JP5190067B2 - Nt−プロbnpと組み合わせてのct−プロet−1による急性冠症候群の診断および危険性の分類 - Google Patents
Nt−プロbnpと組み合わせてのct−プロet−1による急性冠症候群の診断および危険性の分類 Download PDFInfo
- Publication number
- JP5190067B2 JP5190067B2 JP2009541763A JP2009541763A JP5190067B2 JP 5190067 B2 JP5190067 B2 JP 5190067B2 JP 2009541763 A JP2009541763 A JP 2009541763A JP 2009541763 A JP2009541763 A JP 2009541763A JP 5190067 B2 JP5190067 B2 JP 5190067B2
- Authority
- JP
- Japan
- Prior art keywords
- pro
- myocardial infarction
- acute coronary
- marker
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000004476 Acute Coronary Syndrome Diseases 0.000 title claims description 50
- 238000003745 diagnosis Methods 0.000 title claims description 34
- 108010008126 C-terminal proendothelin-1 Proteins 0.000 title claims description 31
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 title claims description 27
- 102400001263 NT-proBNP Human genes 0.000 title claims description 26
- 238000000034 method Methods 0.000 claims description 81
- 208000010125 myocardial infarction Diseases 0.000 claims description 50
- 239000003550 marker Substances 0.000 claims description 32
- 206010000891 acute myocardial infarction Diseases 0.000 claims description 31
- 206010002383 Angina Pectoris Diseases 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 25
- 238000005259 measurement Methods 0.000 claims description 23
- 238000004393 prognosis Methods 0.000 claims description 14
- 102100034296 Natriuretic peptides A Human genes 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 12
- 230000000747 cardiac effect Effects 0.000 claims description 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 9
- 102100032752 C-reactive protein Human genes 0.000 claims description 9
- 239000002934 diuretic Substances 0.000 claims description 9
- 230000001452 natriuretic effect Effects 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 7
- 101800004490 Endothelin-1 Proteins 0.000 claims description 6
- 102000004903 Troponin Human genes 0.000 claims description 6
- 108090001027 Troponin Proteins 0.000 claims description 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 6
- 230000000302 ischemic effect Effects 0.000 claims description 6
- 230000002644 neurohormonal effect Effects 0.000 claims description 6
- 108010012004 proadrenomedullin Proteins 0.000 claims description 6
- 102000034567 proadrenomedullin Human genes 0.000 claims description 6
- 101710187800 Natriuretic peptides A Proteins 0.000 claims description 5
- 229940088597 hormone Drugs 0.000 claims description 5
- 239000005556 hormone Substances 0.000 claims description 5
- 230000002757 inflammatory effect Effects 0.000 claims description 5
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 108010063738 Interleukins Proteins 0.000 claims description 4
- 102000015696 Interleukins Human genes 0.000 claims description 4
- 108010062374 Myoglobin Proteins 0.000 claims description 4
- 102000036675 Myoglobin Human genes 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 239000013610 patient sample Substances 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical group OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 3
- 101800000285 Big gastrin Proteins 0.000 claims description 3
- 102000004420 Creatine Kinase Human genes 0.000 claims description 3
- 108010042126 Creatine kinase Proteins 0.000 claims description 3
- 102400000686 Endothelin-1 Human genes 0.000 claims description 3
- 102000004862 Gastrin releasing peptide Human genes 0.000 claims description 3
- 108090001005 Interleukin-6 Proteins 0.000 claims description 3
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims description 3
- 102000016267 Leptin Human genes 0.000 claims description 3
- 108010092277 Leptin Proteins 0.000 claims description 3
- 102400000569 Myeloperoxidase Human genes 0.000 claims description 3
- 108090000235 Myeloperoxidases Proteins 0.000 claims description 3
- 102100028427 Pro-neuropeptide Y Human genes 0.000 claims description 3
- 108010048233 Procalcitonin Proteins 0.000 claims description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 3
- 230000001154 acute effect Effects 0.000 claims description 3
- 229940047122 interleukins Drugs 0.000 claims description 3
- 229940039781 leptin Drugs 0.000 claims description 3
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 3
- RZIMNEGTIDYAGZ-HNSJZBNRSA-N pro-gastrin Chemical compound N([C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C(=O)[C@@H]1CCC(=O)N1 RZIMNEGTIDYAGZ-HNSJZBNRSA-N 0.000 claims description 3
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims description 3
- 108010088603 proneuropeptide Y Proteins 0.000 claims description 3
