JP5179583B2 - 時間分割アンペロメトリを用いる被分析物濃度の測定システム及び測定方法 - Google Patents
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
Description
Claims (10)
- 被分析物を分析する方法(200)であって、
前記被分析物を含有する液体サンプルに励起電圧を印加するステップ(210)と、
前記励起電圧を印加した後の第1の時間セグメントの間に第1の電流を測定するステップ(220)と、
を含んで構成され、
前記励起電圧を印加した後の第2の時間セグメントの間に第2の電流を測定するステップ(250)と、
測定された前記第1の電流と、前記第1の時間セグメントに関連する第1の較正データ群と、に基づいて、複数の第1の被分析物濃度を算出するステップ(280)と、
測定された前記第2の電流と、前記第2の時間セグメントに関連する第2の較正データ群と、に基づいて、複数の第2の被分析物濃度を算出するステップ(280)と、
前記第1の被分析物濃度のうち少なくとも1つと、前記第2の被分析物濃度のうち少なくとも1つと、に基づいて、最終被分析物濃度を決定するステップ(290)と、
を更に含んで構成され、
前記第1の較正データ群及び前記第2の較正データ群は、それぞれ、異なるヘマトクリット値に関連する、分析方法。 - 前記励起電圧を印加した後の第3の時間セグメントの間に第3の電流を測定するステップと、
測定された前記第3の電流と、前記第3の時間セグメントに関連する第3の較正データ群と、に基づいて、複数の第3の被分析物濃度を算出するステップと、
前記第1の被分析物濃度及び前記第2の被分析物濃度のうち少なくとも1つと、前記第3の被分析物濃度のうち少なくとも1つと、に基づいて、最終被分析物濃度を決定するステップと、
を更に含んで構成される、請求項1記載の分析方法。 - 前記液体サンプルは、グルコースオキシダーゼ及びグルコースデヒドロゲナーゼの少なくとも一方を含む酵素と、フェリシアン化カリウム及びヘキサアンミンルテニウムの少なく一方を含むメディエータと、を含有する、請求項1記載の分析方法。
- 液体中の被分析物を分析するシステム(100)であって、
前記被分析物を含有する液体サンプルに励起電圧を印加するように構成される電極群(22,24)と、
前記励起電圧を印加した後の第1の時間セグメントの間に第1の電流を測定する(220)ように構成されるプロセッサと、
を含んで構成され、
前記プロセッサは、
前記励起電圧を印加した後の第2の時間セグメントの間に第2の電流を測定し(250)、
測定された前記第1の電流と、前記第1の時間セグメントに関連する複数の第1の較正曲線と、に基づいて、複数の第1の被分析物濃度を算出し(280)、
測定された前記第2の電流と、前記第2の時間セグメントに関連する複数の第2の較正曲線と、に基づいて、複数の第2の被分析物濃度を算出し(280)、かつ、
前記第1の被分析物濃度のうち少なくとも1つと、前記第2の被分析物濃度のうち少なくとも1つと、に基づいて、最終被分析物濃度を決定する(290)
ように更に構成され、
前記複数の第1の較正曲線及び前記複数の第2の較正曲線は、それぞれ、異なるヘマトクリット値に関連する、分析システム。 - 前記分析システムは、前記最終被分析物濃度を表す値を表示するように更に構成される、請求項4記載の分析システム。
- 前記励起電圧を印加した後の第3の時間セグメントの間に第3の電流を測定し、
測定された前記第3の電流と、前記第3の時間セグメントに関連する複数の第3の較正曲線と、に基づいて、複数の第3の被分析物濃度を算出し、かつ、
前記第1の被分析物濃度及び前記第2の被分析物濃度のうち少なくとも1つと、前記第3の被分析物濃度のうち少なくとも1つと、に基づいて、最終被分析物濃度を決定する
ように構成されるプロセッサを、
更に含んで構成される、請求項4記載の分析システム。 - 前記被分析物はグルコースであり、前記液体サンプルは血液を含む、請求項4記載の分析システム。
- 前記液体サンプルは、グルコースオキシダーゼ及びグルコースデヒドロゲナーゼの少なくとも一方を含む酵素と、フェリシアン化カリウム及びヘキサアンミンルテニウムの少なく一方を含むメディエータと、を含有する、請求項4記載の分析システム。
- 前記電極群がテストストリップ(10)に収容された、請求項4記載の分析システム。
- 前記プロセッサが測定器に収容された、請求項4記載の分析システム。
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US95207607P | 2007-07-26 | 2007-07-26 | |
US60/952,076 | 2007-07-26 | ||
PCT/US2008/071132 WO2009015319A1 (en) | 2007-07-26 | 2008-07-25 | System and methods for determination of analyte concentration using time resolved amperometry |
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JP2010518401A Active JP5604298B2 (ja) | 2007-07-26 | 2008-07-25 | 時間分解電流測定法を用いて被分析物の濃度を測定する方法及びシステム |
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US (2) | US8088272B2 (ja) |
EP (2) | EP2176652B1 (ja) |
JP (2) | JP5179583B2 (ja) |
AT (1) | ATE523777T1 (ja) |
AU (2) | AU2008279070B2 (ja) |
BR (2) | BRPI0814201A2 (ja) |
MX (3) | MX2010000971A (ja) |
TW (2) | TW200916774A (ja) |
WO (2) | WO2009015319A1 (ja) |
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WO2005078118A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
KR101577176B1 (ko) | 2005-09-30 | 2015-12-14 | 바이엘 헬스케어 엘엘씨 | 게이트형 전압 전류 측정 분석물 결정 방법 |
BRPI0814201A2 (pt) * | 2007-07-26 | 2015-01-27 | Home Diagnostics Inc | Sistema e método de análise de produto de análise em amostra fluida e meio legível em computador |
US8101062B2 (en) * | 2007-07-26 | 2012-01-24 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
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AU2008279070B2 (en) | 2012-12-13 |
EP2176652B1 (en) | 2014-04-23 |
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JP2010534839A (ja) | 2010-11-11 |
WO2009015316A1 (en) | 2009-01-29 |
EP2176653B1 (en) | 2011-09-07 |
TWI453401B (zh) | 2014-09-21 |
WO2009015319A1 (en) | 2009-01-29 |
AU2008279070A1 (en) | 2009-01-29 |
EP2176652A1 (en) | 2010-04-21 |
MX340856B (es) | 2016-07-28 |
BRPI0814202A2 (pt) | 2015-01-27 |
TW200914820A (en) | 2009-04-01 |
JP2010534838A (ja) | 2010-11-11 |
US8088272B2 (en) | 2012-01-03 |
TW200916774A (en) | 2009-04-16 |
EP2176653A1 (en) | 2010-04-21 |
JP5604298B2 (ja) | 2014-10-08 |
BRPI0814202B1 (pt) | 2019-10-29 |
US20090076738A1 (en) | 2009-03-19 |
MX2010000972A (es) | 2010-03-01 |
US20090101523A1 (en) | 2009-04-23 |
ATE523777T1 (de) | 2011-09-15 |
AU2008279067A1 (en) | 2009-01-29 |
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