CN101646945B - 利用CT-proET-1与NT-proBNP的组合进行急性冠状动脉综合征的诊断和风险分层 - Google Patents

利用CT-proET-1与NT-proBNP的组合进行急性冠状动脉综合征的诊断和风险分层 Download PDF

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CN101646945B
CN101646945B CN200780050549.XA CN200780050549A CN101646945B CN 101646945 B CN101646945 B CN 101646945B CN 200780050549 A CN200780050549 A CN 200780050549A CN 101646945 B CN101646945 B CN 101646945B
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probnp
proet
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CN101646945A (zh
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A·博格曼
N·莫根塔勒
J·帕帕索提里奥
J·斯塔克
L·L·恩格
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BRAHMS GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

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  • Urology & Nephrology (AREA)
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  • Biotechnology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
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  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN200780050549.XA 2006-12-22 2007-12-22 利用CT-proET-1与NT-proBNP的组合进行急性冠状动脉综合征的诊断和风险分层 Expired - Fee Related CN101646945B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006060835.6 2006-12-22
DE102006060835A DE102006060835A1 (de) 2006-12-22 2006-12-22 Diagnose und Risikostratifizierung des akuten Koronarsyndroms mittels CT-proET-1 in Kombination mit NT-proBNP
PCT/DE2007/002313 WO2008077396A1 (de) 2006-12-22 2007-12-22 Diagnose und risikostratifizierung des akuten koronarsyndroms mittels ct-proet-1 in kombination mit nt-probnp

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CN101646945A CN101646945A (zh) 2010-02-10
CN101646945B true CN101646945B (zh) 2014-06-04

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US (1) US8524463B2 (enExample)
EP (1) EP2122365B1 (enExample)
JP (1) JP5190067B2 (enExample)
CN (1) CN101646945B (enExample)
DE (1) DE102006060835A1 (enExample)
ES (1) ES2399931T3 (enExample)
WO (1) WO2008077396A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906857B2 (en) * 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
EP2016394A4 (en) 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
DE102007021443A1 (de) * 2007-05-08 2008-11-13 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels NT-proET-1
CN102428368B (zh) * 2009-05-05 2015-04-22 B.R.A.H.M.S有限公司 患有内皮功能/功能障碍相关疾病的患者的基于血管活性激素的分层
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
WO2013013758A1 (en) 2011-07-28 2013-01-31 B.R.A.H.M.S. Gmbh Mid-regional pro-atrial natriuretic peptide (pro-anp) for the identification patients with atrial fibrillation with an onset of less than 48 hours ago
US20140206632A1 (en) * 2013-01-22 2014-07-24 Singulex, Inc. Endothelin in the Diagnosis of Cardiac Disease
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1339107A (zh) * 1999-01-29 2002-03-06 罗赫诊断器材股份有限公司 鉴定n－末端前bnp的方法
CN1459633A (zh) * 2002-05-14 2003-12-03 弗·哈夫曼-拉罗切有限公司 使用标记组合在心脏疾病的情况下作出预后判断
WO2005078456A1 (de) * 2004-02-13 2005-08-25 B.R.A.H.M.S. Aktiengesellschaft Verfahren zur bestimmung der bildung von endothelinen zu zwecken der medizinischen diagnostik, sowie antikörper und kits für die durchführung eines solchen verfahrens
CN1742205A (zh) * 2002-11-21 2006-03-01 因沃耐斯瑞士医学有限公司 组织缺氧的体液指标

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
AU2003302132B2 (en) * 2002-11-21 2008-02-21 Inverness Medical Switzerland Gmbh Bodily fluid markers of tissue hypoxia
DE10351238A1 (de) * 2003-11-03 2005-06-02 Roche Diagnostics Gmbh Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern
ES2300681T3 (es) * 2004-07-22 2008-06-16 Brahms Aktiengesellschaft Procedimiento para el diagnostico y tratamiento de pacientes criticos con endotelina, agonistas de endotelina y antagonistas de adrenomedulina.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1339107A (zh) * 1999-01-29 2002-03-06 罗赫诊断器材股份有限公司 鉴定n－末端前bnp的方法
CN1459633A (zh) * 2002-05-14 2003-12-03 弗·哈夫曼-拉罗切有限公司 使用标记组合在心脏疾病的情况下作出预后判断
CN1742205A (zh) * 2002-11-21 2006-03-01 因沃耐斯瑞士医学有限公司 组织缺氧的体液指标
WO2005078456A1 (de) * 2004-02-13 2005-08-25 B.R.A.H.M.S. Aktiengesellschaft Verfahren zur bestimmung der bildung von endothelinen zu zwecken der medizinischen diagnostik, sowie antikörper und kits für die durchführung eines solchen verfahrens

Also Published As

Publication number Publication date
US20100151504A1 (en) 2010-06-17
CN101646945A (zh) 2010-02-10
EP2122365B1 (de) 2012-12-19
US8524463B2 (en) 2013-09-03
DE102006060835A1 (de) 2008-06-26
EP2122365A1 (de) 2009-11-25
WO2008077396A1 (de) 2008-07-03
ES2399931T3 (es) 2013-04-04
JP2010513880A (ja) 2010-04-30
HK1140547A1 (en) 2010-10-15
JP5190067B2 (ja) 2013-04-24

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