- 108010001670 prosomatostatin Proteins 0.000 claims description 3
- GGYTXJNZMFRSLX-UHFFFAOYSA-N prosomatostatin Chemical compound C1CCC(C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC2C(NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C4=CC=CC=C4NC=3)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(C(=O)NC(CO)C(=O)NC(CSSC2)C(O)=O)C(C)O)C(C)O)=O)N1C(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO GGYTXJNZMFRSLX-UHFFFAOYSA-N 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 claims description 2
- 239000000683 Pro-Opiomelanocortin Substances 0.000 claims description 2
- 102100027467 Pro-opiomelanocortin Human genes 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 108010072272 proendothelin 1 Proteins 0.000 claims description 2
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims 6
- -1 NT-proANP Proteins 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 17
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 230000034994 death Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 230000004064 dysfunction Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010008479 Chest Pain Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 102100036836 Natriuretic peptides B Human genes 0.000 description 3
- 101710187802 Natriuretic peptides B Proteins 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 238000003748 differential diagnosis Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 108050009340 Endothelin Proteins 0.000 description 2
- 102000002045 Endothelin Human genes 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 102000004987 Troponin T Human genes 0.000 description 2
- 108090001108 Troponin T Proteins 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 206010002388 Angina unstable Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010008364 Melanocortins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020001621 Natriuretic Peptide Proteins 0.000 description 1
- 102000004571 Natriuretic peptide Human genes 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 102000013394 Troponin I Human genes 0.000 description 1
- 108010065729 Troponin I Proteins 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003150 biochemical marker Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000012125 lateral flow test Methods 0.000 description 1
- 230000029226 lipidation Effects 0.000 description 1
- 239000002865 melanocortin Substances 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000000692 natriuretic peptide Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000013146 percutaneous coronary intervention Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000004092 self-diagnosis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006060835.6 | 2006-12-22 | ||
| DE102006060835A DE102006060835A1 (de) | 2006-12-22 | 2006-12-22 | Diagnose und Risikostratifizierung des akuten Koronarsyndroms mittels CT-proET-1 in Kombination mit NT-proBNP |
| PCT/DE2007/002313 WO2008077396A1 (de) | 2006-12-22 | 2007-12-22 | Diagnose und risikostratifizierung des akuten koronarsyndroms mittels ct-proet-1 in kombination mit nt-probnp |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513880A JP2010513880A (ja) | 2010-04-30 |
| JP2010513880A5 JP2010513880A5 (enExample) | 2011-11-24 |
| JP5190067B2 true JP5190067B2 (ja) | 2013-04-24 |
Family
ID=39410311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541763A Expired - Fee Related JP5190067B2 (ja) | 2006-12-22 | 2007-12-22 | Nt−プロbnpと組み合わせてのct−プロet−1による急性冠症候群の診断および危険性の分類 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8524463B2 (enExample) |
| EP (1) | EP2122365B1 (enExample) |
| JP (1) | JP5190067B2 (enExample) |
| CN (1) | CN101646945B (enExample) |
| DE (1) | DE102006060835A1 (enExample) |
| ES (1) | ES2399931T3 (enExample) |
| WO (1) | WO2008077396A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| EP2016394A4 (en) | 2006-04-04 | 2013-04-24 | Singulex Inc | METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| DE102007021443A1 (de) * | 2007-05-08 | 2008-11-13 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels NT-proET-1 |
| CN102428368B (zh) * | 2009-05-05 | 2015-04-22 | B.R.A.H.M.S有限公司 | 患有内皮功能/功能障碍相关疾病的患者的基于血管活性激素的分层 |
| AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
| US20120321595A1 (en) | 2009-11-09 | 2012-12-20 | The Brigham And Women's Hospital, Inc. | Treatment of heart disease |
| WO2013013758A1 (en) | 2011-07-28 | 2013-01-31 | B.R.A.H.M.S. Gmbh | Mid-regional pro-atrial natriuretic peptide (pro-anp) for the identification patients with atrial fibrillation with an onset of less than 48 hours ago |
