Biomarkers for ovarian cancer |
| EP1859273B1 (en) * | 2005-02-16 | 2008-09-17 | Dana-Farber Cancer Institute | Methods of detecting ovarian cancer |
| CA2611340A1 (en) * | 2005-06-22 | 2007-01-04 | The Johns Hopkins University | Biomarker for ovarian cancer: ctap3-related proteins |
| JP2008547028A (ja) * | 2005-06-24 | 2008-12-25 | サイファージェン バイオシステムズ， インコーポレイテッド | 卵巣癌用のバイオマーカー |
| ES2748397T3 (es) * | 2006-01-04 | 2020-03-16 | Fujirebio Diagnostics Inc | Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres de ovario |
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