JP5209480B2 - M1受容体にて活性を有する化合物および医薬におけるそれらの使用 - Google Patents

M1受容体にて活性を有する化合物および医薬におけるそれらの使用 Download PDF

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Publication number
JP5209480B2
JP5209480B2 JP2008532866A JP2008532866A JP5209480B2 JP 5209480 B2 JP5209480 B2 JP 5209480B2 JP 2008532866 A JP2008532866 A JP 2008532866A JP 2008532866 A JP2008532866 A JP 2008532866A JP 5209480 B2 JP5209480 B2 JP 5209480B2
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group
formula
compound
salt
fluoro
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Expired - Fee Related
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JP2008532866A
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English (en)
Japanese (ja)
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JP2009512635A (ja
JP2009512635A5 (enExample
Inventor
ブライアン・バジック
デイビッド・グウィン・クーパー
イアン・トムソン・フォーブズ
ヴィンチェンツォ・ガルツィア
ジャン・ジン
シ・ドンチュアン
ポール・ウィリアム・スミス
グラハム・ウォーカー
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GBGB0519950.0A external-priority patent/GB0519950D0/en
Priority claimed from GB0602040A external-priority patent/GB0602040D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2009512635A publication Critical patent/JP2009512635A/ja
Publication of JP2009512635A5 publication Critical patent/JP2009512635A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2008532866A 2005-09-30 2006-09-27 M1受容体にて活性を有する化合物および医薬におけるそれらの使用 Expired - Fee Related JP5209480B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0519950.0 2005-09-30
GBGB0519950.0A GB0519950D0 (en) 2005-09-30 2005-09-30 Compounds
GB0602040A GB0602040D0 (en) 2006-02-01 2006-02-01 Compounds
GB0602040.8 2006-02-01
PCT/GB2006/003590 WO2007036715A2 (en) 2005-09-30 2006-09-27 Compounds which have activity at m1 receptor and their uses in medicine

Publications (3)

Publication Number Publication Date
JP2009512635A JP2009512635A (ja) 2009-03-26
JP2009512635A5 JP2009512635A5 (enExample) 2009-11-12
JP5209480B2 true JP5209480B2 (ja) 2013-06-12

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JP2008532866A Expired - Fee Related JP5209480B2 (ja) 2005-09-30 2006-09-27 M1受容体にて活性を有する化合物および医薬におけるそれらの使用

Country Status (24)

Country Link
US (2) US8283364B2 (enExample)
EP (1) EP1943230B1 (enExample)
JP (1) JP5209480B2 (enExample)
KR (2) KR101374458B1 (enExample)
CN (1) CN101321736B (enExample)
AR (1) AR056103A1 (enExample)
AT (1) ATE492537T1 (enExample)
AU (1) AU2006296369B2 (enExample)
BR (1) BRPI0616609A2 (enExample)
CA (1) CA2624504C (enExample)
CR (1) CR9904A (enExample)
DE (1) DE602006019119D1 (enExample)
EA (1) EA016286B1 (enExample)
IL (1) IL190219A (enExample)
JO (1) JO2634B1 (enExample)
MA (1) MA29849B1 (enExample)
MY (1) MY148504A (enExample)
NO (1) NO20081945L (enExample)
NZ (1) NZ566508A (enExample)
PE (1) PE20070490A1 (enExample)
TW (1) TWI389905B (enExample)
UA (1) UA101299C2 (enExample)
WO (1) WO2007036715A2 (enExample)
ZA (1) ZA200802167B (enExample)

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GB0706165D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0718415D0 (en) 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
WO2009124882A1 (en) * 2008-04-09 2009-10-15 H. Lundbeck A/S Novel piperidinyl-1,3-dihydro-benzoimidazol-2-ones as m1 agonists
GB0817982D0 (en) 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
US20170333407A1 (en) * 2014-11-03 2017-11-23 William Beaumont Hospital Method for treating underactive bladder syndrome
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WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN107673994A (zh) * 2017-04-27 2018-02-09 联化科技股份有限公司 一种芳基甲烷类化合物的制备方法
CN107739342B (zh) * 2017-11-29 2020-01-10 华南理工大学 一种一步合成5-二芳氨基苯并咪唑酮衍生物的方法
CN117049938B (zh) * 2023-06-20 2024-06-14 山东轩德医药科技有限公司 一种6-溴-2,3-二氟甲苯的制备方法

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Also Published As

Publication number Publication date
IL190219A0 (en) 2008-11-03
ZA200802167B (en) 2009-08-26
UA101299C2 (uk) 2013-03-25
MA29849B1 (fr) 2008-10-03
JP2009512635A (ja) 2009-03-26
BRPI0616609A2 (pt) 2011-06-28
US8481566B2 (en) 2013-07-09
TW200806657A (en) 2008-02-01
CR9904A (es) 2008-07-29
JO2634B1 (en) 2012-06-17
EP1943230B1 (en) 2010-12-22
US20080255195A1 (en) 2008-10-16
DE602006019119D1 (de) 2011-02-03
AR056103A1 (es) 2007-09-19
TWI389905B (zh) 2013-03-21
MY148504A (en) 2013-04-30
CA2624504A1 (en) 2007-04-05
KR20130091791A (ko) 2013-08-19
AU2006296369A1 (en) 2007-04-05
EP1943230A2 (en) 2008-07-16
KR101374458B1 (ko) 2014-03-17
CA2624504C (en) 2014-07-08
ATE492537T1 (de) 2011-01-15
KR20080049090A (ko) 2008-06-03
EA200801001A1 (ru) 2008-08-29
US8283364B2 (en) 2012-10-09
EA016286B1 (ru) 2012-03-30
CN101321736B (zh) 2012-04-04
WO2007036715A3 (en) 2007-05-18
WO2007036715A2 (en) 2007-04-05
US20080058378A1 (en) 2008-03-06
NO20081945L (no) 2008-06-04
IL190219A (en) 2012-10-31
CN101321736A (zh) 2008-12-10
PE20070490A1 (es) 2007-05-30
AU2006296369B2 (en) 2012-12-20
NZ566508A (en) 2011-07-29

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