| US20140206632A1 (en) * | 2013-01-22 | 2014-07-24 | Singulex, Inc. | Endothelin in the Diagnosis of Cardiac Disease |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327228C (zh) * | 1999-01-29 | 2007-07-18 | 罗赫诊断器材股份有限公司 | 鉴定样品中的n-末端前bnp的方法 |
| AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| MXPA03004105A (es) | 2002-05-14 | 2004-10-15 | Hoffmann La Roche | Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores. |
| AU2003302132B2 (en) * | 2002-11-21 | 2008-02-21 | Inverness Medical Switzerland Gmbh | Bodily fluid markers of tissue hypoxia |
| GB0227179D0 (en) * | 2002-11-21 | 2002-12-24 | Univ Leicester | Bodily fluid markers of tissue hypoxia |
| DE10351238A1 (de) * | 2003-11-03 | 2005-06-02 | Roche Diagnostics Gmbh | Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern |
| ATE312351T1 (de) | 2004-02-13 | 2005-12-15 | Brahms Ag | Verfahren zur bestimmung der bildung von endothelinen zu zwecken der medizinischen diagnostik, sowie antikörper und kits für die durchführung eines solchen verfahrens |
| ES2300681T3 (es) * | 2004-07-22 | 2008-06-16 | Brahms Aktiengesellschaft | Procedimiento para el diagnostico y tratamiento de pacientes criticos con endotelina, agonistas de endotelina y antagonistas de adrenomedulina. |
-
2006
- 2006-12-22 DE DE102006060835A patent/DE102006060835A1/de not_active Withdrawn
-
2007
- 2007-12-22 JP JP2009541763A patent/JP5190067B2/ja not_active Expired - Fee Related
- 2007-12-22 WO PCT/DE2007/002313 patent/WO2008077396A1/de not_active Ceased
- 2007-12-22 EP EP07856155A patent/EP2122365B1/de active Active
- 2007-12-22 ES ES07856155T patent/ES2399931T3/es active Active
- 2007-12-22 US US12/520,166 patent/US8524463B2/en not_active Expired - Fee Related
- 2007-12-22 CN CN200780050549.XA patent/CN101646945B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100151504A1 (en) | 2010-06-17 |
| CN101646945A (zh) | 2010-02-10 |
| EP2122365B1 (de) | 2012-12-19 |
| US8524463B2 (en) | 2013-09-03 |
| DE102006060835A1 (de) | 2008-06-26 |
| EP2122365A1 (de) | 2009-11-25 |
| CN101646945B (zh) | 2014-06-04 |
| WO2008077396A1 (de) | 2008-07-03 |
| ES2399931T3 (es) | 2013-04-04 |
| JP2010513880A (ja) | 2010-04-30 |
| HK1140547A1 (en) | 2010-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5190067B2 (ja) | Nt−プロbnpと組み合わせてのct−プロet−1による急性冠症候群の診断および危険性の分類 | |
| US7608418B2 (en) | NT-proANP and NT-proBNP for diagnosing cardiac diseases | |
| JP5320294B2 (ja) | プロバソプレシンまたはその断片および部分ペプチド、特にコペプチンまたはニューロフィジンiiを使用する、急性冠動脈症候群についてのリスク層化 | |
| US8465941B2 (en) | Procalcitonin-based diagnosis of infections or inflammatory diseases of the respiratory tract in a patient with heart failure | |
| JP5584473B2 (ja) | Nyhai患者についての心機能不全の診断および危険性層化のためのナトリウム利尿ペプチドのインビトロ決定 | |
| WO2006087373A1 (en) | Use of nt-proanp/nt-probnp ratio for diagnosing cardiac dysfunctions | |
| JP2010507786A5 (enExample) | ||
| CN107064525A (zh) | 用于测定患有心脏病或被怀疑发生或患有心脏病的患者中的氨基末端proANP的方法 | |
| JP2004037455A (ja) | マーカーの組み合わせを用いた心臓疾患症例の予後判定 | |
| JP6441885B2 (ja) | 脳卒中診断のためのNT−proANP及びNT−proBNP | |
| CN101517415A (zh) | 根据gdf-15评价心脏介入风险的工具与方法 | |
| JP6412085B2 (ja) | トロポニンおよびbnpに基づく発作のリスク患者および原因の診断 | |
| JP2010513880A5 (enExample) | ||
| WO2009087190A1 (en) | Means and methods for assessing the risk of patients presenting to emergency units based on gdf-15 | |
| JP5715641B2 (ja) | 急性胸痛を伴い、心筋梗塞を伴わない患者において、心虚血を診断およびモニターするための方法 | |
| KR20210044257A (ko) | 심방 세동의 평가에서의 순환 bmp10 (골형성 단백질 10) | |
| Hammarsten et al. | Copeptin: A new peptide in clinical measurement | |
| Samsudin et al. | Utility of Copeptin in acute Myocardial Infarction | |
| Pratiwi et al. | UJI DIAGNOSTIK NT pro NATRIURETIC PEPTIDE (NTpro BNP) GAGAL JANTUNG KONGESTIF | |
| HK1140547B (en) | Diagnosis and risk classification of acute coronary syndrome by means of ct-proet-1 in combination with nt-probnp | |
| HK1167273B (en) | Detection of bacterial infections in subjects suffering from dyspnea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20101005 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20101005 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110930 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120323 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120329 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120417 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20120515 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120628 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120705 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20121001 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20121227 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130125 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160201 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5190067 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |