JP5203363B2 - Ｕｂｃ１３−ｕｅｖ相互作用を阻害することができる化合物、医薬組成物および治療的使用 - Google Patents
Ｕｂｃ１３−ｕｅｖ相互作用を阻害することができる化合物、医薬組成物および治療的使用 Download PDFInfo
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- JP5203363B2 JP5203363B2 JP2009519999A JP2009519999A JP5203363B2 JP 5203363 B2 JP5203363 B2 JP 5203363B2 JP 2009519999 A JP2009519999 A JP 2009519999A JP 2009519999 A JP2009519999 A JP 2009519999A JP 5203363 B2 JP5203363 B2 JP 5203363B2
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| US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| IN2012DN01378A (OSRAM) * | 2009-07-30 | 2015-06-05 | Salvat Lab Sa | |
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| EP2609135A4 (en) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF |
| CN103619331A (zh) * | 2011-03-23 | 2014-03-05 | 印第安纳大学研究及科技公司 | 抗癌治疗剂 |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子組成物および方法 |
| EA032088B1 (ru) * | 2011-10-27 | 2019-04-30 | Массачусетс Инститьют Оф Текнолоджи | Аминокислотные производные, функционализованные на n-конце, способные образовывать микросферы, инкапсулирующие лекарственное средство |
| US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
| EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| EP2882706A1 (en) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Amine-containing lipidoids and uses thereof |
| IL305374A (en) | 2013-03-14 | 2023-10-01 | Ethris Gmbh | Cftr mrna compositions and related methods and uses |
| JP6586075B2 (ja) | 2013-03-14 | 2019-10-02 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
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| AU2014340155B2 (en) | 2013-10-22 | 2018-11-01 | Massachusetts Institute Of Technology | Lipid formulations for delivery of messenger RNA |
| JP6295767B2 (ja) | 2014-03-25 | 2018-03-20 | 富士通株式会社 | スイッチ装置、情報処理システムおよびスイッチ装置の制御方法 |
| MX373952B (es) | 2014-04-25 | 2020-07-13 | Shire Human Genetic Therapies | Métodos de purificación de arn mensajero. |
| MA48050A (fr) | 2014-05-30 | 2020-02-12 | Translate Bio Inc | Lipides biodégradables pour l'administration d'acides nucléiques |
| EA033966B1 (ru) | 2014-06-24 | 2019-12-13 | Транслейт Био, Инк. | Стереохимически обогащенные композиции для доставки нуклеиновых кислот |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| CN107848988B (zh) | 2015-06-19 | 2021-10-22 | 麻省理工学院 | 烯基取代的2,5-哌嗪二酮和其在组合物中用于向个体或细胞递送药剂的用途 |
| EP3585417B1 (en) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Method of making a codon-optimized cftr mrna |
| EP3624824B1 (en) | 2017-05-16 | 2024-07-10 | Translate Bio, Inc. | Codon-optimized mrna encoding cftr for use in treating cystic fibrosis |
| CA3108544A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| EP3983533B1 (en) * | 2019-06-14 | 2025-01-08 | Children's Hospital Medical Center | Ube2n inhibitors for use in the treatment of acute myelomonocytic leukemia (aml-m4) and/or acute monocytic leukemia (aml-m5). |
| KR20220017075A (ko) | 2020-08-04 | 2022-02-11 | 삼성전자주식회사 | 홈 화면을 복원하는 방법 및 이를 적용한 전자 장치 |
| WO2023225277A1 (en) * | 2022-05-19 | 2023-11-23 | Ohio State Innovation Foundation | Peptidyl flavor modifiers |
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| ES2296484B1 (es) * | 2005-11-23 | 2009-04-01 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir la apoptosis. |
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| CN101506196A (zh) | 2009-08-12 |
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| AU2007275073A1 (en) | 2008-01-24 |
| ES2293834A1 (es) | 2008-03-16 |
| ES2293834B1 (es) | 2009-02-16 |
| EP2045251A4 (en) | 2010-12-01 |
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